JP2016508956A - 局所疼痛の治療のための組成物と治療法 - Google Patents
局所疼痛の治療のための組成物と治療法 Download PDFInfo
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 3
- 235000011083 sodium citrates Nutrition 0.000 description 3
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 3
- 235000010262 sodium metabisulphite Nutrition 0.000 description 3
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 3
- 238000007614 solvation Methods 0.000 description 3
- 239000004334 sorbic acid Substances 0.000 description 3
- 235000010199 sorbic acid Nutrition 0.000 description 3
- 229940075582 sorbic acid Drugs 0.000 description 3
- 210000000278 spinal cord Anatomy 0.000 description 3
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 3
- 238000013222 sprague-dawley male rat Methods 0.000 description 3
- 238000012453 sprague-dawley rat model Methods 0.000 description 3
- 238000001694 spray drying Methods 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- 238000010561 standard procedure Methods 0.000 description 3
- 239000008117 stearic acid Substances 0.000 description 3
- 125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 229920006132 styrene block copolymer Polymers 0.000 description 3
- 235000000346 sugar Nutrition 0.000 description 3
- 150000008163 sugars Chemical class 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 239000000375 suspending agent Substances 0.000 description 3
- 239000003765 sweetening agent Substances 0.000 description 3
- 239000007916 tablet composition Substances 0.000 description 3
- 239000011975 tartaric acid Substances 0.000 description 3
- 235000002906 tartaric acid Nutrition 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 235000010384 tocopherol Nutrition 0.000 description 3
- 229960001295 tocopherol Drugs 0.000 description 3
- 229930003799 tocopherol Natural products 0.000 description 3
- 239000011732 tocopherol Substances 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 230000007704 transition Effects 0.000 description 3
- 150000003626 triacylglycerols Chemical class 0.000 description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- 210000001215 vagina Anatomy 0.000 description 3
- 235000019871 vegetable fat Nutrition 0.000 description 3
- 229920002554 vinyl polymer Polymers 0.000 description 3
- 229920003169 water-soluble polymer Polymers 0.000 description 3
- 235000010493 xanthan gum Nutrition 0.000 description 3
- 239000000230 xanthan gum Substances 0.000 description 3
- 229940082509 xanthan gum Drugs 0.000 description 3
- 239000011787 zinc oxide Substances 0.000 description 3
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 3
- UVNPEUJXKZFWSJ-LMTQTHQJSA-N (R)-N-[(4S)-8-[6-amino-5-[(3,3-difluoro-2-oxo-1H-pyrrolo[2,3-b]pyridin-4-yl)sulfanyl]pyrazin-2-yl]-2-oxa-8-azaspiro[4.5]decan-4-yl]-2-methylpropane-2-sulfinamide Chemical compound CC(C)(C)[S@@](=O)N[C@@H]1COCC11CCN(CC1)c1cnc(Sc2ccnc3NC(=O)C(F)(F)c23)c(N)n1 UVNPEUJXKZFWSJ-LMTQTHQJSA-N 0.000 description 2
- RQFUZUMFPRMVDX-UHFFFAOYSA-N 3-Bromo-1-propanol Chemical compound OCCCBr RQFUZUMFPRMVDX-UHFFFAOYSA-N 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- 210000000621 bronchi Anatomy 0.000 description 2
- 239000012230 colorless oil Substances 0.000 description 2
