JP2016508996A - 酸化ストレス及び/又は酸化還元不均衡の結果生じる病的状態の全身的治療のための組成物 - Google Patents
酸化ストレス及び/又は酸化還元不均衡の結果生じる病的状態の全身的治療のための組成物 Download PDFInfo
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Abstract
Description
本願は、2002年6月19日に出願された米国仮出願第60/389,491号の利益を請求する、2003年6月18日に出願された米国出願第10/463,765号の分割出願である、2009年3月16日に出願された米国出願第12/405,165号の一部継続出願である、2009年8月18日に出願された米国出願第12/543,407号の一部継続出願である、2013年1月28日に出願された米国出願第13/751,429号の一部継続出願の利益を請求するものである。これらの出願は、参照することによってその全体が本明細書に組み込まれる。
本発明において定義される「活性硫黄物質」は、1)硫化物(sulfide)化合物、2)チオ硫酸塩(thiosulfate)化合物、3)チオン酸塩(thionate)化合物、4)亜チオン酸塩(thionite)化合物、及び5)それを必要とする対象に、治療上効果的な又は予防上効果的な量の硫化物化合物、チオ硫酸塩化合物、亜チオン酸塩化合物、又はチオン酸塩化合物を提供し得る化学種、を包含する。このような化学種の非限定的な例には、硫化物化合物(すなわち硫化水素)に生体内変換されることが知られている元素硫黄、並びに/又は、硫化物化合物、チオ硫酸塩化合物、亜チオン酸塩化合物、及び/若しくはチオン酸塩化合物に化学的に及び/若しくは酵素的に形質転換されることが知られているコンジュゲートが含まれる。
本発明は、癌、AIDS、ARC(AIDS関連症候群)、AIDSに続発する悪液質、癌に続発する悪液質、糖尿病、ダウン症候群、心血管疾患、高コレステロール血症、炎症性胃腸障害、癌以外の過剰増殖性疾患、関節炎、代謝症候群、及び神経変性疾患を予防及び治療するために有用な新規な方法に関する。前記疾患状態を治療するために有用なこの新規な方法は、治療的に効果的な量の化合物、すなわち、硫化物化合物、チオ硫酸塩化合物、亜チオン酸塩化合物、チオン酸塩化合物、及びそれを必要とする対象に硫化物化合物、亜チオン酸塩化合物、又はチオン酸塩化合物を提供し得るあらゆる化学種を、それを必要とする哺乳動物の消化管に個別に又は混合して送達することを含む。
本発明の組成物を用いて治療され得る状態には、癌(固形腫瘍と血液学的悪性腫瘍との両方)が含まれる。癌は、通常、調節されていない細胞の成長、悪性腫瘍の形成、及び身体の近隣部分への浸潤によって特徴付けされる。癌はまた、リンパ系又は血流を介して身体のさらに遠位の部分に広がり得る。癌は、タバコの摂取、特定の感染、放射線照射、身体的活動の不足、肥満、及び/又は環境汚染物質に起因する遺伝的ダメージの結果であり得る。癌はまた、遺伝的な継承(genetic heredity)に起因する疾患を生じさせる、細胞内の既存の遺伝子異常の結果であり得る。スクリーニングは、何らかの目立つ症候が現れる前に癌を検出するために用いられ得、癌を発症するリスクが高い者(例えば、癌の家族歴のある人)が治療を受けることができる。癌のためのスクリーニング技術の例には、限定はしないが、身体検査、血液若しくは尿の検査、医療画像、及び/又は遺伝子検査が含まれる。癌の非限定的な例には、膀胱癌、乳癌、結腸及び直腸癌、子宮内膜癌、腎臓又は腎細胞癌、白血病、肺癌、黒色腫、非ホジキンリンパ腫、膵臓癌、前立腺癌、卵巣癌、胃癌、消耗性疾患(すなわち、癌に続発する悪液質、例えば、体重減少、筋萎縮、疲労、虚弱、及び顕著な食欲減退)、及び甲状腺癌が含まれる。
