|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US4704362A
(en)
|
1977-11-08 |
1987-11-03 |
Genentech, Inc. |
Recombinant cloning vehicle microbial polypeptide expression
|
|
US4394448A
(en)
|
1978-02-24 |
1983-07-19 |
Szoka Jr Francis C |
Method of inserting DNA into living cells
|
|
US4391904A
(en)
|
1979-12-26 |
1983-07-05 |
Syva Company |
Test strip kits in immunoassays and compositions therein
|
|
US4399216A
(en)
|
1980-02-25 |
1983-08-16 |
The Trustees Of Columbia University |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4554101A
(en)
|
1981-01-09 |
1985-11-19 |
New York Blood Center, Inc. |
Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
|
|
US4489710A
(en)
|
1981-06-23 |
1984-12-25 |
Xoma Corporation |
Composition and method for transplantation therapy
|
|
US4671958A
(en)
|
1982-03-09 |
1987-06-09 |
Cytogen Corporation |
Antibody conjugates for the delivery of compounds to target sites
|
|
US4766075A
(en)
|
1982-07-14 |
1988-08-23 |
Genentech, Inc. |
Human tissue plasminogen activator
|
|
US5186941A
(en)
|
1983-05-06 |
1993-02-16 |
Vestar, Inc. |
Vesicle formulation for the controlled release of therapeutic agents
|
|
US4625014A
(en)
|
1984-07-10 |
1986-11-25 |
Dana-Farber Cancer Institute, Inc. |
Cell-delivery agent
|
|
US4542225A
(en)
|
1984-08-29 |
1985-09-17 |
Dana-Farber Cancer Institute, Inc. |
Acid-cleavable compound
|
|
US4801542A
(en)
|
1984-10-12 |
1989-01-31 |
Zymogenetics, Inc. |
Expression of biologically active PDGF analogs in eucaryotic cells
|
|
US4638045A
(en)
|
1985-02-19 |
1987-01-20 |
Massachusetts Institute Of Technology |
Non-peptide polyamino acid bioerodible polymers
|
|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
US4751180A
(en)
|
1985-03-28 |
1988-06-14 |
Chiron Corporation |
Expression using fused genes providing for protein product
|
|
GR860984B
(en)
|
1985-04-17 |
1986-08-18 |
Zymogenetics Inc |
Expression of factor vii and ix activities in mammalian cells
|
|
US4935233A
(en)
|
1985-12-02 |
1990-06-19 |
G. D. Searle And Company |
Covalently linked polypeptide cell modulators
|
|
US4935349A
(en)
|
1986-01-17 |
1990-06-19 |
Zymogenetics, Inc. |
Expression of higher eucaryotic genes in aspergillus
|
|
US4800159A
(en)
|
1986-02-07 |
1989-01-24 |
Cetus Corporation |
Process for amplifying, detecting, and/or cloning nucleic acid sequences
|
|
GB2188637B
(en)
|
1986-02-07 |
1990-11-14 |
Oncogen |
Vaccines against melanoma
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US4873192A
(en)
|
1987-02-17 |
1989-10-10 |
The United States Of America As Represented By The Department Of Health And Human Services |
Process for site specific mutagenesis without phenotypic selection
|
|
US5091513A
(en)
|
1987-05-21 |
1992-02-25 |
Creative Biomolecules, Inc. |
Biosynthetic antibody binding sites
|
|
US5132405A
(en)
|
1987-05-21 |
1992-07-21 |
Creative Biomolecules, Inc. |
Biosynthetic antibody binding sites
|
|
US4866042A
(en)
|
1987-11-18 |
1989-09-12 |
Neuwelt Edward A |
