JP2016516055A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016516055A5 JP2016516055A5 JP2016503023A JP2016503023A JP2016516055A5 JP 2016516055 A5 JP2016516055 A5 JP 2016516055A5 JP 2016503023 A JP2016503023 A JP 2016503023A JP 2016503023 A JP2016503023 A JP 2016503023A JP 2016516055 A5 JP2016516055 A5 JP 2016516055A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- methyl
- ylsulfonyl
- antibiotic
- dichlorophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 1- (thiophen-2-yl) cyclopentyl Chemical group 0.000 claims 205
- 230000003115 biocidal Effects 0.000 claims 36
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 30
- 239000003242 anti bacterial agent Substances 0.000 claims 26
- 230000002708 enhancing Effects 0.000 claims 22
- 239000003623 enhancer Substances 0.000 claims 21
- 239000003112 inhibitor Substances 0.000 claims 20
- 230000002401 inhibitory effect Effects 0.000 claims 20
- 229940064005 Antibiotic throat preparations Drugs 0.000 claims 11
- 229940083879 Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Drugs 0.000 claims 11
- 229940042052 Antibiotics for systemic use Drugs 0.000 claims 11
- 229940042786 Antitubercular Antibiotics Drugs 0.000 claims 11
- 229940093922 Gynecological Antibiotics Drugs 0.000 claims 11
- 229940024982 Topical Antifungal Antibiotics Drugs 0.000 claims 11
- 229940079866 intestinal antibiotics Drugs 0.000 claims 11
- 229940005935 ophthalmologic Antibiotics Drugs 0.000 claims 11
- UWYHMGVUTGAWSP-JKIFEVAISA-N Oxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=CC=CC=C1 UWYHMGVUTGAWSP-JKIFEVAISA-N 0.000 claims 9
- 125000001309 chloro group Chemical group Cl* 0.000 claims 9
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 9
- 229960001019 oxacillin Drugs 0.000 claims 9
- 206010041925 Staphylococcal infection Diseases 0.000 claims 7
- 125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 claims 6
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 6
- 125000005809 3,4,5-trimethoxyphenyl group Chemical group [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims 6
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims 6
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 6
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 6
- 150000001412 amines Chemical class 0.000 claims 6
- 125000004244 benzofuran-2-yl group Chemical group [H]C1=C(*)OC2=C([H])C([H])=C([H])C([H])=C12 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 6
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims 3
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 3
- 125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims 3
- NNWUEBIEOFQMSS-UHFFFAOYSA-N 2-methylpiperidine Chemical compound CC1CCCCN1 NNWUEBIEOFQMSS-UHFFFAOYSA-N 0.000 claims 3
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims 3
- FSEXLNMNADBYJU-UHFFFAOYSA-N 2-phenylquinoline Chemical compound C1=CC=CC=C1C1=CC=C(C=CC=C2)C2=N1 FSEXLNMNADBYJU-UHFFFAOYSA-N 0.000 claims 3
- 125000006275 3-bromophenyl group Chemical group [H]C1=C([H])C(Br)=C([H])C(*)=C1[H] 0.000 claims 3
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 3
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 3
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims 3
- 125000002528 4-isopropyl benzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])*)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