本発明の組成物はまた、後天性免疫不全症候群(AIDS)/ヒト免疫不全ウイルス感染(HIV)、及びAIDS関連症候群(ARC)を治療するために有用である。ARCは、AIDSにおける低下した又は正常な抗体反応性と比較して上昇した又は過剰活性なB細胞液性免疫応答、AIDSにさらに典型的なリンパ球の変性及び枯渇をもたらす、ARCリンパ節における濾胞過形成又は混合過形成、並びにカポジ肉腫の局在化などの一連の組織病理学的病変の進行によって特徴付けされる。これらの症候は、ARCSに罹患している患者の、AIDSへの移行の前兆である。
本発明の組成物はまた、糖尿病及びその合併症を治療及び予防するために有用であり得る。糖尿病は、身体がインスリンを十分に生産しないため、又は細胞が生産されたインスリンに応答しないため、人の血糖値が高くなるあらゆる代謝疾患であり得る。糖尿病の非限定的な例には、1型糖尿病、2型糖尿病、妊娠糖尿病、先天的糖尿病、嚢胞性線維症関連糖尿病、ステロイド糖尿病、成人の潜在的自己免疫性糖尿病、及び単一遺伝子の糖尿病が含まれる。糖尿病に伴う合併症には、限定はしないが、低血糖、糖尿病性ケトアシドーシス、非ケトン性高浸透圧性昏睡、心血管疾患、慢性腎不全、糖尿病性腎症、糖尿病性神経障害、糖尿病に関連する足部の問題(例えば、糖尿病性の足部潰瘍)、及び糖尿病性網膜症が含まれる。
本発明の組成物はまた、心血管疾患の治療及び予防において有用である。本明細書において用いられる場合、心血管疾患には、限定はしないが、動脈硬化、不整脈、冠動脈性心疾患、虚血、虚血再かん流障害、内皮機能障害、特に血管の弾力性に影響するこれらの機能障害、再狭窄、血栓症、狭心症、高血圧、心筋症、高血圧性心疾患、心不全、肺性心、心律動異常、心内膜炎、炎症性心肥大、心筋炎、心筋梗塞、心臓弁膜症、脳卒中及び脳血管疾患、大動脈弁狭窄、鬱血性心不全、並びに末梢動脈疾患が含まれる。一つの態様において、本発明には、長期的な治療のために組成物を投与する方法が含まれる。別の態様において、本発明にはまた、急性治療のために組成物を投与する方法が含まれる。
本発明の組成物はまた、神経変性疾患を治療及び予防するために用いられ得る。神経変性疾患は、ニューロンの死滅を含む、ニューロンの構造又は機能の進行性の喪失によって特徴付けされる、あらゆる疾患である。神経変性疾患は、遺伝子突然変異(例えば、CAGヌクレオチドトリプレット突然変異)、タンパク質のミスフォールディング(例えば、アルファ-シヌクレインの凝集、高リン酸化型タウタンパク質、及びベータアミロイドの凝集)、タンパク質分解経路(例えば、ユビキチン-プロテアソーム経路及び自食作用-リソソーム経路)における調節異常、膜のダメージ、ミトコンドリアの機能障害、軸索輸送の不良、並びにプログラム細胞死経路(例えば、アポトーシス、自食作用の、及び細胞質の)の調節異常によって生じ得る。神経変性疾患の例には、限定はしないが、アルツハイマー病、パーキンソン病、ハンチントン病、筋萎縮性側索硬化症(ALS)、クロイツフェルト・ヤコブ病、原発性進行性失語症、進行性核上麻痺、脊髄小脳失調症3型、前頭側頭認知症、レビー小体を伴う認知症、大脳皮質基底核変性症、プリオン病、多系統萎縮症、遺伝性痙性対麻痺、フリードライヒ失調症、小児の神経発達障害、及びアミロイドーシスが含まれる。
本発明の治療物質はまた、他の状態、例えば、炎症性胃腸疾患(例えば、過敏性腸疾患)、癌以外の過剰増殖性疾患(例えば、肝臓疾患、肺疾患、特に肺水腫及び線維症、乾癬)、メタボリック症候群、不安神経症、良性前立腺過形成(BPH)、手根管症候群、双極性障害、白内障、セリアック病、慢性疲労症候群、COPD、鬱病、線維筋痛、GERD、緑内障、高血圧、甲状腺機能亢進症、インフルエンザ、腎臓結石、ライム病、睡眠時無呼吸、全身性エリテマトーデス(SLE)、耳鳴り、肝硬変を治療することにおいて有用である。
