JP2016504312A5 - - Google Patents
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- Publication number
- JP2016504312A5 JP2016504312A5 JP2015547026A JP2015547026A JP2016504312A5 JP 2016504312 A5 JP2016504312 A5 JP 2016504312A5 JP 2015547026 A JP2015547026 A JP 2015547026A JP 2015547026 A JP2015547026 A JP 2015547026A JP 2016504312 A5 JP2016504312 A5 JP 2016504312A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- lipid
- particles
- hydrophobic
- lipids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002245 particle Substances 0.000 claims description 28
- 150000002632 lipids Chemical class 0.000 claims description 24
- 230000002209 hydrophobic effect Effects 0.000 claims description 17
- 229920001184 polypeptide Polymers 0.000 claims description 13
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 13
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 13
- 230000004576 lipid-binding Effects 0.000 claims description 11
- 102000017852 Saposin Human genes 0.000 claims description 5
- 108050007079 Saposin Proteins 0.000 claims description 5
- 102000004895 Lipoproteins Human genes 0.000 claims description 3
- 108090001030 Lipoproteins Proteins 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims 16
- 108090000623 proteins and genes Proteins 0.000 claims 16
- 238000000034 method Methods 0.000 claims 11
- 239000003795 chemical substances by application Substances 0.000 claims 9
- 239000004480 active ingredient Substances 0.000 claims 5
- 108010052285 Membrane Proteins Proteins 0.000 claims 3
- 102000018697 Membrane Proteins Human genes 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 239000003599 detergent Substances 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 239000002537 cosmetic Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 150000002894 organic compounds Chemical class 0.000 claims 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 2
- 150000003904 phospholipids Chemical class 0.000 claims 2
- 238000000746 purification Methods 0.000 claims 2
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 1
- QTTLKKFUOJQIRB-JOLIRYOJSA-N 1-(3-O-sulfo-beta-D-galactosyl)-N-[(2R)-2-hydroxylignoceroyl]sphingosine Chemical compound CCCCCCCCCCCCCCCCCCCCCC[C@@H](O)C(=O)N[C@H]([C@H](O)\C=C\CCCCCCCCCCCCC)CO[C@@H]1O[C@H](CO)[C@H](O)[C@H](OS(O)(=O)=O)[C@H]1O QTTLKKFUOJQIRB-JOLIRYOJSA-N 0.000 claims 1
- PAZGBAOHGQRCBP-DDDNOICHSA-N 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C/CCCCCCCC PAZGBAOHGQRCBP-DDDNOICHSA-N 0.000 claims 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 229930182558 Sterol Natural products 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 238000001042 affinity chromatography Methods 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 239000012459 cleaning agent Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 150000001982 diacylglycerols Chemical class 0.000 claims 1
- 238000000502 dialysis Methods 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 238000007865 diluting Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000009509 drug development Methods 0.000 claims 1
- 238000007877 drug screening Methods 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 150000002270 gangliosides Chemical class 0.000 claims 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol Substances OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 1
- 150000002339 glycosphingolipids Chemical class 0.000 claims 1