- 125000004217 4-methoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])* 0.000 claims 3
- 125000004863 4-trifluoromethoxyphenyl group Chemical group [H]C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1* 0.000 claims 3
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 3
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
- 239000004305 biphenyl Substances 0.000 claims 3
- 125000000319 biphenyl-4-yl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 3
- 125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 238000002347 injection Methods 0.000 claims 3
- 239000007924 injection Substances 0.000 claims 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 claims 3
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims 3
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
- 229940002612 prodrugs Drugs 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
- 206010014665 Endocarditis Diseases 0.000 claims 2
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims 2
- 229950009506 Penicillinase Drugs 0.000 claims 2
- 108010087702 Penicillinase Proteins 0.000 claims 2
- 210000003491 Skin Anatomy 0.000 claims 2
- 229940076185 Staphylococcus aureus Drugs 0.000 claims 2
- 241000191967 Staphylococcus aureus Species 0.000 claims 2
- 239000003782 beta lactam antibiotic agent Substances 0.000 claims 2
- 238000001361 intraarterial administration Methods 0.000 claims 2
- 238000007918 intramuscular administration Methods 0.000 claims 2
- 229960003085 meticillin Drugs 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000000699 topical Effects 0.000 claims 2
- 239000002132 β-lactam antibiotic Substances 0.000 claims 2
- 206010060968 Arthritis infective Diseases 0.000 claims 1
- 206010060945 Bacterial infection Diseases 0.000 claims 1
- 210000004556 Brain Anatomy 0.000 claims 1
- 210000004289 Cerebral Ventricles Anatomy 0.000 claims 1
- LQOLIRLGBULYKD-JKIFEVAISA-N Cloxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=CC=CC=C1Cl LQOLIRLGBULYKD-JKIFEVAISA-N 0.000 claims 1
- YFAGHNZHGGCZAX-JKIFEVAISA-N Dicloxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=C(Cl)C=CC=C1Cl YFAGHNZHGGCZAX-JKIFEVAISA-N 0.000 claims 1
- 229940095399 Enema Drugs 0.000 claims 1
- 241000792859 Enema Species 0.000 claims 1
- 229960004273 Floxacillin Drugs 0.000 claims 1
- UIOFUWFRIANQPC-JKIFEVAISA-N Floxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=C(F)C=CC=C1Cl UIOFUWFRIANQPC-JKIFEVAISA-N 0.000 claims 1
- 210000001035 Gastrointestinal Tract Anatomy 0.000 claims 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims 1
- 210000004400 Mucous Membrane Anatomy 0.000 claims 1
- GPXLMGHLHQJAGZ-JTDSTZFVSA-N Nafcillin Chemical compound C1=CC=CC2=C(C(=O)N[C@@H]3C(N4[C@H](C(C)(C)S[C@@H]43)C(O)=O)=O)C(OCC)=CC=C21 GPXLMGHLHQJAGZ-JTDSTZFVSA-N 0.000 claims 1
- JQXXHWHPUNPDRT-ZNQWNCHJSA-N O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)Nc2c(O)c3c(O)c4C)C)OC)c4c1c3c(O)c2C=NN1CCN(C)CC1 Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)Nc2c(O)c3c(O)c4C)C)OC)c4c1c3c(O)c2C=NN1CCN(C)CC1 JQXXHWHPUNPDRT-ZNQWNCHJSA-N 0.000 claims 1
- 206010031252 Osteomyelitis Diseases 0.000 claims 1
- 206010035664 Pneumonia Diseases 0.000 claims 1
- 210000000664 Rectum Anatomy 0.000 claims 1
- 229940081190 Rifampin Drugs 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 206010062255 Soft tissue infection Diseases 0.000 claims 1
