CA2890964C - Image analysis for breast cancer prognosis - Google Patents

Image analysis for breast cancer prognosis Download PDF

Info

Publication number
CA2890964C
CA2890964C CA2890964A CA2890964A CA2890964C CA 2890964 C CA2890964 C CA 2890964C CA 2890964 A CA2890964 A CA 2890964A CA 2890964 A CA2890964 A CA 2890964A CA 2890964 C CA2890964 C CA 2890964C
Authority
CA
Canada
Prior art keywords
score
heterogeneity
her2
breast cancer
view
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2890964A
Other languages
English (en)
French (fr)
Other versions
CA2890964A1 (en
Inventor
Srinivas Chukka
Anindya SARKAR
Crystal SCHEMP
Olcay SERTEL
Shalini Singh
Raymond Tubbs
Paul Michael WARING
Nikolaus Wick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Melbourne
Cleveland Clinic Foundation
Ventana Medical Systems Inc
Original Assignee
University of Melbourne
Cleveland Clinic Foundation
Ventana Medical Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Melbourne, Cleveland Clinic Foundation, Ventana Medical Systems Inc filed Critical University of Melbourne
Publication of CA2890964A1 publication Critical patent/CA2890964A1/en
Application granted granted Critical
Publication of CA2890964C publication Critical patent/CA2890964C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57415Specifically defined cancers of breast
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H30/00ICT specially adapted for the handling or processing of medical images
    • G16H30/20ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/54Determining the risk of relapse

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Primary Health Care (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Databases & Information Systems (AREA)
  • Data Mining & Analysis (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
CA2890964A 2012-12-28 2013-12-19 Image analysis for breast cancer prognosis Active CA2890964C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261747148P 2012-12-28 2012-12-28
US61/747,148 2012-12-28
PCT/EP2013/077295 WO2014102130A1 (en) 2012-12-28 2013-12-19 Image analysis for breast cancer prognosis

Publications (2)

Publication Number Publication Date
CA2890964A1 CA2890964A1 (en) 2014-07-03
CA2890964C true CA2890964C (en) 2023-07-25

Family

ID=49917058

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2890964A Active CA2890964C (en) 2012-12-28 2013-12-19 Image analysis for breast cancer prognosis

Country Status (8)

Country Link
US (2) US11211167B2 (enExample)
EP (1) EP2939026B1 (enExample)
JP (1) JP6405319B2 (enExample)
AU (1) AU2013369439B2 (enExample)
CA (1) CA2890964C (enExample)
DK (1) DK2939026T3 (enExample)
ES (1) ES2639559T3 (enExample)
WO (1) WO2014102130A1 (enExample)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105008919B (zh) * 2013-03-06 2018-11-13 生物研究技术公司 分子成像和相关方法
EP3155592B1 (en) * 2014-06-10 2019-09-11 Leland Stanford Junior University Predicting breast cancer recurrence directly from image features computed from digitized immunohistopathology tissue slides
EP3227833B1 (en) * 2014-12-03 2024-12-25 Ventana Medical Systems, Inc. Systems and methods for early-stage cancer prognosis
US9953133B2 (en) 2015-06-03 2018-04-24 General Electric Company Biological data annotation and visualization
US10672505B2 (en) 2015-06-03 2020-06-02 General Electric Company Biological data annotation and visualization
US9613254B1 (en) 2015-09-30 2017-04-04 General Electric Company Quantitative in situ characterization of heterogeneity in biological samples
US20170234874A1 (en) * 2015-10-07 2017-08-17 Clearbridge Biophotonics Pte Ltd. Integrated visual morphology and cell protein expression using resonance-light scattering
WO2018118786A1 (en) * 2016-12-19 2018-06-28 Ventana Medical Systems, Inc. Methods and systems for quantitative immunohistochemistry
JP7278224B2 (ja) * 2017-06-02 2023-05-19 コーニンクレッカ フィリップス エヌ ヴェ 医用画像の病変の定量化される態様
CN107271671A (zh) * 2017-06-05 2017-10-20 龚畅 一种预测er(+)乳腺癌新辅助化疗效果的试剂盒和系统
US10586376B2 (en) * 2017-06-13 2020-03-10 Optrascan, Inc. Automated method of predicting efficacy of immunotherapy approaches
RU2664671C1 (ru) * 2017-07-28 2018-08-21 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Петрова" Министерства здравоохранения Российской Федерации Способ прогноза рака молочной железы
CN111448584B (zh) * 2017-12-05 2023-09-26 文塔纳医疗系统公司 计算肿瘤空间和标记间异质性的方法
JP7197584B2 (ja) * 2017-12-06 2022-12-27 ベンタナ メディカル システムズ, インコーポレイテッド デジタル病理学分析結果の格納および読み出し方法
US11568657B2 (en) 2017-12-06 2023-01-31 Ventana Medical Systems, Inc. Method of storing and retrieving digital pathology analysis results
EP3721373B1 (en) 2017-12-07 2025-03-05 Ventana Medical Systems, Inc. Deep-learning systems and methods for joint cell and region classification in biological images
EP3729369A2 (en) 2017-12-24 2020-10-28 Ventana Medical Systems, Inc. Computational pathology approach for retrospective analysis of tissue-based companion diagnostic driven clinical trial studies
US11621058B2 (en) 2018-02-08 2023-04-04 Ohio State Innovation Foundation Synthetic IHC-stained digital sides generated using artificial neural networks
WO2019197509A1 (en) 2018-04-13 2019-10-17 Ventana Medical Systems, Inc. Systems for cell shape estimation
US12020493B2 (en) 2018-07-27 2024-06-25 Ventana Medical Systems, Inc. Systems for automated in situ hybridization analysis
WO2020046773A1 (en) 2018-08-31 2020-03-05 Ventana Medical Systems, Inc. Contextually adaptive digital pathology interface
WO2020056338A1 (en) * 2018-09-14 2020-03-19 Prelude Corporation Method of selection for treatment of subjects at risk of invasive breast cancer
JP7228031B2 (ja) 2018-10-15 2023-02-22 ベンタナ メディカル システムズ, インコーポレイテッド 細胞の分類のためのシステムおよび方法
CN113226157B (zh) * 2018-12-19 2025-03-18 匹兹堡大学高等教育联邦体系 用于原位或体外多参数细胞和亚细胞成像数据的计算系统病理学空间分析平台
JP7227389B2 (ja) 2019-02-13 2023-02-21 ベンタナ メディカル システムズ, インコーポレイテッド マルチチャネル画像における自己蛍光の寄与を算出するシステムおよび方法
JP7593112B2 (ja) * 2019-02-15 2024-12-03 コニカミノルタ株式会社 情報提供方法、情報提供装置及びプログラム
US11726757B2 (en) * 2019-08-14 2023-08-15 Nvidia Corporation Processor for performing dynamic programming according to an instruction, and a method for configuring a processor for dynamic programming via an instruction
EP4022286A1 (en) 2019-08-28 2022-07-06 Ventana Medical Systems, Inc. Label-free assessment of biomarker expression with vibrational spectroscopy
KR20220064379A (ko) 2019-09-09 2022-05-18 페이지.에이아이, 인크. 바이오마커들을 추론하기 위해 슬라이드의 이미지들을 처리하기 위한 시스템들 및 방법들
CN110853022B (zh) * 2019-11-14 2020-11-06 腾讯科技(深圳)有限公司 病理切片图像的处理方法、装置、系统及存储介质
WO2021146705A1 (en) 2020-01-19 2021-07-22 Ventana Medical Systems, Inc. Non-tumor segmentation to support tumor detection and analysis
CN115088022A (zh) 2020-02-11 2022-09-20 文塔纳医疗系统公司 用于训练机器学习算法和维护患者隐私的联邦学习系统
US20210287801A1 (en) * 2020-03-11 2021-09-16 Biosyntagma, Inc. Method for predicting disease state, therapeutic response, and outcomes by spatial biomarkers
CN115552534A (zh) * 2020-03-18 2022-12-30 赛诺菲 用于预测表达水平的系统和方法
CN115997241A (zh) * 2020-08-13 2023-04-21 佩治人工智能公司 处理电子图像进行连续生物标志物预测的系统和方法
DE102020211271A1 (de) * 2020-09-08 2022-03-10 Siemens Healthcare Gmbh Erzeugung eines Biomarkers quantifizierend eine räumliche Homogenität einer medizinischen Parameterkarte
EP4217393A1 (en) * 2020-09-22 2023-08-02 Ventana Medical Systems, Inc. Prediction of response to epidermal growth factor receptor-directed therapies using epiregulin and amphiregulin
CN112801939B (zh) * 2020-12-31 2022-07-22 杭州迪英加科技有限公司 一种用于提高病理图像ki67指标准确性的方法
US20240295561A1 (en) * 2021-06-17 2024-09-05 Konica Minolta, Inc. Quantification method and labeling method
CN113970638B (zh) * 2021-10-24 2023-02-03 清华大学 确定胃癌极早期发生风险及评估胃癌前病变进展风险的分子标志及其在诊断试剂盒中的应用
CN119654686A (zh) * 2022-08-08 2025-03-18 文塔纳医疗系统公司 用于对数字化病理学载玻片的定量的系统和方法
WO2024178422A1 (en) * 2023-02-24 2024-08-29 Ohio State Innovation Foundation Novel image-based metrics of her2 heterogeneity
WO2024259271A2 (en) * 2023-06-15 2024-12-19 New York University Systems, methods and computer-accessible medium for determining and/or analysing cancer outcome(s) and/or treatment responses
WO2025014787A1 (en) * 2023-07-07 2025-01-16 Ventana Medical Systems, Inc. Brightfield triplex immunohistochemistry assay for evaluating the colocalization of the er, pr, and ki-67 biomarkers in cells
WO2025106811A1 (en) * 2023-11-15 2025-05-22 4D Path Inc. Systems and methods for image-based disease characterization
KR20250156974A (ko) 2024-04-26 2025-11-04 사회복지법인 삼성생명공익재단 딥러닝 모델을 이용한 종양 미세환경 예측 방법 및 분석장치

