JP2016199583A5 - - Google Patents
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- JP2016199583A5 JP2016199583A5 JP2016152696A JP2016152696A JP2016199583A5 JP 2016199583 A5 JP2016199583 A5 JP 2016199583A5 JP 2016152696 A JP2016152696 A JP 2016152696A JP 2016152696 A JP2016152696 A JP 2016152696A JP 2016199583 A5 JP2016199583 A5 JP 2016199583A5
- Authority
- JP
- Japan
- Prior art keywords
- dota
- complex
- scn
- reaction mixture
- radioactive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 229940125666 actinium-225 Drugs 0.000 claims 18
- 230000002285 radioactive effect Effects 0.000 claims 10
- 239000011541 reaction mixture Substances 0.000 claims 8
- UDOPJKHABYSVIX-UHFFFAOYSA-N 2-[4,7,10-tris(carboxymethyl)-6-[(4-isothiocyanatophenyl)methyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid Chemical compound C1N(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CCN(CC(O)=O)C1CC1=CC=C(N=C=S)C=C1 UDOPJKHABYSVIX-UHFFFAOYSA-N 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 230000009920 chelation Effects 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 239000002738 chelating agent Substances 0.000 claims 3
- 238000010668 complexation reaction Methods 0.000 claims 3
- 238000001914 filtration Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- WXTMDXOMEHJXQO-UHFFFAOYSA-N 2,5-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC(O)=CC=C1O WXTMDXOMEHJXQO-UHFFFAOYSA-N 0.000 claims 2
- XSVWFLQICKPQAA-UHFFFAOYSA-N 2-[4,10-bis(carboxymethyl)-7-[2-(2,5-dioxopyrrolidin-1-yl)oxy-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid Chemical compound C1CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CCN1CC(=O)ON1C(=O)CCC1=O XSVWFLQICKPQAA-UHFFFAOYSA-N 0.000 claims 2
- QQINRWTZWGJFDB-YPZZEJLDSA-N actinium-225 Chemical compound [225Ac] QQINRWTZWGJFDB-YPZZEJLDSA-N 0.000 claims 2
- 230000000536 complexating effect Effects 0.000 claims 2
- 229940051022 radioimmunoconjugate Drugs 0.000 claims 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 claims 1
- 239000007995 HEPES buffer Substances 0.000 claims 1
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 239000007853 buffer solution Substances 0.000 claims 1
- 239000013522 chelant Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229960005219 gentisic acid Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22771009P | 2009-07-22 | 2009-07-22 | |
| US61/227,710 | 2009-07-22 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012521780A Division JP5985392B2 (ja) | 2009-07-22 | 2010-07-22 | 放射性免疫複合体を生成するための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016199583A JP2016199583A (ja) | 2016-12-01 |
| JP2016199583A5 true JP2016199583A5 (https=) | 2017-01-26 |
Family
ID=43499411
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012521780A Active JP5985392B2 (ja) | 2009-07-22 | 2010-07-22 | 放射性免疫複合体を生成するための方法 |
| JP2016152696A Pending JP2016199583A (ja) | 2009-07-22 | 2016-08-03 | 放射性免疫複合体を生成するための方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012521780A Active JP5985392B2 (ja) | 2009-07-22 | 2010-07-22 | 放射性免疫複合体を生成するための方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9603954B2 (https=) |
| EP (1) | EP2456472B1 (https=) |
| JP (2) | JP5985392B2 (https=) |
| CN (2) | CN104710504B (https=) |
| CA (1) | CA2768658C (https=) |
| IN (1) | IN2012DN00551A (https=) |
| RU (2) | RU2704802C2 (https=) |
| WO (1) | WO2011011592A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201208309D0 (en) * | 2012-05-11 | 2012-06-27 | Algeta As | Complexes |
| US20150157742A1 (en) * | 2013-12-11 | 2015-06-11 | The European Atomic Energy Community (Euratom), Represented By The European Commission | SYNTHESIS OF BIOLOGICAL COMPOUNDS LABELED WITH THE ALPHA EMITTER Ac-225 |
