JP2020517959A - 流体特性の横方向検出 - Google Patents
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Abstract
Description
流体プラグを受け取るための入口または流体プラグを除くための出口を有するミクロ流体流路と、流体プラグの長軸が、その元の配向とは対照的に、ミクロ流体流路の壁(例えば、直立した側壁)に対して垂直方向(すなわち、横方向)に本質的に配向し、より長い長軸がより狭い入口流路の長手方向に配向しているように、流体プラグの向きを変えるための柱系フロー分配器と、を備え、該ミクロ流体流路の幅Wは、入口または出口流路の幅wよりも実質的に大きく、
該ミクロ流体装置は、少なくとも1つの検出器を用いて、流体の物理的または化学的特性を検出するように適合されており、該ミクロ流体装置は、ミクロ流体流路の幅方向に、ミクロ流体流路全域にわたって配置された検出領域において特性を検出するように構成されており、該ミクロ流体装置は、柱系フロー分配器の出口または入口の距離D内に配置された検出領域を有するように構成されており、該距離Dは、ミクロ流体流路の幅Wより小さい。
そこで、例えば、従来システムなどの長い経路長が得られる、そこで、U形状流路または従来システムにおいて測定が行われ、Z形状流路において測定が行われることである。
Claims (15)
- 流体の特性を検出するためのミクロ流体装置(100)であって、
該ミクロ流体装置(100)が、少なくとも流体プラグを受け取るための入口(120)または流体プラグを除くための出口を有するミクロ流体流路(110)と、流体プラグの長軸が、その元の配向とは対照的に、ミクロ流体流路の壁に対して垂直方向(すなわち、横方向)に本質的に配向し、より長い長軸がより狭い入口流路の長手方向に配向しているように、流体プラグの向きを変えるための柱系フロー分配器(130)と、を備え、該ミクロ流体流路の幅Wが入口または出口流路の幅wよりも実質的に大きく、
該ミクロ流体装置(100)が少なくとも1つの検出器(200)を用いて流体の物理的または化学的特性を検出するように適合されており、該ミクロ流体装置(100)がミクロ流体流路(110)の幅方向にミクロ流体流路(110)にわたって配置された検出領域(210)において前記特性を検出するように構成されており、該ミクロ流体装置(100)がミクロ流体流路の幅Wより小さい柱系フロー分配器(130)の出口または入口の距離D内に配置された検出領域(210)を有するように構成されている、
ミクロ流体装置(100)。 - 前記検出領域内のミクロ流体流路(110)の幅(W)が、少なくとも0.2mm、好ましくは、少なくとも1mm、例えば、少なくとも10mmである、請求項1に記載のミクロ流体装置(100)。
- 前記ミクロ流体装置が、試料の光学特性を決定するために、試料と放射光線との間の相互作用を提供するように適合されている、前記請求項のうちのいずれか一項に記載のミクロ流体装置(100)。
- 前記システムが、限定された検出領域における前記放射線を制限するためのコリメート手段および/またはガイド手段を備える、請求項3に記載のミクロ流体装置(100)。
- 前記ガイド手段は、放射線が前記限定された検出領域内にとどまるように、放射線を方向転換させる反射体もしくは反射面であるか、または前記限定された検出領域の外側で発生する放射線を低減するための吸収体もしくは吸収面である、請求項4に記載のミクロ流体装置(100)。
- 前記システムが、光ファイバーを使用して、放射線源からの放射線を結合するように、および/または検出器に向けて放射線を脱結合するように適合されている、請求項3〜5のうちのいずれか一項に記載のミクロ流体装置(100)。
- 前記ミクロ流体装置が、放射線源および/または光学検出器を備える、請求項3〜6のうちのいずれか一項に記載のミクロ流体装置(100)。
- 前記ミクロ流体装置が、前記導波路内を移動する放射線の相互作用を誘発するための、前記ミクロ流体流路の実質的に幅方向にミクロ流体流路内に配置された導波路と、ミクロ流体流路内の試料流体と、を備える、請求項3に記載のミクロ流体装置(100)。
- 前記導波路が、前記ミクロ流体流路内の前記試料流体とのエバネッセント波相互作用を誘発するために配置されている、請求項8に記載のミクロ流体装置(100)。
- 前記ミクロ流体装置が、抵抗、インピーダンス、静電容量、または電流密度のうちのいずれか1つを検出するための電気的検出器を備える、前記請求項のうちのいずれか一項に記載のミクロ流体装置(100)。
- 前記電気的検出器が、少なくとも1つの作用電極、および少なくとも1つの対向電極を備える、請求項10に記載のミクロ流体装置(100)。
- 前記電気的検出器の位置での前記ミクロ流体流路の高さが、前記ミクロ流体流路の残りの部分の平均よりも実質的に小さい、請求項10〜11のうちのいずれか一項に記載のミクロ流体装置(100)。
- 前記ミクロ流体装置が、化学検出器を備える、前記請求項のうちのいずれか一項に記載のミクロ流体装置(100)。
- 請求項1〜13のうちのいずれか一項に記載のミクロ流体装置を備える検出システム。
- 前記システムが、一体型放射線源、一体型検出器、検出データを処理し、そこから前記試料流体の特性を引き出すためのプロセッサー、および前記試料流体の特性を出力するための出力手段のうちの1つ以上をさらに備える、請求項14に記載の検出システム。
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EP17168557.1 | 2017-04-27 | ||
EP17168557.1A EP3396355A1 (en) | 2017-04-27 | 2017-04-27 | Lateral detection of fluid properties |
PCT/EP2018/060979 WO2018197712A1 (en) | 2017-04-27 | 2018-04-27 | Lateral detection of fluid properties |
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JP2020517959A true JP2020517959A (ja) | 2020-06-18 |