本発明はまた、1日に1回摂取するための、並びに全体的健康を維持及び促進するための医療食品としての、本明細書において記載される治療物質に関する。一つの態様において、本発明の治療物質は、システイン及びその誘導体の補充源を提供するためのパラビタミン(paravitamin)として用いられる。システイン及びその誘導体(例えば、グルタチオン、タウリン、胆汁酸、硫化水素、及び硫酸イオンとのタウリンコンジュゲート)は、ビタミンの役割と類似の役割を果たしている。抗酸化ビタミンのように、システイン及びその誘導体は、酸化剤/抗酸化剤バランスにおいて、及び代謝プロセスの調節において間接的に役割を果たしている。普通の食餌の最初にシステインを補充することは、様々な有利な影響を有し得、例えば、システインの補充は、筋肉機能、免疫機能、血漿アルブミン濃度の増大、及びTNF-α濃度の低下をもたらし得る。補充はまた、複数の加齢関連プロセスの原動力である、システインレベル及びグルタチオンレベルの身体蓄積を回復させ得る。
本発明はまた、上記の物質の1つ以上、及び場合によって1つ以上の薬学的に許容可能な賦形剤、担体、希釈剤、又はアジュバントを含む、医薬組成物に関する。
当業者には、患者又は非ヒト哺乳動物に投与される前述の組成物の実際の1日投薬量は、場合によっては完全に医師又は獣医師の裁量の範囲内であることが予想されよう。したがって、もし他の要素が等しければ、平均体重(すなわち約70kg)の成人男性の1日投薬量は、子供(又は平均的な男性よりも体重の低い非ヒト哺乳動物)の1日投薬量よりも多くなるが、例えば平均的な男性よりも重いヒト又は非ヒト哺乳動物を扱う場合には、その逆が予想される。
本発明はまた、前述の活性成分と以下の活性物質及び/又は化合物との投与を伴う組み合わせ療法の使用を含む。
本発明の組成物は、心血管疾患の第2の予防薬として用いられる1つ以上の薬剤と組み合わせて投与され得る。予防薬の例には、限定はしないが、βブロッカー(例えば、非選択的作用物質、例えば、アルプレノロール(alprenolol)、カルテオロール(carteolol)、オクスプレノロール(oxprenolol)、ソタロール(sotalol)、チモロール(timolol)、例えば、β1選択的作用物質、例えば、アセブトロール(acebutolol)、ベタキソロール(betaxolol)、セリプロロール(celiprolol)、メトプロロール(metoprolol)、例えば、β2選択的作用物質、例えば、ブタキサミン(butaxamine)、例えば、β3選択的作用物質、例えば、SR 59230A)、スタチン(例えば、アトルバスタチン(atorvastatin)、セリバスタチン(cerivastatin)、フルバスタチン(fluvastatin)、ロバスタチン(lovastatin)、メバスタチン(mevastatin)、プラバスタチン(pravastatin)、シンバスタチン(simvastatin)、及びロスバスタチン(rosuvastatin))、フィブラート(例えば、ベザフィブラート(bezafibrate)、シプロフィブラート(ciprofibrate)、クロフィブラート(clofibrate)、ゲムフィブロジル(gemfibrozil)、及びフェノフィブラート(fenofibrate))、ビグアニド(例えば、メトホルミン(metformin)、フェンホルミン(phenformin)、ブホルミン(buformin)、及びプログアニル(proguanil))、降圧剤、及び/又はACE阻害剤(例えば、スルフヒドリル含有作用物質、例えば、カプトプリル(captopril)、ゾフェノプリル(zofenopril)、例えば、ジカルボン酸塩含有作用物質、例えば、エナラプリル(enelapril)、ラミプリル(ramipril)、キナプリル(quinapril)、ペリンドプリル(perindopril)、イミダプリル(imidapril)、例えば、リン酸塩含有作用物質、例えば、フォシノプリル(fosinopril))が含まれる。
