JP2016516449A - Ｈｌａマーカーを使用する母体血液中の胎児ｄｎａ分率の決定方法 - Google Patents

Ｈｌａマーカーを使用する母体血液中の胎児ｄｎａ分率の決定方法 Download PDF

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JP2016516449A
JP2016516449A JP2016512364A JP2016512364A JP2016516449A JP 2016516449 A JP2016516449 A JP 2016516449A JP 2016512364 A JP2016512364 A JP 2016512364A JP 2016512364 A JP2016512364 A JP 2016512364A JP 2016516449 A JP2016516449 A JP 2016516449A
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exon
hla
maternal
allele
sample
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JP2016516449A5 (enExample
Inventor
エー．エーリッヒ ヘンリー
エー．エーリッヒ ヘンリー
ホグランド ブライアン
ホグランド ブライアン
ホルコム シェリー
ホルコム シェリー
ムーンサミー プリシラ
ムーンサミー プリシラ
ニュートン ニコラス
ニュートン ニコラス
ラストロウ メリンダ
ラストロウ メリンダ
ツァン アリソン
ツァン アリソン
シェーンブルナー ナンシー
シェーンブルナー ナンシー
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of JP2016516449A publication Critical patent/JP2016516449A/ja
Publication of JP2016516449A5 publication Critical patent/JP2016516449A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2016512364A 2013-05-09 2014-05-07 Ｈｌａマーカーを使用する母体血液中の胎児ｄｎａ分率の決定方法 Pending JP2016516449A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361821620P 2013-05-09 2013-05-09
US61/821,620 2013-05-09
US201361861316P 2013-08-01 2013-08-01
US61/861,316 2013-08-01
PCT/EP2014/059348 WO2014180910A1 (en) 2013-05-09 2014-05-07 Method of determining the fraction of fetal dna in maternal blood using hla markers

Publications (2)

Publication Number Publication Date
JP2016516449A true JP2016516449A (ja) 2016-06-09
JP2016516449A5 JP2016516449A5 (enExample) 2017-06-08

Family

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Family Applications (1)

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JP2016512364A Pending JP2016516449A (ja) 2013-05-09 2014-05-07 Ｈｌａマーカーを使用する母体血液中の胎児ｄｎａ分率の決定方法

Country Status (6)

Country Link
US (1) US20150203914A1 (enExample)
EP (1) EP2994538A1 (enExample)
JP (1) JP2016516449A (enExample)
CN (1) CN105189787A (enExample)
CA (1) CA2909479A1 (enExample)
WO (1) WO2014180910A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10131947B2 (en) * 2011-01-25 2018-11-20 Ariosa Diagnostics, Inc. Noninvasive detection of fetal aneuploidy in egg donor pregnancies
CN108256296B (zh) * 2017-12-29 2021-05-25 北京科迅生物技术有限公司 数据处理装置
RU2681488C1 (ru) * 2018-04-19 2019-03-06 Федеральное государственное бюджетное образовательное учреждение дополнительного профессионального образования "Российская медицинская академия непрерывного профессионального образования" Министерства здравоохранения Российской Федерации Способ прогнозирования состояния плода человека накануне родов
WO2021026828A1 (zh) * 2019-08-14 2021-02-18 深圳华大基因股份有限公司 确定孕妇血液中胎儿核酸浓度的方法及设备
PL445283A1 (pl) * 2023-06-20 2024-12-23 Instytut Centrum Zdrowia Matki Polki Sposób nieinwazyjnej analizy płodowego DNA oraz frakcji płodu z wykorzystaniem reakcji multipleks digital PCR

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070134658A1 (en) * 2003-03-05 2007-06-14 Genetic Technologies Limited, A.C.N. 009 212 328 Identification of fetal dna and fetal cell markers in maternal plasma or serum
JP2011500041A (ja) * 2007-10-16 2011-01-06 エフ．ホフマン−ラ ロシュ アーゲー クローナルシークエンシングによる高分解能かつ高効率のｈｌａ遺伝子型決定法
US20120196754A1 (en) * 2010-12-07 2012-08-02 Stanford University Non-invasive determination of fetal inheritance of parental haplotypes at the genome-wide scale

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
GB9626815D0 (en) 1996-12-23 1997-02-12 Cemu Bioteknik Ab Method of sequencing DNA
GB9704444D0 (en) 1997-03-04 1997-04-23 Isis Innovation Non-invasive prenatal diagnosis
US6274320B1 (en) 1999-09-16 2001-08-14 Curagen Corporation Method of sequencing a nucleic acid
US7867703B2 (en) 2004-08-26 2011-01-11 Agilent Technologies, Inc. Element defined sequence complexity reduction
US8383338B2 (en) 2006-04-24 2013-02-26 Roche Nimblegen, Inc. Methods and systems for uniform enrichment of genomic regions
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8315817B2 (en) 2007-01-26 2012-11-20 Illumina, Inc. Independently removable nucleic acid sequencing system and method
EP2126765B1 (en) 2007-01-26 2011-08-24 Illumina Inc. Nucleic acid sequencing system and method
US20100261189A1 (en) * 2008-10-03 2010-10-14 Roche Molecular Systems, Inc. System and method for detection of HLA Variants
HUE061110T2 (hu) * 2009-11-05 2023-05-28 Univ Hong Kong Chinese Magzati genomelemzés anyai biológiai mintából

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070134658A1 (en) * 2003-03-05 2007-06-14 Genetic Technologies Limited, A.C.N. 009 212 328 Identification of fetal dna and fetal cell markers in maternal plasma or serum
JP2011500041A (ja) * 2007-10-16 2011-01-06 エフ．ホフマン−ラ ロシュ アーゲー クローナルシークエンシングによる高分解能かつ高効率のｈｌａ遺伝子型決定法
US20120196754A1 (en) * 2010-12-07 2012-08-02 Stanford University Non-invasive determination of fetal inheritance of parental haplotypes at the genome-wide scale

Also Published As

Publication number Publication date
CA2909479A1 (en) 2014-11-13
US20150203914A1 (en) 2015-07-23
WO2014180910A1 (en) 2014-11-13
EP2994538A1 (en) 2016-03-16
CN105189787A (zh) 2015-12-23

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