JP2016509864A5 - - Google Patents
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- JP2016509864A5 JP2016509864A5 JP2015562504A JP2015562504A JP2016509864A5 JP 2016509864 A5 JP2016509864 A5 JP 2016509864A5 JP 2015562504 A JP2015562504 A JP 2015562504A JP 2015562504 A JP2015562504 A JP 2015562504A JP 2016509864 A5 JP2016509864 A5 JP 2016509864A5
- Authority
- JP
- Japan
- Prior art keywords
- segment
- seq
- virus
- identity
- influenza
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 71
- 241000713196 Influenza B virus Species 0.000 claims description 48
- 210000004027 cell Anatomy 0.000 claims description 33
- 101710085035 RNA-directed RNA polymerase catalytic subunit Proteins 0.000 claims description 26
- 229960005486 vaccine Drugs 0.000 claims description 24
- 241000700605 Viruses Species 0.000 claims description 14
- 108090000623 proteins and genes Proteins 0.000 claims description 12
- 102000004169 proteins and genes Human genes 0.000 claims description 12
- 230000003612 virological effect Effects 0.000 claims description 11
- 238000012258 culturing Methods 0.000 claims description 10
- 208000037798 influenza B Diseases 0.000 claims description 6
- 241000845082 Panama Species 0.000 claims description 4
- 239000000427 antigen Substances 0.000 claims description 4
- 102000036639 antigens Human genes 0.000 claims description 4
- 108091007433 antigens Proteins 0.000 claims description 4
- 208000037797 influenza A Diseases 0.000 claims description 4
- 210000003501 vero cell Anatomy 0.000 claims description 4
- 210000004962 mammalian cell Anatomy 0.000 claims description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 241000713174 Influenza B virus (B/Ann Arbor/1/1966 [wild- type]) Species 0.000 claims description 2
- 101710128560 Initiator protein NS1 Proteins 0.000 claims description 2
- 101710144127 Non-structural protein 1 Proteins 0.000 claims description 2
- 101710144128 Non-structural protein 2 Proteins 0.000 claims description 2
- 101710199667 Nuclear export protein Proteins 0.000 claims description 2
- 101001039853 Sonchus yellow net virus Matrix protein Proteins 0.000 claims description 2
- 108091034135 Vault RNA Proteins 0.000 claims description 2
- 210000000991 chicken egg Anatomy 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- 210000002845 virion Anatomy 0.000 claims description 2
- 239000000277 virosome Substances 0.000 claims description 2
- 229940126581 whole-virion vaccine Drugs 0.000 claims description 2
- 241000271566 Aves Species 0.000 claims 2
- 230000000415 inactivating effect Effects 0.000 description 1
- 150000007523 nucleic acids Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361779888P | 2013-03-13 | 2013-03-13 | |
| US61/779,888 | 2013-03-13 | ||
| PCT/IB2014/059729 WO2014141125A2 (en) | 2013-03-13 | 2014-03-13 | Influenza virus reassortment |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016509864A JP2016509864A (ja) | 2016-04-04 |
| JP2016509864A5 true JP2016509864A5 (cg-RX-API-DMAC7.html) | 2017-04-20 |
| JP6525469B2 JP6525469B2 (ja) | 2019-06-05 |
Family
ID=50440715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015562504A Active JP6525469B2 (ja) | 2013-03-13 | 2014-03-13 | インフルエンザｂ型ウイルス再集合 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10232031B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2968512A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6525469B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20150130344A (cg-RX-API-DMAC7.html) |
| CN (2) | CN105338999B (cg-RX-API-DMAC7.html) |
| AU (2) | AU2014229255B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112015021880A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2905612A1 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1218511A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL240936B (cg-RX-API-DMAC7.html) |
| MX (1) | MX372963B (cg-RX-API-DMAC7.html) |
| SG (1) | SG11201507454XA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014141125A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102939103A (zh) | 2010-03-30 | 2013-02-20 | 西奈山医学院 | 流感病毒疫苗及其应用 |