本発明の組成物は、1つ以上の抗神経変性薬剤と組み合わせて投与され得る。抗神経変性薬の例には、限定はしないが、アセチルコリンエステラーゼ阻害剤(例えば、ドネペジル(donepezil)、ガランタミン(galantamine)、及びリバスチグミン(rivastigmine))、抗グルタミン酸塩作用物質(例えば、アマンタジン(amantadnie)、GABA作動性薬、バルプロ酸)、レセルピン(reserpine)、テトラベナジン(tetrabenazine)、典型的な/非典型的な神経遮断薬、三環系抗鬱剤、SSRI、カルバマゼピン(carbamazepine)、バクロフェン(baclofen)、チザニジン(tizanidine)、ヒデルギン、コリン、ピラセタム、及びラモトリジン(lamotrigine)が含まれる。
本発明の組成物は、1つ以上の抗炎症薬と組み合わせて投与され得る。抗炎症薬の例には、限定はしないが、ステロイド(例えば糖質コルチコイド、例えばコルチコステロイド)、非ステロイド抗炎症薬(NSAID)(例えば、アスピリン(aspirin)、ジフルニサル(diflunisal)、サルサレート(salsalate)、イブプロフェン(ibuprofen)、ナプロキセン(naproxen)、フェノプロフェン(fenoprofen)、ケトプロフェン(ketoprofen)、フルルビプロフェン(flurbiprofen)、スリンダク(sulindac)、エトドラク(etodolac)、ケトロラック(ketorolac)、ナブメトン(nabumetone)、ピロキシカム(piroxicam)、メロキシカム(meloxicam)、テノキシカム(tenoxicam)、メフェナム酸、フルフェナム酸、トルフェナム酸、セレコキシブ(celecoxib)、ロフェコキシブ(rofecoxib)、パレコキシブ(parecoxib)、エトリコキシブ(etoricoxib)、フィロコキシブ(firocoxib)、ニメスリド(nimesulide)、及びリコフェロン(licofelone))、免疫選択的な抗炎症性誘導体(ImSAID)(例えば、フェニルアラニン-グルタミン-グリシン(FEG)及びそのD-異性体形態(feG))、並びに/又はハーブ(例えば、ハルパゴフィツム属(Harpagophytum)、ヒソップ、ショウガ、ターメリック、アルニカ・モンタナ(Arnica Montana)、及び柳の樹皮)が含まれる。
本発明の組成物は、全体的健康を促進及び/又は維持するために、1つ以上の食餌補助食品と組み合わせて投与され得る。食餌補助食品の例には、限定はしないが、ビタミン(例えば、ビタミンA、ビタミンB1、B2、B3、B5、B6、B7、B9、B12、ビタミンC、ビタミンD、補酵素Q、ビタミンE、及びビタミンK)、ミネラル(例えば、カリウム、塩素、ナトリウム、カルシウム、マグネシウム、リン、亜鉛、鉄、マンガン、銅、ヨウ素、セレン、及びモリブデン)、ハーブ若しくは植物(例えば、セイヨウオトギリソウ、カヴァ、シラジット、及び漢方薬)、アミノ酸(例えば、グリシン、セリン、メチオニン、システイン、アスパラギン酸、グルタミン酸、グルタミン、トリプトファン、及びフェニルアラニン)、グルコサミン、コンドロイチン硫酸、ビンポセチン、プラミラセタム、硫化ジアリル、上記のいずれかの濃縮物、構成要素、抽出物、及び/若しくは組み合わせ、並びに/又は微量栄養素が含まれる。
本発明の組成物は、1つ以上の抗癌薬と組み合わせて製剤化又は投与され得る。抗癌剤の例には、限定はしないが、化学療法剤(例えば、三酸化ヒ素、シスプラチン(cisplatin)、カルボプラチン(carboplatin)、クロラムブシル(chlorambucil)、メルファラン(melphalan)、ネダプラチン(nedaplatin)、オキサリプラチン(oxaliplatin)、トリプラチン(triplatin)四硝酸塩、サトラプラチン(satraplatin)、イマチニブ(imatinib)、ニロチニブ(nilotinib)、ダサチニブ(dasatinib)、及びラジシコール(radicicol))、免疫調節剤(例えば、メトトレキサート(methotrexate)、レフルノミド(leflunomide)、シクロホスファミド(cyclophosphamide)、シクロスポリン(cyclosporine)A、ミノサイクリイン(minocycline)、アザチオプリン(azathioprine)、抗生物質(例えば、タクロリムス(tacrolimus))、メチルプレドニゾロン(methylprednisolone)、コルチコステロイド、ステロイド、ミコフェノール酸モフェチル(mycophenolate