JP2016508440A - 化学反応器デバイス - Google Patents
化学反応器デバイス Download PDFInfo
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Abstract
Description
B=1.25×W
である。(図1に示されるように)Wはカラムのエッジの通路の幅であり、Bはエッジから離れたカラムの柱間の通路の幅である。
H=A+B/u+C.u (A,B,Cは定数、uは移動相の線速度)
を用いて、バンド分散を表現すると、本発明の構造は、格別に低いA値(経路内の流動の違いに起因した分散の代表)と低いB値(長手拡散に起因した分散の代表)をもたらす。
Claims (21)
- 流体流動に基づく化学反応器デバイス(100)であって、
流路壁(122)により規定される流体流路(120)を備えた基板(110)と、
流路(120)内に位置付けられた一連の規則的な柱構造体(130)と、
を有し、
流路(120)は注入口と排出口を備え、且つ流路(120)は注入口から排出口まで流路(120)内の液体の平均的流体流動方向に従った長手軸を持ち、
各柱構造体(130)は、流路(120)の長手軸方向の長さと、長手軸に垂直な方向の幅を持ち、
各柱構造体(130)の幅と長さの比率は少なくとも7である、化学反応器デバイス(100)。 - 各柱構造体(130)の幅と長さの比率は少なくとも10である、請求項1に記載の化学反応器デバイス(100)。
- 流路壁(122)と隣接する非接触の柱構造体(130)の壁との間の最小距離(W)は、2つの隣接する柱構造体(130)間の最小距離(B)の0.9倍より大きい、請求項1又は請求項2に記載の化学反応器デバイス(100)。
- 流路壁(122)と隣接する非接触の柱構造体(130)の壁との間の最小距離(W)は、2つの隣接する柱構造体(130)間の最小距離(B)より大きい、請求項1から請求項3のいずれかに記載の化学反応器デバイス(100)。
- 流路壁(122)と隣接する非接触の柱構造体(130)の壁との間の最小距離(W)と、2つの隣接する柱構造体(130)間の最小距離(B)は、長手軸に垂直な、流路(120)の幅方向で計測される、請求項3又は請求項4に記載の化学反応器デバイス(100)。
- 柱構造体(130)は、一連の連結された長手及び横断のマイクロ流路を定めるように位置付けられ、
第1のサブセットの長手マイクロ流路は、長手軸方向に伸び、2つの柱構造体(130)の壁により規定され、
第2のサブセットの長手マイクロ流路は、長手軸方向に伸び、流路壁(122)と柱構造体(130)の壁とにより規定され、
第1のサブセットの最小幅(B)は、第2のサブセットの最小幅(W)より小さいか同じである、請求項1から請求項5のいずれかに記載の化学反応器デバイス(100)。 - 柱構造体(130)は、微細加工された柱構造体である、請求項1から請求項6のいずれかに記載の化学反応器デバイス(100)。
- 柱構造体(130)の幅と長さの比率は、少なくとも12である、請求項1から請求項7のいずれかに記載の化学反応器デバイス(100)。
- 2つの隣接する柱構造体(130)間の最小距離(B)は、流路壁(122)と隣接する非接触の柱構造体(130)の壁との間の最小距離(W)の0.5倍から0.8倍の間である、請求項1から請求項8のいずれかに記載の化学反応器デバイス(100)。
- 各柱構造体(130)の断面は多角形である、請求項1から請求項9のいずれかに記載の化学反応器デバイス(100)。
- 各柱構造体(130)の断面は六角形である、請求項10に記載の化学反応器デバイス(100)。
- 各柱構造体(130)は、流路の長手軸に従って位置している側壁により、幅方向を囲まれ、前記側壁の長さは、柱構造体(130)の長さの少なくとも0.02倍である、請求項10又は請求項11に記載の化学反応器デバイス(100)。
- 流路(120)と、柱構造体(130)により形成されるマイクロ流路は、さらに、基板により、両側を制限される、請求項1から請求項12のいずれかに記載の化学反応器デバイス(100)。
- 化学反応器は液体クロマトグラフィー分離装置である、請求項1から請求項13のいずれかに記載の化学反応器デバイス(100)。
- 流路壁(122)は膜により形成される、請求項1から請求項14のいずれかに記載の化学反応器デバイス(100)。
- 流路壁(122)は、流路の長手軸において、少なくとも一部以上が平らである、請求項1から請求項15のいずれかに記載の化学反応器デバイス(100)。
- 化学反応器デバイス(100)を製造するために基板内で構造体のリソグラフィを適用するためのマスクであって、
化学反応器デバイス(100)の流路(120)内に位置付けられる一連の規則的な柱構造体(130)を規定するための設計要素を含み、
各柱構造体(130)は、流路(120)の長手軸方向の長さと、長手軸に垂直な方向の幅を持ち、
前記設計要素は、結果として生じる各柱構造体(130)の幅と長さの比率が少なくとも7になるように、前記マスクに設けられる、マスク。 - 流路(120)を規定する流路壁(122)と隣接する非接触の柱構造体(130)の壁との間の最小距離(W)が、2つの隣接する柱構造体(130)間の最小距離(B)の0.9倍より大きくなるような方法で、結果として生じる柱構造体(130)が流路(120)内に位置付けられるように、前記設計要素は規定される、請求項17に記載のマスク。
