JP2016515561A5 - - Google Patents

Download PDF

Info

Publication number
JP2016515561A5
JP2016515561A5 JP2016504661A JP2016504661A JP2016515561A5 JP 2016515561 A5 JP2016515561 A5 JP 2016515561A5 JP 2016504661 A JP2016504661 A JP 2016504661A JP 2016504661 A JP2016504661 A JP 2016504661A JP 2016515561 A5 JP2016515561 A5 JP 2016515561A5
Authority
JP
Japan
Prior art keywords
alkyl
optionally
compound
compound according
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016504661A
Other languages
English (en)
Japanese (ja)
Other versions
JP6453845B2 (ja
JP2016515561A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2014/056081 external-priority patent/WO2014154762A1/en
Publication of JP2016515561A publication Critical patent/JP2016515561A/ja
Publication of JP2016515561A5 publication Critical patent/JP2016515561A5/ja
Application granted granted Critical
Publication of JP6453845B2 publication Critical patent/JP6453845B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016504661A 2013-03-27 2014-03-26 Brd4阻害薬としてのジヒドロキナゾリノン類似体 Active JP6453845B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13161487 2013-03-27
EP13161487.7 2013-03-27
PCT/EP2014/056081 WO2014154762A1 (en) 2013-03-27 2014-03-26 Dihydroquinazolinone analogues as brd4 inhibitors

Publications (3)

Publication Number Publication Date
JP2016515561A JP2016515561A (ja) 2016-05-30
JP2016515561A5 true JP2016515561A5 (US20040106767A1-20040603-C00005.png) 2017-05-18
JP6453845B2 JP6453845B2 (ja) 2019-01-16

Family

ID=47997212

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016504661A Active JP6453845B2 (ja) 2013-03-27 2014-03-26 Brd4阻害薬としてのジヒドロキナゾリノン類似体

Country Status (4)

Country Link
US (1) US9199988B2 (US20040106767A1-20040603-C00005.png)
EP (1) EP2978758B1 (US20040106767A1-20040603-C00005.png)
JP (1) JP6453845B2 (US20040106767A1-20040603-C00005.png)
WO (1) WO2014154762A1 (US20040106767A1-20040603-C00005.png)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9266891B2 (en) 2012-11-16 2016-02-23 Boehringer Ingelheim International Gmbh Substituted [1,2,4]triazolo[4,3-A]pyrazines that are BRD4 inhibitors
WO2014080290A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Cyclic amines as bromodomain inhibitors
US9765039B2 (en) 2012-11-21 2017-09-19 Zenith Epigenetics Ltd. Biaryl derivatives as bromodomain inhibitors
KR20150096794A (ko) 2012-12-21 2015-08-25 제니쓰 에피제네틱스 코포레이션 브로모도메인 저해제로서의 신규한 헤테로사이클릭 화합물
EP2970282B1 (en) 2013-03-15 2019-08-21 Incyte Holdings Corporation Tricyclic heterocycles as bet protein inhibitors
US9636328B2 (en) 2013-06-21 2017-05-02 Zenith Epigenetics Ltd. Substituted bicyclic compounds as bromodomain inhibitors
CN109939113B (zh) 2013-06-21 2022-02-15 恒翼生物医药科技(上海)有限公司 双环溴结构域抑制剂
EP3019502B1 (en) 2013-07-08 2017-05-17 Incyte Holdings Corporation Tricyclic heterocycles as bet protein inhibitors
CA2919948C (en) 2013-07-31 2020-07-21 Zenith Epigenetics Corp. Novel quinazolinones as bromodomain inhibitors
WO2015081189A1 (en) 2013-11-26 2015-06-04 Incyte Corporation Bicyclic heterocycles as bet protein inhibitors
US9399640B2 (en) 2013-11-26 2016-07-26 Incyte Corporation Substituted pyrrolo[2,3-c]pyridines and pyrazolo[3,4-c]pyridines as BET protein inhibitors
US9309246B2 (en) 2013-12-19 2016-04-12 Incyte Corporation Tricyclic heterocycles as BET protein inhibitors
KR101918375B1 (ko) * 2013-12-19 2018-11-13 길리애드 사이언시즈, 인코포레이티드 이온 채널 조정제로서의 융합된 헤테로시클릭 화합물
BR112016015311B1 (pt) 2014-01-09 2023-01-24 Orion Corporation Compostos derivados heterocíclicos bicíclicos, composição farmacêutica que compreende os mesmos e uso dos ditos compostos para tratar uma doença associada com bromodomínio
MY180775A (en) 2014-04-23 2020-12-09 Incyte Corp 1h-pyrrolo[2,3-c]pyridin-7(6h)-ones and pyrazolo[3,4-c]pyridin-7(6h)-ones as inhibitors of bet proteins
JP6599979B2 (ja) 2014-09-15 2019-10-30 インサイト・コーポレイション Betタンパク質阻害剤として用いるための三環式複素環化合物
EP3227280B1 (en) 2014-12-01 2019-04-24 Zenith Epigenetics Ltd. Substituted pyridines as bromodomain inhibitors
WO2016087936A1 (en) 2014-12-01 2016-06-09 Zenith Epigenetics Corp. Substituted pyridinones as bromodomain inhibitors
CA2966449A1 (en) 2014-12-11 2016-06-16 Zenith Epigenetics Ltd. Substituted heterocycles as bromodomain inhibitors
EP3233846A4 (en) 2014-12-17 2018-07-18 Zenith Epigenetics Ltd. Inhibitors of bromodomains
WO2016203335A1 (en) 2015-06-18 2016-12-22 Pfizer Inc. Novel pyrido[2,3-b]pyrazinones as bet-family bromodomain inhibitors
CN105130880B (zh) * 2015-09-18 2017-07-11 上海皓伯化工科技有限公司 一种制备1‑(3‑甲氧丙基)哌啶‑4‑胺的方法
TW201722966A (zh) 2015-10-29 2017-07-01 英塞特公司 Bet蛋白質抑制劑之非晶固體形式
CN105541825A (zh) * 2015-12-28 2016-05-04 中国药科大学 三氮唑衍生物制备方法及其作为药物的用途
EP4234554A3 (en) 2016-06-20 2023-12-27 Incyte Corporation Crystalline solid forms of a bet inhibitor
CN107056771A (zh) * 2017-01-23 2017-08-18 中国药科大学 Bromodomain蛋白二价抑制剂及其制备方法和应用
JPWO2021065980A1 (US20040106767A1-20040603-C00005.png) 2019-09-30 2021-04-08
WO2021175432A1 (en) 2020-03-04 2021-09-10 Boehringer Ingelheim International Gmbh Method for administration of an anti cancer agent
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms
WO2023274418A1 (zh) * 2021-07-02 2023-01-05 南京明德新药研发有限公司 蛋白降解靶向嵌合体类化合物
CN114437041B (zh) * 2022-02-25 2023-11-10 湖北科技学院 一类具有抗肿瘤活性的4-四唑基取代-3,4-二氢喹唑啉衍生物及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0919432D0 (en) * 2009-11-05 2009-12-23 Glaxosmithkline Llc Use
GB0919423D0 (en) * 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds

Similar Documents

Publication Publication Date Title
JP2016515561A5 (US20040106767A1-20040603-C00005.png)
JP2016530259A5 (US20040106767A1-20040603-C00005.png)
JP2016531126A5 (US20040106767A1-20040603-C00005.png)
JP2014511892A5 (US20040106767A1-20040603-C00005.png)
JP2016508134A5 (US20040106767A1-20040603-C00005.png)
JP2015537020A5 (US20040106767A1-20040603-C00005.png)
JP2013518107A5 (US20040106767A1-20040603-C00005.png)
JP2014511891A5 (US20040106767A1-20040603-C00005.png)
JP2020097577A5 (US20040106767A1-20040603-C00005.png)
JP2019524883A5 (US20040106767A1-20040603-C00005.png)
JP2017510610A5 (US20040106767A1-20040603-C00005.png)
MX2020010300A (es) Sales monoacidas de 6-aminoisoquinolinas y usos de las mismas.
JP2014510149A5 (US20040106767A1-20040603-C00005.png)
JP2015516427A5 (US20040106767A1-20040603-C00005.png)
JP2019505529A5 (US20040106767A1-20040603-C00005.png)
JP2015512432A5 (US20040106767A1-20040603-C00005.png)
JP2017533930A5 (US20040106767A1-20040603-C00005.png)
JP2016528273A5 (US20040106767A1-20040603-C00005.png)
JP2015521156A5 (US20040106767A1-20040603-C00005.png)
JP2019535723A5 (US20040106767A1-20040603-C00005.png)
JP2015516419A5 (US20040106767A1-20040603-C00005.png)
RU2018101431A (ru) Ингибиторы индоламин-2,3-диоксигеназы
JP2018521056A5 (US20040106767A1-20040603-C00005.png)
JP2014148552A5 (US20040106767A1-20040603-C00005.png)
RU2016151973A (ru) Пиридиноны, замещенные фенилом и трет-бутилуксусной кислотой, обладающие анти-вич эффектами