JP2016503167A5 - - Google Patents
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- JP2016503167A5 JP2016503167A5 JP2015550033A JP2015550033A JP2016503167A5 JP 2016503167 A5 JP2016503167 A5 JP 2016503167A5 JP 2015550033 A JP2015550033 A JP 2015550033A JP 2015550033 A JP2015550033 A JP 2015550033A JP 2016503167 A5 JP2016503167 A5 JP 2016503167A5
- Authority
- JP
- Japan
- Prior art keywords
- score
- her2
- heterogeneity
- breast cancer
- determining
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 19
- 102000015694 estrogen receptors Human genes 0.000 claims 17
- 108010038795 estrogen receptors Proteins 0.000 claims 17
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 14
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 14
- 102000003998 progesterone receptors Human genes 0.000 claims 11
- 108090000468 progesterone receptors Proteins 0.000 claims 11
- 206010006187 Breast cancer Diseases 0.000 claims 10
- 208000026310 Breast neoplasm Diseases 0.000 claims 10
- 239000002131 composite material Substances 0.000 claims 7
- -1 Ki-67 Proteins 0.000 claims 6
- 238000003364 immunohistochemistry Methods 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 101000611441 Solanum lycopersicum Pathogenesis-related leaf protein 6 Proteins 0.000 claims 4
- 230000000750 progressive effect Effects 0.000 claims 2
- 239000000090 biomarker Substances 0.000 claims 1
- 230000002055 immunohistochemical effect Effects 0.000 claims 1
- 210000001165 lymph node Anatomy 0.000 claims 1
- 230000000007 visual effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261747148P | 2012-12-28 | 2012-12-28 | |
| US61/747,148 | 2012-12-28 | ||
| PCT/EP2013/077295 WO2014102130A1 (en) | 2012-12-28 | 2013-12-19 | Image analysis for breast cancer prognosis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016503167A JP2016503167A (ja) | 2016-02-01 |
| JP2016503167A5 true JP2016503167A5 (enExample) | 2016-12-28 |
| JP6405319B2 JP6405319B2 (ja) | 2018-10-17 |
Family
ID=49917058
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015550033A Active JP6405319B2 (ja) | 2012-12-28 | 2013-12-19 | 乳癌予知のための画像分析 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11211167B2 (enExample) |
| EP (1) | EP2939026B1 (enExample) |
| JP (1) | JP6405319B2 (enExample) |
| AU (1) | AU2013369439B2 (enExample) |
| CA (1) | CA2890964C (enExample) |
| DK (1) | DK2939026T3 (enExample) |
| ES (1) | ES2639559T3 (enExample) |
| WO (1) | WO2014102130A1 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105008919B (zh) * | 2013-03-06 | 2018-11-13 | 生物研究技术公司 | 分子成像和相关方法 |
| EP3155592B1 (en) * | 2014-06-10 | 2019-09-11 | Leland Stanford Junior University | Predicting breast cancer recurrence directly from image features computed from digitized immunohistopathology tissue slides |
| EP3227833B1 (en) * | 2014-12-03 | 2024-12-25 | Ventana Medical Systems, Inc. | Systems and methods for early-stage cancer prognosis |
| US9953133B2 (en) | 2015-06-03 | 2018-04-24 | General Electric Company | Biological data annotation and visualization |
| US10672505B2 (en) | 2015-06-03 | 2020-06-02 | General Electric Company | Biological data annotation and visualization |
| US9613254B1 (en) | 2015-09-30 | 2017-04-04 | General Electric Company | Quantitative in situ characterization of heterogeneity in biological samples |
| US20170234874A1 (en) * | 2015-10-07 | 2017-08-17 | Clearbridge Biophotonics Pte Ltd. | Integrated visual morphology and cell protein expression using resonance-light scattering |
| WO2018118786A1 (en) * | 2016-12-19 | 2018-06-28 | Ventana Medical Systems, Inc. | Methods and systems for quantitative immunohistochemistry |