- 108010088160 Staphylococcal Protein A Proteins 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 230000001580 bacterial Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229960003326 cloxacillin Drugs 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229960001585 dicloxacillin Drugs 0.000 claims 1
- 239000003221 ear drop Substances 0.000 claims 1
- 230000002500 effect on skin Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000007920 enema Substances 0.000 claims 1
- 230000001747 exhibiting Effects 0.000 claims 1
- 229960005394 flucloxacillin Drugs 0.000 claims 1
- 238000005755 formation reaction Methods 0.000 claims 1
- 229960002518 gentamicin Drugs 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000010253 intravenous injection Methods 0.000 claims 1
- 238000007914 intraventricular administration Methods 0.000 claims 1
- 201000009906 meningitis Diseases 0.000 claims 1
- 229960000515 nafcillin Drugs 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 229960001225 rifampicin Drugs 0.000 claims 1
- 201000009890 sinusitis Diseases 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 210000001519 tissues Anatomy 0.000 claims 1
- 229960005486 vaccines Drugs 0.000 claims 1
- 0 *C(Nc1nc(-c2ccccn2)c[s]1)=O Chemical compound *C(Nc1nc(-c2ccccn2)c[s]1)=O 0.000 description 1
- IBXXUUCWLNVTPQ-UHFFFAOYSA-N Oc1ccc(C2(CCCCC2)c2cc(Br)ccc2)cc1 Chemical compound Oc1ccc(C2(CCCCC2)c2cc(Br)ccc2)cc1 IBXXUUCWLNVTPQ-UHFFFAOYSA-N 0.000 description 1
Claims (20)
- ïŒïœïŒæçç©è³ªãåã³
ïŒïœïŒæçç©è³ªå¢åŒ·å€
ã®çµåããå«ãããããŠçèææçã®æå¶å€ã§ãã£ãŠã
åèšæå¶å€ãããããŠçèææçã«çœ¹ã£ãŠãã察象ããæãã¯ãããŠçèææçã«çœ¹ãå±éºæ§ããã察象ã«æäžããã
åèšæçç©è³ªå¢åŒ·å€ãã次åŒïŒ
ïŒåŒäžãïŒããâïŒïŒâã¯ãããã§ããã·ïŒã¡ãã«ãïŒâïŒããªãã§ã³âïŒâã€ã«ïŒã·ã¯ããã³ãã«ãïŒïŒïŒïŒïŒïŒïŒâããã©ãããããã¿ã¬ã³âïŒâã€ã«ãïŒâã€ãœãããã«âïŒïŒšâãã©ãŸãŒã«âïŒâã€ã«ãïŒâïŒããªãã§ã³âïŒâã€ã«ïŒãããªã³âïŒâã€ã«ãïŒïŒïŒâãžããããã³ãŸïŒ»ïœïŒœïŒ»ïŒïŒïŒïŒœãžãªãã·ã³âïŒâã€ã«ãïŒïŒïŒâãžã¯ãããã§ãã«ãïŒïŒïŒâãžã¯ãããã§ãã«ãïŒïŒïŒâãžã¯ããããªãã§ã³âïŒâã€ã«ãïŒïŒïŒâãžãã«ãªããã§ãã«ãïŒâããã¢ããªãã§ã³âïŒâã€ã«ãïŒâã¯ããããªãã§ã³âïŒâã€ã«ãïŒâãããã«ãïŒâãã§ããã·ãã§ãã«ãïŒâãã§ãã«ãããªã³âïŒâã€ã«ãïŒâããªã«ãïŒâïŒïŒâã¯ãããã§ãã«ïŒâïŒâã¡ãã«ã€ãœãªããµãŸãŒã«âïŒâã€ã«ãïŒïŒïŒïŒïŒâããªã¡ããã·ãã§ãã«ãïŒïŒïŒâãžã¯ãããã§ãã«ãïŒïŒïŒâãžã¡ããã·ãã§ãã«ãïŒâããã¢ãã§ãã«ãïŒâã¯ãããã³ãŸïŒ»ïœïŒœããªãã§ã³âïŒâã€ã«ãïŒâã¯ãããã§ãã«ãïŒâãã«ãªããã§ãã«ãïŒâã¡ããã·ãã§ãã«ãïŒâïœâãããã·ãã§ãã«ãïŒâãã§ããã·ãã§ãã«ãïŒâããªã«ãïŒâããªãã«ãªãã¡ãã«ãã§ãã«ãïŒâïŒïŒïŒïŒâãžã¡ãã«ã¢ã«ããªãã¹ã«ããã«ïŒãã§ãã«ãïŒâïŒïŒâãšãã«ãããªãžã³âïŒâã€ã«ã¹ã«ããã«ïŒãã§ãã«ãïŒâïŒïŒâã¡ãã«ãããªãžã³âïŒâã€ã«ã¹ã«ããã«ïŒãã§ãã«ãïŒâïŒïŒâãã§ãã«ãããªã³ïŒãïŒâïŒïŒïŒïŒâãžãããã€ãœãããªã³âïŒïŒïŒïŒšïŒâã€ã«ã¹ã«ããã«ïŒãã§ãã«ãïŒâïŒïŒïŒïŒâãžããããããªã³âïŒïŒïŒïŒšïŒâã€ã«ã¹ã«ããã«ïŒãã§ãã«ãïŒâïŒïŒïŒïŒâãžã¡ãã«ãããªãžã³âïŒâã€ã«ã¹ã«ããã«ïŒãã§ãã«ãïŒâïŒïŒïŒïŒâãžã¡ãã«ãªããµãŸãªãžã³âïŒâã€ã«ã¹ã«ããã«ïŒãã§ãã«ãïŒâïŒã¢ã«ããªãã¹ã«ããã«ïŒãã§ãã«ãïŒâïŒïŒ®ïŒïŒ®âãžã¢ãªã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®ïŒïŒ®âãžãšãã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®ïŒïŒ®âãžã€ãœããã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®ïŒïŒ®âãžã¡ãã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®âãšãã«ââãã³ãžã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®âãšãã«ââïœâããã«âã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®âãšãã«ââãã§ãã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®âã€ãœãããã«ââãã³ãžã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã« ïŒâïŒïŒ®âã¡ãã«ââãã³ãžã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®âã¡ãã«ââã·ã¯ãããã·ã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®âã¡ãã«ââïœâããã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®âã¡ãã«ââãã§ãã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒãããªãžã³âïŒâã€ã«ã¹ã«ããã«ïŒãã§ãã«ãïŒâïŒãããªãžã³âïŒâã€ã«ã¹ã«ããã«ïŒãã§ãã«ãïŒâãã³ãŸã€ã«ãã§ãã«ãïŒâãã³ãžã«ãã§ãã«ãïŒâããã§ãã«ãïŒâã¯ãããã§ãã«ãïŒâãžãã§ãã«ãïŒâãšããã·ãã§ãã«ãïŒâãã«ãªããã§ãã«ãïŒâãã§ããã·ãã§ãã«ãïŒâïœïœ ïœïœâããã«ãã§ãã«ãïŒâã¡ããã·ãã³ãŸãã©ã³âïŒâã€ã«ããã³ãŸïŒ»ïœïŒœãã¢ãŸãŒã«âïŒâã€ã«ããã³ãŸïŒ»ïœïŒœãã¢ãŸãŒã«âïŒâã€ã«ããã³ãŸïŒ»ïœïŒœãã¢ãŸãŒã«âïŒâã€ã«ããã³ãŸãã©ã³âïŒâã€ã«ããžãã§ãã«ã¡ãã«ãã¡ãã«âïŒâãã³ãŸãšãŒãããã§ãã«ãåã¯ããªãã§ã³âïŒâã€ã«ã§ãããã
ïŒããïŒïŒïŒïŒïŒïŒïŒâããã©ãããããã¿ã¬ã³âïŒâã€ã«ãïŒâïŒã¡ãã«ããªïŒãã§ãã«ãïŒïŒïŒâãžãããâïŒïŒïŒâãžãªãã·ã³âïŒâã€ã«ãïŒïŒïŒâãžããããã³ãŸïŒ»ïœïŒœïŒ»ïŒïŒïŒïŒœâãžãªãã·ã³âïŒâã€ã«ãïŒïŒïŒâãžããããã³ãŸïŒ»ïœïŒœïŒ»ïŒïŒïŒïŒœâãžãªãã·ã³âïŒâã€ã«ãïŒïŒïŒâãžã¯ãããã§ãã«ãïŒïŒïŒâãžã¡ããã·ãã§ãã«ãïŒïŒïŒâãžã¡ãã«ãã§ãã«ãïŒïŒïŒâãžã¯ãããã§ãã«ãïŒïŒïŒâãžã¯ããããªãã§ã³âïŒâã€ã« ïŒïŒïŒâãžã¡ãã«ãã§ãã«ãïŒâããã¢ããªãã§ã³âïŒâã€ã«ãïŒâã¯ãããã§ãã«ãïŒâã¯ããããªãã§ã³âïŒâã€ã«ãïŒâã¯ããããªãã§ã³âïŒâã€ã«ãïŒâãã©ãã«ãïŒâã¡ããã·ãã§ãã«ãïŒâããªãžãã«ãïŒâïŒã¡ãã«ããªïŒãã§ãã«ãïŒïŒïŒïŒïŒâããªã¡ããã·ãã§ãã«ãïŒïŒïŒâãžã¡ããã·ãã§ãã«ãïŒïŒïŒâãžã¡ãã«ãã§ãã«ãïŒïŒïŒâãžã¡ããã·ãã§ãã«ãïŒâã¡ããã·ãã§ãã«ãïŒâããªãžãã«ãïŒâã¯ãããã§ãã«ãïŒâïŒã¡ãã«ããªïŒãã§ãã«ãïŒâããã¢ãã§ãã«ãïŒâãšããã·ãã§ãã«ãïŒâãã«ãªããã§ãã«ãïŒâã€ãœãããã«ãã³ãžã«ãïŒâã¡ããã·ãã³ãžã«ãïŒâã¡ããã·ãã§ãã«ãïŒâããªãžãã«ãïŒâããªãã«ãªãã¡ããã·ãã§ãã«ãïŒâãšããã·ãã³ãŸãã©ã³âïŒâã€ã«ãïŒâã¡ããã·ãã³ãŸãã©ã³âïŒâã€ã«ããã³ãŸãã©ã³âïŒâã€ã«ããã³ãžã«ããã§ãã«ãåã¯ããªãã§ã³âïŒâã€ã«ã§ãããïŒ
ã®ååç©ãåã¯æ¬¡ã®æ§é ïŒ
ãæããæçç©è³ªå¢åŒ·å€ãåã¯æ¬¡åŒïŒ
ïŒåŒäžãããïŒâãã§ããã·ãã§ãã«ãïŒâããã¢ããªãã§ã³âïŒâã€ã«ãåã¯ïŒïŒïŒâãžã¯ãããã§ãã«ã§ãããïŒ
ãæããæçç©è³ªå¢åŒ·å€ãåã¯æ¬¡åŒïŒ
ïŒåŒäžããããã«ãªãåã¯ã¯ããã§ãããïŒ
ãæããæçç©è³ªå¢åŒ·å€ãåã¯æ¬¡ã®æ§é ïŒ
ãæããæçç©è³ªå¢åŒ·å€ãåã¯æ¬¡ã®æ§é ïŒ
ãæããæçç©è³ªå¢åŒ·å€ãåã¯æ¬¡ã®æ§é ïŒ
ãæããæçç©è³ªå¢åŒ·å€ãåã¯æ¬¡ã®æ§é ïŒ
ãæããæçç©è³ªå¢åŒ·å€ãåã¯æ¬¡ã®æ§é ïŒ
ãæããæçç©è³ªå¢åŒ·å€ãåã¯æ¬¡ã®æ§é ïŒ
ãæããæçç©è³ªå¢åŒ·å€ãåã¯æ¬¡ã®æ§é ïŒ
ãæããæçç©è³ªå¢åŒ·å€ãåã¯æ¬¡åŒïŒ
ïŒåŒäžãïŒããâïŒïŒâïŒãã§ãã«ã¢ããïŒâââïŒãã§ãã«ïŒã¢ã»ãã¢ããïŒã¢ãã³ãâïŒâïŒïŒ®âïŒïŒ®ââãžã¡ãã«ã¢ãã³ïŒãããã«ã¢ãã³ãâïŒïŒâââãã§ãã«ã¢ã»ãã¢ããïŒã¢ãã³ãåã¯ããããã·ã«ã§ããããïŒããïœïœ ïœïœâããã«ãã€ãœãããã«åã¯ãã§ãã«ã§ããããïŒããæ°ŽçŽ åã¯ã¯ããã§ãããïŒ
ãæããæçç©è³ªå¢åŒ·å€ãåã¯æ¬¡ã®æ§é ïŒ
ãæããæçç©è³ªå¢åŒ·å€ãåã¯æ¬¡åŒïŒ
ïŒåŒäžãããïŒïŒšâã€ã³ããŸãŒã«âïŒâã€ã«ãåã¯ïŒâïŒïŒâã¡ããã·ãã§ããã·ïŒã¡ãã«ãªããµãžã¢ãŸãŒã«âïŒâã€ã«âã¡ãã«ã§ãããïŒ
ãæããæçç©è³ªå¢åŒ·å€ãåã¯æ¬¡åŒïŒ
ïŒåŒäžãïŒåã³ïŒ²ïŒããããããå¥ã ã«æ°ŽçŽ ãã¡ãã«ãã¯ããåã¯ã¡ãã«ããªã§ãããïŒ
ãæããæçç©è³ªå¢åŒ·å€ãåã¯ãã®ãããã©ãã°è¥ããã¯å¹æµãåŸãå¡©ã§ãããåèšæå¶å€ã - æçç©è³ªããããã·ãªããŒãŒèæ§Î²âã©ã¯ã¿ã æçç©è³ªã§ãããè«æ±é ïŒã«èšèŒã®æå¶å€ã
- ããã·ãªããŒãŒèæ§Î²âã©ã¯ã¿ã æçç©è³ªãããªããµã·ãªã³ãã¡ãã·ãªã³ãããã·ãªã³ãã¯ãããµã·ãªã³ããžã¯ãããµã·ãªã³åã¯ãã«ã¯ãããµã·ãªã³ã§ãããè«æ±é ïŒã«èšèŒã®æå¶å€ã
- 察象ãããããŠçèææçã®æ€æ»ãåãã察象ãããããŠçèææçãšèšºæãããŠãã察象ãããããŠçèææçã«çœ¹ãå±éºæ§ããã察象ããæãã¯ãããŠçèææçã®ïŒåã¯ïŒä»¥äžã®çç¶ã瀺ã察象ã§ãããè«æ±é ïŒãïŒã®ããããã«èšèŒã®æå¶å€ã
- ãããŠçèææçããé»è²ãããŠçèãåã¯ã¡ãã·ãªã³èæ§é»è²ãããŠçèïŒïŒïŒ²ïŒ³ïŒ¡ïŒã§ãããè«æ±é ïŒã«èšèŒã®æå¶å€ã
- 察象ããèªç¶åŒã®å¿å èçåã¯äººå·¥åŒã®å¿å èçã«çœ¹ã£ãŠãã察象ããæãã¯çœ¹ãå±éºæ§ããã察象ã§ãããè«æ±é ïŒã«èšèŒã®æå¶å€ã
- æçç©è³ªãããªããµã·ãªã³ã§ãããåèšãªããµã·ãªã³ããïŒãïŒæéæ¯ã«ïŒãïŒïœã®çšéã§ã察象ã®éèå ã«æäžããããè«æ±é ïŒã«èšèŒã®æå¶å€ã
- 察象ããé¢ç¯ææçãé«èçã骚é«çãèºçãæè¡çãå¯éŒ»è çãåã¯ç®èè¥ããã¯è»çµç¹ææçã«çœ¹ã£ãŠãã察象ããæãã¯çœ¹ãå±éºæ§ããã察象ã§ãããè«æ±é ïŒã«èšèŒã®æå¶å€ã