- 210000004884 grey matter Anatomy 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- DDOVBCWVTOHGCU-QMXMISKISA-N n-[(e,2s,3r)-3-hydroxy-1-[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxynonadec-4-en-2-yl]octadecanamide Chemical compound CCCCCCCCCCCCCCCCCC(=O)N[C@H]([C@H](O)\C=C\CCCCCCCCCCCCCC)CO[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O DDOVBCWVTOHGCU-QMXMISKISA-N 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 claims 1
- 230000035764 nutrition Effects 0.000 claims 1
- 108091005706 peripheral membrane proteins Proteins 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001095 phosphatidyl group Chemical group 0.000 claims 1
- 150000008105 phosphatidylcholines Chemical class 0.000 claims 1
- 150000003905 phosphatidylinositols Chemical class 0.000 claims 1
- 239000004476 plant protection product Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 238000001338 self-assembly Methods 0.000 claims 1
- -1 serine (PS) Chemical class 0.000 claims 1
- 238000001542 size-exclusion chromatography Methods 0.000 claims 1
- 150000003432 sterols Chemical class 0.000 claims 1
- 235000003702 sterols Nutrition 0.000 claims 1
- 108091005703 transmembrane proteins Proteins 0.000 claims 1
- 102000035160 transmembrane proteins Human genes 0.000 claims 1
- 238000005199 ultracentrifugation Methods 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 210000004885 white matter Anatomy 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 2
- 235000018417 cysteine Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12197904.1 | 2012-12-18 | ||
| EP12197904.1A EP2745834B1 (en) | 2012-12-18 | 2012-12-18 | Salipro particles |
| PCT/EP2013/076404 WO2014095576A1 (en) | 2012-12-18 | 2013-12-12 | Salipro particles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016504312A JP2016504312A (ja) | 2016-02-12 |
| JP2016504312A5 true JP2016504312A5 (enExample) | 2017-01-26 |
| JP6293779B2 JP6293779B2 (ja) | 2018-03-14 |
Family
ID=47458700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015547026A Active JP6293779B2 (ja) | 2012-12-18 | 2013-12-12 | Ｓａｌｉｐｒｏ粒子 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9884128B2 (enExample) |
| EP (1) | EP2745834B1 (enExample) |
| JP (1) | JP6293779B2 (enExample) |
| CN (1) | CN105188672B (enExample) |
| DK (1) | DK2745834T3 (enExample) |
| ES (1) | ES2608857T3 (enExample) |
| WO (1) | WO2014095576A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011072117A1 (en) | 2009-12-09 | 2011-06-16 | The Procter & Gamble Company | Fabric and home care products |
| EP2745834B1 (en) * | 2012-12-18 | 2016-09-28 | Jens Frauenfeld | Salipro particles |
| CA3163156C (en) * | 2014-07-31 | 2025-07-08 | Illumina Inc | HYBRID NANOPORE SENSORS |
| JP2017008047A (ja) * | 2015-06-25 | 2017-01-12 | 参天製薬株式会社 | 注射剤 |
| CA3050808A1 (en) * | 2016-01-25 | 2017-08-03 | Universitat Bern | Nanospheres of sec14-like proteins and cognate ligands |
| EP3284460A1 (en) | 2016-08-19 | 2018-02-21 | Salipro Biotech AG | Saposin lipoprotein particles and libraries from crude membranes |
| WO2018181538A1 (ja) * | 2017-03-31 | 2018-10-04 | 株式会社カネカ | ナノディスクとその製造方法 |
| CN108444876B (zh) * | 2018-03-09 | 2020-06-16 | 国家纳米科学中心 | 一种纳米颗粒表面吸附蛋白配体状态的测定方法 |
| CN109134643B (zh) * | 2018-08-03 | 2021-12-31 | 五邑大学 | 一种复杂结构膜蛋白-脂质体的体外重组方法 |
| EP3725304A1 (en) * | 2019-04-15 | 2020-10-21 | Salipro Biotech AB | Production of salipro particles |
| CN110292916B (zh) * | 2019-06-26 | 2020-11-03 | 中国科学院过程工程研究所 | 一种磷脂纳米盘层析介质及其制备方法和应用 |
| AU2021409906A1 (en) | 2020-12-23 | 2023-06-15 | Regeneron Pharmaceuticals, Inc. | Methods for obtaining antibodies that bind transmembrane proteins and cells that produce the same |
| WO2023001912A1 (en) | 2021-07-22 | 2023-01-26 | Salipro Biotech AB | Methods for structure determination and drug design using salipro particles |