| JP7278224B2 (ja) * | 2017-06-02 | 2023-05-19 | コーニンクレッカ フィリップス エヌ ヴェ | 医用画像の病変の定量化される態様 |
| CN107271671A (zh) * | 2017-06-05 | 2017-10-20 | 龚畅 | 一种预测er（+）乳腺癌新辅助化疗效果的试剂盒和系统 |
| US10586376B2 (en) * | 2017-06-13 | 2020-03-10 | Optrascan, Inc. | Automated method of predicting efficacy of immunotherapy approaches |
| RU2664671C1 (ru) * | 2017-07-28 | 2018-08-21 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Петрова" Министерства здравоохранения Российской Федерации | Способ прогноза рака молочной железы |
| CN111448584B (zh) * | 2017-12-05 | 2023-09-26 | 文塔纳医疗系统公司 | 计算肿瘤空间和标记间异质性的方法 |
| JP7197584B2 (ja) * | 2017-12-06 | 2022-12-27 | ベンタナ メディカル システムズ， インコーポレイテッド | デジタル病理学分析結果の格納および読み出し方法 |
| US11568657B2 (en) | 2017-12-06 | 2023-01-31 | Ventana Medical Systems, Inc. | Method of storing and retrieving digital pathology analysis results |
| EP3721373B1 (en) | 2017-12-07 | 2025-03-05 | Ventana Medical Systems, Inc. | Deep-learning systems and methods for joint cell and region classification in biological images |
| EP3729369A2 (en) | 2017-12-24 | 2020-10-28 | Ventana Medical Systems, Inc. | Computational pathology approach for retrospective analysis of tissue-based companion diagnostic driven clinical trial studies |
| US11621058B2 (en) | 2018-02-08 | 2023-04-04 | Ohio State Innovation Foundation | Synthetic IHC-stained digital sides generated using artificial neural networks |
| WO2019197509A1 (en) | 2018-04-13 | 2019-10-17 | Ventana Medical Systems, Inc. | Systems for cell shape estimation |
| US12020493B2 (en) | 2018-07-27 | 2024-06-25 | Ventana Medical Systems, Inc. | Systems for automated in situ hybridization analysis |
| WO2020046773A1 (en) | 2018-08-31 | 2020-03-05 | Ventana Medical Systems, Inc. | Contextually adaptive digital pathology interface |
| WO2020056338A1 (en) * | 2018-09-14 | 2020-03-19 | Prelude Corporation | Method of selection for treatment of subjects at risk of invasive breast cancer |
| JP7228031B2 (ja) | 2018-10-15 | 2023-02-22 | ベンタナ メディカル システムズ， インコーポレイテッド | 細胞の分類のためのシステムおよび方法 |
| CN113226157B (zh) * | 2018-12-19 | 2025-03-18 | 匹兹堡大学高等教育联邦体系 | 用于原位或体外多参数细胞和亚细胞成像数据的计算系统病理学空间分析平台 |
| JP7227389B2 (ja) | 2019-02-13 | 2023-02-21 | ベンタナ メディカル システムズ， インコーポレイテッド | マルチチャネル画像における自己蛍光の寄与を算出するシステムおよび方法 |
| JP7593112B2 (ja) * | 2019-02-15 | 2024-12-03 | コニカミノルタ株式会社 | 情報提供方法、情報提供装置及びプログラム |
| US11726757B2 (en) * | 2019-08-14 | 2023-08-15 | Nvidia Corporation | Processor for performing dynamic programming according to an instruction, and a method for configuring a processor for dynamic programming via an instruction |
| EP4022286A1 (en) | 2019-08-28 | 2022-07-06 | Ventana Medical Systems, Inc. | Label-free assessment of biomarker expression with vibrational spectroscopy |
| KR20220064379A (ko) | 2019-09-09 | 2022-05-18 | 페이지.에이아이, 인크. | 바이오마커들을 추론하기 위해 슬라이드의 이미지들을 처리하기 위한 시스템들 및 방법들 |
| CN110853022B (zh) * | 2019-11-14 | 2020-11-06 | 腾讯科技（深圳）有限公司 | 病理切片图像的处理方法、装置、系统及存储介质 |
| WO2021146705A1 (en) | 2020-01-19 | 2021-07-22 | Ventana Medical Systems, Inc. | Non-tumor segmentation to support tumor detection and analysis |
| CN115088022A (zh) | 2020-02-11 | 2022-09-20 | 文塔纳医疗系统公司 | 用于训练机器学习算法和维护患者隐私的联邦学习系统 |
| US20210287801A1 (en) * | 2020-03-11 | 2021-09-16 | Biosyntagma, Inc. | Method for predicting disease state, therapeutic response, and outcomes by spatial biomarkers |
| CN115552534A (zh) * | 2020-03-18 | 2022-12-30 | 赛诺菲 | 用于预测表达水平的系统和方法 |
| CN115997241A (zh) * | 2020-08-13 | 2023-04-21 | 佩治人工智能公司 | 处理电子图像进行连续生物标志物预测的系统和方法 |