Method for the delivery of genetic material across the blood brain barrier
|
|
US5720937A
(en)
|
1988-01-12 |
1998-02-24 |
Genentech, Inc. |
In vivo tumor detection assay
|
|
WO1989006692A1
(en)
|
1988-01-12 |
1989-07-27 |
Genentech, Inc. |
Method of treating tumor cells by inhibiting growth factor receptor function
|
|
DE3815826A1
(de)
|
1988-05-09 |
1989-11-23 |
Henkel Kgaa |
Verfahren zur herstellung von vicinal diacyloxysubstituierten verbindungen
|
|
US5470829A
(en)
|
1988-11-17 |
1995-11-28 |
Prisell; Per |
Pharmaceutical preparation
|
|
CA2006596C
(en)
|
1988-12-22 |
2000-09-05 |
Rika Ishikawa |
Chemically-modified g-csf
|
|
US5089261A
(en)
|
1989-01-23 |
1992-02-18 |
Cetus Corporation |
Preparation of a polymer/interleukin-2 conjugate
|
|
HUT64022A
(en)
|
1989-04-19 |
1993-11-29 |
Enzon Inc |
Process for producing active polyalkileneoxide carbonates for the modification of polypeptides
|
|
US5122614A
(en)
|
1989-04-19 |
1992-06-16 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
|
US5324844A
(en)
|
1989-04-19 |
1994-06-28 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
|
IL90193A
(en)
|
1989-05-04 |
1993-02-21 |
Biomedical Polymers Int |
Polurethane-based polymeric materials and biomedical articles and pharmaceutical compositions utilizing the same
|
|
US5672683A
(en)
|
1989-09-07 |
1997-09-30 |
Alkermes, Inc. |
Transferrin neuropharmaceutical agent fusion protein
|
|
US6018031A
(en)
|
1989-10-20 |
2000-01-25 |
Trustees Of Dartmouth College |
Binding agents specific for IgA receptor
|
|
CA2026147C
(en)
|
1989-10-25 |
2006-02-07 |
Ravi J. Chari |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
US5312808A
(en)
|
1989-11-22 |
1994-05-17 |
Enzon, Inc. |
Fractionation of polyalkylene oxide-conjugated hemoglobin solutions
|
|
US5650388A
(en)
|
1989-11-22 |
1997-07-22 |
Enzon, Inc. |
Fractionated polyalkylene oxide-conjugated hemoglobin solutions
|
|
NL194941C
(nl)
|
1990-02-15 |
2003-08-04 |
Cordis Corp |
Werkwijze voor het aanbrengen van een fysiologisch actieve verbinding op een substraatoppervlak.
|
|
US5171264A
(en)
|
1990-02-28 |
1992-12-15 |
Massachusetts Institute Of Technology |
Immobilized polyethylene oxide star molecules for bioapplications
|
|
US5275838A
(en)
|
1990-02-28 |
1994-01-04 |
Massachusetts Institute Of Technology |
Immobilized polyethylene oxide star molecules for bioapplications
|
|
US5219564A
(en)
|
1990-07-06 |
1993-06-15 |
Enzon, Inc. |
Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
|
|
US5965695A
(en)
|
1990-05-15 |
1999-10-12 |
Chiron Corporation |
Modified peptide and peptide libraries with protease resistance, derivatives thereof and methods of producing and screening such
|
|
WO1992000748A1
(en)
|
1990-07-06 |
1992-01-23 |
Enzon, Inc. |
Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
|
|
FR2672053B1
(fr)
|
1991-01-30 |
1993-04-23 |
Atochem |
Polyether bloc amides, leur procede de synthese.
|
|
FR2673946B1
(fr)
|
1991-03-15 |
1993-05-28 |
Atochem |
Polyether bloc amides, leur procede de synthese.