| CA2949365A1 (en) * | 2014-05-16 | 2015-11-19 | Memorial Sloan Kettering Cancer Center | One-step labeling of antibodies to high specific activity with actinium-225 |
| CN108348604B (zh) * | 2015-09-08 | 2022-04-29 | 沃特世科技公司 | 用于分析抗体-药物缀合物的多维色谱方法 |
| US11896683B2 (en) | 2016-12-16 | 2024-02-13 | The Australian National University | Radiolabelled material for targeted administration |
| DK3568205T3 (da) | 2017-01-12 | 2023-10-09 | Radiomedix Inc | Behandling af cancerceller, der overeksprimerer somatostatinreceptorer ved at anvende radioisotop-chelaterede ocreotid-derivater |
| EP3661557B1 (en) * | 2017-07-31 | 2025-09-03 | Actinium Pharmaceuticals, Inc. | Treatments for a hematological malignancy |
| CN109550061A (zh) * | 2017-09-26 | 2019-04-02 | 南京江原安迪科正电子研究发展有限公司 | 一种用于放射性核素标记抗体的试剂盒及应用 |
| WO2022056354A1 (en) * | 2020-09-11 | 2022-03-17 | Actinium Pharmaceuticals, Inc. | Trophoblast glycoprotein radioimmunotherapy for the treatment of solid cancers |
| US12551584B1 (en) | 2020-12-07 | 2026-02-17 | Actinium Pharmaceuticals, Inc. | Lewis Y radioimmunotherapy for the treatment of cancer |
| US12447218B1 (en) * | 2021-02-09 | 2025-10-21 | Actinium Pharmaceuticals, Inc. | Radioconjugates directed to MHC-complexed antigens in cancer |
| US20250339571A1 (en) * | 2021-08-27 | 2025-11-06 | Actinium Pharmaceuticals, Inc. | Radioimmunoconjugates targeting phosphatidylserine for use in the treatment of cancer |
| WO2023183927A2 (en) | 2022-03-24 | 2023-09-28 | Actinium Pharmaceuticals, Inc. | Humanized anti-cd45 antibodies |
| US20250177583A1 (en) | 2022-03-30 | 2025-06-05 | Nihon Medi-Physics Co., Ltd. | Method for producing complex |
| EP4536278A2 (en) | 2022-06-07 | 2025-04-16 | Actinium Pharmaceuticals, Inc. | Bifunctional chelators and conjugates |
| AU2023330110A1 (en) | 2022-08-22 | 2025-03-06 | Abdera Therapeutics Inc. | Dll3 binding molecules and uses thereof |
| US20250388688A1 (en) | 2024-04-04 | 2025-12-25 | Ethyreal Bio, Inc. | Anti-tshr antibodies and uses thereof |
| US12600794B2 (en) | 2024-07-23 | 2026-04-14 | Abdera Therapeutics Inc. | 5T4 binding polypeptides and uses thereof |
Family Cites Families (40)
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| US4001387A (en) | 1973-07-30 | 1977-01-04 | Medi-Physics, Inc. | Process for preparing radiopharmaceuticals |
| US4305922A (en) | 1978-10-04 | 1981-12-15 | University Patents, Inc. | Labeling proteins with 99m-Tc by ligand exchange |
| US4296785A (en) | 1979-07-09 | 1981-10-27 | Mallinckrodt, Inc. | System for generating and containerizing radioisotopes |
| US4454106A (en) | 1982-06-07 | 1984-06-12 | Gansow Otto A | Use of metal chelate conjugated monoclonal antibodies |
| US4472509A (en) | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4732864A (en) | 1983-10-06 | 1988-03-22 | E. I. Du Pont De Nemours And Company | Trace-labeled conjugates of metallothionein and target-seeking biologically active molecules |
| US4894364A (en) | 1983-10-26 | 1990-01-16 | Greer Sheldon B | Method and materials for sensitizing neoplastic tissue to radiation |
| US4828991A (en) | 1984-01-31 | 1989-05-09 | Akzo N.V. | Tumor specific monoclonal antibodies |
| US4663129A (en) | 1985-01-30 | 1987-05-05 | The United States Of America As Represented By The United States Department Of Energy | Isotopic generator for bismuth-212 and lead-212 from radium |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5306509A (en) | 1987-03-17 | 1994-04-26 | Turner Robert E | Prevention and treatment of oral lesions |
| AU2068588A (en) | 1987-08-12 | 1989-02-16 | Immunomedics Inc. | Preparation of radiolabeled conjugates |
| US4833329A (en) | 1987-11-20 | 1989-05-23 | Mallinckrodt, Inc. | System for generating and containerizing radioisotopes |
| US5612016A (en) * | 1988-04-01 | 1997-03-18 | Immunomedics, Inc. | Conjugates of antibodies and bifunctional ligands |