- 229940125904 compound 1 Drugs 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 208000037765 diseases and disorders Diseases 0.000 description 2
- ZJXZSIYSNXKHEA-UHFFFAOYSA-N ethyl dihydrogen phosphate Chemical compound CCOP(O)(O)=O ZJXZSIYSNXKHEA-UHFFFAOYSA-N 0.000 description 2
- 210000000867 larynx Anatomy 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 230000009469 supplementation Effects 0.000 description 2
- 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 1
- WZQOHNGMKICLPL-AAQCHOMXSA-N 3-[2-[(2,6-dimethylphenyl)carbamoyl]piperidin-1-yl]propyl (5z,8z,11z,14z,17z)-icosa-5,8,11,14,17-pentaenoate Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)OCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C WZQOHNGMKICLPL-AAQCHOMXSA-N 0.000 description 1
- DYRIBFOWRXHQNS-UHFFFAOYSA-N CC(NCCCOC)=O Chemical compound CC(NCCCOC)=O DYRIBFOWRXHQNS-UHFFFAOYSA-N 0.000 description 1
- KIQLLHYPNCPLAJ-UHFFFAOYSA-N CNCCSCCNC Chemical compound CNCCSCCNC KIQLLHYPNCPLAJ-UHFFFAOYSA-N 0.000 description 1
- WWJHSKHOCSUEHQ-SNVBAGLBSA-N C[C@]1(CCCCC(OC)=O)SSCC1 Chemical compound C[C@]1(CCCCC(OC)=O)SSCC1 WWJHSKHOCSUEHQ-SNVBAGLBSA-N 0.000 description 1
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 1
- 238000002716 delivery method Methods 0.000 description 1
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
- 229940093471 ethyl oleate Drugs 0.000 description 1
- DKXULEFCEORBJK-UHFFFAOYSA-N magnesium;octadecanoic acid Chemical compound [Mg].CCCCCCCCCCCCCCCCCC(O)=O DKXULEFCEORBJK-UHFFFAOYSA-N 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1843CH2012 | 2012-05-10 | ||
IN1843/CHE/2012 | 2012-05-10 | ||
PCT/IB2013/051268 WO2013168006A2 (en) | 2012-05-10 | 2013-02-16 | Compositions and methods for the treatment of local pain |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2016508956A true JP2016508956A (ja) | 2016-03-24 |
Family
ID=54193695
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015510898A Pending JP2016508956A (ja) | 2012-05-10 | 2013-02-16 | 局所疼痛の治療のための組成物と治療法 |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP2882745A2 (zh) |
JP (1) | JP2016508956A (zh) |
CN (1) | CN105612155A (zh) |
AU (1) | AU2013257727B2 (zh) |
CA (1) | CA2873138A1 (zh) |
SG (1) | SG11201407323WA (zh) |
WO (1) | WO2013168006A2 (zh) |
ZA (1) | ZA201408055B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2021152048A (ja) * | 2016-12-26 | 2021-09-30 | セリックス バイオ プライヴェート リミテッドCellix Bio Private Limited | 慢性疼痛の処置のための組成物及び方法 |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8361067B2 (en) | 2002-09-30 | 2013-01-29 | Relievant Medsystems, Inc. | Methods of therapeutically heating a vertebral body to treat back pain |
AU2012362524B2 (en) | 2011-12-30 | 2018-12-13 | Relievant Medsystems, Inc. | Systems and methods for treating back pain |
US10588691B2 (en) | 2012-09-12 | 2020-03-17 | Relievant Medsystems, Inc. | Radiofrequency ablation of tissue within a vertebral body |
WO2014071161A1 (en) | 2012-11-05 | 2014-05-08 | Relievant Medsystems, Inc. | System and methods for creating curved paths through bone and modulating nerves within the bone |
US9724151B2 (en) | 2013-08-08 | 2017-08-08 | Relievant Medsystems, Inc. | Modulating nerves within bone using bone fasteners |