- 流路(120)を規定する流路壁(122)と隣接する非接触の柱構造体(130)の壁との間の最小距離(W)が、2つの隣接する柱構造体(130)間の最小距離(B)より大きくなるような方法で、結果として生じる柱構造体(130)が流路(120)内に位置付けられるように、前記設計要素は規定される、請求項18に記載のマスク。
- 前記設計要素は、結果として生じる柱構造体(130)が、流路(120)の長手軸に従って位置している側壁により幅方向を囲まれ、前記側壁の長さが柱構造体(130)の長さの少なくとも0.02倍となるように、適応される、請求項17又は請求項19に記載のマスク。
- 化学反応器デバイスの製造方法であって、請求項17から請求項20のいずれかのマスクを使用した、柱構造体を備えた流路のリソグラフィの実施を含む方法。
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BE2013/0078A BE1022314B1 (nl) | 2013-02-05 | 2013-02-05 | Chemische reactor inrichting |
PCT/IB2014/058808 WO2014122592A1 (en) | 2013-02-05 | 2014-02-05 | Chemical reactor device |
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AU (1) | AU2014213666B2 (ja) |
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Cited By (3)
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JP2019524428A (ja) * | 2016-07-04 | 2019-09-05 | ファーマフルーイディクス エヌブイ | 化学反応器の生産 |
JP2020517959A (ja) * | 2017-04-27 | 2020-06-18 | ファルマフルイディクス・ナムローゼ・フェンノートシャップPharmaFluidics NV | 流体特性の横方向検出 |
JP7508506B2 (ja) | 2016-07-04 | 2024-07-01 | ファーマフルーイディクス エヌブイ | 化学反応器の生産 |
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SG2013047410A (en) * | 2013-06-19 | 2015-01-29 | Lai Huat Goi | An apparatus for generating nanobubbles |
WO2016037150A1 (en) * | 2014-09-05 | 2016-03-10 | Imagine Tf, Llc | Microstructure separation filters |
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BE1026910B1 (nl) * | 2018-12-21 | 2020-07-22 | Pharmafluidics N V | Chemische reactoren |
BE1027013B1 (nl) * | 2019-01-31 | 2020-09-01 | Pharmafluidics N V | Filter voor chemische reactoren |
BE1028976B1 (nl) | 2020-12-30 | 2022-08-01 | Pharmafluidics N V | Pilaarstructuren |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996010747A1 (en) * | 1994-09-30 | 1996-04-11 | Abbott Laboratories | Devices and methods utilizing arrays of structures for analyte capture |
JP2004170396A (ja) * | 2002-10-30 | 2004-06-17 | Nec Corp | 分離装置およびその製造方法、ならびに分析システム |
JP2010528276A (ja) * | 2007-05-23 | 2010-08-19 | ブレイエ・ユニバージテイト・ブリュッセル | 微細加工分離チャネルに試料及びキャリア液を分配する装置 |
US20110000624A1 (en) * | 2007-12-21 | 2011-01-06 | Nederlandse Organisatie Voor Toegepast Natuurwetenschappelijk Onderzoek Tno | Multiple connected channel micro evaporator |
JP2011174856A (ja) * | 2010-02-25 | 2011-09-08 | Tokyo Electron Ltd | クロマトグラフィー用カラム、その製造方法、および分析装置 |
JP2013542051A (ja) * | 2010-08-24 | 2013-11-21 | ケムトリックス ベーフェー | マイクロ流体装置 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2396408C (en) * | 2001-08-03 | 2006-03-28 | Nec Corporation | Fractionating apparatus having colonies of pillars arranged in migration passage at interval and process for fabricating pillars |
