JP2016506736A5 - - Google Patents
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- Publication number
- JP2016506736A5 JP2016506736A5 JP2015556262A JP2015556262A JP2016506736A5 JP 2016506736 A5 JP2016506736 A5 JP 2016506736A5 JP 2015556262 A JP2015556262 A JP 2015556262A JP 2015556262 A JP2015556262 A JP 2015556262A JP 2016506736 A5 JP2016506736 A5 JP 2016506736A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- heregulin
- cells
- chga
- kinase inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 13
- 210000004027 cell Anatomy 0.000 claims 8
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 210000003890 endocrine cell Anatomy 0.000 claims 6
- 210000004039 endoderm cell Anatomy 0.000 claims 6
- 239000003590 rho kinase inhibitor Substances 0.000 claims 6
- 102000010792 Chromogranin A Human genes 0.000 claims 4
- 108010038447 Chromogranin A Proteins 0.000 claims 4
- 108060006698 EGF receptor Proteins 0.000 claims 4
- 102000001301 EGF receptor Human genes 0.000 claims 4
- 102000004877 Insulin Human genes 0.000 claims 4
- 108090001061 Insulin Proteins 0.000 claims 4
- NGOGFTYYXHNFQH-UHFFFAOYSA-N fasudil Chemical compound C=1C=CC2=CN=CC=C2C=1S(=O)(=O)N1CCCNCC1 NGOGFTYYXHNFQH-UHFFFAOYSA-N 0.000 claims 4
- 229960002435 fasudil Drugs 0.000 claims 4
- 229940125396 insulin Drugs 0.000 claims 4
- 210000002660 insulin-secreting cell Anatomy 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 210000002438 upper gastrointestinal tract Anatomy 0.000 claims 4
- 102000048238 Neuregulin-1 Human genes 0.000 claims 3
- 108090000556 Neuregulin-1 Proteins 0.000 claims 3
- 102000001708 Protein Isoforms Human genes 0.000 claims 3
- 108010029485 Protein Isoforms Proteins 0.000 claims 3
- 230000003213 activating effect Effects 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 claims 2
- 108091005735 TGF-beta receptors Proteins 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 230000000692 anti-sense effect Effects 0.000 claims 2
- 230000002860 competitive effect Effects 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 230000009368 gene silencing by RNA Effects 0.000 claims 2
- 239000008103 glucose Substances 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000011435 rock Substances 0.000 claims 2
- 230000000638 stimulation Effects 0.000 claims 2
- 102100028096 Homeobox protein Nkx-6.2 Human genes 0.000 claims 1
- 101000578254 Homo sapiens Homeobox protein Nkx-6.1 Proteins 0.000 claims 1
- 101000578258 Homo sapiens Homeobox protein Nkx-6.2 Proteins 0.000 claims 1
- 102000014413 Neuregulin Human genes 0.000 claims 1
- 108050003475 Neuregulin Proteins 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/761,078 | 2013-02-06 | ||
| US13/761,078 US9109245B2 (en) | 2009-04-22 | 2013-02-06 | Cell compositions derived from dedifferentiated reprogrammed cells |
| PCT/US2014/015156 WO2014124172A1 (en) | 2013-02-06 | 2014-02-06 | Cell compositions derived from dedifferentiated reprogrammed cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019078983A Division JP6721752B2 (ja) | 2013-02-06 | 2019-04-18 | 脱分化したリプログラミングされた細胞から導出された細胞組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016506736A JP2016506736A (ja) | 2016-03-07 |