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| US4923985A (en) | 1988-05-25 | 1990-05-08 | The United States Of America As Represented By The Department Of Health & Human Services | Process for synthesizing macrocyclic chelates |
| US5292868A (en) | 1989-05-26 | 1994-03-08 | Akzo N.V. | Chelating agents for attaching metal ions to proteins |
| DE69007430T2 (de) | 1989-06-19 | 1994-07-07 | Akzo Nobel N.V., Arnheim/Arnhem | Radioimmuntherapie unter alphapartikelausstrahlung. |
| CA2063551C (en) | 1989-07-12 | 2000-05-16 | Jacobus D.M. Herscheid | Method for preparing radiodiagnostic gaseous radionuclide and apparatus |
| US5443816A (en) | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
| LU87684A1 (de) | 1990-02-23 | 1991-10-08 | Euratom | Verfahren zur erzeugung von aktinium-225 und wismut-213 |
| US5038046A (en) | 1990-07-10 | 1991-08-06 | Biotechnetics | Method and generator for producing radioactive lead-212 |
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| IL113610A0 (en) * | 1994-06-03 | 1995-08-31 | Immunomedics Inc | A method of radiolabeling a protein, radiolabeled proteins prepared thereby and diagnostic kits containing the same |
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| WO1999066951A2 (en) | 1998-06-22 | 1999-12-29 | Immunomedics, Inc. | Use of bi-specific antibodies for pre-targeting diagnosis and therapy |
| AU2002211232B2 (en) | 2000-09-15 | 2006-10-19 | Sloan Kettering Institute For Cancer Research | Targeted alpha particle therapy using actinium-225 conjugates |
| US6670456B2 (en) * | 2001-02-28 | 2003-12-30 | Dow Global Technologies Inc. | Actinium-225 complexes and conjugates for targeted radiotherapy |
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| US7666414B2 (en) | 2001-06-01 | 2010-02-23 | Cornell Research Foundation, Inc. | Methods for treating prostate cancer using modified antibodies to prostate-specific membrane antigen |
| AU2003210149B2 (en) | 2002-01-03 | 2008-10-09 | Bayer Schering Pharma Aktiengesellschaft | Conjugates comprising an antibody specific for the ED-B domain of fibronectin and their use for the detection and treatment of tumours |
| US20040022726A1 (en) | 2002-06-03 | 2004-02-05 | Goldenberg David M. | Methods and compositions for intravesical therapy of bladder cancer |
| US20030086868A1 (en) * | 2002-08-12 | 2003-05-08 | Dangshe Ma | Actinium-225 complexes and conjugates for radioimmunotherapy |
| US20060058218A1 (en) | 2004-09-10 | 2006-03-16 | General Electric Company | Solid phase conjugation of complexing agents and targeting moieties |
| US7736647B2 (en) | 2005-06-15 | 2010-06-15 | Monoclonal Antibodies Therapeutics | Anti-CD71 monoclonal antibodies and uses thereof for treating malignant tumor cells |
| EP2015775B1 (en) | 2006-05-03 | 2011-06-01 | Bayer Schering Pharma Aktiengesellschaft | Combination of an anti edb fibronectin domain antibody l19-sip and an anti-egfr antibody |
-
2010
- 2010-07-22 CA CA2768658A patent/CA2768658C/en active Active
- 2010-07-22 IN IN551DEN2012 patent/IN2012DN00551A/en unknown
- 2010-07-22 RU RU2015137512A patent/RU2704802C2/ru active
- 2010-07-22 WO PCT/US2010/042885 patent/WO2011011592A1/en not_active Ceased
- 2010-07-22 RU RU2012106301/15A patent/RU2565402C2/ru active
- 2010-07-22 EP EP10802893.7A patent/EP2456472B1/en active Active
- 2010-07-22 US US13/386,316 patent/US9603954B2/en active Active
- 2010-07-22 CN CN201510083376.8A patent/CN104710504B/zh active Active
- 2010-07-22 JP JP2012521780A patent/JP5985392B2/ja active Active
- 2010-07-22 CN CN201080036704.4A patent/CN102596258B/zh active Active
-
2016
- 2016-08-03 JP JP2016152696A patent/JP2016199583A/ja active Pending
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