|
|
AU1676992A
(en)
|
1991-03-18 |
1992-10-21 |
Enzon, Inc. |
Hydrazine containing conjugates of polypeptides and glycopolypeptides with polymers
|
|
US5281698A
(en)
|
1991-07-23 |
1994-01-25 |
Cetus Oncology Corporation |
Preparation of an activated polymer ester for protein conjugation
|
|
US5932211A
(en)
|
1991-11-12 |
1999-08-03 |
Women's And Children's Hospital |
Glycosylation variants of iduronate 2-sulfatase
|
|
EP1136556B1
(en)
|
1991-11-25 |
2005-06-08 |
Enzon, Inc. |
Method of producing multivalent antigen-binding proteins
|
|
DE69310148T2
(de)
|
1992-02-13 |
1997-07-31 |
Carlsberg A/S, Kopenhagen/Koebenhavn |
Polyethylenglykol oder polypropylenglykol enthaltend polymer
|
|
WO1994001463A1
(en)
|
1992-07-10 |
1994-01-20 |
University Of British Columbia |
USE OF p97 AND IRON BINDING PROTEINS AS DIAGNOSTIC AND THERAPEUTIC AGENTS
|
|
US5981194A
(en)
|
1992-07-10 |
1999-11-09 |
University Of British Columbia |
Use of p97 and iron binding proteins as diagnostic and therapeutic agents
|
|
US20020119095A1
(en)
|
1992-07-10 |
2002-08-29 |
Reinhard Gabathuler |
Chemotherapeutic agents conjugated to p97 and their methods of use in treating neurological tumours
|
|
WO1994004193A1
(en)
|
1992-08-21 |
1994-03-03 |
Enzon, Inc. |
Novel attachment of polyalkylene oxides to bio-effecting substances
|
|
US5614549A
(en)
|
1992-08-21 |
1997-03-25 |
Enzon, Inc. |
High molecular weight polymer-based prodrugs
|
|
US6765087B1
(en)
|
1992-08-21 |
2004-07-20 |
Vrije Universiteit Brussel |
Immunoglobulins devoid of light chains
|
|
ATE199392T1
(de)
|
1992-12-04 |
2001-03-15 |
Medical Res Council |
Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung
|
|
US5298643A
(en)
|
1992-12-22 |
1994-03-29 |
Enzon, Inc. |
Aryl imidate activated polyalkylene oxides
|
|
US5349001A
(en)
|
1993-01-19 |
1994-09-20 |
Enzon, Inc. |
Cyclic imide thione activated polyalkylene oxides
|
|
US5321095A
(en)
|
1993-02-02 |
1994-06-14 |
Enzon, Inc. |
Azlactone activated polyalkylene oxides
|
|
ATE204325T1
(de)
|
1993-04-29 |
2001-09-15 |
Unilever Nv |
Herstellung von antikörpern oder funktionstüchtig gemachten teilen davon, abgeleitet von schweren ketten von immunglobulinen von camelidae
|
|
AU7109494A
(en)
|
1993-06-16 |
1995-01-03 |
Enzon, Inc. |
Conjugated biodhesives
|
|
US5840900A
(en)
|
1993-10-20 |
1998-11-24 |
Enzon, Inc. |
High molecular weight polymer-based prodrugs
|
|
US5965566A
(en)
|
1993-10-20 |
1999-10-12 |
Enzon, Inc. |
High molecular weight polymer-based prodrugs
|
|
US5880131A
(en)
|
1993-10-20 |
1999-03-09 |
Enzon, Inc. |
High molecular weight polymer-based prodrugs
|
|
US5643575A
(en)
|
1993-10-27 |
1997-07-01 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5605976A
(en)
|
1995-05-15 |
1997-02-25 |
Enzon, Inc. |
Method of preparing polyalkylene oxide carboxylic acids
|
|
US5919455A
(en)
|
1993-10-27 |
1999-07-06 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5446090A
(en)
|
1993-11-12 |
1995-08-29 |