| JP2016506736A5 true JP2016506736A5 (enExample) | 2017-03-09 |
| JP6517702B2 JP6517702B2 (ja) | 2019-05-22 |
Family
ID=50239931
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015556262A Active JP6517702B2 (ja) | 2013-02-06 | 2014-02-06 | 脱分化したリプログラミングされた細胞から導出された細胞組成物 |
| JP2019078983A Active JP6721752B2 (ja) | 2013-02-06 | 2019-04-18 | 脱分化したリプログラミングされた細胞から導出された細胞組成物 |
| JP2020104982A Active JP7250731B2 (ja) | 2013-02-06 | 2020-06-18 | 脱分化したリプログラミングされた細胞から導出された細胞組成物 |
| JP2022172222A Active JP7550830B2 (ja) | 2013-02-06 | 2022-10-27 | 脱分化したリプログラミングされた細胞から導出された細胞組成物 |
| JP2024151116A Pending JP2025000625A (ja) | 2013-02-06 | 2024-09-03 | 脱分化したリプログラミングされた細胞から導出された細胞組成物 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019078983A Active JP6721752B2 (ja) | 2013-02-06 | 2019-04-18 | 脱分化したリプログラミングされた細胞から導出された細胞組成物 |
| JP2020104982A Active JP7250731B2 (ja) | 2013-02-06 | 2020-06-18 | 脱分化したリプログラミングされた細胞から導出された細胞組成物 |
| JP2022172222A Active JP7550830B2 (ja) | 2013-02-06 | 2022-10-27 | 脱分化したリプログラミングされた細胞から導出された細胞組成物 |
| JP2024151116A Pending JP2025000625A (ja) | 2013-02-06 | 2024-09-03 | 脱分化したリプログラミングされた細胞から導出された細胞組成物 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP2954045A1 (enExample) |
| JP (5) | JP6517702B2 (enExample) |
| AU (4) | AU2014214879A1 (enExample) |
| CA (2) | CA2898431C (enExample) |
| HK (1) | HK1218139A1 (enExample) |
| IL (5) | IL321825A (enExample) |
| RU (2) | RU2675928C2 (enExample) |
| WO (1) | WO2014124172A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9109245B2 (en) | 2009-04-22 | 2015-08-18 | Viacyte, Inc. | Cell compositions derived from dedifferentiated reprogrammed cells |
| SG11201700874SA (en) | 2014-08-04 | 2017-03-30 | Takeda Pharmaceuticals Co | Method for proliferation of pancreatic progenitor cells |
| MA45479A (fr) * | 2016-04-14 | 2019-02-20 | Janssen Biotech Inc | Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen |
| EP3690022A1 (en) * | 2016-05-18 | 2020-08-05 | Keio University | Cell culture medium for culturing organoid, culture method, and organoid |
| EP3587560A4 (en) | 2017-01-27 | 2020-12-16 | Kaneka Corporation | Endodermal cell mass, and method for producing any one of three primary germ layer cell mass from pluripotent cells |
| NZ800904A (en) | 2017-06-14 | 2025-08-29 | Vertex Pharma | Devices and methods for delivering therapeutics |
| EP3654996A4 (en) * | 2017-07-21 | 2021-03-24 | Semma Therapeutics, Inc. | REAGGREGATION OF PANCREATIC BETA CELLS DERIVED FROM STEM CELLS |
| CN112912490B (zh) * | 2018-08-03 | 2023-12-26 | 千纸鹤治疗公司 | 细胞制造方法 |
| EP3854869A4 (en) * | 2018-09-19 | 2022-09-07 | Takeda Pharmaceutical Company Limited | INSULIN-PRODUCING CELLS |
| EP3976236A1 (en) | 2019-05-31 | 2022-04-06 | W.L. Gore & Associates Inc. | A biocompatible membrane composite |
| CA3257300A1 (en) | 2019-05-31 | 2025-06-12 | W. L. Gore & Associates, Inc. | Cell encapsulation devices with controlled oxygen diffusion distances |
| EP3975926A1 (en) | 2019-05-31 | 2022-04-06 | W.L. Gore & Associates, Inc. | A biocompatible membrane composite |
