JP2016505513A5 - - Google Patents
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- JP2016505513A5 JP2016505513A5 JP2015540262A JP2015540262A JP2016505513A5 JP 2016505513 A5 JP2016505513 A5 JP 2016505513A5 JP 2015540262 A JP2015540262 A JP 2015540262A JP 2015540262 A JP2015540262 A JP 2015540262A JP 2016505513 A5 JP2016505513 A5 JP 2016505513A5
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- Prior art keywords
- seq
- antibody
- antigen
- binding fragment
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000427 antigen Substances 0.000 claims 23
- 102000036639 antigens Human genes 0.000 claims 23
- 108091007433 antigens Proteins 0.000 claims 23
- 239000012634 fragment Substances 0.000 claims 23
- 239000000611 antibody drug conjugate Substances 0.000 claims 21
- 229940049595 antibody-drug conjugate Drugs 0.000 claims 21
- 102000001760 Notch3 Receptor Human genes 0.000 claims 15
- 108010029756 Notch3 Receptor Proteins 0.000 claims 15
- 125000003275 alpha amino acid group Chemical group 0.000 claims 15
- 206010028980 Neoplasm Diseases 0.000 claims 12
- 201000011510 cancer Diseases 0.000 claims 10
- 238000000034 method Methods 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000036210 malignancy Effects 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- IHPVMHRTGNEZNG-SJZZQOMKSA-N (2s)-2-[[(2r,3r)-3-methoxy-3-[(2s)-1-[(3r,4s,5s)-3-methoxy-5-methyl-4-[methyl-[(2s)-3-methyl-2-[[(2s)-2-methylpyrrolidine-2-carbonyl]amino]butanoyl]amino]heptanoyl]pyrrolidin-2-yl]-2-methylpropanoyl]amino]-3-phenylpropanoic acid Chemical compound C([C@H](NC(=O)[C@H](C)[C@@H](OC)[C@@H]1CCCN1C(=O)C[C@H]([C@H]([C@@H](C)CC)N(C)C(=O)[C@@H](NC(=O)[C@@]1(C)NCCC1)C(C)C)OC)C(O)=O)C1=CC=CC=C1 IHPVMHRTGNEZNG-SJZZQOMKSA-N 0.000 claims 1
- ZNENPPNSQVNMCG-BZXSYZDRSA-N (2s)-2-[[(2r,3r)-3-methoxy-3-[(2s)-1-[(3r,4s,5s)-3-methoxy-5-methyl-4-[methyl-[(2s)-3-methyl-2-[[2-methyl-2-(methylamino)propanoyl]amino]butanoyl]amino]heptanoyl]pyrrolidin-2-yl]-2-methylpropanoyl]amino]-3-phenylpropanoic acid Chemical compound CNC(C)(C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 ZNENPPNSQVNMCG-BZXSYZDRSA-N 0.000 claims 1
- -1 1,3-thiazol-2-yl Chemical group 0.000 claims 1
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 125000002068 L-phenylalanino group Chemical group [H]OC(=O)[C@@]([H])(N([H])[*])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000029052 T-cell acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000000389 T-cell leukemia Diseases 0.000 claims 1
- 208000028530 T-cell lymphoblastic leukemia/lymphoma Diseases 0.000 claims 1
- 206010042971 T-cell lymphoma Diseases 0.000 claims 1
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 230000001908 autoinhibitory effect Effects 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 230000001268 conjugating effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000004477 skin sarcoma Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261723772P | 2012-11-07 | 2012-11-07 | |
| US61/723,772 | 2012-11-07 | ||
| US201361889744P | 2013-10-11 | 2013-10-11 | |
| US61/889,744 | 2013-10-11 | ||
| PCT/IB2013/059893 WO2014072897A1 (en) | 2012-11-07 | 2013-11-04 | Anti-notch3 antibodies and antibody-drug conjugates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017073900A Division JP2017186337A (ja) | 2012-11-07 | 2017-04-03 | 抗ｎｏｔｃｈ３抗体および抗体−薬物コンジュゲート |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016505513A JP2016505513A (ja) | 2016-02-25 |
| JP2016505513A5 true JP2016505513A5 (cg-RX-API-DMAC7.html) | 2016-06-23 |
Family
ID=49585464
