JP2016513970A5 - - Google Patents
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- Publication number
- JP2016513970A5 JP2016513970A5 JP2016501585A JP2016501585A JP2016513970A5 JP 2016513970 A5 JP2016513970 A5 JP 2016513970A5 JP 2016501585 A JP2016501585 A JP 2016501585A JP 2016501585 A JP2016501585 A JP 2016501585A JP 2016513970 A5 JP2016513970 A5 JP 2016513970A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- nucleic acid
- dengue
- virus
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000007523 nucleic acids Chemical group 0.000 claims description 57
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 27
- 239000000203 mixture Substances 0.000 claims description 27
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 21
- 241000725619 Dengue virus Species 0.000 claims description 20
- 241000700605 Viruses Species 0.000 claims description 18
- 229920001184 polypeptide Polymers 0.000 claims description 17
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 17
- 230000002238 attenuated effect Effects 0.000 claims description 16
- 230000002163 immunogen Effects 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 230000028993 immune response Effects 0.000 claims description 6
- 230000001939 inductive effect Effects 0.000 claims description 6
- 229960005486 vaccine Drugs 0.000 claims description 6
- 241000710831 Flavivirus Species 0.000 claims description 3
- 241000710772 Yellow fever virus Species 0.000 claims description 2
- 229940051021 yellow-fever virus Drugs 0.000 claims description 2
- 208000001490 Dengue Diseases 0.000 claims 32
- 206010012310 Dengue fever Diseases 0.000 claims 32
- 208000025729 dengue disease Diseases 0.000 claims 32
- 108020004707 nucleic acids Proteins 0.000 claims 12
- 102000039446 nucleic acids Human genes 0.000 claims 12
- 239000002773 nucleotide Substances 0.000 claims 11
- 125000003729 nucleotide group Chemical group 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 239000000546 pharmaceutical excipient Substances 0.000 claims 8
- 241000894007 species Species 0.000 claims 5
- 241000710815 Dengue virus 2 Species 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241000024188 Andala Species 0.000 claims 1
- 241000710829 Dengue virus group Species 0.000 claims 1
- 241000711549 Hepacivirus C Species 0.000 claims 1
- 241000710842 Japanese encephalitis virus Species 0.000 claims 1
- 241000710771 Tick-borne encephalitis virus Species 0.000 claims 1
- 241000710886 West Nile virus Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000035772 mutation Effects 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 3
- 108090000944 RNA Helicases Proteins 0.000 description 2
- 102000004409 RNA Helicases Human genes 0.000 description 2
- 210000003501 vero cell Anatomy 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 102100029226 Cancer-related nucleoside-triphosphatase Human genes 0.000 description 1
- 241000282552 Chlorocebus aethiops Species 0.000 description 1
- 108060004795 Methyltransferase Proteins 0.000 description 1
- 108010075285 Nucleoside-Triphosphatase Proteins 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108010022999 Serine Proteases Proteins 0.000 description 1
- 102000012479 Serine Proteases Human genes 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 108700030379 flavivirus NS3 Proteins 0.000 description 1
- 230000009851 immunogenic response Effects 0.000 description 1
- 235000019833 protease Nutrition 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361800204P | 2013-03-15 | 2013-03-15 | |
| US61/800,204 | 2013-03-15 | ||
| PCT/US2014/024603 WO2014150939A2 (en) | 2013-03-15 | 2014-03-12 | Compositions and methods for dengue virus chimeric constructs in vaccines |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019105307A Division JP7050031B2 (ja) | 2013-03-15 | 2019-06-05 | ワクチンにおけるデングウイルスキメラおよび組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016513970A JP2016513970A (ja) | 2016-05-19 |
| JP2016513970A5 true JP2016513970A5 (https=) | 2017-04-13 |