- æçç©è³ªãããªããµã·ãªã³ã§ããã
åèšãªããµã·ãªã³ããïŒãïŒæéæ¯ã«ïŒãïŒïœã®çšéã§ã察象ã®éèå è¥ããã¯çèå ã«æäžãããããæãã¯
åèšãªããµã·ãªã³ããïŒãïŒæéæ¯ã«ïŒïŒïŒïœïœãïŒïœã®çšéã§ã察象ã®çµå£ã§æäžããããè«æ±é ïŒã«èšèŒã®æå¶å€ã - è¿çã®åœ¢æè¥ããã¯çºçãäœæžããäœçšãåã¯å¯Ÿè±¡ã«ããã现èéãäœæžããäœçšãæãããè«æ±é ïŒã«èšèŒã®æå¶å€ã
- ã²ã³ã¿ãã€ã·ã³åã¯ãªãã¡ã³ãã³ã§ãã第ïŒã®æçç©è³ªãããã«çµã¿åãããŠå«ããè«æ±é ïŒã«èšèŒã®æå¶å€ã
- æçç©è³ªããïŒïŒïŒïœïœïŒïœïœãïŒïŒïœïœïŒïœïœã®çšéã§æäžããããåã³ïŒåã¯
æçç©è³ªå¢åŒ·å€ããïŒïŒïŒïœïœïŒïœïœãïŒïŒïŒïœïœïŒïœïœã®çšéã§æäžããããè«æ±é ïŒã«èšèŒã®æå¶å€ã - 察象ããå°å æ£è ã§ãããè«æ±é ïŒïŒã«èšèŒã®æå¶å€ã
- æçç©è³ªãããªããµã·ãªã³ã§ããã
åèšãªããµã·ãªã³ããïŒãïŒïŒæéæ¯ã«ïŒïŒïœïœïŒïœïœãïŒïŒïœïœïŒïœïœã®çšéã§ãå°å æ£è ã®éèå è¥ããã¯çèå ã«æäžãããããæãã¯
åèšãªããµã·ãªã³ããïŒæéæ¯ã«ïŒïŒïŒïŒïœïœïŒïœïœã®çšéã§ãå°å æ£è ã®çµå£ã§æäžããããè«æ±é ïŒïŒã«èšèŒã®æå¶å€ã - 察象ãžã®æäžããçµå£ãèäžãåäžãæ¶å管ãçŽè žãç®èäžïŒå±æïŒãç®å ãç®äžãçµéŒ»ãéèå ãåèå ãçèå ãå¿èå ã骚å ãããèäžãè ¹è å ãèè±è å ãç¡åäœå ã海綿äœå ãè£å ãåå®®å ã硬èå€ãè³å ãè³å®€å ãå±æãçµè žãåã¯éçµå£æäžãç®èäžãžã®å¡åžãåžå ¥ãæµ£è žãç¹çŒãç¹è³ãç²èããã®åžåãå£ãçµèæ é€ãã¥ãŒããçµåäºæè žæ é€ãã¥ãŒããåå€ãéèå ãžã®æ³šå°ãåèå ãžã®æ³šå°ã骚é«å ãžã®æ³šå°ãçèçµç¹å ãžã®æ³šå°ãè³å ãžã®æ³šå°ãè³å®€ç³»å ãžã®æ³šå°ãåã¯ç®äžãžã®æ³šå°ã«ãããè«æ±é ïŒã«èšèŒã®æå¶å€ã
- æçç©è³ªåã³æçç©è³ªå¢åŒ·å€ããåäžçµæç©äžã§æäžãããããæãã¯åæã«æäžããããè«æ±é ïŒã«èšèŒã®æå¶å€ã
- æçç©è³ªããæçç©è³ªå¢åŒ·å€ã®æäžã®æ倧ïŒïŒæéåã«æäžãããããæçç©è³ªå¢åŒ·å€ããæçç©è³ªã®æäžã®æ倧ïŒïŒæéåã«æäžãããããæãã¯æçç©è³ªåã³æçç©è³ªå¢åŒ·å€ããçžäºã®ïŒïŒæé以å ã«æäžããããè«æ±é ïŒã«èšèŒã®æå¶å€ã
- æçç©è³ªãšã
ïŒåŒäžãïŒããâïŒïŒâã¯ãããã§ããã·ïŒã¡ãã«ãïŒâïŒããªãã§ã³âïŒâã€ã«ïŒã·ã¯ããã³ãã«ãïŒïŒïŒïŒïŒïŒïŒâããã©ãããããã¿ã¬ã³âïŒâã€ã«ãïŒâã€ãœãããã«âïŒïŒšâãã©ãŸãŒã«âïŒâã€ã«ãïŒâïŒããªãã§ã³âïŒâã€ã«ïŒãããªã³âïŒâã€ã«ãïŒïŒïŒâãžããããã³ãŸïŒ»ïœïŒœïŒ»ïŒïŒïŒïŒœãžãªãã·ã³âïŒâã€ã«ãïŒïŒïŒâãžã¯ãããã§ãã«ãïŒïŒïŒâãžã¯ãããã§ãã«ãïŒïŒïŒâãžã¯ããããªãã§ã³âïŒâã€ã«ãïŒïŒïŒâãžãã«ãªããã§ãã«ãïŒâããã¢ããªãã§ã³âïŒâã€ã«ãïŒâã¯ããããªãã§ã³âïŒâã€ã«ãïŒâãããã«ãïŒâãã§ããã·ãã§ãã«ãïŒâãã§ãã«ãããªã³âïŒâã€ã«ãïŒâããªã«ãïŒâïŒïŒâã¯ãããã§ãã«ïŒâïŒâã¡ãã«ã€ãœãªããµãŸãŒã«âïŒâã€ã«ãïŒïŒïŒïŒïŒâããªã¡ããã·ãã§ãã«ãïŒïŒïŒâãžã¯ãããã§ãã«ãïŒïŒïŒâãžã¡ããã·ãã§ãã«ãïŒâããã¢ãã§ãã«ãïŒâã¯ãããã³ãŸïŒ»ïœïŒœããªãã§ã³âïŒâã€ã«ãïŒâã¯ãããã§ãã«ãïŒâãã«ãªããã§ãã«ãïŒâã¡ããã·ãã§ãã«ãïŒâïœâãããã·ãã§ãã«ãïŒâãã§ããã·ãã§ãã«ãïŒâããªã«ãïŒâããªãã«ãªãã¡ãã«ãã§ãã«ãïŒâïŒïŒïŒïŒâãžã¡ãã«ã¢ã«ããªãã¹ã«ããã«ïŒãã§ãã«ãïŒâïŒïŒâãšãã«ãããªãžã³âïŒâã€ã«ã¹ã«ããã«ïŒãã§ãã«ãïŒâïŒïŒâã¡ãã«ãããªãžã³âïŒâã€ã«ã¹ã«ããã«ïŒãã§ãã«ãïŒâïŒïŒâãã§ãã«ãããªã³ïŒãïŒâïŒïŒïŒïŒâãžãããã€ãœãããªã³âïŒïŒïŒïŒšïŒâã€ã«ã¹ã«ããã«ïŒãã§ãã«ãïŒâïŒïŒïŒïŒâãžããããããªã³âïŒïŒïŒïŒšïŒâã€ã«ã¹ã«ããã«ïŒãã§ãã«ãïŒâïŒïŒïŒïŒâãžã¡ãã«ãããªãžã³âïŒâã€ã«ã¹ã«ããã«ïŒãã§ãã«ãïŒâïŒïŒïŒïŒâãžã¡ãã«ãªããµãŸãªãžã³âïŒâã€ã«ã¹ã«ããã«ïŒãã§ãã«ãïŒâïŒã¢ã«ããªãã¹ã«ããã«ïŒãã§ãã«ãïŒâïŒïŒ®ïŒïŒ®âãžã¢ãªã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®ïŒïŒ®âãžãšãã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®ïŒïŒ®âãžã€ãœããã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®ïŒïŒ®âãžã¡ãã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®âãšãã«ââãã³ãžã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®âãšãã«ââïœâããã«âã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®âãšãã«ââãã§ãã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®âã€ãœãããã«ââãã³ãžã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã« ïŒâïŒïŒ®âã¡ãã«ââãã³ãžã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®âã¡ãã«ââã·ã¯ãããã·ã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®âã¡ãã«ââïœâããã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®âã¡ãã«ââãã§ãã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒãããªãžã³âïŒâã€ã«ã¹ã«ããã«ïŒãã§ãã«ãïŒâïŒãããªãžã³âïŒâã€ã«ã¹ã«ããã«ïŒãã§ãã«ãïŒâãã³ãŸã€ã«ãã§ãã«ãïŒâãã³ãžã«ãã§ãã«ãïŒâããã§ãã«ãïŒâã¯ãããã§ãã«ãïŒâãžãã§ãã«ãïŒâãšããã·ãã§ãã«ãïŒâãã«ãªããã§ãã«ãïŒâãã§ããã·ãã§ãã«ãïŒâïœïœ ïœïœâããã«ãã§ãã«ãïŒâã¡ããã·ãã³ãŸãã©ã³âïŒâã€ã«ããã³ãŸïŒ»ïœïŒœãã¢ãŸãŒã«âïŒâã€ã«ããã³ãŸïŒ»ïœïŒœãã¢ãŸãŒã«âïŒâã€ã«ããã³ãŸïŒ»ïœïŒœãã¢ãŸãŒã«âïŒâã€ã«ããã³ãŸãã©ã³âïŒâã€ã«ããžãã§ãã«ã¡ãã«ãã¡ãã«âïŒâãã³ãŸãšãŒãããã§ãã«ãåã¯ããªãã§ã³âïŒâã€ã«ã§ãããã
ïŒããïŒïŒïŒïŒïŒïŒïŒâããã©ãããããã¿ã¬ã³âïŒâã€ã«ãïŒâïŒã¡ãã«ããªïŒãã§ãã«ãïŒïŒïŒâãžãããâïŒïŒïŒâãžãªãã·ã³âïŒâã€ã«ãïŒïŒïŒâãžããããã³ãŸïŒ»ïœïŒœïŒ»ïŒïŒïŒïŒœâãžãªãã·ã³âïŒâã€ã«ãïŒïŒïŒâãžããããã³ãŸïŒ»ïœïŒœïŒ»ïŒïŒïŒïŒœâãžãªãã·ã³âïŒâã€ã«ãïŒïŒïŒâãžã¯ãããã§ãã«ãïŒïŒïŒâãžã¡ããã·ãã§ãã«ãïŒïŒïŒâãžã¡ãã«ãã§ãã«ãïŒïŒïŒâãžã¯ãããã§ãã«ãïŒïŒïŒâãžã¯ããããªãã§ã³âïŒâã€ã« ïŒïŒïŒâãžã¡ãã«ãã§ãã«ãïŒâããã¢ããªãã§ã³âïŒâã€ã«ãïŒâã¯ãããã§ãã«ãïŒâã¯ããããªãã§ã³âïŒâã€ã«ãïŒâã¯ããããªãã§ã³âïŒâã€ã«ãïŒâãã©ãã«ãïŒâã¡ããã·ãã§ãã«ãïŒâããªãžãã«ãïŒâïŒã¡ãã«ããªïŒãã§ãã«ãïŒïŒïŒïŒïŒâããªã¡ããã·ãã§ãã«ãïŒïŒïŒâãžã¡ããã·ãã§ãã«ãïŒïŒïŒâãžã¡ãã«ãã§ãã«ãïŒïŒïŒâãžã¡ããã·ãã§ãã«ãïŒâã¡ããã·ãã§ãã«ãïŒâããªãžãã«ãïŒâã¯ãããã§ãã«ãïŒâïŒã¡ãã«ããªïŒãã§ãã«ãïŒâããã¢ãã§ãã«ãïŒâãšããã·ãã§ãã«ãïŒâãã«ãªããã§ãã«ãïŒâã€ãœãããã«ãã³ãžã«ãïŒâã¡ããã·ãã³ãžã«ãïŒâã¡ããã·ãã§ãã«ãïŒâããªãžãã«ãïŒâããªãã«ãªãã¡ããã·ãã§ãã«ãïŒâãšããã·ãã³ãŸãã©ã³âïŒâã€ã«ãïŒâã¡ããã·ãã³ãŸãã©ã³âïŒâã€ã«ããã³ãŸãã©ã³âïŒâã€ã«ããã³ãžã«ããã§ãã«ãåã¯ããªãã§ã³âïŒâã€ã«ã§ãããïŒ
ïŒåŒäžãããïŒâãã§ããã·ãã§ãã«ãïŒâããã¢ããªãã§ã³âïŒâã€ã«ãè¥ããã¯ïŒïŒïŒâãžã¯ãããã§ãã«ã§ãããïŒã
ïŒåŒäžããããã«ãªãè¥ããã¯ã¯ããã§ãããïŒã
ïŒåŒäžãïŒããâïŒïŒâïŒãã§ãã«ã¢ããïŒâââïŒãã§ãã«ïŒã¢ã»ãã¢ããïŒã¢ãã³ãâïŒâïŒïŒ®âïŒïŒ®ââãžã¡ãã«ã¢ãã³ïŒãããã«ã¢ãã³ãâïŒïŒâââãã§ãã«ã¢ã»ãã¢ããïŒã¢ãã³ãè¥ããã¯ããããã·ã«ã§ããããïŒããïœïœ ïœïœâããã«ãã€ãœãããã«è¥ããã¯ãã§ãã«ã§ããããïŒããæ°ŽçŽ åã¯ã¯ããã§ãããïŒã
ïŒåŒäžãããïŒïŒšâã€ã³ããŸãŒã«âïŒâã€ã«ãè¥ããã¯ïŒâïŒïŒâã¡ããã·ãã§ããã·ïŒã¡ãã«ãªããµãžã¢ãŸãŒã«âïŒâã€ã«âã¡ãã«ã§ãããïŒãåã³
ïŒåŒäžãïŒåã³ïŒ²ïŒããããããå¥ã ã«æ°ŽçŽ ãã¡ãã«ãã¯ããè¥ããã¯ã¡ãã«ããªã§ãããïŒ
ãããªã矀ããéžæãããååç©ãåã¯ãã®ãããã©ãã°è¥ããã¯å¹æµãåŸãå¡©ãšãå«ãå»è¬çµæç©ã - ãããªãæçç©è³ªããããŠçèã¯ã¯ãã³çµæç©ãåã³ïŒåã¯ç¬¬ïŒã®ãããŠçèã¿ã³ãã¯è³ªã«ç¹ç°çã«çµåããããªãããããããã«å«ããè«æ±é ïŒïŒã«èšèŒã®å»è¬çµæç©ã
- æçç©è³ªãå«ãè¬åŠçã«èš±å®¹ãããçµæç©ãšã
ïŒåŒäžãïŒããâïŒïŒâã¯ãããã§ããã·ïŒã¡ãã«ãïŒâïŒããªãã§ã³âïŒâã€ã«ïŒã·ã¯ããã³ãã«ãïŒïŒïŒïŒïŒïŒïŒâããã©ãããããã¿ã¬ã³âïŒâã€ã«ãïŒâã€ãœãããã«âïŒïŒšâãã©ãŸãŒã«âïŒâã€ã«ãïŒâïŒããªãã§ã³âïŒâã€ã«ïŒãããªã³âïŒâã€ã«ãïŒïŒïŒâãžããããã³ãŸïŒ»ïœïŒœïŒ»ïŒïŒïŒïŒœãžãªãã·ã³âïŒâã€ã«ãïŒïŒïŒâãžã¯ãããã§ãã«ãïŒïŒïŒâãžã¯ãããã§ãã«ãïŒïŒïŒâãžã¯ããããªãã§ã³âïŒâã€ã«ãïŒïŒïŒâãžãã«ãªããã§ãã«ãïŒâããã¢ããªãã§ã³âïŒâã€ã«ãïŒâã¯ããããªãã§ã³âïŒâã€ã«ãïŒâãããã«ãïŒâãã§ããã·ãã§ãã«ãïŒâãã§ãã«ãããªã³âïŒâã€ã«ãïŒâããªã«ãïŒâïŒïŒâã¯ãããã§ãã«ïŒâïŒâã¡ãã«ã€ãœãªããµãŸãŒã«âïŒâã€ã«ãïŒïŒïŒïŒïŒâããªã¡ããã·ãã§ãã«ãïŒïŒïŒâãžã¯ãããã§ãã«ãïŒïŒïŒâãžã¡ããã·ãã§ãã«ãïŒâããã¢ãã§ãã«ãïŒâã¯ãããã³ãŸïŒ»ïœïŒœããªãã§ã³âïŒâã€ã«ãïŒâã¯ãããã§ãã«ãïŒâãã«ãªããã§ãã«ãïŒâã¡ããã·ãã§ãã«ãïŒâïœâãããã·ãã§ãã«ãïŒâãã§ããã·ãã§ãã«ãïŒâããªã«ãïŒâããªãã«ãªãã¡ãã«ãã§ãã«ãïŒâïŒïŒïŒïŒâãžã¡ãã«ã¢ã«ããªãã¹ã«ããã«ïŒãã§ãã«ãïŒâïŒïŒâãšãã«ãããªãžã³âïŒâã€ã«ã¹ã«ããã«ïŒãã§ãã«ãïŒâïŒïŒâã¡ãã«ãããªãžã³âïŒâã€ã«ã¹ã«ããã«ïŒãã§ãã«ãïŒâïŒïŒâãã§ãã«ãããªã³ïŒãïŒâïŒïŒïŒïŒâãžãããã€ãœãããªã³âïŒïŒïŒïŒšïŒâã€ã«ã¹ã«ããã«ïŒãã§ãã«ãïŒâïŒïŒïŒïŒâãžããããããªã³âïŒïŒïŒïŒšïŒâã€ã«ã¹ã«ããã«ïŒãã§ãã«ãïŒâïŒïŒïŒïŒâãžã¡ãã«ãããªãžã³âïŒâã€ã«ã¹ã«ããã«ïŒãã§ãã«ãïŒâïŒïŒïŒïŒâãžã¡ãã«ãªããµãŸãªãžã³âïŒâã€ã«ã¹ã«ããã«ïŒãã§ãã«ãïŒâïŒã¢ã«ããªãã¹ã«ããã«ïŒãã§ãã«ãïŒâïŒïŒ®ïŒïŒ®âãžã¢ãªã