AU2020346827A1 (en) | 2019-09-12 | 2022-03-31 | Relievant Medsystems, Inc. | Systems and methods for tissue modulation |
US12082876B1 (en) | 2020-09-28 | 2024-09-10 | Relievant Medsystems, Inc. | Introducer drill |
JP2024505335A (ja) | 2020-12-22 | 2024-02-06 | リリーバント メドシステムズ、インコーポレイテッド | 脊椎神経調節の候補の予測 |
GB202305212D0 (en) * | 2023-04-06 | 2023-05-24 | Elixa Mediscience Ltd | Compounds |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09500620A (ja) * | 1993-06-28 | 1997-01-21 | アストラ・アクチエボラーグ | 極小の運動遮断で鎮痛効果を示す医薬の製造におけるロピバカインの使用 |
JP2001522888A (ja) * | 1997-11-19 | 2001-11-20 | ダーウィン・ディスカバリー・リミテッド | 麻酔用製剤 |
JP2004531543A (ja) * | 2001-04-30 | 2004-10-14 | トロムスドルフ ゲーエムベーハー ウント コンパニー カーゲー アルツナイミッテル | 医薬として活性なウリジンエステル |
WO2009061497A1 (en) * | 2007-11-07 | 2009-05-14 | Svip5 Llc | Slow release of organic salts of local anesthetics for pain relief |
US20120022147A1 (en) * | 2011-08-17 | 2012-01-26 | Krisani Biosciences (P) Ltd | 2, 6 xylidine derivatives for the treatment of pain |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1187813A (zh) * | 1995-05-01 | 1998-07-15 | 斯科舍集团有限公司 | 作为生物活性化合物的脂肪酸酯 |
GB9704349D0 (en) * | 1997-03-03 | 1997-04-23 | Chiroscience Ltd | Levobupivacaine and its use |
US8846068B2 (en) * | 2008-04-18 | 2014-09-30 | Warsaw Orthopedic, Inc. | Methods and compositions for treating post-operative pain comprising a local anesthetic |
-
2013
- 2013-02-16 SG SG11201407323WA patent/SG11201407323WA/en unknown
- 2013-02-16 EP EP13788349.2A patent/EP2882745A2/en not_active Withdrawn
- 2013-02-16 CN CN201380030659.5A patent/CN105612155A/zh active Pending
- 2013-02-16 CA CA2873138A patent/CA2873138A1/en not_active Abandoned
- 2013-02-16 WO PCT/IB2013/051268 patent/WO2013168006A2/en active Application Filing
- 2013-02-16 AU AU2013257727A patent/AU2013257727B2/en not_active Ceased
- 2013-02-16 JP JP2015510898A patent/JP2016508956A/ja active Pending
-
2014
- 2014-11-04 ZA ZA2014/08055A patent/ZA201408055B/en unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09500620A (ja) * | 1993-06-28 | 1997-01-21 | アストラ・アクチエボラーグ | 極小の運動遮断で鎮痛効果を示す医薬の製造におけるロピバカインの使用 |
JP2001522888A (ja) * | 1997-11-19 | 2001-11-20 | ダーウィン・ディスカバリー・リミテッド | 麻酔用製剤 |
JP2004531543A (ja) * | 2001-04-30 | 2004-10-14 | トロムスドルフ ゲーエムベーハー ウント コンパニー カーゲー アルツナイミッテル | 医薬として活性なウリジンエステル |
WO2009061497A1 (en) * | 2007-11-07 | 2009-05-14 | Svip5 Llc | Slow release of organic salts of local anesthetics for pain relief |
US20120022147A1 (en) * | 2011-08-17 | 2012-01-26 | Krisani Biosciences (P) Ltd | 2, 6 xylidine derivatives for the treatment of pain |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2021152048A (ja) * | 2016-12-26 | 2021-09-30 | セリックス バイオ プライヴェート リミテッドCellix Bio Private Limited | 慢性疼痛の処置のための組成物及び方法 |
JP7283792B2 (ja) | 2016-12-26 | 2023-05-30 | セリックス バイオ プライヴェート リミテッド | 慢性疼痛の処置のための組成物及び方法 |
Also Published As
Publication number | Publication date |
---|---|
ZA201408055B (en) | 2016-03-30 |
SG11201407323WA (en) | 2014-12-30 |
CN105612155A (zh) | 2016-05-25 |
WO2013168006A3 (en) | 2016-09-01 |
AU2013257727B2 (en) | 2016-04-28 |
WO2013168006A2 (en) | 2013-11-14 |
EP2882745A2 (en) | 2015-06-17 |
CA2873138A1 (en) | 2013-11-14 |
AU2013257727A1 (en) | 2014-11-27 |
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