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444487A (en) 1979-07-02 1984-04-24 Xerox Corporation Multiple-flash fuser
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4745055A (en) 1985-05-07 1988-05-17 California Biotechnology Inc. Fused protein for enzyme immunoassay system
EP0256654B1 (en) 1986-07-07 1996-09-18 Centocor, Inc. Chimeric murine/human immunoglobulin specific for tumour-associated 17-1A Antigen
GB8626412D0 (en) 1986-11-05 1986-12-03 Clark M R Antibodies
US6283761B1 (en) 1992-09-08 2001-09-04 Raymond Anthony Joao Apparatus and method for processing and/or for providing healthcare information and/or healthcare-related information
GB0229734D0 (en) 2002-12-23 2003-01-29 Qinetiq Ltd Grading oestrogen and progesterone receptors expression
US20050136549A1 (en) * 2003-10-30 2005-06-23 Bioimagene, Inc. Method and system for automatically determining diagnostic saliency of digital images
US8787651B2 (en) * 2010-09-28 2014-07-22 Flagship Biosciences, LLC Methods for feature analysis on consecutive tissue sections
US9286672B2 (en) * 2012-01-10 2016-03-15 Rutgers, The State University Of New Jersey Integrated multivariate image-based method for disease outcome predicition
JP2013200287A (ja) 2012-03-26 2013-10-03 Kawasaki Gakuen Ki−67インデックス算定二重染色法を用いた陽性率測定方法

