JP2016516028A5 - - Google Patents
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- Publication number
- JP2016516028A5 JP2016516028A5 JP2016500471A JP2016500471A JP2016516028A5 JP 2016516028 A5 JP2016516028 A5 JP 2016516028A5 JP 2016500471 A JP2016500471 A JP 2016500471A JP 2016500471 A JP2016500471 A JP 2016500471A JP 2016516028 A5 JP2016516028 A5 JP 2016516028A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- optionally substituted
- inden
- hydrogen
- hydroxymethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C[C@](CC1*)(C(*)CC1I)C(CC1)C(*)C(CC2*)C1(*)C2(*)N=* Chemical compound C[C@](CC1*)(C(*)CC1I)C(CC1)C(*)C(CC2*)C1(*)C2(*)N=* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361785860P | 2013-03-14 | 2013-03-14 | |
| US61/785,860 | 2013-03-14 | ||
| PCT/US2014/019125 WO2014143561A1 (en) | 2013-03-14 | 2014-02-27 | Ship1 modulators and methods related thereto |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016516028A JP2016516028A (ja) | 2016-06-02 |
| JP2016516028A5 true JP2016516028A5 (cg-RX-API-DMAC7.html) | 2017-02-09 |
| JP6407950B2 JP6407950B2 (ja) | 2018-10-17 |
Family
ID=50288306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016500471A Expired - Fee Related JP6407950B2 (ja) | 2013-03-14 | 2014-02-27 | Ｓｈｉｐ１モジュレーターおよびそれに関連する組成物および方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10100056B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2970100A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6407950B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20150130426A (cg-RX-API-DMAC7.html) |
| CN (1) | CN105209429B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2014228574B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112015022577A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2902764A1 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1220173A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL241168A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2015011280A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2015143675A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014143561A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2015133177A (ru) | 2013-01-09 | 2017-02-14 | Экуинокс Фармасьютикалз (Кэнэда) Инк. | Модуляторы ship1 и связанные с ними способы |
| KR102427491B1 (ko) | 2013-03-14 | 2022-08-01 | 에퀴녹스 파머수티칼스 (캐나다) 인코포레이티드 | Ship1 조절제 및 그와 관련된 방법 |
| JP6407950B2 (ja) | 2013-03-14 | 2018-10-17 | アクイノックス ファーマシューティカルズ （カナダ） インコーポレイテッド | Ｓｈｉｐ１モジュレーターおよびそれに関連する組成物および方法 |
| US9944590B2 (en) | 2015-06-26 | 2018-04-17 | Aquinox Pharmaceuticals (Canada) Inc. | Crystalline solid forms of the acetate salt of (1S,3S,4R)-4-((3aS,4R,5S,7aS)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1H-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol |
| US10053415B2 (en) | 2016-01-20 | 2018-08-21 | Aquinox Pharmaceuticals (Canada) Inc. | Synthesis of a substituted indene derivative |
| WO2017149052A1 (en) | 2016-03-02 | 2017-09-08 | Patheon Austria Gmbh Co. & Kg | Process and intermediates for the production of 17(20)-ene b-seco steroids |
| WO2018126040A1 (en) | 2016-12-28 | 2018-07-05 | Aquinox Pharmaceuticals (Canada) Inc. | Crystalline solid forms of (1s,3s,4r)-4-((3as,4r,5s,7as)-4- (aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3- (hydroxymethyl)-4-methylcyclohexanol |
| CN112543753A (zh) | 2018-04-06 | 2021-03-23 | 塔罗制药公司 | 可用于治疗疼痛和炎症的茚衍生物 |
| US20210024571A1 (en) | 2018-04-06 | 2021-01-28 | Aquinox Pharmaceuticals (Canada) Inc. | Hexadecahydro-1h-cyclopenta[a]phenanthrene derivatives useful in treating pain and inflammation |
| EP3774746A1 (en) | 2018-04-06 | 2021-02-17 | Aquinox Pharmaceuticals (Canada) Inc. | Indene derivatives useful in treating pain and inflammation |
| CN111056962B (zh) * | 2019-11-28 | 2022-08-05 | 重庆爱旭龙科技有限公司 | 一种诺司普托及其醋酸盐的制备方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1084718B (de) | 1958-07-08 | 1960-07-07 | Bayer Ag | Verfahren zur Herstellung von Secosteroiden |
| SE345995B (cg-RX-API-DMAC7.html) | 1969-01-31 | 1972-06-19 | Bristol Myers Co | |