-
2013
- 2013-02-05 BE BE2013/0078A patent/BE1022314B1/nl active
-
2014
- 2014-02-05 CA CA2900217A patent/CA2900217C/en active Active
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- 2014-02-05 AU AU2014213666A patent/AU2014213666B2/en active Active
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Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996010747A1 (en) * | 1994-09-30 | 1996-04-11 | Abbott Laboratories | Devices and methods utilizing arrays of structures for analyte capture |
JP2004170396A (ja) * | 2002-10-30 | 2004-06-17 | Nec Corp | 分離装置およびその製造方法、ならびに分析システム |
JP2010528276A (ja) * | 2007-05-23 | 2010-08-19 | ブレイエ・ユニバージテイト・ブリュッセル | 微細加工分離チャネルに試料及びキャリア液を分配する装置 |
US20110000624A1 (en) * | 2007-12-21 | 2011-01-06 | Nederlandse Organisatie Voor Toegepast Natuurwetenschappelijk Onderzoek Tno | Multiple connected channel micro evaporator |
JP2011174856A (ja) * | 2010-02-25 | 2011-09-08 | Tokyo Electron Ltd | クロマトグラフィー用カラム、その製造方法、および分析装置 |
JP2013542051A (ja) * | 2010-08-24 | 2013-11-21 | ケムトリックス ベーフェー | マイクロ流体装置 |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2019524428A (ja) * | 2016-07-04 | 2019-09-05 | ファーマフルーイディクス エヌブイ | 化学反応器の生産 |
JP2022126635A (ja) * | 2016-07-04 | 2022-08-30 | ファーマフルーイディクス エヌブイ | 化学反応器の生産 |
US11724259B2 (en) | 2016-07-04 | 2023-08-15 | Pharmafluidics Nv | Production of chemical reactors |
JP7508506B2 (ja) | 2016-07-04 | 2024-07-01 | ファーマフルーイディクス エヌブイ | 化学反応器の生産 |
JP2020517959A (ja) * | 2017-04-27 | 2020-06-18 | ファルマフルイディクス・ナムローゼ・フェンノートシャップPharmaFluidics NV | 流体特性の横方向検出 |
US11619587B2 (en) | 2017-04-27 | 2023-04-04 | Pharmafluidics Nv | Lateral detection of fluid properties |
JP7320454B2 (ja) | 2017-04-27 | 2023-08-03 | ファルマフルイディクス・ナムローゼ・フェンノートシャップ | 流体特性の横方向検出 |
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JP6437459B2 (ja) | 2018-12-12 |
DK2953716T3 (en) | 2017-08-28 |
AU2014213666A1 (en) | 2015-08-20 |
EP2953716A1 (en) | 2015-12-16 |
CA2900217C (en) | 2021-10-12 |
CN105102113A (zh) | 2015-11-25 |
BE1022314B1 (nl) | 2016-03-15 |
US20160001199A1 (en) | 2016-01-07 |
WO2014122592A1 (en) | 2014-08-14 |
AU2014213666B2 (en) | 2017-02-23 |
CA2900217A1 (en) | 2014-08-14 |
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CN105102113B (zh) | 2018-05-29 |
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