| DE102020211271A1 (de) * | 2020-09-08 | 2022-03-10 | Siemens Healthcare Gmbh | Erzeugung eines Biomarkers quantifizierend eine räumliche Homogenität einer medizinischen Parameterkarte |
| EP4217393A1 (en) * | 2020-09-22 | 2023-08-02 | Ventana Medical Systems, Inc. | Prediction of response to epidermal growth factor receptor-directed therapies using epiregulin and amphiregulin |
| CN112801939B (zh) * | 2020-12-31 | 2022-07-22 | 杭州迪英加科技有限公司 | 一种用于提高病理图像ki67指标准确性的方法 |
| US20240295561A1 (en) * | 2021-06-17 | 2024-09-05 | Konica Minolta, Inc. | Quantification method and labeling method |
| CN113970638B (zh) * | 2021-10-24 | 2023-02-03 | 清华大学 | 确定胃癌极早期发生风险及评估胃癌前病变进展风险的分子标志及其在诊断试剂盒中的应用 |
| CN119654686A (zh) * | 2022-08-08 | 2025-03-18 | 文塔纳医疗系统公司 | 用于对数字化病理学载玻片的定量的系统和方法 |
| WO2024178422A1 (en) * | 2023-02-24 | 2024-08-29 | Ohio State Innovation Foundation | Novel image-based metrics of her2 heterogeneity |
| WO2024259271A2 (en) * | 2023-06-15 | 2024-12-19 | New York University | Systems, methods and computer-accessible medium for determining and/or analysing cancer outcome(s) and/or treatment responses |
| WO2025014787A1 (en) * | 2023-07-07 | 2025-01-16 | Ventana Medical Systems, Inc. | Brightfield triplex immunohistochemistry assay for evaluating the colocalization of the er, pr, and ki-67 biomarkers in cells |
| WO2025106811A1 (en) * | 2023-11-15 | 2025-05-22 | 4D Path Inc. | Systems and methods for image-based disease characterization |
| KR20250156974A (ko) | 2024-04-26 | 2025-11-04 | 사회복지법인 삼성생명공익재단 | 딥러닝 모델을 이용한 종양 미세환경 예측 방법 및 분석장치 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4444487A (en) | 1979-07-02 | 1984-04-24 | Xerox Corporation | Multiple-flash fuser |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4745055A (en) | 1985-05-07 | 1988-05-17 | California Biotechnology Inc. | Fused protein for enzyme immunoassay system |
| EP0256654B1 (en) | 1986-07-07 | 1996-09-18 | Centocor, Inc. | Chimeric murine/human immunoglobulin specific for tumour-associated 17-1A Antigen |
| GB8626412D0 (en) | 1986-11-05 | 1986-12-03 | Clark M R | Antibodies |
| US6283761B1 (en) | 1992-09-08 | 2001-09-04 | Raymond Anthony Joao | Apparatus and method for processing and/or for providing healthcare information and/or healthcare-related information |
| GB0229734D0 (en) | 2002-12-23 | 2003-01-29 | Qinetiq Ltd | Grading oestrogen and progesterone receptors expression |
| US20050136549A1 (en) * | 2003-10-30 | 2005-06-23 | Bioimagene, Inc. | Method and system for automatically determining diagnostic saliency of digital images |
| US8787651B2 (en) * | 2010-09-28 | 2014-07-22 | Flagship Biosciences, LLC | Methods for feature analysis on consecutive tissue sections |
| US9286672B2 (en) * | 2012-01-10 | 2016-03-15 | Rutgers, The State University Of New Jersey | Integrated multivariate image-based method for disease outcome predicition |
| JP2013200287A (ja) | 2012-03-26 | 2013-10-03 | Kawasaki Gakuen | Ｋｉ−６７インデックス算定二重染色法を用いた陽性率測定方法 |
-
2013
- 2013-12-19 CA CA2890964A patent/CA2890964C/en active Active
- 2013-12-19 EP EP13815724.3A patent/EP2939026B1/en active Active
- 2013-12-19 JP JP2015550033A patent/JP6405319B2/ja active Active
- 2013-12-19 DK DK13815724.3T patent/DK2939026T3/en active
- 2013-12-19 WO PCT/EP2013/077295 patent/WO2014102130A1/en not_active Ceased
- 2013-12-19 US US14/653,831 patent/US11211167B2/en active Active
- 2013-12-19 AU AU2013369439A patent/AU2013369439B2/en active Active
- 2013-12-19 ES ES13815724.3T patent/ES2639559T3/es active Active
-
2021
- 2021-10-28 US US17/512,812 patent/US20220051804A1/en active Pending
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