| US3682983A (en) | 1969-11-12 | 1972-08-08 | Klaus Prezewowsky | Preparation of {66 {11 {11 -17 ethinyl steroids |
| US3962275A (en) | 1972-06-05 | 1976-06-08 | Hoffmann-La Roche Inc. | 7-oxa steroids |
| US3869467A (en) | 1972-06-05 | 1975-03-04 | Hoffmann La Roche | 17-{62 -Hydroxy-17-{60 -methyl-5-{60 -androstano{9 3,2-c{9 or{8 2,3-d{9 isoxazoles |
| JPH01290624A (ja) | 1988-05-16 | 1989-11-22 | Shiono Chem Kk | ５，６―セコ―ステロール誘導体血清脂質低下剤 |
| JPH07502511A (ja) | 1991-12-20 | 1995-03-16 | グラクソ、インコーポレーテッド | ５‐α‐テストステロンレダクターゼ阻害剤 |
| JPH05221924A (ja) | 1992-02-17 | 1993-08-31 | Shiono Chem Kk | セコステロール化合物 |
| JPH05221901A (ja) | 1992-02-17 | 1993-08-31 | Shiono Chem Kk | セコステロール誘導体 |
| US5464866A (en) | 1992-08-17 | 1995-11-07 | Alcon Laboratories, Inc. | Substituted hydrindanes for the treatment of angiogenesis-dependent diseases |
| AP459A (en) | 1992-12-18 | 1996-02-14 | Glaxo Wellcome Inc | Substituted 6-azaandrostenones. |
| DK0972762T3 (da) | 1993-07-09 | 2004-02-09 | Theramex | Hidtil ukendte strukturelle analoger af vitamin D |
| US5541322A (en) | 1994-10-14 | 1996-07-30 | Glaxo Wellcome Inc. | Synthesis of 6-azaandrostenones |
| US6046185A (en) | 1996-07-11 | 2000-04-04 | Inflazyme Pharmaceuticals Ltd. | 6,7-oxygenated steroids and uses related thereto |
| WO2000063323A1 (en) | 1999-04-16 | 2000-10-26 | Nippon Mitsubishi Oil Corporation | Fluids for traction drive |
| AU5208401A (en) | 2000-04-28 | 2001-11-12 | Inflazyme Pharm Ltd | 3-nitrogen-6,7-dioxygen steroids and uses related thereto |
| JP2004534042A (ja) | 2001-05-22 | 2004-11-11 | インフラジム ファーマシューティカルズ リミテッド | ステロイド−５−エン化合物のステロイド−５−エン−７−オン化合物へのアリル酸化、続くヒドロホウ素化および酸化による、６，７−ジヒドロキシステロイドの生成のための方法およびこの方法の中間体 |
| CA2463136A1 (en) | 2001-10-17 | 2003-04-24 | Raymond Andersen | Ship 1 modulators |
| ATE433458T1 (de) | 2002-10-17 | 2009-06-15 | Univ British Columbia | Modulatoren von ship-1 |
| DE602004031410D1 (de) * | 2003-04-15 | 2011-03-31 | Aquinox Pharmaceuticals Inc | Inden derivate als pharmazeutika |
| US20110263539A1 (en) | 2006-06-21 | 2011-10-27 | The University Of British Columbia | Ship 1 modulator compounds |
| JP5769726B2 (ja) | 2009-12-04 | 2015-08-26 | アキノックス・ファーマシューティカルズ・（カナダ）・インコーポレイテッドＡｑｕｉｎｏｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ （Ｃａｎａｄａ） Ｉｎｃ． | Ｓｈｉｐ１モジュレーターおよびそれに関連する方法 |
| KR102427491B1 (ko) | 2013-03-14 | 2022-08-01 | 에퀴녹스 파머수티칼스 (캐나다) 인코포레이티드 | Ship1 조절제 및 그와 관련된 방법 |
| JP6407950B2 (ja) | 2013-03-14 | 2018-10-17 | アクイノックス ファーマシューティカルズ （カナダ） インコーポレイテッド | Ｓｈｉｐ１モジュレーターおよびそれに関連する組成物および方法 |
| US9944590B2 (en) | 2015-06-26 | 2018-04-17 | Aquinox Pharmaceuticals (Canada) Inc. | Crystalline solid forms of the acetate salt of (1S,3S,4R)-4-((3aS,4R,5S,7aS)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1H-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol |
| US10053415B2 (en) | 2016-01-20 | 2018-08-21 | Aquinox Pharmaceuticals (Canada) Inc. | Synthesis of a substituted indene derivative |
-
2014
- 2014-02-27 JP JP2016500471A patent/JP6407950B2/ja not_active Expired - Fee Related
- 2014-02-27 WO PCT/US2014/019125 patent/WO2014143561A1/en not_active Ceased
- 2014-02-27 HK HK16108135.1A patent/HK1220173A1/zh unknown
- 2014-02-27 EP EP14710726.2A patent/EP2970100A1/en not_active Withdrawn
- 2014-02-27 CA CA2902764A patent/CA2902764A1/en not_active Abandoned
- 2014-02-27 MX MX2015011280A patent/MX2015011280A/es unknown
- 2014-02-27 KR KR1020157028155A patent/KR20150130426A/ko not_active Withdrawn
- 2014-02-27 RU RU2015143675A patent/RU2015143675A/ru not_active Application Discontinuation
- 2014-02-27 AU AU2014228574A patent/AU2014228574B2/en not_active Ceased
- 2014-02-27 US US14/772,737 patent/US10100056B2/en active Active
- 2014-02-27 BR BR112015022577A patent/BR112015022577A2/pt not_active IP Right Cessation
- 2014-02-27 CN CN201480026640.8A patent/CN105209429B/zh not_active Expired - Fee Related
-
2015
- 2015-09-03 IL IL241168A patent/IL241168A0/en unknown
-
2018
- 2018-09-12 US US16/129,586 patent/US20190023709A1/en not_active Abandoned