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015540262A Pending JP2016505513A (ja) | 2012-11-07 | 2013-11-04 | 抗ｎｏｔｃｈ３抗体および抗体−薬物コンジュゲート |
| JP2017073900A Withdrawn JP2017186337A (ja) | 2012-11-07 | 2017-04-03 | 抗ｎｏｔｃｈ３抗体および抗体−薬物コンジュゲート |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017073900A Withdrawn JP2017186337A (ja) | 2012-11-07 | 2017-04-03 | 抗ｎｏｔｃｈ３抗体および抗体−薬物コンジュゲート |
Country Status (19)
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9173661B2 (en) | 2006-02-27 | 2015-11-03 | Biomet Manufacturing, Llc | Patient specific alignment guide with cutting surface and laser indicator |
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| US9345548B2 (en) | 2006-02-27 | 2016-05-24 | Biomet Manufacturing, Llc | Patient-specific pre-operative planning |
| US9113971B2 (en) | 2006-02-27 | 2015-08-25 | Biomet Manufacturing, Llc | Femoral acetabular impingement guide |
| US8535387B2 (en) | 2006-02-27 | 2013-09-17 | Biomet Manufacturing, Llc | Patient-specific tools and implants |
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| US8377066B2 (en) | 2006-02-27 | 2013-02-19 | Biomet Manufacturing Corp. | Patient-specific elbow guides and associated methods |
| US8092465B2 (en) | 2006-06-09 | 2012-01-10 | Biomet Manufacturing Corp. | Patient specific knee alignment guide and associated method |
| US10278711B2 (en) | 2006-02-27 | 2019-05-07 | Biomet Manufacturing, Llc | Patient-specific femoral guide |
| US9289253B2 (en) | 2006-02-27 | 2016-03-22 | Biomet Manufacturing, Llc | Patient-specific shoulder guide |
| US7967868B2 (en) | 2007-04-17 | 2011-06-28 | Biomet Manufacturing Corp. | Patient-modified implant and associated method |
| US8407067B2 (en) | 2007-04-17 | 2013-03-26 | Biomet Manufacturing Corp. | Method and apparatus for manufacturing an implant |
| US8608748B2 (en) | 2006-02-27 | 2013-12-17 | Biomet Manufacturing, Llc | Patient specific guides |
| US9339278B2 (en) | 2006-02-27 | 2016-05-17 | Biomet Manufacturing, Llc | Patient-specific acetabular guides and associated instruments |
| US8603180B2 (en) | 2006-02-27 | 2013-12-10 | Biomet Manufacturing, Llc | Patient-specific acetabular alignment guides |
| US9918740B2 (en) | 2006-02-27 | 2018-03-20 | Biomet Manufacturing, Llc | Backup surgical instrument system and method |
| US8568487B2 (en) | 2006-02-27 | 2013-10-29 | Biomet Manufacturing, Llc | Patient-specific hip joint devices |
| US9795399B2 (en) | 2006-06-09 | 2017-10-24 | Biomet Manufacturing, Llc | Patient-specific knee alignment guide and associated method |
| EP2032166B1 (en) * | 2006-06-13 | 2013-04-10 | OncoMed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
| JP5248494B2 (ja) * | 2006-07-11 | 2013-07-31 | ユニバーシティ・オブ・メディシン・アンド・デンティストリー・オブ・ニュージャージー | タンパク質、それをコードする核酸および関連する使用方法 |
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| US9271744B2 (en) | 2010-09-29 | 2016-03-01 | Biomet Manufacturing, Llc | Patient-specific guide for partial acetabular socket replacement |
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| US9968376B2 (en) | 2010-11-29 | 2018-05-15 | Biomet Manufacturing, Llc | Patient-specific orthopedic instruments |
| US9241745B2 (en) | 2011-03-07 | 2016-01-26 | Biomet Manufacturing, Llc | Patient-specific femoral version guide |
| US8715289B2 (en) | 2011-04-15 | 2014-05-06 | Biomet Manufacturing, Llc | Patient-specific numerically controlled instrument |
| US8668700B2 (en) | 2011-04-29 | 2014-03-11 | Biomet Manufacturing, Llc | Patient-specific convertible guides |
| US8956364B2 (en) | 2011-04-29 | 2015-02-17 | Biomet Manufacturing, Llc | Patient-specific partial knee guides and other instruments |