Shearwater Polymers, Inc. |
Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
|
|
US5618528A
(en)
|
1994-02-28 |
1997-04-08 |
Sterling Winthrop Inc. |
Biologically compatible linear block copolymers of polyalkylene oxide and peptide units
|
|
CZ292061B6
(cs)
|
1994-03-17 |
2003-07-16 |
Merck Patent Gmbh |
Jednořetězcové fragmenty protilátek a protilátky proti receptoru epidermálního růstového faktoru, způsob jejich přípravy a farmaceutický prostředek, který je obsahuje
|
|
US5686110A
(en)
|
1994-06-02 |
1997-11-11 |
Enzon, Inc. |
Water soluble complex of an alkyl or olefinic end capped polyalkylene oxide and a water insoluble substance
|
|
US5730990A
(en)
|
1994-06-24 |
1998-03-24 |
Enzon, Inc. |
Non-antigenic amine derived polymers and polymer conjugates
|
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
|
US6169073B1
(en)
|
1995-02-16 |
2001-01-02 |
Bayer Corporation |
Peptides and peptidomimetics with structural similarity to human p53 that activate p53 function
|
|
US5756593A
(en)
|
1995-05-15 |
1998-05-26 |
Enzon, Inc. |
Method of preparing polyalkyene oxide carboxylic acids
|
|
US5672662A
(en)
|
1995-07-07 |
1997-09-30 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
|
|
WO1997006833A1
(en)
|
1995-08-11 |
1997-02-27 |
Dendritech, Inc. |
Hyper comb-branched polymer conjugates
|
|
PT2111876E
(pt)
|
1995-12-18 |
2011-12-23 |
Angiodevice Internat Gmbh |
Composições de polímero reticulado e seus métodos de utilização
|
|
RU2199347C2
(ru)
|
1996-08-02 |
2003-02-27 |
Орто-Макнейл Фармасьютикал, Инк. |
Полипептиды, обладающие единственным ковалентно связанным n-концевым водорастворимым полимером
|
|
US6214966B1
(en)
|
1996-09-26 |
2001-04-10 |
Shearwater Corporation |
Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
|
|
JP2002505574A
(ja)
|
1997-04-30 |
2002-02-19 |
エンゾン,インコーポレイテッド |
ポリアルキレンオキシド修飾された単鎖ポリペプチド
|
|
US5990237A
(en)
|
1997-05-21 |
1999-11-23 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
|
|
US6011042A
(en)
|
1997-10-10 |
2000-01-04 |
Enzon, Inc. |
Acyl polymeric derivatives of aromatic hydroxyl-containing compounds
|
|
US6111107A
(en)
|
1997-11-20 |
2000-08-29 |
Enzon, Inc. |
High yield method for stereoselective acylation of tertiary alcohols
|
|
TW492882B
(en)
|
1997-11-28 |
2002-07-01 |
Caleb Pharmaceuticals Inc |
Cholinergic antagonist plaster composition
|
|
JP4465109B2
(ja)
|
1997-12-17 |
2010-05-19 |
エンゾン ファーマシューティカルズ,インコーポレーテッド |
アミノ及びヒドロキシル含有生物活性剤のポリマープロドラッグ
|
|
US6180095B1
(en)
|
1997-12-17 |
2001-01-30 |
Enzon, Inc. |
Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
|
|
US5985263A
(en)
|
1997-12-19 |
1999-11-16 |
Enzon, Inc. |
Substantially pure histidine-linked protein polymer conjugates
|
|
US5965119A
(en)
|
1997-12-30 |
1999-10-12 |
Enzon, Inc. |
Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents
|
|
ES2222689T3
(es)
|
1998-03-12 |
2005-02-01 |
Nektar Therapeutics Al, Corporation |
Derivados del polietilenglicol con grupos reactivos proximales.