mofetil)、ラパマイシン(rapamycin)、ミゾリビン(mizoribine)、デオキシスペルグアリン、ブレキナル(brequinar)、T細胞受容体調節物質、及びサイトカイン受容体調節物質)、抗血管新生剤(例えば、ベバシズマブ(bevacizumab)、スラミン(suramin)、及びテトラチオモリブデート(etrathiomolybdate))、有糸分裂阻害剤(例えば、パクリタキセル(paclitaxel)、ビノレルビン(vinorelbine)、ドセタキセル(docetaxel)、アバジタキセル(abazitaxel)、イクサベピロン(ixabepilone)、ラロタキセル(larotaxel)、オルタタキセル(ortataxel)、テセタキセル(tesetaxel)、ビンブラスチン(vinblastine)、ビンクリスチン(vincristine)、ビンフルニン(vinflunine)、及びビンデシン(vindesine))、ヌクレオシド類似体(例えば、ゲムシタビン(gemcitabine)、アザシチジン(azacitidine)、カペシタビン(capecitabine)、カルモフール(carmofur)、クラドリビン(cladribine)、クロファラビン(clofarabine)、シタラビン(cytarabine)、デシタビン(decitabine)、フロキシウリジン(floxuridine)、フルダラビン(fludarabine)、フルオロウラシル(fluorouracil)、メルカプトプリン(mercaptopurine)、ペントスタチン(pentostatin)、テガフール(tegafur)、及びチオグアニン(thioguanine))、DNA挿入剤(例えば、ドキソルビシン(doxorubicin)、アクチノマイシン(actinomycin)、ブレオマイシン(bleomycin)、マイトマイシン(mitomycin)、及びプリカマイシン(plicamycin))、トポイソメラーゼ阻害剤(例えば、イリノテカン(irinotecan)、アクラルビシン(aclarubicin)、アムルビシン(amrubicin)、ベロテカン(belotecan)、カンプトセシン(camptothecin)、ダウノルビシン(daunorubicin)、エピルビシン(epirubicin)、エトポシド(etoposide)、イダルビシン(idarubicin)、ミトキサントロン(mitoxantrone)、ピラルビシン(pirarubicin)、ピキサントロン(pixantrone)、ルビテカン(rubitecan)、テニポシド(teniposide)、トポテカン(topotecan)、バルルビシン(valrubicin)、及びゾルビシン(zorubicin))、葉酸代謝拮抗物質(例えば、ペメトレキセド(pemetrexed)、アミノプテリン(aminopterin)、メトトレキサート、プララトレキサート(pralatrexate)、及びラルチトレキセド(raltitrexed))、マイトカン(mitocans)(例えば、ジクロロ酢酸ナトリウム及び3-ブロモピルビン酸)、及び他の標的化剤(例えば、癌に関与する特定の酵素若しくはタンパク質と標的化する作用物質、又は特定の器官若しくは癌のタイプを標的化する作用物質)、及びその組み合わせが含まれる。
本発明はまた、メタボリック症候群を治療又は予防するために用いられる薬剤を用いる組み合わせ療法の使用を含む。このカテゴリーの薬剤は、患者内に存在するメタボリック症候群の特異的構成要素を標的化するように作られるべきである。例えば、コレステロールを低下させる薬剤のクラスには、スタチン及びフィブラートが含まれる。様々なクラスの血圧薬物もまた使用され得る(例えば、心臓のリスクを低減させるためのアスピリン、並びにオメガ3-脂肪酸及び魚油などの補助食品)。メトホルミン(Metformin)などの、2型糖尿病を治療するために用いられる薬剤もまた、メタボリック症候群を有する人々における糖尿病の発病を予防することが見出されている。
本発明はまた、免疫刺激剤(例えば、プロラクチン、成長ホルモン、ビタミンD、デオキシコール酸)、ホルモンアンタゴニスト及びアゴニスト(例えば、トリヨードサイロニン、インスリン)、抗ウイルス剤(例えば没食子酸)、AIDSの治療において用いられる薬剤(例えば、組み合わせ生成物、例えば、エファビレンツ(efavirenze)、テノフォビル(tenofovir)、エムトリシタビン(emtricitabine)、リルピビリン(rilpivirine)、コビシスタット(cobicistat)、ヌクレオシド逆転写酵素阻害剤(NRTI)、例えば、ラミブジン(lamivudine)、アバカビル(abacavir)、ザルシタビン(zalcitabine)、ジソプロキシル(disoproxil)、フマル酸塩、ジダノシン(didanosine)、ddC、AZT、ZDV、非ヌクレオシド逆転写酵素阻害剤(NNRTI)、例えば、リルピビリン、エトラビリン(etravirine)、デラビルジン(delavirdine)、ネビラピン(nevirapine)、プロテアーゼ阻害剤、例えば、アンプレナビル(amprenavir)、チプラナビル(tipranavir)、サキナビル(saquinavir)、融合阻害剤、CCR5共受容体アンタゴニスト、及びHIVインテグラーゼ鎖転移阻害剤)、及び抗生物質との組み合わせ療法の使用を含む。
本発明は、以下の非限定的な実施例によって説明され得る。これらの実施例は、例示的な目的のために記載されるにすぎず、多くの他の変形も使用され得る。
214重量部の硫化水素ナトリウム(NaSH)、640重量部の蒸留水、及び2000重量部の食品グレードの微晶質セルロースを、室温で完全に混合した。最終粉末混合物を用いて、標準的なツーピースの硬ゼラチンカプセルをカプセル当たり1000ミリグラムで充填した。
372重量部のチオ硫酸ナトリウム(Na2S2O3)、640重量部の蒸留水、及び2000重量部の食品グレードの微晶質セルロースを、室温で完全に混合した。得られた粉末混合物を用いて、標準的なツーピースの硬ゼラチンカプセルをカプセル当たり1000ミリグラムで充填した。
464重量部のメタ重亜硫酸カリウム(K2S2O5)、640重量部の蒸留水、及び2000重量部の食品グレードの微晶質セルロースを、室温で完全に混合した。得られた粉末混合物を用いて、標準的なツーピースの硬ゼラチンカプセルをカプセル当たり1000ミリグラムで充填した。
1532重量部のチオ硫酸ナトリウム(Na2S2O3)、232重量部のメタ重亜硫酸カリウム、212重量部のメタ重亜硫酸ナトリウム、418重量部の硫化ナトリウム九水和物、1090重量部の蒸留水、及び2000重量部の食品グレードの微晶質セルロースを、室温で完全に混合した。得られた粉末混合物を用いて、標準的なツーピースの硬ゼラチンカプセルをカプセル当たり1000ミリグラムで充填した。
患者:男性、74歳。
患者:男性、15歳。
患者:男性、38歳。
患者:男性、63歳。
患者:男性、15歳。
患者:男性、4歳。
患者:男性、68歳。
患者:女性、44歳。
患者:女性、55歳。
患者:男性、75歳。
患者:女性、26歳。
患者:女性、49歳。
患者:男性、42歳。
患者:女性、34歳。
患者:男性、58歳。
患者:男性、63歳。
患者:男性、74歳。
患者:男性、76歳。
患者:女性、56歳。
患者:男性、50歳。
患者:女性、58歳。
患者:男性、63歳。
患者:女性、3歳。
患者:女性、3歳。
患者:女性、3歳。
患者:女性、4歳。
患者:女性、4歳。
患者:女性、4歳。
患者:女性、4歳。
患者:女性、4歳。
患者:女性、4歳。
患者:男性、68歳。