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| US8532807B2 (en) | 2011-06-06 | 2013-09-10 | Biomet Manufacturing, Llc | Pre-operative planning and manufacturing method for orthopedic procedure |
| US9084618B2 (en) | 2011-06-13 | 2015-07-21 | Biomet Manufacturing, Llc | Drill guides for confirming alignment of patient-specific alignment guides |
| US8764760B2 (en) | 2011-07-01 | 2014-07-01 | Biomet Manufacturing, Llc | Patient-specific bone-cutting guidance instruments and methods |
| US8597365B2 (en) | 2011-08-04 | 2013-12-03 | Biomet Manufacturing, Llc | Patient-specific pelvic implants for acetabular reconstruction |
| US9066734B2 (en) | 2011-08-31 | 2015-06-30 | Biomet Manufacturing, Llc | Patient-specific sacroiliac guides and associated methods |
| US9295497B2 (en) | 2011-08-31 | 2016-03-29 | Biomet Manufacturing, Llc | Patient-specific sacroiliac and pedicle guides |
| US9386993B2 (en) | 2011-09-29 | 2016-07-12 | Biomet Manufacturing, Llc | Patient-specific femoroacetabular impingement instruments and methods |
| US9301812B2 (en) | 2011-10-27 | 2016-04-05 | Biomet Manufacturing, Llc | Methods for patient-specific shoulder arthroplasty |
| US9451973B2 (en) | 2011-10-27 | 2016-09-27 | Biomet Manufacturing, Llc | Patient specific glenoid guide |
| ES2635542T3 (es) | 2011-10-27 | 2017-10-04 | Biomet Manufacturing, Llc | Guías glenoideas específicas para el paciente |
| US9554910B2 (en) | 2011-10-27 | 2017-01-31 | Biomet Manufacturing, Llc | Patient-specific glenoid guide and implants |
| KR20130046337A (ko) | 2011-10-27 | 2013-05-07 | 삼성전자주식회사 | 멀티뷰 디바이스 및 그 제어방법과, 디스플레이장치 및 그 제어방법과, 디스플레이 시스템 |
| US9060788B2 (en) | 2012-12-11 | 2015-06-23 | Biomet Manufacturing, Llc | Patient-specific acetabular guide for anterior approach |
| US9204977B2 (en) | 2012-12-11 | 2015-12-08 | Biomet Manufacturing, Llc | Patient-specific acetabular guide for anterior approach |
| WO2014100435A1 (en) | 2012-12-19 | 2014-06-26 | Aveo Pharmaceuticals, Inc. | Anti-notch3 antibodies |
| US9839438B2 (en) | 2013-03-11 | 2017-12-12 | Biomet Manufacturing, Llc | Patient-specific glenoid guide with a reusable guide holder |
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| US9826981B2 (en) | 2013-03-13 | 2017-11-28 | Biomet Manufacturing, Llc | Tangential fit of patient-specific guides |
| US9498233B2 (en) | 2013-03-13 | 2016-11-22 | Biomet Manufacturing, Llc. | Universal acetabular guide and associated hardware |
| EP3611189A1 (en) * | 2013-03-14 | 2020-02-19 | Novartis AG | Antibodies against notch 3 |
| US9683039B2 (en) * | 2013-03-14 | 2017-06-20 | New York University | Notch agonists for the treatment of cancer |
| US9517145B2 (en) | 2013-03-15 | 2016-12-13 | Biomet Manufacturing, Llc | Guide alignment system and method |
| US20150112349A1 (en) | 2013-10-21 | 2015-04-23 | Biomet Manufacturing, Llc | Ligament Guide Registration |
| US10282488B2 (en) | 2014-04-25 | 2019-05-07 | Biomet Manufacturing, Llc | HTO guide with optional guided ACL/PCL tunnels |
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| EP3149024B9 (en) * | 2014-05-28 | 2021-10-27 | Agensys, Inc. | Cytotoxic dolaproine-dolaisoleuine peptide derivatives for the treatment of cancer |
| US9839436B2 (en) | 2014-06-03 | 2017-12-12 | Biomet Manufacturing, Llc | Patient-specific glenoid depth control |
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| US10428143B2 (en) | 2014-09-28 | 2019-10-01 | The Regents Of The University Of California | Modulation of stimulatory and non-stimulatory myeloid cells |