| EP2758075B1 (en) | 2011-09-20 | 2023-05-03 | Icahn School of Medicine at Mount Sinai | Influenza virus vaccines and uses thereof |
| SG11201504728RA (en) | 2012-12-18 | 2015-07-30 | Icahn School Med Mount Sinai | Influenza virus vaccines and uses thereof |
| US9908930B2 (en) | 2013-03-14 | 2018-03-06 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| JP2018504412A (ja) | 2015-01-23 | 2018-02-15 | アイカーン スクール オブ メディシン アット マウント サイナイ | インフルエンザウイルスワクチン接種レジメン |
| EP3313439A2 (en) | 2015-06-26 | 2018-05-02 | Seqirus UK Limited | Antigenically matched influenza vaccines |
| WO2017005880A1 (en) | 2015-07-07 | 2017-01-12 | Seqirus UK Limited | Influenza potency assays |
| CN109641041A (zh) | 2016-06-15 | 2019-04-16 | 西奈山伊坎医学院 | 流感病毒血细胞凝集素蛋白及其用途 |
| EP3606555A4 (en) | 2017-04-07 | 2021-08-04 | Icahn School of Medicine at Mount Sinai | INFLUENZA VIRUS TYPE B ANTI-NEURAMINIDASE ANTIBODIES AND THEIR USES |
| AU2018357917B2 (en) | 2017-10-30 | 2024-08-01 | Takeda Pharmaceutical Company Limited | Environmentally compatible detergents for inactivation of lipid-enveloped viruses |
| CN108018300B (zh) * | 2017-11-21 | 2020-08-28 | 浙江迪福润丝生物科技有限公司 | 区分免疫和感染动物h7亚型禽流感疫苗株及其制备方法和应用 |
| US12364746B2 (en) | 2018-06-21 | 2025-07-22 | Icahn School Of Medicine At Mount Sinai | Mosaic influenza virus hemagglutinin polypeptides and uses thereof |
| WO2021173965A1 (en) * | 2020-02-28 | 2021-09-02 | Massachusetts Institute Of Technology | Identification of variable influenza residues and uses thereof |
| CN114262694B (zh) * | 2021-12-06 | 2023-11-03 | 军事科学院军事医学研究院军事兽医研究所 | 以B型流感病毒为载体的SARS-CoV-2疫苗候选株及其构建方法和应用 |
| CN116063409A (zh) * | 2022-09-09 | 2023-05-05 | 中山大学·深圳 | 一种乙型流感Mosaic重组蛋白、重组质粒及其构建方法和应用 |
| CN118978590B (zh) * | 2024-10-12 | 2025-01-21 | 北京溯本源和生物科技有限公司 | 一种利用重组流感病毒免疫小鼠制备杂交瘤单抗的方法及应用 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU212924B (en) | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
| WO1995011700A1 (en) | 1993-10-29 | 1995-05-04 | Pharmos Corp. | Submicron emulsions as vaccine adjuvants |
| DE19612967A1 (de) | 1996-04-01 | 1997-10-02 | Behringwerke Ag | Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren |
| DE19612966B4 (de) | 1996-04-01 | 2009-12-10 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren |
| TW570803B (en) | 1997-04-09 | 2004-01-11 | Duphar Int Res | Influenza vaccine |
| US6080725A (en) | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
| PT1098961E (pt) | 1998-06-12 | 2008-04-23 | Mount Sinai School Of Med Of T | Vírus atenuados produzidos por engenharia genética indutores de interferão |
| IT1307930B1 (it) * | 1999-01-26 | 2001-11-29 | Sinco Ricerche Spa | Articoli trasparenti in resina poliestere (mg32). |
| IL148673A0 (en) | 1999-09-24 | 2002-09-12 | Smithkline Beecham Biolog | Intranasal influenza virus vaccine |
| US6825036B2 (en) | 2000-03-03 | 2004-11-30 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Cell usable in serum-free culture and suspension culture and process for producing virus for vaccine by using the cell |
| WO2002024878A2 (en) | 2000-09-25 | 2002-03-28 | Bayer Aktiengesellschaft | Human e3 ubiquitin protein ligase-like enzyme |
| CN1582333B (zh) | 2000-09-25 | 2010-06-16 | 波利门科学生物免疫研究有限公司 | 活疫苗及生产方法 |
| GB0024089D0 (en) | 2000-10-02 | 2000-11-15 | Smithkline Beecham Biolog | Novel compounds |
| WO2002067983A1 (en) | 2001-02-23 | 2002-09-06 | Glaxosmithkline Biologicals S.A. | Novel vaccine |
| EP2281573A3 (en) | 2001-02-23 | 2011-12-07 | GlaxoSmithKline Biologicals s.a. | Influenza vaccine formulations for intradermal delivery |
| MY134424A (en) | 2001-05-30 | 2007-12-31 | Saechsisches Serumwerk | Stable influenza virus preparations with low or no amount of thiomersal |
| PL1742659T3 (pl) | 2004-04-05 | 2013-08-30 | Zoetis Services Llc | Poddane mikrofluidyzacji emulsje typu olej w wodzie oraz kompozycje szczepionek |
| WO2005113756A1 (en) | 2004-05-14 | 2005-12-01 | Glaxosmithkline Biologicals S.A. | Method |