本発明はその具体的な実施形態に関連して記載されてきたが、さらなる変更が可能であること、及び、この特許出願が、通常は本発明の原理に従うあらゆる変形、使用、又は適用をも網羅するものであり、本開示からのこのような逸脱を、本発明が関係する技術分野の通常の技術の範囲内として、且つ、本発明の趣旨の範囲内で、先に記載された基本的な特徴に適用され得るとして含むことが理解されよう。
Claims (10)
- 活性硫黄物質及び場合によって腸溶性担体を含む、経口投与のための単位投薬形態の医薬組成物であって、前記活性硫黄物質が、それを必要とする対象に、治療上効果的な又は予防上効果的な量の硫化物化合物、亜チオン酸塩化合物、チオン酸塩化合物、チオ硫酸塩化合物、又はその水和物、塩、若しくは混合物を提供し得る、医薬組成物。
- 硫化物化合物、亜チオン酸塩化合物、チオン酸塩化合物、チオ硫酸塩化合物、又はその水和物、塩、若しくは混合物からなる群から選択される活性硫黄物質と、
摂取されると、対象の胃において前記活性硫黄物質を実質的に放出することなく、前記活性硫黄物質を前記対象の下部消化管に送達することができる、カプセル形態の腸溶性担体と
を含む、請求項1に記載の組成物。 - 前記活性硫黄物質が、約50mgから約1500mgまでの量で存在する、請求項1に記載の組成物。
- 前記腸溶性担体が、湿潤微晶質セルロース、湿潤粉末セルロース、ヒプロメロース、酢酸フタル酸セルロース、ジェランガム、アクリル酸メチル-メタクリル酸コポリマー、酢酸コハク酸セルロース、ヒドロキシルプロピルメチルセルロースフタレート、ヒドロキシルプロピルメチル酢酸コハク酸セルロース、ポリ酢酸ビニルフタレート、メタクリル酸メチル-メタクリル酸コポリマー、アルギン酸ナトリウム、及びステアリン酸からなる群から選択される、請求項1に記載の組成物。
- 約214重量部の硫化水素ナトリウム(NaSH)、約640重量部の蒸留水、及び約2000重量部の食品グレードの微晶質セルロースを含む、請求項1に記載の組成物。
- 約372重量部のチオ硫酸ナトリウム(Na2S2O3)、約640重量部の蒸留水、及び約2000重量部の食品グレードの微晶質セルロースを含む、請求項1に記載の組成物。
- 前記単位投薬形態が、硬ゼラチンカプセルである、請求項1に記載の組成物。
- 前記単位投薬形態が、acid-armor capsules(商標)及びDRcaps acid-resistant capsules(商標)からなる群から選択される、耐酸性のカプセルである、請求項1に記載の組成物。
- 第3の作用物質をさらに含む、請求項1に記載の組成物。
- 前記第3の作用物質が、ビタミン、微量栄養素、補酵素Q10、グルコサミン、コンドロイチン硫酸、トリヨードサイロニン、ビンポセチン、プラミラセタム、ピラセタム、ヒデルギン、コリン、ニアー、没食子酸、硫化ジアリル、抗癌剤、免疫刺激剤、抗生物質、ホルモンアンタゴニスト、抗ウイルス剤、降圧剤、インスリン、及び抗炎症剤からなる群から選択される、請求項9に記載の組成物。
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US13/751,429 US20130136725A1 (en) | 2002-06-19 | 2013-01-28 | Compositions for systemic treatment of pathological conditions resulting from oxidative stress and/or redox imbalance |
PCT/MX2014/000029 WO2014116097A2 (es) | 2013-01-28 | 2014-01-28 | Composiciones para tratamiento sistémico de condiciones patológicas resultantes de estrés oxidativo y/o desequilibrio redox |
