JP2016197112A5 - - Google Patents
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- JP2016197112A5 JP2016197112A5 JP2016118888A JP2016118888A JP2016197112A5 JP 2016197112 A5 JP2016197112 A5 JP 2016197112A5 JP 2016118888 A JP2016118888 A JP 2016118888A JP 2016118888 A JP2016118888 A JP 2016118888A JP 2016197112 A5 JP2016197112 A5 JP 2016197112A5
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- JP
- Japan
- Prior art keywords
- pkc
- isozyme
- peptide
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- level
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 102000003923 Protein Kinase C Human genes 0.000 claims 33
- 108090000315 Protein Kinase C Proteins 0.000 claims 33
- 108010044467 Isoenzymes Proteins 0.000 claims 31
- 210000004027 cell Anatomy 0.000 claims 17
- 108090000765 processed proteins & peptides Proteins 0.000 claims 17
- 208000024827 Alzheimer disease Diseases 0.000 claims 16
- 238000000034 method Methods 0.000 claims 16
- 230000002093 peripheral effect Effects 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 5
- 102000014458 Protein Kinase C-epsilon Human genes 0.000 claims 4
- 108010078137 Protein Kinase C-epsilon Proteins 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 230000026731 phosphorylation Effects 0.000 claims 3
- 238000006366 phosphorylation reaction Methods 0.000 claims 3
- 102100024924 Protein kinase C alpha type Human genes 0.000 claims 2
- 101710109947 Protein kinase C alpha type Proteins 0.000 claims 2
- 102100037314 Protein kinase C gamma type Human genes 0.000 claims 2
- 101710144823 Protein kinase C gamma type Proteins 0.000 claims 2
- 210000000601 blood cell Anatomy 0.000 claims 2
- 230000002500 effect on skin Effects 0.000 claims 2
- 210000002950 fibroblast Anatomy 0.000 claims 2
- 150000002611 lead compounds Chemical class 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 210000004927 skin cell Anatomy 0.000 claims 2
- 239000012190 activator Substances 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 229940000406 drug candidate Drugs 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24836109P | 2009-10-02 | 2009-10-02 | |
| US61/248,361 | 2009-10-02 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012532353A Division JP6013184B2 (ja) | 2009-10-02 | 2010-10-01 | アルツハイマー病末梢細胞におけるｐｋｃアイソザイムプロセッシングの異常変化 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016197112A JP2016197112A (ja) | 2016-11-24 |
| JP2016197112A5 true JP2016197112A5 (enExample) | 2017-03-23 |
Family
ID=43302691
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012532353A Active JP6013184B2 (ja) | 2009-10-02 | 2010-10-01 | アルツハイマー病末梢細胞におけるｐｋｃアイソザイムプロセッシングの異常変化 |
| JP2016118888A Pending JP2016197112A (ja) | 2009-10-02 | 2016-06-15 | アルツハイマー病末梢細胞におけるｐｋｃアイソザイムプロセッシングの異常変化 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012532353A Active JP6013184B2 (ja) | 2009-10-02 | 2010-10-01 | アルツハイマー病末梢細胞におけるｐｋｃアイソザイムプロセッシングの異常変化 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20110212474A1 (enExample) |
| EP (1) | EP2483695A2 (enExample) |
| JP (2) | JP6013184B2 (enExample) |
| CN (1) | CN102741696A (enExample) |
| BR (1) | BR112012007557A2 (enExample) |
| CA (1) | CA2776498A1 (enExample) |
| WO (1) | WO2011041670A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016516201A (ja) * | 2013-03-15 | 2016-06-02 | ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート | 神経保護性ｐｋｃ活性化因子を特定する方法 |
| CA2978740A1 (en) | 2015-03-06 | 2016-09-15 | Blanchette Rockefeller Neurosciences Institute | Methods for classifying populations including alzheimer's disease populations |
| JP7134874B2 (ja) * | 2016-02-22 | 2022-09-12 | ザ・ウエスト・バージニア・ユニバーシティー・ボード・オブ・ガバナース・オン・ビハーフ・オブ・ウエスト・バージニア・ユニバーシティー | 軽度認知障害（ｍｃｉ）の診断、アルツハイマー病（ａｄ）型認知症の発症の予測、ならびにｍｃｉの処置または認知症発症の予防のための薬剤のスクリーニングおよびモニタリング |
| WO2018183669A1 (en) * | 2017-03-31 | 2018-10-04 | NeuroDiagnostics LLC | LYMPHOCYTE-BASED PKCε TEST FOR ALZHEIMER'S DISEASE |
| CN115078570B (zh) * | 2022-05-30 | 2024-05-28 | 郑州大学第一附属医院 | Tau蛋白639位硫氰酸氨基酸修饰在快速质谱法检测阿尔茨海默症中的应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6080784A (en) * | 1986-06-11 | 2000-06-27 | Procyon Pharmaceuticals, Inc. | Protein kinase C modulators N |
