JP2016516449A5 - - Google Patents
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- Publication number
- JP2016516449A5 JP2016516449A5 JP2016512364A JP2016512364A JP2016516449A5 JP 2016516449 A5 JP2016516449 A5 JP 2016516449A5 JP 2016512364 A JP2016512364 A JP 2016512364A JP 2016512364 A JP2016512364 A JP 2016512364A JP 2016516449 A5 JP2016516449 A5 JP 2016516449A5
- Authority
- JP
- Japan
- Prior art keywords
- sample
- hla allele
- maternal
- exon
- allele
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108700028369 Alleles Proteins 0.000 claims 35
- 238000000034 method Methods 0.000 claims 30
- 230000008774 maternal effect Effects 0.000 claims 27
- 230000001605 fetal effect Effects 0.000 claims 15
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 239000008280 blood Substances 0.000 claims 8
- 210000004369 blood Anatomy 0.000 claims 8
- 201000011461 pre-eclampsia Diseases 0.000 claims 6
- 210000003754 fetus Anatomy 0.000 claims 5
- 239000000061 acid fraction Substances 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 238000012163 sequencing technique Methods 0.000 claims 4
- 108091093088 Amplicon Proteins 0.000 claims 2
- 208000031404 Chromosome Aberrations Diseases 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 2
- 230000002759 chromosomal effect Effects 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 101100284398 Bos taurus BoLA-DQB gene Proteins 0.000 claims 1
- 206010008805 Chromosomal abnormalities Diseases 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 230000004544 DNA amplification Effects 0.000 claims 1
- 101150034979 DRB3 gene Proteins 0.000 claims 1
- 101150082328 DRB5 gene Proteins 0.000 claims 1
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 claims 1
- 102100028976 HLA class I histocompatibility antigen, B alpha chain Human genes 0.000 claims 1
- 102100028971 HLA class I histocompatibility antigen, C alpha chain Human genes 0.000 claims 1
- 108010075704 HLA-A Antigens Proteins 0.000 claims 1
- 108010058607 HLA-B Antigens Proteins 0.000 claims 1
- 108010052199 HLA-C Antigens Proteins 0.000 claims 1
- 101001100327 Homo sapiens RNA-binding protein 45 Proteins 0.000 claims 1
- 101100278514 Oryza sativa subsp. japonica DRB2 gene Proteins 0.000 claims 1
- 101100117565 Oryza sativa subsp. japonica DRB4 gene Proteins 0.000 claims 1
- 101100117569 Oryza sativa subsp. japonica DRB6 gene Proteins 0.000 claims 1
- 102100038823 RNA-binding protein 45 Human genes 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 238000007847 digital PCR Methods 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361821620P | 2013-05-09 | 2013-05-09 | |
| US61/821,620 | 2013-05-09 | ||
| US201361861316P | 2013-08-01 | 2013-08-01 | |
| US61/861,316 | 2013-08-01 | ||
| PCT/EP2014/059348 WO2014180910A1 (en) | 2013-05-09 | 2014-05-07 | Method of determining the fraction of fetal dna in maternal blood using hla markers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016516449A JP2016516449A (ja) | 2016-06-09 |
| JP2016516449A5 true JP2016516449A5 (enExample) | 2017-06-08 |
Family
ID=50680043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016512364A Pending JP2016516449A (ja) | 2013-05-09 | 2014-05-07 | Ｈｌａマーカーを使用する母体血液中の胎児ｄｎａ分率の決定方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20150203914A1 (enExample) |
| EP (1) | EP2994538A1 (enExample) |
| JP (1) | JP2016516449A (enExample) |
| CN (1) | CN105189787A (enExample) |
| CA (1) | CA2909479A1 (enExample) |
| WO (1) | WO2014180910A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10131947B2 (en) * | 2011-01-25 | 2018-11-20 | Ariosa Diagnostics, Inc. | Noninvasive detection of fetal aneuploidy in egg donor pregnancies |
| CN108256296B (zh) * | 2017-12-29 | 2021-05-25 | 北京科迅生物技术有限公司 | 数据处理装置 |
| RU2681488C1 (ru) * | 2018-04-19 | 2019-03-06 | Федеральное государственное бюджетное образовательное учреждение дополнительного профессионального образования "Российская медицинская академия непрерывного профессионального образования" Министерства здравоохранения Российской Федерации | Способ прогнозирования состояния плода человека накануне родов |
| WO2021026828A1 (zh) * | 2019-08-14 | 2021-02-18 | 深圳华大基因股份有限公司 | 确定孕妇血液中胎儿核酸浓度的方法及设备 |
| PL445283A1 (pl) * | 2023-06-20 | 2024-12-23 | Instytut Centrum Zdrowia Matki Polki | Sposób nieinwazyjnej analizy płodowego DNA oraz frakcji płodu z wykorzystaniem reakcji multipleks digital PCR |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9620209D0 (en) | 1996-09-27 | 1996-11-13 | Cemu Bioteknik Ab | Method of sequencing DNA |
| GB9626815D0 (en) | 1996-12-23 | 1997-02-12 | Cemu Bioteknik Ab | Method of sequencing DNA |
| GB9704444D0 (en) | 1997-03-04 | 1997-04-23 | Isis Innovation | Non-invasive prenatal diagnosis |
| US6274320B1 (en) | 1999-09-16 | 2001-08-14 | Curagen Corporation | Method of sequencing a nucleic acid |
| EP1599608A4 (en) * | 2003-03-05 | 2007-07-18 | Genetic Technologies Ltd | Identification of fetal DNA and fetal cell marker in maternal plasma or serum |
| US7867703B2 (en) | 2004-08-26 | 2011-01-11 | Agilent Technologies, Inc. | Element defined sequence complexity reduction |
| US8383338B2 (en) | 2006-04-24 | 2013-02-26 | Roche Nimblegen, Inc. | Methods and systems for uniform enrichment of genomic regions |
| US8262900B2 (en) | 2006-12-14 | 2012-09-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
| US8315817B2 (en) | 2007-01-26 | 2012-11-20 | Illumina, Inc. | Independently removable nucleic acid sequencing system and method |
| EP2126765B1 (en) | 2007-01-26 | 2011-08-24 | Illumina Inc. | Nucleic acid sequencing system and method |
| JP2011500041A (ja) * | 2007-10-16 | 2011-01-06 | エフ．ホフマン−ラ ロシュ アーゲー | クローナルシークエンシングによる高分解能かつ高効率のｈｌａ遺伝子型決定法 |
| US20100261189A1 (en) * | 2008-10-03 | 2010-10-14 | Roche Molecular Systems, Inc. | System and method for detection of HLA Variants |
| HUE061110T2 (hu) * | 2009-11-05 | 2023-05-28 | Univ Hong Kong Chinese | Magzati genomelemzés anyai biológiai mintából |
| WO2012078792A2 (en) * | 2010-12-07 | 2012-06-14 | Stanford University | Non-invasive determination of fetal inheritance of parental haplotypes at the genome-wide scale |
-
2014
- 2014-05-07 CA CA2909479A patent/CA2909479A1/en not_active Abandoned
- 2014-05-07 EP EP14722211.1A patent/EP2994538A1/en not_active Withdrawn
- 2014-05-07 WO PCT/EP2014/059348 patent/WO2014180910A1/en not_active Ceased
- 2014-05-07 JP JP2016512364A patent/JP2016516449A/ja active Pending
- 2014-05-07 CN CN201480026232.2A patent/CN105189787A/zh active Pending
- 2014-05-09 US US14/273,763 patent/US20150203914A1/en not_active Abandoned
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