JPWO2018197712A5 JPWO2018197712A5 (ja) | 2023-05-12 |
JP7320454B2 JP7320454B2 (ja) | 2023-08-03 |
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EP (3) | EP3396355A1 (ja) |
JP (1) | JP7320454B2 (ja) |
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AU (2) | AU2018259109B2 (ja) |
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Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002221485A (ja) * | 2000-11-22 | 2002-08-09 | Minolta Co Ltd | マイクロチップ |
JP2006300726A (ja) * | 2005-04-20 | 2006-11-02 | Hokkaido Univ | フォトニック結晶集積型分離・計測デバイス |
JP2007113979A (ja) * | 2005-10-19 | 2007-05-10 | Ebara Corp | マルチ分光分析装置 |
JP2007248253A (ja) * | 2006-03-15 | 2007-09-27 | Omron Corp | 光学部品、光学センサ、表面プラズモンセンサ及び指紋認証装置 |
JP2009063601A (ja) * | 2008-12-26 | 2009-03-26 | Nec Corp | マイクロチップ、マイクロチップの製造方法および成分検出方法 |
JP2009175108A (ja) * | 2008-01-28 | 2009-08-06 | Sharp Corp | 分析用マイクロ流路デバイス |
JPWO2009031375A1 (ja) * | 2007-09-07 | 2010-12-09 | 国立大学法人 筑波大学 | 電気化学的センサ装置及びこれを用いた電気化学的測定方法 |
US20130079248A1 (en) * | 2011-09-26 | 2013-03-28 | Samsung Electronics Co., Ltd. | Fluid controlling apparatus and filter and biochip including the fluid controlling apparatus |
JP2015001416A (ja) * | 2013-06-14 | 2015-01-05 | 日本電信電話株式会社 | フローセルおよび送液方法 |
JP2016508440A (ja) * | 2013-02-05 | 2016-03-22 | ファルマフライディクス・ナムローゼ・フェンノートシャップPharmafluidics Nv | 化学反応器デバイス |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2407701A1 (en) * | 2000-04-28 | 2001-11-08 | Edgelight Biosciences, Inc. | Micro-array evanescent wave fluorescence detection device |
DE60234572D1 (de) * | 2001-02-15 | 2010-01-14 | Caliper Life Sciences Inc | Mikrofluidische systeme mit verbesserten detektionssystemen |
WO2003006964A1 (en) * | 2001-07-12 | 2003-01-23 | Aclara Biosciences, Inc. | Submersible light-directing member for material excitation in microfluidic devices |
US20050095602A1 (en) * | 2003-11-04 | 2005-05-05 | West Jason A. | Microfluidic integrated microarrays for biological detection |
US20070009382A1 (en) * | 2005-07-05 | 2007-01-11 | William Bedingham | Heating element for a rotating multiplex fluorescence detection device |
US8064063B2 (en) * | 2006-07-20 | 2011-11-22 | Trinean Nv | Optical characterisation methods and systems |
EP1881318A1 (en) * | 2006-07-20 | 2008-01-23 | Universiteit Gent | Optical characterisation methods and systems |
CN101688854A (zh) * | 2007-05-23 | 2010-03-31 | Vrije布鲁塞尔大学 | 用于横跨微构分离通道分配试样和载液的设备 |
JP2009031375A (ja) | 2007-07-25 | 2009-02-12 | Hiroshi Fukuhara | 銘板貼り付け冶具 |
US7952705B2 (en) * | 2007-08-24 | 2011-05-31 | Dynamic Throughput Inc. | Integrated microfluidic optical device for sub-micro liter liquid sample microspectroscopy |
JP5231782B2 (ja) * | 2007-10-26 | 2013-07-10 | 学校法人常翔学園 | 固液分離機能を有する装置及びその製造方法 |
US8477298B2 (en) | 2009-09-30 | 2013-07-02 | Corning Incorporated | Angle-cleaved optical fibers and methods of making and using same |
