JP2016514957A5 - - Google Patents

Info

Publication number

JP2016514957A5

JP2016514957A5 JP2015561647A JP2015561647A JP2016514957A5 JP 2016514957 A5 JP2016514957 A5 JP 2016514957A5 JP 2015561647 A JP2015561647 A JP 2015561647A JP 2015561647 A JP2015561647 A JP 2015561647A JP 2016514957 A5 JP2016514957 A5 JP 2016514957A5

Authority

JP

Japan

Prior art keywords

host cell

cell according

recombinant polypeptide

acid sequence

nucleic acid

Prior art date

2014-03-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 210000004027 cell Anatomy 0.000 claims 20
• 229920001184 polypeptide Polymers 0.000 claims 11
• 102000004196 processed proteins & peptides Human genes 0.000 claims 11
• 108090000765 processed proteins & peptides Proteins 0.000 claims 11
• 150000007523 nucleic acids Chemical group 0.000 claims 5
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
• 239000012634 fragment Substances 0.000 claims 4
• 102000009027 Albumins Human genes 0.000 claims 2
• 108010088751 Albumins Proteins 0.000 claims 2
• 101150047030 ERO1 gene Proteins 0.000 claims 2
• 101150057849 Padi1 gene Proteins 0.000 claims 2
• 108091005804 Peptidases Proteins 0.000 claims 2
• 241000235648 Pichia Species 0.000 claims 2
• 239000004365 Protease Substances 0.000 claims 2
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 2
• 125000003275 alpha amino acid group Chemical group 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• 210000005253 yeast cell Anatomy 0.000 claims 2
• 101100408676 Caenorhabditis elegans pmt-1 gene Proteins 0.000 claims 1
• 241000222120 Candida <Saccharomycetales> Species 0.000 claims 1
• 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 claims 1
• 102400000322 Glucagon-like peptide 1 Human genes 0.000 claims 1
• DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 1
• 241000235649 Kluyveromyces Species 0.000 claims 1
• 101100494726 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) pep-4 gene Proteins 0.000 claims 1
• 102000006010 Protein Disulfide-Isomerase Human genes 0.000 claims 1
• 241000235070 Saccharomyces Species 0.000 claims 1
• 241000235346 Schizosaccharomyces Species 0.000 claims 1
• 241000311088 Schwanniomyces Species 0.000 claims 1
• 241000235013 Yarrowia Species 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 210000002472 endoplasmic reticulum Anatomy 0.000 claims 1
• 108020001507 fusion proteins Proteins 0.000 claims 1
• 102000037865 fusion proteins Human genes 0.000 claims 1
• 238000012239 gene modification Methods 0.000 claims 1
• 230000005017 genetic modification Effects 0.000 claims 1
• 235000013617 genetically modified food Nutrition 0.000 claims 1
• 239000001963 growth medium Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 108020003519 protein disulfide isomerase Proteins 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1