| JP6818548B2 JP6818548B2 (ja) | 2021-01-20 |
Family
ID=50678274
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501585A Active JP6818548B2 (ja) | 2013-03-15 | 2014-03-12 | ワクチンにおけるデングウイルスキメラ構築物に関する組成物および方法 |
| JP2019105307A Active JP7050031B2 (ja) | 2013-03-15 | 2019-06-05 | ワクチンにおけるデングウイルスキメラおよび組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019105307A Active JP7050031B2 (ja) | 2013-03-15 | 2019-06-05 | ワクチンにおけるデングウイルスキメラおよび組成物 |
Country Status (33)
| Country | Link |
|---|---|
| US (6) | US9783579B2 (https=) |
| EP (5) | EP2968516B1 (https=) |
| JP (2) | JP6818548B2 (https=) |
| KR (4) | KR102389908B1 (https=) |
| CN (5) | CN113637693B (https=) |
| AR (4) | AR095598A1 (https=) |
| AU (2) | AU2014235476B2 (https=) |
| CA (4) | CA3177574C (https=) |
| CR (1) | CR20150569A (https=) |
| DK (1) | DK4129330T5 (https=) |
| DO (1) | DOP2015000232A (https=) |
| EC (1) | ECSP23013715A (https=) |
| ES (2) | ES2933970T3 (https=) |
| FI (2) | FI3539565T3 (https=) |
| FR (1) | FR22C1064I2 (https=) |
| HR (1) | HRP20231581T1 (https=) |
| HU (2) | HUE061507T2 (https=) |
| LT (2) | LT4129330T (https=) |
| LU (1) | LUC00329I2 (https=) |
| MX (5) | MX374519B (https=) |
| MY (1) | MY187796A (https=) |
| NL (1) | NL301223I2 (https=) |
| NO (1) | NO2023026I1 (https=) |
| NZ (1) | NZ630869A (https=) |
| PE (2) | PE20160027A1 (https=) |
| PH (1) | PH12015502120B1 (https=) |
| PL (1) | PL3539565T3 (https=) |
| PT (1) | PT3539565T (https=) |
| SG (3) | SG10201913387XA (https=) |
| SI (1) | SI4129330T1 (https=) |
| TW (4) | TWI733646B (https=) |
| UY (1) | UY35489A (https=) |
| WO (1) | WO2014150939A2 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2968516B1 (en) | 2013-03-15 | 2022-01-12 | Takeda Vaccines, Inc. | Compositions and methods for dengue virus chimeric constructs in vaccines |
| US10004795B2 (en) * | 2015-09-08 | 2018-06-26 | Fundacao Butantan | Process for preparing an attenuated tetravalent dengue vaccine |
| KR102373570B1 (ko) * | 2015-11-27 | 2022-03-10 | 케이엠 바이올로직스 가부시키가이샤 | 뎅기 바이러스 약독주를 뱅크화한 생바이러스, 및 그것들을 항원으로 하는 뎅기 백신 |
| JP2019511533A (ja) * | 2016-04-13 | 2019-04-25 | タケダ ワクチン, インコーポレイテッドTakeda Vaccines, Inc. | 小児及び若年成人のデングウイルスに対するワクチンの組成物及び方法 |
| US11464815B2 (en) | 2018-09-05 | 2022-10-11 | Takeda Vaccines, Inc. | Dengue vaccine unit dose and administration thereof |
| US11426461B2 (en) | 2018-09-05 | 2022-08-30 | Takeda Vaccines, Inc. | Methods for preventing dengue and hepatitis A |
| EP3846849A1 (en) | 2018-09-05 | 2021-07-14 | Takeda Vaccines, Inc. | Dengue vaccine unit dose and administration thereof |
| BR112022015710A2 (pt) | 2020-02-27 | 2022-09-27 | Takeda Vaccines Inc | Método para remover dna de célula hospedeira a partir da preparação de vírus |
| WO2021173597A1 (en) * | 2020-02-28 | 2021-09-02 | Merck Sharp & Dohme Corp. | Dengue serotype specific rt-pcr multiplex assay |
| EP3892737A1 (en) * | 2020-04-09 | 2021-10-13 | Takeda Vaccines, Inc. | Qualitative and quantitative determination of single virus haplotypes in complex samples |
| WO2023147342A2 (en) | 2022-01-25 | 2023-08-03 | Takeda Vaccines, Inc. | Large-scale flaviviral vaccine production and manufacture |
| US20250177511A1 (en) | 2022-02-15 | 2025-06-05 | Takeda Vaccines, Inc. | Dengue vaccine batch mixing process |
| US20250342705A1 (en) | 2022-05-04 | 2025-11-06 | Takeda Vaccines, Inc. | Computer-based determination of flavivirus infectivity |
| CN116479167A (zh) * | 2022-08-30 | 2023-07-25 | 深圳大学 | 登革病毒的pcr检测方法 |
| EP4605562A1 (en) * | 2022-10-20 | 2025-08-27 | Takeda Vaccines, Inc. | A method for detecting the presence of a dengue virus serotype in a sample containing at least one dengue virus serotype |
| WO2024108087A1 (en) | 2022-11-18 | 2024-05-23 | Takeda Vaccines, Inc. | A method for determining the proportion of a live, attenuated flavivirus having a nucleotide sequence comprising at least one attenuation locus in a formulation |
| EP4626574A1 (en) | 2022-11-29 | 2025-10-08 | Takeda Vaccines, Inc. | Large-scale flaviviral vaccine production and manufacture |