| EP4123307A1 (en) | 2021-07-22 | 2023-01-25 | Salipro Biotech AB | Methods for structure determination and drug design using salipro particles |
| CN117017940B (zh) * | 2023-07-05 | 2025-09-09 | 中国医学科学院医药生物技术研究所 | 纳米药物组合物、其制备方法及其用途 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5652339A (en) | 1993-12-31 | 1997-07-29 | Rotkreuzstiftung Zentrallaboratorium | Method of producing reconstituted lipoproteins |
| US20020177551A1 (en) | 2000-05-31 | 2002-11-28 | Terman David S. | Compositions and methods for treatment of neoplastic disease |
| US7083958B2 (en) | 2000-11-20 | 2006-08-01 | The Board Of Trustees Of The University Of Illinois | Membrane scaffold proteins |
| US7622437B2 (en) | 2000-11-20 | 2009-11-24 | The Board Of Trustees Of The University Of Illinois | Tissue factor compositions and methods |
| US7592008B2 (en) | 2000-11-20 | 2009-09-22 | The Board Of Trustees Of The University Of Illinois, A Body Corporate And Politic Of The State Of Illinois | Membrane scaffold proteins |
| AU2002225670B2 (en) | 2000-11-20 | 2006-05-11 | The Board Of Trustees Of The University Of Illinois | Membrane scaffold proteins |
| TW201424770A (zh) | 2003-02-14 | 2014-07-01 | Childrens Hosp & Res Ct Oak | 親脂藥物傳送媒介物及其使用方法 |
| US7834147B2 (en) | 2003-04-28 | 2010-11-16 | Childrens Hospital Medical Center | Saposin C-DOPS: a novel anti-tumor agent |
| JP4786538B2 (ja) | 2003-10-01 | 2011-10-05 | チルドレンズ ホスピタル アンド リサーチ センター アット オークランド | 親油性薬物送達ビヒクルおよびその使用方法 |
| US20070117179A1 (en) | 2005-09-27 | 2007-05-24 | Invitrogen Corporation | In vitro protein synthesis systems for membrane proteins that include adolipoproteins and phospholipid-adolipoprotein particles |
| BRPI0717475A2 (pt) * | 2006-10-20 | 2014-03-11 | Childrens Hosp Medical Center | Vesículas unilamelares de fosfolipídio elipsoidal de formação espontânea |
| WO2008106660A2 (en) | 2007-03-01 | 2008-09-04 | Invitrogen Corporation | Isolated phospholipid-protein particles |
| US8227392B2 (en) * | 2008-01-25 | 2012-07-24 | Exxonmobil Research And Engineering Company | Base stocks and lubricant blends containing poly-alpha olefins |
| US8999320B2 (en) | 2008-01-30 | 2015-04-07 | The Rockefeller University | Nanoscale bound bilayers, methods of use and production |
| WO2010053489A1 (en) * | 2008-11-07 | 2010-05-14 | Children's Hospital Medical Center | Fusogenic properties of saposin c and related proteins and peptides for application to transmembrane drug delivery systems |
| US10525152B2 (en) | 2009-10-09 | 2020-01-07 | Signablok, Inc. | Methods and compositions for targeted imaging |
| US20120190609A1 (en) | 2010-08-30 | 2012-07-26 | Martin Bader | Method for producing a lipid particle, the lipid particle itself and its use |
| US9585972B2 (en) * | 2011-05-09 | 2017-03-07 | Sherry L. Thornton | Method for imaging a site of arthritis in an animal |
| EP2745834B1 (en) * | 2012-12-18 | 2016-09-28 | Jens Frauenfeld | Salipro particles |
| PL3043814T3 (pl) * | 2013-09-13 | 2021-05-17 | Salipro Biotech AB | Antygen i sposób jego wytwarzania |
-
2012
- 2012-12-18 EP EP12197904.1A patent/EP2745834B1/en active Active
- 2012-12-18 ES ES12197904.1T patent/ES2608857T3/es active Active
- 2012-12-18 DK DK12197904.1T patent/DK2745834T3/en active
-
2013
- 2013-12-12 JP JP2015547026A patent/JP6293779B2/ja active Active
- 2013-12-12 WO PCT/EP2013/076404 patent/WO2014095576A1/en not_active Ceased
- 2013-12-12 US US14/649,095 patent/US9884128B2/en active Active
- 2013-12-12 CN CN201380066602.0A patent/CN105188672B/zh active Active
-
2018
- 2018-01-10 US US15/867,270 patent/US20180236099A1/en not_active Abandoned
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