|
|
US6153655A
(en)
|
1998-04-17 |
2000-11-28 |
Enzon, Inc. |
Terminally-branched polymeric linkers and polymeric conjugates containing the same
|
|
US7214658B2
(en)
|
2004-07-06 |
2007-05-08 |
Tact Ip, Llc |
Method of delivering a TNF antagonist to the brain of a human by perispinal administration without direct intrathecal injection
|
|
US6419934B1
(en)
|
1999-02-24 |
2002-07-16 |
Edward L. Tobinick |
TNF modulators for treating neurological disorders associated with viral infection
|
|
US6419944B2
(en)
|
1999-02-24 |
2002-07-16 |
Edward L. Tobinick |
Cytokine antagonists for the treatment of localized disorders
|
|
US6982089B2
(en)
|
1999-02-24 |
2006-01-03 |
Tact Ip, Llc |
Cytokine antagonists for neurological and neuropsychiatric disorders
|
|
US6537549B2
(en)
|
1999-02-24 |
2003-03-25 |
Edward L. Tobinick |
Cytokine antagonists for the treatment of localized disorders
|
|
US6015557A
(en)
|
1999-02-24 |
2000-01-18 |
Tobinick; Edward L. |
Tumor necrosis factor antagonists for the treatment of neurological disorders
|
|
US6177077B1
(en)
|
1999-02-24 |
2001-01-23 |
Edward L. Tobinick |
TNT inhibitors for the treatment of neurological disorders
|
|
US6507788B1
(en)
*
|
1999-02-25 |
2003-01-14 |
Société de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.) |
Rational selection of putative peptides from identified nucleotide, or peptide sequences, of unknown function
|
|
US6387620B1
(en)
|
1999-07-28 |
2002-05-14 |
Gilead Sciences, Inc. |
Transcription-free selex
|
|
US6642038B1
(en)
|
1999-09-14 |
2003-11-04 |
Genzyme Glycobiology Research Institute, Inc. |
GlcNAc phosphotransferase of the lysosomal targeting pathway
|
|
CA2386762C
(en)
|
1999-10-08 |
2009-06-16 |
Shearwater Corporation |
Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
|
|
JP2003525038A
(ja)
|
2000-02-08 |
2003-08-26 |
ユニバーシティー オブ ブリティッシュ コロンビア |
治療薬をスクリーニングするための組成物および方法
|
|
US6261595B1
(en)
|
2000-02-29 |
2001-07-17 |
Zars, Inc. |
Transdermal drug patch with attached pocket for controlled heating device
|
|
WO2001075178A2
(en)
|
2000-04-04 |
2001-10-11 |
Enanta Pharmaceuticals, Inc. |
Methods for identifying peptide aptamers capable of altering a cell phenotype
|
|
AU2001255771B2
(en)
|
2000-05-01 |
2007-05-31 |
Biomarin Pharmaceutical Inc. |
Enzymes useful for treating and methods for treating MPS-VI and cell lines for producing such enzymes recombinantly
|
|
WO2002013843A2
(en)
|
2000-08-17 |
2002-02-21 |
University Of British Columbia |
Chemotherapeutic agents conjugated to p97 and their methods of use in treating neurological tumours
|
|
AU2001285020A1
(en)
|
2000-08-17 |
2002-02-25 |
Synapse Technologies, Inc. |
P97-active agent conjugates and their methods of use
|
|
US6376190B1
(en)
|
2000-09-22 |
2002-04-23 |
Somalogic, Inc. |
Modified SELEX processes without purified protein
|
|
US6596541B2
(en)
|
2000-10-31 |
2003-07-22 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
CN100488563C
(zh)
|
2001-02-19 |
2009-05-20 |
默克专利有限公司 |
免疫原性降低的经修饰抗egfr抗体
|
|
US7595378B2
(en)
|
2001-06-13 |
2009-09-29 |
Genmab A/S |
Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
|
|
AU2002345673B2
(en)
|
2001-06-13 |
2007-04-26 |
Genmab A/S |
Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
|
|
WO2003009815A2
(en)
|
2001-07-25 |
2003-02-06 |
