JP2015509110A5 - - Google Patents

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Publication number
JP2015509110A5
JP2015509110A5 JP2014555351A JP2014555351A JP2015509110A5 JP 2015509110 A5 JP2015509110 A5 JP 2015509110A5 JP 2014555351 A JP2014555351 A JP 2014555351A JP 2014555351 A JP2014555351 A JP 2014555351A JP 2015509110 A5 JP2015509110 A5 JP 2015509110A5
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JP
Japan
Prior art keywords
tautomer
compound
pharmaceutically acceptable
alkyl
acceptable salt
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JP2014555351A
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English (en)
Japanese (ja)
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JP6002785B2 (ja
JP2015509110A (ja
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Priority claimed from PCT/IB2013/050555 external-priority patent/WO2013114250A1/en
Publication of JP2015509110A publication Critical patent/JP2015509110A/ja
Publication of JP2015509110A5 publication Critical patent/JP2015509110A5/ja
Application granted granted Critical
Publication of JP6002785B2 publication Critical patent/JP6002785B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2014555351A 2012-02-03 2013-01-22 ナトリウムチャネルモジュレーターとしてのベンゾイミダゾールおよびイミダゾピリジン誘導体 Expired - Fee Related JP6002785B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261594460P 2012-02-03 2012-02-03
US61/594,460 2012-02-03
PCT/IB2013/050555 WO2013114250A1 (en) 2012-02-03 2013-01-22 Benziimidazole and imidazopyridine derivatives as sodium channel modulators

Publications (3)

Publication Number Publication Date
JP2015509110A JP2015509110A (ja) 2015-03-26
JP2015509110A5 true JP2015509110A5 (cg-RX-API-DMAC7.html) 2016-02-12
JP6002785B2 JP6002785B2 (ja) 2016-10-05

Family

ID=47846092

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014555351A Expired - Fee Related JP6002785B2 (ja) 2012-02-03 2013-01-22 ナトリウムチャネルモジュレーターとしてのベンゾイミダゾールおよびイミダゾピリジン誘導体

Country Status (9)

Country Link
US (1) US8927587B2 (cg-RX-API-DMAC7.html)
EP (1) EP2809655B1 (cg-RX-API-DMAC7.html)
JP (1) JP6002785B2 (cg-RX-API-DMAC7.html)
AR (1) AR089865A1 (cg-RX-API-DMAC7.html)
CA (1) CA2861439C (cg-RX-API-DMAC7.html)
ES (1) ES2548228T3 (cg-RX-API-DMAC7.html)
TW (1) TW201341370A (cg-RX-API-DMAC7.html)
UY (1) UY34602A (cg-RX-API-DMAC7.html)
WO (1) WO2013114250A1 (cg-RX-API-DMAC7.html)

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US11529337B2 (en) 2018-02-12 2022-12-20 Vertex Pharmaceuticals Incorporated Method of treating pain
US12440481B2 (en) 2019-01-10 2025-10-14 Vertex Pharmaceuticals Incorporated Esters and carbamates as modulators of sodium channels
WO2020146682A1 (en) 2019-01-10 2020-07-16 Vertex Pharmaceuticals Incorporated Carboxamides as modulators of sodium channels
WO2020176763A1 (en) 2019-02-27 2020-09-03 Vertex Pharmaceuticals Incorporated Dosage form comprising prodrug of na 1.8 sodium channel inhibitor
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WO2022108849A1 (en) * 2020-11-17 2022-05-27 Arisan Therapeutics Inc. Heterocyclic compounds as therapeutic agents
AU2022283934A1 (en) 2021-06-04 2023-11-30 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofuran-2-carboxamides as modulators of sodium channels
SMT202500481T1 (it) 2021-06-04 2026-01-12 Vertex Pharma N-(idrossialchil(etero)aril)tetraidrofuran carbossammidi come modulatori di canali del sodio
HRP20260068T1 (hr) 2021-06-04 2026-02-27 Vertex Pharmaceuticals Incorporated Čvrsti farmaceutski oblici i režimi doziranja koji obuhvaćaju (2r,3s,4s,5r)-4-[[3-(3,4-difluor-2-metoksifenil)-4,5-dimetil-5-(trifluormetil)tetrahidrofuran-2-karbonil]amino]piridin-2-karboksamid
CA3221938A1 (en) 2021-06-04 2022-12-08 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofuran analogs as modulators of sodium channels
US20240400544A1 (en) 2021-06-04 2024-12-05 Vertex Pharmaceuticals Incorporated N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamide analogs as modulators of sodium channels
WO2022256842A1 (en) 2021-06-04 2022-12-08 Vertex Pharmaceuticals Incorporated Hydroxy and (halo)alkoxy substituted tetrahydrofurans as modulators of sodium channels
CN114249654B (zh) * 2021-12-30 2023-11-14 江苏广域化学有限公司 烷基苯胺类化合物的制备方法
AU2023209523A1 (en) 2022-01-18 2024-08-15 Chengdu Kanghong Pharmaceutical Co., Ltd. Aromatic fused ring nav1.8 inhibitor, and use thereof
CN114288289A (zh) * 2022-02-17 2022-04-08 昆山彭济凯丰生物科技有限公司 具有镇痛和/或止痒功能的药物组合物及其应用
CA3257285A1 (en) 2022-04-22 2023-10-26 Vertex Pharmaceuticals Incorporated HETEROARYL COMPOUNDS FOR PAIN RELIEF
WO2023205463A1 (en) 2022-04-22 2023-10-26 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
US20230382910A1 (en) 2022-04-22 2023-11-30 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
CA3256248A1 (en) 2022-04-22 2023-10-26 Vertex Pharmaceuticals Incorporated HETEROARYL COMPOUNDS FOR PAIN RELIEF
JP2025516005A (ja) 2022-04-25 2025-05-23 サイトワン セラピューティクス インコーポレイテッド 疼痛の処置のためのｎａｖ１．８の二環式複素環アミド阻害剤
WO2024123815A1 (en) 2022-12-06 2024-06-13 Vertex Pharmaceuticals Incorporated Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels
CN116621789A (zh) * 2023-05-31 2023-08-22 上海吉奉生物科技有限公司 一种(4s)-3-[2-[[芴甲氧羰基]氨基]乙酰基]-2,2-二甲基-4-恶唑烷羧酸的合成方法
WO2025090465A1 (en) 2023-10-23 2025-05-01 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
WO2025090516A1 (en) 2023-10-23 2025-05-01 Vertex Pharmaceuticals Incorporated Methods of preparing compounds for treating pain and solid forms thereof
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