| US9826994B2 (en) | 2014-09-29 | 2017-11-28 | Biomet Manufacturing, Llc | Adjustable glenoid pin insertion guide |
| US9833245B2 (en) | 2014-09-29 | 2017-12-05 | Biomet Sports Medicine, Llc | Tibial tubercule osteotomy |
| US10617670B2 (en) * | 2014-10-10 | 2020-04-14 | Pfizer Inc. | Synergistic auristatin combinations |
| US9820868B2 (en) | 2015-03-30 | 2017-11-21 | Biomet Manufacturing, Llc | Method and apparatus for a pin apparatus |
| US10568647B2 (en) | 2015-06-25 | 2020-02-25 | Biomet Manufacturing, Llc | Patient-specific humeral guide designs |
| US10226262B2 (en) | 2015-06-25 | 2019-03-12 | Biomet Manufacturing, Llc | Patient-specific humeral guide designs |
| US11142573B2 (en) * | 2016-04-29 | 2021-10-12 | Aveo Pharmaceuticals, Inc. | Anti-Notch3 antibody |
| CN105968038A (zh) * | 2016-05-09 | 2016-09-28 | 湖北华世通生物医药科技有限公司 | 二肽类化合物的盐酸盐及其制备方法 |
| US10722310B2 (en) | 2017-03-13 | 2020-07-28 | Zimmer Biomet CMF and Thoracic, LLC | Virtual surgery planning system and method |
| US10858443B2 (en) | 2017-05-31 | 2020-12-08 | Trustees Of Boston University | Synthetic notch protein for modulating gene expression |
| IL321287A (en) | 2017-12-12 | 2025-08-01 | Pionyr Immunotherapeutics Inc | Anti-trem2 antibodies and related methods |
| CN108753833B (zh) * | 2018-05-28 | 2021-12-03 | 上海海洋大学 | 斑马鱼notch3基因突变体的制备方法 |
| US11912763B2 (en) | 2018-06-17 | 2024-02-27 | L & L Biopharma Co., Ltd. | Antibody targeting CLDN18.2, bispecific antibody, ADC, and CAR, and applications thereof |
| WO2025011561A1 (en) * | 2023-07-10 | 2025-01-16 | Wuxi Xdc (Shanghai) Co., Ltd. | Antibody-drug conjugates and production thereof |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
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2013
- 2013-11-04 TW TW102139960A patent/TW201431880A/zh unknown
- 2013-11-04 TW TW104121691A patent/TWI589590B/zh not_active IP Right Cessation
- 2013-11-04 BR BR112015010436A patent/BR112015010436A2/pt not_active IP Right Cessation
- 2013-11-04 RU RU2015116480A patent/RU2015116480A/ru not_active Application Discontinuation
- 2013-11-04 KR KR1020157015019A patent/KR20150082548A/ko not_active Abandoned
- 2013-11-04 TW TW106112626A patent/TW201726746A/zh unknown
- 2013-11-04 JP JP2015540262A patent/JP2016505513A/ja active Pending
- 2013-11-04 WO PCT/IB2013/059893 patent/WO2014072897A1/en not_active Ceased
- 2013-11-04 EP EP13792099.7A patent/EP2917240A1/en not_active Ceased
- 2013-11-04 PE PE2015000604A patent/PE20150892A1/es not_active Application Discontinuation
- 2013-11-04 MX MX2015005810A patent/MX2015005810A/es unknown
- 2013-11-04 SG SG11201503469WA patent/SG11201503469WA/en unknown
- 2013-11-04 AU AU2013343045A patent/AU2013343045A1/en not_active Abandoned
- 2013-11-04 CN CN201380069303.2A patent/CN104903351A/zh active Pending
- 2013-11-04 CA CA2890571A patent/CA2890571A1/en active Pending
- 2013-11-04 HK HK16102254.9A patent/HK1214282A1/zh unknown
- 2013-11-06 AR ARP130104060A patent/AR093377A1/es unknown
- 2013-11-06 US US14/073,273 patent/US9433687B2/en not_active Expired - Fee Related
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2015
- 2015-04-30 IL IL238567A patent/IL238567A0/en unknown
- 2015-05-05 PH PH12015501000A patent/PH12015501000A1/en unknown
- 2015-05-06 SA SA515360395A patent/SA515360395B1/ar unknown
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2016
- 2016-07-27 US US15/221,049 patent/US20170014526A1/en not_active Abandoned
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2017
- 2017-04-03 JP JP2017073900A patent/JP2017186337A/ja not_active Withdrawn
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