Biomarin Pharmaceutical Inc. |
Compositions and methods for modulating blood-brain barrier transport
|
|
US7179617B2
(en)
|
2001-10-10 |
2007-02-20 |
Neose Technologies, Inc. |
Factor IX: remolding and glycoconjugation of Factor IX
|
|
ES2411007T3
(es)
|
2001-10-10 |
2013-07-04 |
Novo Nordisk A/S |
Remodelación y glicoconjugación de péptidos
|
|
US20030072761A1
(en)
|
2001-10-16 |
2003-04-17 |
Lebowitz Jonathan |
Methods and compositions for targeting proteins across the blood brain barrier
|
|
US20050158296A1
(en)
|
2002-01-11 |
2005-07-21 |
Starr Christopher M. |
Use of p97 as an enzyme delivery system for the delivery of therapeutic lysosomal enzymes
|
|
US7244592B2
(en)
|
2002-03-07 |
2007-07-17 |
Dyax Corp. |
Ligand screening and discovery
|
|
DK1583562T3
(da)
*
|
2003-01-06 |
2011-09-19 |
Angiochem Inc |
Angiopep-1, beslægtede forbindelser og anvendelser deraf
|
|
US7419811B2
(en)
|
2003-02-28 |
2008-09-02 |
The Board Of Trustees Of The University Of Illinois |
Use of specifically engineered enzymes to enhance the efficacy of prodrugs
|
|
AU2003286870A1
(en)
|
2003-06-05 |
2005-01-04 |
Salk Institute For Biological Studies |
Targeting polypeptides to the central nervous system
|
|
US20050026823A1
(en)
|
2003-06-20 |
2005-02-03 |
Biomarin Pharmaceutical Inc. |
Use of the chaperone receptor-associated protein (RAP) for the delivery of therapeutic compounds to the brain and other tissues
|
|
CA2542099A1
(en)
|
2003-10-11 |
2005-04-21 |
Inex Pharmaceuticals Corporation |
Methods and compositions for enhancing innate immunity and antibody dependent cellular cytotoxicity
|
|
DE10355904A1
(de)
|
2003-11-29 |
2005-06-30 |
Merck Patent Gmbh |
Feste Formen von anti-EGFR-Antikörpern
|
|
CA2556245A1
(en)
|
2004-02-06 |
2005-08-25 |
Biomarin Pharmaceutical Inc. |
Manufacture of highly phosphorylated lysosomal enzymes and uses thereof
|
|
CN101010303A
(zh)
*
|
2004-09-01 |
2007-08-01 |
阿斯利康(瑞典)有限公司 |
喹唑啉酮衍生物和它们作为b-raf抑制剂的用途
|
|
US7462697B2
(en)
|
2004-11-08 |
2008-12-09 |
Epitomics, Inc. |
Methods for antibody engineering
|
|
US8236306B2
(en)
|
2004-12-18 |
2012-08-07 |
Edward Lewis Tobinick |
Methods to facilitate transmission of large molecules across the blood-brain, blood-eye, and blood-nerve barriers
|
|
EP1844073A1
(en)
|
2005-01-31 |
2007-10-17 |
Ablynx N.V. |
Method for generating variable domain sequences of heavy chain antibodies
|
|
US7842467B1
(en)
*
|
2005-05-12 |
2010-11-30 |
Celera Corporation |
Breast disease targets and uses thereof
|
|
PT1951759E
(pt)
|
2005-11-12 |
2010-04-01 |
Lilly Co Eli |
Anticorpos anti-egfr
|
|
KR101866623B1
(ko)
|
2005-11-28 |
2018-07-04 |
젠맵 에이/에스 |
재조합 1가 항체 및 그의 제조 방법
|
|
US7498142B2
(en)
|
2006-01-31 |
2009-03-03 |
Yeda Research And Development Co., Ltd. |
Methods of identifying combinations of antibodies with an improved anti-tumor activity and compositions and methods using the antibodies
|
|
JP5959795B2
(ja)
|
2006-08-18 |
2016-08-02 |
アーメイゲン・テクノロジーズ・インコーポレイテッドArmagen Technologies, Inc. |
血液脳関門送達のための物質
|
|
US7985783B2
(en)
|
2006-09-21 |
2011-07-26 |
The Regents Of The University Of California |
Aldehyde tags, uses thereof in site-specific protein modification
|
|
EP2125024B1
(en)
|
2007-03-23 |
2013-02-13 |
TO-BBB Holding B.V. |
Targeted intracellular delivery of antiviral agents