CN102062729A (zh) * | 2009-11-11 | 2011-05-18 | 中国科学院半导体研究所 | 双通道微环形腔结构传感器与微流通道的集成结构及其制作方法 |
CN102665847A (zh) | 2009-12-25 | 2012-09-12 | 学校法人常翔学园 | 具有固液分离功能的装置、μ-TAS设备及固液分离方法 |
US9170138B2 (en) * | 2010-10-01 | 2015-10-27 | The Board Of Trustees Of The Leland Stanford Junior University | Enhanced microfluidic electromagnetic measurements |
US9999886B2 (en) * | 2010-10-07 | 2018-06-19 | The Regents Of The University Of California | Methods and systems for on demand droplet generation and impedance based detection |
CN105301174B (zh) * | 2014-07-16 | 2017-07-18 | 中国科学院苏州纳米技术与纳米仿生研究所 | 用于微流控芯片的试剂滴定方法及装置、微流控芯片 |
US10451540B2 (en) | 2015-01-19 | 2019-10-22 | Entegris, Inc. | Multi-pass gas cell with mirrors in openings of cylindrical wall for IR and UV monitoring |
WO2017049279A1 (en) * | 2015-09-18 | 2017-03-23 | Rheomics Inc. | Flow cells utilizing surface-attached structures, and related systems and methods |
-
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- 2017-04-27 EP EP17168557.1A patent/EP3396355A1/en not_active Withdrawn
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- 2018-04-27 US US16/608,443 patent/US11619587B2/en active Active
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Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002221485A (ja) * | 2000-11-22 | 2002-08-09 | Minolta Co Ltd | マイクロチップ |
JP2006300726A (ja) * | 2005-04-20 | 2006-11-02 | Hokkaido Univ | フォトニック結晶集積型分離・計測デバイス |
JP2007113979A (ja) * | 2005-10-19 | 2007-05-10 | Ebara Corp | マルチ分光分析装置 |
JP2007248253A (ja) * | 2006-03-15 | 2007-09-27 | Omron Corp | 光学部品、光学センサ、表面プラズモンセンサ及び指紋認証装置 |
JPWO2009031375A1 (ja) * | 2007-09-07 | 2010-12-09 | 国立大学法人 筑波大学 | 電気化学的センサ装置及びこれを用いた電気化学的測定方法 |
JP2009175108A (ja) * | 2008-01-28 | 2009-08-06 | Sharp Corp | 分析用マイクロ流路デバイス |
JP2009063601A (ja) * | 2008-12-26 | 2009-03-26 | Nec Corp | マイクロチップ、マイクロチップの製造方法および成分検出方法 |
US20130079248A1 (en) * | 2011-09-26 | 2013-03-28 | Samsung Electronics Co., Ltd. | Fluid controlling apparatus and filter and biochip including the fluid controlling apparatus |
JP2016508440A (ja) * | 2013-02-05 | 2016-03-22 | ファルマフライディクス・ナムローゼ・フェンノートシャップPharmafluidics Nv | 化学反応器デバイス |
JP2015001416A (ja) * | 2013-06-14 | 2015-01-05 | 日本電信電話株式会社 | フローセルおよび送液方法 |
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US20210072154A1 (en) | 2021-03-11 |
EP3396355A1 (en) | 2018-10-31 |
AU2018259109B2 (en) | 2024-01-25 |
CN110546480A (zh) | 2019-12-06 |
EP3615915B1 (en) | 2024-05-15 |
WO2018197712A1 (en) | 2018-11-01 |
JP7320454B2 (ja) | 2023-08-03 |
AU2024202739A1 (en) | 2024-05-16 |
CA3059661A1 (en) | 2018-11-01 |
EP4372363A2 (en) | 2024-05-22 |
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US11619587B2 (en) | 2023-04-04 |
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