| WO2025122855A1 (en) | 2023-12-08 | 2025-06-12 | Takeda Vaccines, Inc. | A method for determining the concentration of residual vero cell genomic dna in a sample containing virus obtained from production in vero cells |
| CN119824145A (zh) * | 2025-03-03 | 2025-04-15 | 广州市疾病预防控制中心(广州市卫生检验中心、广州市食品安全风险监测与评估中心、广州医科大学公共卫生研究院) | 一种对登革病毒的逆转录产物进行扩增的pcr引物、pcr试剂盒以及检测登革病毒的方法 |
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| US11464815B2 (en) | 2018-09-05 | 2022-10-11 | Takeda Vaccines, Inc. | Dengue vaccine unit dose and administration thereof |
| EP3892737A1 (en) | 2020-04-09 | 2021-10-13 | Takeda Vaccines, Inc. | Qualitative and quantitative determination of single virus haplotypes in complex samples |
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2014
- 2014-03-12 EP EP14722014.9A patent/EP2968516B1/en active Active
- 2014-03-12 PH PH1/2015/502120A patent/PH12015502120B1/en unknown
- 2014-03-12 CN CN202110718694.2A patent/CN113637693B/zh active Active
- 2014-03-12 SG SG10201913387XA patent/SG10201913387XA/en unknown
- 2014-03-12 JP JP2016501585A patent/JP6818548B2/ja active Active
- 2014-03-12 KR KR1020157029897A patent/KR102389908B1/ko active Active
- 2014-03-12 SI SI201432055T patent/SI4129330T1/sl unknown
- 2014-03-12 CA CA3177574A patent/CA3177574C/en active Active
- 2014-03-12 NZ NZ630869A patent/NZ630869A/en unknown
- 2014-03-12 CN CN202110723336.0A patent/CN113637086B/zh active Active
- 2014-03-12 CA CA3166063A patent/CA3166063A1/en active Pending
- 2014-03-12 EP EP22204593.2A patent/EP4183411A1/en active Pending
- 2014-03-12 EP EP20154012.7A patent/EP3689374B1/en active Active
- 2014-03-12 LT LTEP22182269.5T patent/LT4129330T/lt unknown
- 2014-03-12 ES ES20154012T patent/ES2933970T3/es active Active
- 2014-03-12 PE PE2015001953A patent/PE20160027A1/es unknown
- 2014-03-12 KR KR1020227013084A patent/KR102626270B1/ko active Active
- 2014-03-12 CN CN202110718703.8A patent/CN113637694B/zh active Active
- 2014-03-12 WO PCT/US2014/024603 patent/WO2014150939A2/en not_active Ceased
- 2014-03-12 MY MYPI2015002317A patent/MY187796A/en unknown
- 2014-03-12 AU AU2014235476A patent/AU2014235476B2/en active Active
- 2014-03-12 DK DK22182269.5T patent/DK4129330T5/da active
- 2014-03-12 CN CN202010617988.1A patent/CN111778263B/zh active Active
- 2014-03-12 EP EP19168475.2A patent/EP3539565B1/en active Active
- 2014-03-12 CN CN201480028001.5A patent/CN105451763B/zh active Active
- 2014-03-12 KR KR1020247001384A patent/KR102775714B1/ko active Active
- 2014-03-12 MX MX2015012893A patent/MX374519B/es active IP Right Grant
- 2014-03-12 HU HUE19168475A patent/HUE061507T2/hu unknown
- 2014-03-12 HR HRP20231581TT patent/HRP20231581T1/hr unknown
- 2014-03-12 EP EP22182269.5A patent/EP4129330B1/en active Active
- 2014-03-12 SG SG10201913435TA patent/SG10201913435TA/en unknown
- 2014-03-12 CA CA2903231A patent/CA2903231C/en active Active
- 2014-03-12 PL PL19168475.2T patent/PL3539565T3/pl unknown
- 2014-03-12 SG SG11201507460PA patent/SG11201507460PA/en unknown
- 2014-03-12 KR KR1020257006481A patent/KR20250033325A/ko active Pending
- 2014-03-12 ES ES22182269T patent/ES2965652T3/es active Active
- 2014-03-12 CA CA3177572A patent/CA3177572C/en active Active
- 2014-03-12 PT PT191684752T patent/PT3539565T/pt unknown
- 2014-03-12 FI FIEP19168475.2T patent/FI3539565T3/fi active
- 2014-03-12 PE PE2021000217A patent/PE20211814A1/es unknown
- 2014-03-13 US US14/209,808 patent/US9783579B2/en active Active
- 2014-03-14 TW TW103109624A patent/TWI733646B/zh active
- 2014-03-14 TW TW108114540A patent/TWI726312B/zh active
- 2014-03-14 TW TW114128176A patent/TW202545972A/zh unknown
- 2014-03-14 TW TW110111747A patent/TWI894248B/zh active
- 2014-03-17 UY UY35489A patent/UY35489A/es active IP Right Grant
- 2014-03-17 AR ARP140101223A patent/AR095598A1/es active IP Right Grant
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2015
- 2015-09-11 DO DO2015000232A patent/DOP2015000232A/es unknown
- 2015-09-14 MX MX2023000349A patent/MX2023000349A/es unknown
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