|
|
US9365634B2
(en)
|
2007-05-29 |
2016-06-14 |
Angiochem Inc. |
Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
|
|
US20110124576A1
(en)
|
2007-08-08 |
2011-05-26 |
Novozymes A/S |
Transferrin Variants and Conjugates
|
|
HUE035182T2
(hu)
|
2008-03-18 |
2018-05-02 |
Genentech Inc |
Anti-HER2 antitest-hatóanyag-konjugátum és pertuzumab kombinációi
|
|
EP2123258A1
(en)
*
|
2008-05-23 |
2009-11-25 |
Liplasome Pharma A/S |
Liposomes for drug delivery
|
|
EP2216341A1
(en)
*
|
2009-02-10 |
2010-08-11 |
Novozymes Biopharma UK Limited |
Transferrin variants and conjugates
|
|
HRP20190690T1
(hr)
|
2009-10-09 |
2019-06-28 |
Armagen, Inc. |
Postupci i pripravci za povećanje aktiviteta iduronat-2-sulfataze u centralnom nervnom sustavu
|
|
DK2560687T3
(en)
|
2010-04-19 |
2017-09-18 |
Nlife Therapeutics S L |
Preparations and Methods for Selective Delivery of Oligonucleotide Molecules to Specific Neuron Types
|
|
FR2959229B1
(fr)
|
2010-04-21 |
2013-01-18 |
Vect Horus |
Derives peptidiques, leur preparation et leurs utilisations
|
|
PL2593131T3
(pl)
|
2010-06-25 |
2020-01-31 |
Shire Human Genetic Therapies, Inc. |
Sposoby i kompozycje do dostarczania sulfatazy-2-iduronianiu do oun
|
|
EP3103469B1
(en)
|
2010-06-25 |
2020-12-09 |
Shire Human Genetic Therapies, Inc. |
Cns delivery of therapeutic agents
|
|
KR101535791B1
(ko)
|
2010-11-12 |
2015-07-10 |
주식회사 녹십자 |
개량형 이듀로네이트-2-설파타제 및 이의 용도
|
|
EP2717917B1
(en)
|
2011-07-05 |
2016-04-20 |
biOasis Technologies Inc |
P97-antibody conjugates
|
|
CA2842492A1
(en)
*
|
2011-08-05 |
2013-02-14 |
Bioasis Technologies, Inc. |
P97 fragments with transfer activity
|
|
HK1202431A1
(en)
|
2012-05-02 |
2015-10-02 |
Symphogen A/S |
Humanized pan-her antibody compositions
|
|
US20140004097A1
(en)
|
2012-06-29 |
2014-01-02 |
Shire Human Genetic Therapies, Inc. |
Method of producing recombinant iduronate-2-sulfatase
|
|
CA3140358A1
(en)
|
2012-07-31 |
2014-02-06 |
Bioasis Technologies, Inc. |
Dephosphorylated lysosomal storage disease proteins and methods of use thereof
|
|
US8753426B2
(en)
|
2012-08-03 |
2014-06-17 |
Air Products And Chemicals, Inc. |
Polymers, polymer membranes and methods of producing the same
|
|
JP2016503394A
(ja)
|
2012-10-26 |
2016-02-04 |
エヌライフ、セラピューティックス、ソシエダッド、リミターダNlife Therapeutics, S.L. |
細胞型へのオリゴヌクレオチド分子の選択的送達のための組成物および方法
|
|
GB201303308D0
(en)
|
2013-02-25 |
2013-04-10 |
Oxford Biotherapeutics Ltd |
Therapeutic and diagnostic target
|
|
AU2014243816B2
(en)
|
2013-03-13 |
2019-01-31 |
Bioasis Technologies Inc. |
Fragments of p97 and uses thereof
|
|
WO2015031673A2
(en)
|
2013-08-28 |
2015-03-05 |
Bioasis Technologies Inc. |
Cns-targeted conjugates having modified fc regions and methods of use thereof
|
|
US9209965B2
(en)
|
2014-01-14 |
2015-12-08 |
Microsemi Semiconductor Ulc |
Network interface with clock recovery module on line card
|
|
CA2935195A1
(en)
|
2014-02-03 |
2015-08-06 |
Bioasis Technologies, Inc. |
P97 fusion proteins
|
|
JP6605482B2
(ja)
|
2014-02-19 |
2019-11-13 |
バイオアシス テクノロジーズ インコーポレイテッド |
P97−ids融合タンパク質
|
|
EP3137610B1
(en)
|
2014-05-01 |
2019-03-06 |
Bioasis Technologies, Inc. |
P97-polynucleotide conjugates
|
|
CA3011382A1
(en)
|
2016-01-13 |
2017-07-20 |
Bioasis Technologies, Inc. |
Blood-brain barrier vector compounds and conjugates thereof
|