| CN114173837A (zh) | 2019-05-31 | 2022-03-11 | W.L.戈尔及同仁股份有限公司 | 生物相容性膜复合材料 |
| IL300105A (en) | 2020-07-31 | 2023-03-01 | Vertex Pharma | Pancreatic endocrine cell differentiation |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000059525A2 (en) * | 1999-04-06 | 2000-10-12 | Genentech, Inc. | USE OF ErbB RECEPTOR LIGANDS IN TREATING DIABETES |
| US6759039B2 (en) * | 2000-06-30 | 2004-07-06 | Amcyte, Inc. | Culturing pancreatic stem cells having a specified, intermediate stage of development |
| WO2002059278A2 (en) * | 2001-01-24 | 2002-08-01 | The Government Of The United States Of America, As Represented By The Secretary Of Department Of Health & Human Services | Differentiation of stem cells to pancreatic endocrine cells |
| SG169324A1 (en) * | 2005-10-14 | 2011-03-30 | Univ Minnesota | Differentiation of non-embryonic stem cells to cells having a pancreatic phenotype |
| WO2007143193A1 (en) * | 2006-06-02 | 2007-12-13 | University Of Georgia Research Foundation, Inc. | Pancreatic and liver endoderm cells and tissue by differentiation of definitive endoderm cells obtained from human embryonic stems |
| JP2012508584A (ja) * | 2008-11-14 | 2012-04-12 | ヴィアサイト，インコーポレイテッド | ヒト多能性幹細胞由来膵臓細胞のカプセル化 |
| DK2421957T3 (da) * | 2009-04-22 | 2021-01-25 | Viacyte Inc | Cellesammensætninger afledt af dedifferentierede omprogrammerede celler |
| US9109245B2 (en) * | 2009-04-22 | 2015-08-18 | Viacyte, Inc. | Cell compositions derived from dedifferentiated reprogrammed cells |
| US8685726B2 (en) * | 2009-04-27 | 2014-04-01 | Viacyte, Inc. | Small molecules supporting pluripotent cell growth and methods thereof |
-
2014
- 2014-02-06 EP EP14708981.7A patent/EP2954045A1/en active Pending
- 2014-02-06 CA CA2898431A patent/CA2898431C/en active Active
- 2014-02-06 AU AU2014214879A patent/AU2014214879A1/en not_active Abandoned
- 2014-02-06 JP JP2015556262A patent/JP6517702B2/ja active Active
- 2014-02-06 HK HK16106057.9A patent/HK1218139A1/zh unknown
- 2014-02-06 IL IL321825A patent/IL321825A/en unknown
- 2014-02-06 RU RU2015131279A patent/RU2675928C2/ru active
- 2014-02-06 WO PCT/US2014/015156 patent/WO2014124172A1/en not_active Ceased
- 2014-02-06 RU RU2018144412A patent/RU2754089C2/ru active
- 2014-02-06 CA CA3212301A patent/CA3212301A1/en active Pending
- 2014-02-06 IL IL290717A patent/IL290717B2/en unknown
-
2015
- 2015-07-15 IL IL239953A patent/IL239953B/en active IP Right Grant
-
2019
- 2019-02-26 AU AU2019201314A patent/AU2019201314B2/en active Active
- 2019-04-18 JP JP2019078983A patent/JP6721752B2/ja active Active
-
2020
- 2020-06-18 JP JP2020104982A patent/JP7250731B2/ja active Active
-
2021
- 2021-05-10 IL IL283088A patent/IL283088B/en unknown
-
2022
- 2022-01-07 AU AU2022200075A patent/AU2022200075C1/en active Active
- 2022-10-27 JP JP2022172222A patent/JP7550830B2/ja active Active
-
2023
- 2023-04-26 AU AU2023202507A patent/AU2023202507B2/en active Active
-
2024
- 2024-03-25 IL IL311689A patent/IL311689B2/en unknown
- 2024-09-03 JP JP2024151116A patent/JP2025000625A/ja active Pending
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