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®ïŒïŒ®âãžãšãã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®ïŒïŒ®âãžã€ãœããã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®ïŒïŒ®âãžã¡ãã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®âãšãã«ââãã³ãžã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®âãšãã«ââïœâããã«âã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®âãšãã«ââãã§ãã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®âã€ãœãããã«ââãã³ãžã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã« ïŒâïŒïŒ®âã¡ãã«ââãã³ãžã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®âã¡ãã«ââã·ã¯ãããã·ã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®âã¡ãã«ââïœâããã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒïŒ®âã¡ãã«ââãã§ãã«ã¹ã«ãã¡ã¢ã€ã«ïŒãã§ãã«ãïŒâïŒãããªãžã³âïŒâã€ã«ã¹ã«ããã«ïŒãã§ãã«ãïŒâïŒãããªãžã³âïŒâã€ã«ã¹ã«ããã«ïŒãã§ãã«ãïŒâãã³ãŸã€ã«ãã§ãã«ãïŒâãã³ãžã«ãã§ãã«ãïŒâããã§ãã«ãïŒâã¯ãããã§ãã«ãïŒâãžãã§ãã«ãïŒâãšããã·ãã§ãã«ãïŒâãã«ãªããã§ãã«ãïŒâãã§ããã·ãã§ãã«ãïŒâïœïœ ïœïœâããã«ãã§ãã«ãïŒâã¡ããã·ãã³ãŸãã©ã³âïŒâã€ã«ããã³ãŸïŒ»ïœïŒœãã¢ãŸãŒã«âïŒâã€ã«ããã³ãŸïŒ»ïœïŒœãã¢ãŸãŒã«âïŒâã€ã«ããã³ãŸïŒ»ïœïŒœãã¢ãŸãŒã«âïŒâã€ã«ããã³ãŸãã©ã³âïŒâã€ã«ããžãã§ãã«ã¡ãã«ãã¡ãã«âïŒâãã³ãŸãšãŒãããã§ãã«ãåã¯ããªãã§ã³âïŒâã€ã«ã§ãããã
ïŒããïŒïŒïŒïŒïŒïŒïŒâããã©ãããããã¿ã¬ã³âïŒâã€ã«ãïŒâïŒã¡ãã«ããªïŒãã§ãã«ãïŒïŒïŒâãžãããâïŒïŒïŒâãžãªãã·ã³âïŒâã€ã«ãïŒïŒïŒâãžããããã³ãŸïŒ»ïœïŒœïŒ»ïŒïŒïŒïŒœâãžãªãã·ã³âïŒâã€ã«ãïŒïŒïŒâãžããããã³ãŸïŒ»ïœïŒœïŒ»ïŒïŒïŒïŒœâãžãªãã·ã³âïŒâã€ã«ãïŒïŒïŒâãžã¯ãããã§ãã«ãïŒïŒïŒâãžã¡ããã·ãã§ãã«ãïŒïŒïŒâãžã¡ãã«ãã§ãã«ãïŒïŒïŒâãžã¯ãããã§ãã«ãïŒïŒïŒâãžã¯ããããªãã§ã³âïŒâã€ã« ïŒïŒïŒâãžã¡ãã«ãã§ãã«ãïŒâããã¢ããªãã§ã³âïŒâã€ã«ãïŒâã¯ãããã§ãã«ãïŒâã¯ããããªãã§ã³âïŒâã€ã«ãïŒâã¯ããããªãã§ã³âïŒâã€ã«ãïŒâãã©ãã«ãïŒâã¡ããã·ãã§ãã«ãïŒâããªãžãã«ãïŒâïŒã¡ãã«ããªïŒãã§ãã«ãïŒïŒïŒïŒïŒâããªã¡ããã·ãã§ãã«ãïŒïŒïŒâãžã¡ããã·ãã§ãã«ãïŒïŒïŒâãžã¡ãã«ãã§ãã«ãïŒïŒïŒâãžã¡ããã·ãã§ãã«ãïŒâã¡ããã·ãã§ãã«ãïŒâããªãžãã«ãïŒâã¯ãããã§ãã«ãïŒâïŒã¡ãã«ããªïŒãã§ãã«ãïŒâããã¢ãã§ãã«ãïŒâãšããã·ãã§ãã«ãïŒâãã«ãªããã§ãã«ãïŒâã€ãœãããã«ãã³ãžã«ãïŒâã¡ããã·ãã³ãžã«ãïŒâã¡ããã·ãã§ãã«ãïŒâããªãžãã«ãïŒâããªãã«ãªãã¡ããã·ãã§ãã«ãïŒâãšããã·ãã³ãŸãã©ã³âïŒâã€ã«ãïŒâã¡ããã·ãã³ãŸãã©ã³âïŒâã€ã«ããã³ãŸãã©ã³âïŒâã€ã«ããã³ãžã«ããã§ãã«ãåã¯ããªãã§ã³âïŒâã€ã«ã§ãããïŒã
ïŒåŒäžãããïŒâãã§ããã·ãã§ãã«ãïŒâããã¢ããªãã§ã³âïŒâã€ã«ãè¥ããã¯ïŒïŒïŒâãžã¯ãããã§ãã«ã§ãããïŒã
ïŒåŒäžããããã«ãªãè¥ããã¯ã¯ããã§ãããïŒã
ïŒåŒäžãïŒããâïŒïŒâïŒãã§ãã«ã¢ããïŒâââïŒãã§ãã«ïŒã¢ã»ãã¢ããïŒã¢ãã³ãâïŒâïŒïŒ®âïŒïŒ®ââãžã¡ãã«ã¢ãã³ïŒãããã«ã¢ãã³ãâïŒïŒâââãã§ãã«ã¢ã»ãã¢ããïŒã¢ãã³ãè¥ããã¯ããããã·ã«ã§ããããïŒããïœïœ ïœïœâããã«ãã€ãœãããã«è¥ããã¯ãã§ãã«ã§ããããïŒããæ°ŽçŽ åã¯ã¯ããã§ãããïŒã
ïŒåŒäžãããïŒïŒšâã€ã³ããŸãŒã«âïŒâã€ã«ãè¥ããã¯ïŒâïŒïŒâã¡ããã·ãã§ããã·ïŒã¡ãã«ãªããµãžã¢ãŸãŒã«âïŒâã€ã«âã¡ãã«ã§ãããïŒãåã³
ïŒåŒäžãïŒåã³ïŒ²ïŒããããããå¥ã ã«æ°ŽçŽ ãã¡ãã«ãã¯ããè¥ããã¯ã¡ãã«ããªã§ãããïŒã
ãããªã矀ããéžæãããæçç©è³ªå¢åŒ·å€ãåã¯ãã®ãããã©ãã°è¥ããã¯å¹æµãåŸãå¡©ãå«ãè¬åŠçã«èš±å®¹ãããçµæç©ãšãå«ãã现èææçãæ²»çããããã®ç³»ã
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361789716P | 2013-03-15 | 2013-03-15 | |
US61/789,716 | 2013-03-15 | ||
PCT/US2014/029237 WO2014144710A1 (en) | 2013-03-15 | 2014-03-14 | Methods and compositions for bacteria infections |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2016516055A JP2016516055A (ja) | 2016-06-02 |
JP2016516055A5 true JP2016516055A5 (ja) | 2017-04-20 |
Family
ID=51537766
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016503023A Pending JP2016516055A (ja) | 2013-03-15 | 2014-03-14 | 现èææçã«å¯Ÿããæ¹æ³åã³çµæç© |
Country Status (4)
Country | Link |
---|---|