Also Published As

Publication number Publication date
EP2939026A1 (en) 2015-11-04
JP2016503167A (ja) 2016-02-01
JP6405319B2 (ja) 2018-10-17
CA2890964A1 (en) 2014-07-03
WO2014102130A1 (en) 2014-07-03
AU2013369439A1 (en) 2015-05-28
DK2939026T3 (en) 2017-09-11
ES2639559T3 (es) 2017-10-27
US20150347702A1 (en) 2015-12-03
US20220051804A1 (en) 2022-02-17
US11211167B2 (en) 2021-12-28
EP2939026B1 (en) 2017-07-05
AU2013369439B2 (en) 2019-01-17

Similar Documents

Publication Publication Date Title
US20220051804A1 (en) Image Analysis for Breast Cancer Prognosis
Wolff et al. Human epidermal growth factor receptor 2 testing in breast cancer
Lloyd et al. Using image analysis as a tool for assessment of prognostic and predictive biomarkers for breast cancer: How reliable is it?
Brügmann et al. Digital image analysis of membrane connectivity is a robust measure of HER2 immunostains
Zhong et al. A comparison of visual assessment and automated digital image analysis of Ki67 labeling index in breast cancer
KR102179848B1 (ko) 종양 조직 중 면역 세포를 정량화하는 방법 및 이의 사용
Holten-Rossing et al. Optimizing HER2 assessment in breast cancer: application of automated image analysis
CN112789684B (zh) 用于预测对pd-1轴导向疗法的应答的方法和系统
US20110111435A1 (en) Detecting Cell Surface Markers
US20130338016A1 (en) Method For Integrated Pathology Diagnosis And Digital Biomarker Pattern Analysis
Varga et al. Standardization for Ki-67 assessment in moderately differentiated breast cancer. A retrospective analysis of the SAKK 28/12 study
Sun et al. Quantum dot-based immunofluorescent imaging of Ki67 and identification of prognostic value in HER2-positive (non-luminal) breast cancer
Qi et al. Concordance of the 21-gene assay between core needle biopsy and resection specimens in early breast cancer patients
Kim et al. Risk factors associated with discordant Ki-67 levels between preoperative biopsy and postoperative surgical specimens in breast cancers
Ibrahim et al. Improving mitotic cell counting accuracy and efficiency using phosphohistone‐H3 (PHH3) antibody counterstained with haematoxylin and eosin as part of breast cancer grading
JP2015525358A (ja) 組織切片中の単一細胞におけるマーカー定量
Cho et al. The long-term prognostic performance of Ki-67 in primary operable breast cancer and evaluation of its optimal cutoff value
Roberts et al. Reliability of a computational platform as a surrogate for manually interpreted immunohistochemical markers in breast tumor tissue microarrays
Liu et al. A comparative performance analysis of multispectral and rgb imaging on her2 status evaluation for the prediction of breast cancer prognosis
Nassar et al. Trainable immunohistochemical HER2/neu image analysis: a multisite performance study using 260 breast tissue specimens
Miller et al. Objective analysis of cancer stem cell marker expression using immunohistochemistry
Jing et al. Validity and reliability of Ki-67 assessment in oestrogen receptor positive breast cancer
Ali et al. Mast cells in the microenvironment of hepatocellular carcinoma confer favorable prognosis: a retrospective study using QuPath image analysis software
Hsieh et al. Programmed death-ligand 1 expression by digital image analysis advances thyroid cancer diagnosis among encapsulated follicular lesions
CN115552248A (zh) 用于评价肿瘤样品中egfr和egfr配体表达的组织化学系统和方法

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20181204

EEER Examination request

Effective date: 20181204

EEER Examination request

Effective date: 20181204

EEER Examination request

Effective date: 20181204

EEER Examination request

Effective date: 20181204

EEER Examination request

Effective date: 20181204