| AU2005245943A1 (en) | 2004-05-20 | 2005-12-01 | Id Biomedical Corporation | Process for the production of an influenza vaccine |
| ES2550007T3 (es) * | 2004-05-24 | 2015-11-03 | Medimmune, Llc | Sistema multi-plásmido para la producción de virus de la gripe |
| EP2368975B1 (en) | 2004-12-23 | 2014-09-17 | MedImmune, LLC | Non-tumorigenic MDCK cell line for propagating viruses |
| EP2441471B1 (en) * | 2005-03-08 | 2014-10-08 | MedImmune, LLC | Reassortant influenza viruses |
| FR2884255B1 (fr) | 2005-04-11 | 2010-11-05 | Vivalis | Utilisation de lignees de cellules souches aviaires ebx pour la production de vaccin contre la grippe |
| US7691368B2 (en) | 2005-04-15 | 2010-04-06 | Merial Limited | Vaccine formulations |
| EP1917361A4 (en) | 2005-06-21 | 2009-07-29 | Medimmune Vaccines Inc | METHODS AND COMPOSITIONS FOR EXPRESSING NEGATIVE SENSE RNA VIRUS IN CANINE CELLS |
| US8703095B2 (en) | 2005-07-07 | 2014-04-22 | Sanofi Pasteur S.A. | Immuno-adjuvant emulsion |
| CN104474543A (zh) | 2005-11-01 | 2015-04-01 | 诺华疫苗和诊断有限两合公司 | 经由β-丙内酯处理的残留细胞DNA水平降低的细胞衍生病毒疫苗 |
| KR20080069232A (ko) | 2005-11-04 | 2008-07-25 | 노바티스 백신즈 앤드 다이아그노스틱스 에스.알.엘. | 스플리트 인플루엔자 백신에 대한 보조제로서 유리 수성상계면활성제를 갖는 에멀젼 |
| NZ567979A (en) | 2005-11-04 | 2012-02-24 | Novartis Vaccines & Diagnostic | Adjuvanted influenza vaccines including a cytokine-inducing agents which is an agonist of Toll-Like Receptor 7 |
| FR2896162B1 (fr) | 2006-01-13 | 2008-02-15 | Sanofi Pasteur Sa | Emulsion huile dans eau thermoreversible |
| CN1810961B (zh) * | 2006-02-22 | 2010-05-12 | 中国人民解放军军事医学科学院微生物流行病研究所 | 一种重组流感病毒及其制备方法与应用 |
| EP2010557B1 (en) * | 2006-03-31 | 2014-02-26 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines |
| AU2007240448B8 (en) | 2006-04-19 | 2014-03-06 | Medimmune Llc. | Methods and compositions for expressing negative-sense viral RNA in canine cells |
| CN101522218B (zh) | 2006-10-12 | 2012-09-26 | 葛兰素史密丝克莱恩生物有限公司 | 包含水包油乳液佐剂的疫苗 |
| EP2121011B1 (en) | 2006-12-06 | 2014-05-21 | Novartis AG | Vaccines including antigen from four strains of influenza virus |
| EP2045323A1 (en) | 2007-10-05 | 2009-04-08 | Avir Green Hills Biotechnology Research Development Trade Ag | Linear expression constructs for production of influenza virus particles |
| JP2011527581A (ja) * | 2008-07-11 | 2011-11-04 | メディミューン，エルエルシー | インフルエンザ赤血球凝集素およびノイラミニダーゼ変異体 |
| CN107365751B (zh) | 2008-12-16 | 2021-07-09 | 纳米医疗公司 | 流感疫苗的生产 |
| EP2401384B1 (en) | 2009-05-21 | 2012-10-03 | Novartis AG | Reverse genetics using non-endogenous pol i promoters |
| CN104862335A (zh) | 2009-07-31 | 2015-08-26 | 诺华股份有限公司 | 反向遗传系统 |
| WO2011048560A1 (en) | 2009-10-20 | 2011-04-28 | Novartis Ag | Improved reverse genetics methods for virus rescue |
| AU2011254204B2 (en) | 2010-05-21 | 2015-08-20 | Seqirus UK Limited | Influenza virus reassortment method |
-
2014
- 2014-03-13 EP EP14715683.0A patent/EP2968512A2/en not_active Withdrawn
- 2014-03-13 HK HK16106531.5A patent/HK1218511A1/zh unknown
- 2014-03-13 AU AU2014229255A patent/AU2014229255B2/en active Active
- 2014-03-13 WO PCT/IB2014/059729 patent/WO2014141125A2/en not_active Ceased
- 2014-03-13 CA CA2905612A patent/CA2905612A1/en not_active Abandoned
- 2014-03-13 MX MX2015011529A patent/MX372963B/es active IP Right Grant
- 2014-03-13 KR KR1020157027045A patent/KR20150130344A/ko not_active Ceased
- 2014-03-13 BR BR112015021880A patent/BR112015021880A2/pt not_active IP Right Cessation
- 2014-03-13 CN CN201480027225.4A patent/CN105338999B/zh active Active
- 2014-03-13 CN CN202010070674.4A patent/CN111334530A/zh active Pending
- 2014-03-13 SG SG11201507454XA patent/SG11201507454XA/en unknown
- 2014-03-13 JP JP2015562504A patent/JP6525469B2/ja active Active
- 2014-03-13 US US14/775,066 patent/US10232031B2/en active Active
-
2015
- 2015-08-31 IL IL24093615A patent/IL240936B/en active IP Right Grant
-
2019
- 2019-03-13 AU AU2019201704A patent/AU2019201704A1/en not_active Abandoned
- 2019-10-18 US US16/657,082 patent/US10864264B2/en active Active
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