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KR20200083509A (ko) | 2017-10-25 | 2020-07-08 | 4틴4 파마슈티컬스 게엠베하 | 특이적 dpp3-에피토프에 대하여 지시되고 이에 결합하는 dpp3 결합제 및 산화적 스트레스와 연관되는 질환 / 급성 병태의 예방 또는 치료에서의 그의 용도 |
US20220062169A1 (en) * | 2019-01-19 | 2022-03-03 | Goldred Nanobiotech Co., Ltd. | Ocular lens, pharmaceutical composition, and uses thereof |
BR112022017277A2 (pt) | 2020-03-16 | 2022-10-18 | 4TEEN4 Pharmaceuticals GmbH | Dpp3 em pacientes infectados com coronavírus |
EP3922993A1 (en) | 2020-06-12 | 2021-12-15 | 4TEEN4 Pharmaceuticals GmbH | Dpp3 in patients infected with coronavirus |
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US20090304819A1 (en) * | 2002-06-19 | 2009-12-10 | Gabriel Gojon-Romanillos | Systemic Treatment of Pathological Conditions Resulting from Oxidative Stress and/or Redox Imbalance |
JP2012532824A (ja) * | 2009-07-08 | 2012-12-20 | ホープ メディカル エンタープライゼズ,インコーポレイテッド ディービーエー ホープ ファーマシュティカルズ | チオ硫酸ナトリウムを含有する薬学的組成物 |
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DE3419686A1 (de) | 1983-05-26 | 1984-11-29 | T and R Chemicals, Inc., Clint, Tex. | Verwendung einer zusammensetzung mit therapeutischer wirksamkeit |
IL81166A (en) | 1987-01-05 | 1990-03-19 | Kaplan Ephraim | Pharmaceutically active combination comprising an ionic vanadium compound and thiosulfate or sulfite compound and optionally selenium |
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WO2014116097A3 (es) | 2014-12-04 |
HK1217175A1 (zh) | 2016-12-30 |
AU2014210447A1 (en) | 2015-08-20 |
CA2898596A1 (en) | 2014-07-31 |
CN105228633A (zh) | 2016-01-06 |
KR20160140331A (ko) | 2016-12-07 |
WO2014116097A2 (es) | 2014-07-31 |
MX2015009403A (es) | 2017-07-04 |
EP2949332A2 (en) | 2015-12-02 |
EP2949332A4 (en) | 2016-07-27 |
BR112015017440A2 (pt) | 2017-07-11 |
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