CA2768658C - Methods for generating radioimmunoconjugates - Google Patents

Methods for generating radioimmunoconjugates Download PDF

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Publication number
CA2768658C
CA2768658C CA2768658A CA2768658A CA2768658C CA 2768658 C CA2768658 C CA 2768658C CA 2768658 A CA2768658 A CA 2768658A CA 2768658 A CA2768658 A CA 2768658A CA 2768658 C CA2768658 C CA 2768658C
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Canada
Prior art keywords
acid
reaction mixture
dota
antibody
hum195
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Active
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CA2768658A
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English (en)
French (fr)
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CA2768658A1 (en
Inventor
Jaime Simon
A. Gaylord King
Josue Manuel Moreno Bermudez
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Actinium Pharmaceuticals Inc
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Actinium Pharmaceuticals Inc
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Publication of CA2768658A1 publication Critical patent/CA2768658A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA2768658A 2009-07-22 2010-07-22 Methods for generating radioimmunoconjugates Active CA2768658C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22771009P 2009-07-22 2009-07-22
US61/227,710 2009-07-22
PCT/US2010/042885 WO2011011592A1 (en) 2009-07-22 2010-07-22 Methods for generating radioimmunoconjugates

Publications (2)

Publication Number Publication Date
CA2768658A1 CA2768658A1 (en) 2011-01-27
CA2768658C true CA2768658C (en) 2018-04-03

Family

ID=43499411

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2768658A Active CA2768658C (en) 2009-07-22 2010-07-22 Methods for generating radioimmunoconjugates

Country Status (8)

Country Link
US (1) US9603954B2 (https=)
EP (1) EP2456472B1 (https=)
JP (2) JP5985392B2 (https=)
CN (2) CN104710504B (https=)
CA (1) CA2768658C (https=)
IN (1) IN2012DN00551A (https=)
RU (2) RU2704802C2 (https=)
WO (1) WO2011011592A1 (https=)

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CA2949365A1 (en) * 2014-05-16 2015-11-19 Memorial Sloan Kettering Cancer Center One-step labeling of antibodies to high specific activity with actinium-225
CN108348604B (zh) * 2015-09-08 2022-04-29 沃特世科技公司 用于分析抗体-药物缀合物的多维色谱方法
US11896683B2 (en) 2016-12-16 2024-02-13 The Australian National University Radiolabelled material for targeted administration
DK3568205T3 (da) 2017-01-12 2023-10-09 Radiomedix Inc Behandling af cancerceller, der overeksprimerer somatostatinreceptorer ved at anvende radioisotop-chelaterede ocreotid-derivater
EP3661557B1 (en) * 2017-07-31 2025-09-03 Actinium Pharmaceuticals, Inc. Treatments for a hematological malignancy
CN109550061A (zh) * 2017-09-26 2019-04-02 南京江原安迪科正电子研究发展有限公司 一种用于放射性核素标记抗体的试剂盒及应用
WO2022056354A1 (en) * 2020-09-11 2022-03-17 Actinium Pharmaceuticals, Inc. Trophoblast glycoprotein radioimmunotherapy for the treatment of solid cancers
US12551584B1 (en) 2020-12-07 2026-02-17 Actinium Pharmaceuticals, Inc. Lewis Y radioimmunotherapy for the treatment of cancer
US12447218B1 (en) * 2021-02-09 2025-10-21 Actinium Pharmaceuticals, Inc. Radioconjugates directed to MHC-complexed antigens in cancer
US20250339571A1 (en) * 2021-08-27 2025-11-06 Actinium Pharmaceuticals, Inc. Radioimmunoconjugates targeting phosphatidylserine for use in the treatment of cancer
WO2023183927A2 (en) 2022-03-24 2023-09-28 Actinium Pharmaceuticals, Inc. Humanized anti-cd45 antibodies
US20250177583A1 (en) 2022-03-30 2025-06-05 Nihon Medi-Physics Co., Ltd. Method for producing complex
EP4536278A2 (en) 2022-06-07 2025-04-16 Actinium Pharmaceuticals, Inc. Bifunctional chelators and conjugates
AU2023330110A1 (en) 2022-08-22 2025-03-06 Abdera Therapeutics Inc. Dll3 binding molecules and uses thereof
US20250388688A1 (en) 2024-04-04 2025-12-25 Ethyreal Bio, Inc. Anti-tshr antibodies and uses thereof
US12600794B2 (en) 2024-07-23 2026-04-14 Abdera Therapeutics Inc. 5T4 binding polypeptides and uses thereof

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Also Published As

Publication number Publication date
CA2768658A1 (en) 2011-01-27
CN102596258B (zh) 2015-01-28
CN104710504B (zh) 2019-09-13
RU2704802C2 (ru) 2019-10-31
RU2015137512A (ru) 2018-12-25
JP2016199583A (ja) 2016-12-01
EP2456472A4 (en) 2014-08-27
RU2565402C2 (ru) 2015-10-20
RU2012106301A (ru) 2013-08-27
HK1211304A1 (en) 2016-05-20
EP2456472A1 (en) 2012-05-30
RU2015137512A3 (https=) 2019-04-02
EP2456472C0 (en) 2024-03-27
IN2012DN00551A (https=) 2015-06-12
WO2011011592A1 (en) 2011-01-27
JP2013500258A (ja) 2013-01-07
CN104710504A (zh) 2015-06-17
US20120220754A1 (en) 2012-08-30
JP5985392B2 (ja) 2016-09-06
EP2456472B1 (en) 2024-03-27
US9603954B2 (en) 2017-03-28
CN102596258A (zh) 2012-07-18

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