US (2) | US9675592B2 (ja) |
EP (1) | EP2969003A4 (ja) |
JP (1) | JP2016516055A (ja) |
WO (1) | WO2014144710A1 (ja) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018177871A1 (de) * | 2017-03-30 | 2018-10-04 | Bayer Cropscience Aktiengesellschaft | Substituierte n-(1,3,4-oxadiazol-2-yl)arylcarbonsÀureamide und ihre verwendung als herbizide |
JP7408064B2 (ja) * | 2017-08-21 | 2024-01-05 | ãã€ã¯ããã€ãªãã£ãã¯ã¹ïŒ ã€ã³ã¯ïŒ | æèå€ãšããŠæçšãªä»£è¬çã«å®å®ããïœïŒã¢ã·ã«ã¢ãããªããµãžã¢ãŸãŒã« |
WO2019199496A1 (en) * | 2018-04-12 | 2019-10-17 | Purdue Research Foundation | Benzamide antibacterial agents |
CN109503510B (zh) * | 2019-01-03 | 2020-07-03 | å±±äžå€§åŠ | äžç§é²éŸæèçå»åç±»ååç©åå ¶å¶å€æ¹æ³ |
EP3958679A4 (en) * | 2019-04-26 | 2023-08-16 | Purdue Research Foundation | ANTIBACTERIAL AGENTS CONTAINING CF3, OCF3, SCF3 AND SF5 |
WO2020223551A1 (en) * | 2019-04-30 | 2020-11-05 | Integral Early Discovery, Inc. | Inhibiting otub1 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5587358A (en) | 1994-05-09 | 1996-12-24 | Asahi Kasei Kogyo Kabushiki Kaisha | Potentiators of antimicrobial activity |
US9155792B2 (en) | 2006-02-13 | 2015-10-13 | Trustees Of Boston University | RecA inhibitors with antibiotic activity, compositions and methods of use |
EP2704726B1 (en) | 2011-05-04 | 2018-10-31 | Trustees of Boston University | Proton-motive force stimulation to potentiate aminoglycoside antibiotics against persistent bacteria |
US9861619B2 (en) | 2012-11-01 | 2018-01-09 | The University Of Chicago | Antibiotic methods and compositions for bacteria infections |
-
2014
- 2014-03-14 JP JP2016503023A patent/JP2016516055A/ja active Pending
- 2014-03-14 US US14/776,965 patent/US9675592B2/en active Active
- 2014-03-14 EP EP14764384.5A patent/EP2969003A4/en not_active Withdrawn
- 2014-03-14 WO PCT/US2014/029237 patent/WO2014144710A1/en active Application Filing
-
2017
- 2017-06-09 US US15/618,258 patent/US20170273954A1/en not_active Abandoned
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2016516055A5 (ja) | ||
JP2017528507A5 (ja) | ||
RU2011153772A (ru) | ЀÑПÑОÑПваММÑе аЌОМПÑÑОазПлÑÐœÑе пÑПОзвПЎМÑе | |
JP2017528503A5 (ja) | ||
CA2409741A1 (en) | Tnf-.alpha. production inhibitors | |
WO2012048181A4 (en) | Novel substituted quinoline compounds as s-nitrosoglutathione reductase inhibitors | |
RU2008135979A (ru) | Ð¡ÐŸÐµÐŽÐžÐœÐµÐœÐžÑ Ð³ÐžÐŽÑПкÑОакÑОлаОЌЎа | |
US11779559B2 (en) | Compositions for treating fungal and bacterial biofilms and methods of using the same | |
JP2015521617A5 (ja) | ||
JP2020512337A5 (ja) | ||
MX2012001160A (es) | Agonistas del receptor de esfingosina-1-fosfato. | |
HRP20110436T1 (hr) | Supstituirani karboksamidi kao antagonisti metabotropnih receptora iz skupine i | |
US20220110897A1 (en) | Compositions and methods for treating biofilms | |
CA2673809C (en) | Thioxanthene derivates useful to treat infectious diseases | |
JP2003518106A5 (ja) | ||
JP2015526475A5 (ja) | ||
JP2014517848A5 (ja) | ||
CN113827592B (zh) | äžç§å»äºåç·äºé ®åºååç©åšæ²»çèŽç æ§ææäžçåºçš | |
AU2010240999B2 (en) | Thioxanthene derivatives for the treatment of infectious diseases | |
JP2008519848A5 (ja) | ||
TWI455937B (zh) | å ·ææè掻æ§ä¹ïŒïŒçŸ¥ä¹åºïŒïŒïœïŒå¹åïŒïŒïŒé ®è¡çç©åå ¶æ°®éçæé¡äŒŒç© | |
JP2016537344A5 (ja) | ||
RU2008105832A (ru) | ÐÑгаМОÑеÑкОе ÑÐŸÐµÐŽÐžÐœÐµÐœÐžÑ | |
JP2019536799A5 (ja) | ||
JP2009500440A (ja) | æ§æ¬²é害治ççšå»è¬çµæç© |