| US5385915A (en) * | 1990-05-16 | 1995-01-31 | The Rockefeller University | Treatment of amyloidosis associated with Alzheimer disease using modulators of protein phosphorylation |
| US5242932A (en) * | 1991-12-17 | 1993-09-07 | The Rockefeller University | Treatment of amyloidosis associated with alzheimer disease |
| US5976816A (en) * | 1993-05-03 | 1999-11-02 | The United States Of America As Represented By The Department Of Health And Human Services | Cell tests for alzheimer's disease |
| US20030108956A1 (en) * | 1993-05-03 | 2003-06-12 | Alkon Daniel L. | Cell tests for Alzheimer's disease |
| US6107050A (en) * | 1993-05-03 | 2000-08-22 | The United States Of America As Represented By The Department Of Health And Human Services | Diagnostic test for alzheimers disease |
| US7625697B2 (en) * | 1994-06-17 | 2009-12-01 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for constructing subarrays and subarrays made thereby |
| WO1997032020A2 (en) * | 1996-02-29 | 1997-09-04 | Mount Sinai Hospital Corporation | Shc proteins |
| WO2001027624A2 (en) * | 1999-10-08 | 2001-04-19 | Superarray, Inc. | Compositions and methods for detecting protein modification and enzymatic activity |
| AUPR215700A0 (en) * | 2000-12-19 | 2001-01-25 | Fujisawa Pharmaceutical Co., Ltd. | Carboxylic acid compound having cyclopropane ring |
| CA2437497A1 (en) * | 2001-02-06 | 2002-08-15 | Incyte Genomics, Inc. | Lipid-associated molecules |
| ATE394115T1 (de) | 2001-02-27 | 2008-05-15 | Brni Neurosciences Inst | Diagnose der alzheimer-krankheit auf basis von mitogenaktivierter proteinkinase-phosphorylierung |
| US20040014678A1 (en) * | 2001-08-08 | 2004-01-22 | Antonella Favit | Prevention of beta-amyloid neurotoxicity by blockade of the ubiquitin-proteasome proteolytoc pathway |
| US7608406B2 (en) * | 2001-08-20 | 2009-10-27 | Biosite, Inc. | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
| US6897014B2 (en) | 2002-02-15 | 2005-05-24 | Fuji Photo Film Co., Ltd. | Silver halide photographic light-sensitive material, photographic emulsion, and mercapto group-containing polymer compound used for them |
| ITMI20031098A1 (it) * | 2003-05-30 | 2004-11-30 | Indena Spa | Composti utili nella terapia del morbo di alzheimer e formulazioni che li contengono |
| KR100574017B1 (ko) | 2003-08-11 | 2006-04-26 | 삼성전자주식회사 | 잉크젯 프린터의 잉크 카트리지 |
| US8199333B2 (en) | 2005-05-27 | 2012-06-12 | Carl Zeiss Smt Gmbh | Optical scattering disk, use thereof, and wavefront measuring apparatus |
| US20070054890A1 (en) * | 2005-07-29 | 2007-03-08 | Alkon Daniel L | Protein synthesis required for long-term memory is induced by PKC activation on days preceding associative learning |
| US7595167B2 (en) * | 2005-10-11 | 2009-09-29 | Blanchette Rockefeller Neurosciences Institute | Alzheimer's disease-specific alterations of the Erk1/Erk2 phosphorylation ratio |
| US20090029873A1 (en) * | 2005-10-11 | 2009-01-29 | Blanchette Rockefeller Neurosciences Institute | Alzheimer's Disease-Specific Alterations of the Erk1/Erk2 Phosphorylation Ratio-Alzheimer's Disease-Specific Molecular Biomarkers (Adsmb) |
| WO2007044094A1 (en) * | 2005-10-11 | 2007-04-19 | Blanchette Rockefeller Neurosciences Institute | Alzheimer's disease-specific alterations of the erk1/erk2 phosphorylation ratio as alzheimer's disease-specific molecular biomarkers (adsmb) |
| KR20140049054A (ko) | 2007-02-09 | 2014-04-24 | 블랜체트 록펠러 뉴로사이언시즈 인스티튜트 | 두부 외상으로 유발된 기억 장애 및 뇌 손상에 대한 브리오스타틴, 브리오로그 및 기타 관련 물질의 치료학적 효과 |
-
2010
- 2010-10-01 BR BR112012007557A patent/BR112012007557A2/pt not_active Application Discontinuation
- 2010-10-01 CA CA2776498A patent/CA2776498A1/en not_active Abandoned
- 2010-10-01 WO PCT/US2010/051112 patent/WO2011041670A2/en not_active Ceased
- 2010-10-01 EP EP10821325A patent/EP2483695A2/en not_active Withdrawn
- 2010-10-01 CN CN2010800551432A patent/CN102741696A/zh active Pending
- 2010-10-01 JP JP2012532353A patent/JP6013184B2/ja active Active
- 2010-10-01 US US12/895,957 patent/US20110212474A1/en not_active Abandoned
-
2016
- 2016-06-15 JP JP2016118888A patent/JP2016197112A/ja active Pending
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