CA2776498A1 - Abnormal alterations of pkc isozymes processing in alzheimer's disease peripheral cells - Google Patents
Abnormal alterations of pkc isozymes processing in alzheimer's disease peripheral cells Download PDFInfo
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- CA2776498A1 CA2776498A1 CA2776498A CA2776498A CA2776498A1 CA 2776498 A1 CA2776498 A1 CA 2776498A1 CA 2776498 A CA2776498 A CA 2776498A CA 2776498 A CA2776498 A CA 2776498A CA 2776498 A1 CA2776498 A1 CA 2776498A1
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
- G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
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| PCT/US2010/051112 WO2011041670A2 (en) | 2009-10-02 | 2010-10-01 | Abnormal alterations of pkc isozymes processing in alzheimer's disease peripheral cells |
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| CA2776498A1 true CA2776498A1 (en) | 2011-04-07 |
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| JP2016516201A (ja) * | 2013-03-15 | 2016-06-02 | ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート | 神経保護性ｐｋｃ活性化因子を特定する方法 |
| CA2978740A1 (en) | 2015-03-06 | 2016-09-15 | Blanchette Rockefeller Neurosciences Institute | Methods for classifying populations including alzheimer's disease populations |
| JP7134874B2 (ja) * | 2016-02-22 | 2022-09-12 | ザ・ウエスト・バージニア・ユニバーシティー・ボード・オブ・ガバナース・オン・ビハーフ・オブ・ウエスト・バージニア・ユニバーシティー | 軽度認知障害（ｍｃｉ）の診断、アルツハイマー病（ａｄ）型認知症の発症の予測、ならびにｍｃｉの処置または認知症発症の予防のための薬剤のスクリーニングおよびモニタリング |
| WO2018183669A1 (en) * | 2017-03-31 | 2018-10-04 | NeuroDiagnostics LLC | LYMPHOCYTE-BASED PKCε TEST FOR ALZHEIMER'S DISEASE |
| CN115078570B (zh) * | 2022-05-30 | 2024-05-28 | 郑州大学第一附属医院 | Tau蛋白639位硫氰酸氨基酸修饰在快速质谱法检测阿尔茨海默症中的应用 |
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| US6080784A (en) * | 1986-06-11 | 2000-06-27 | Procyon Pharmaceuticals, Inc. | Protein kinase C modulators N |
| US5385915A (en) * | 1990-05-16 | 1995-01-31 | The Rockefeller University | Treatment of amyloidosis associated with Alzheimer disease using modulators of protein phosphorylation |
| US5242932A (en) * | 1991-12-17 | 1993-09-07 | The Rockefeller University | Treatment of amyloidosis associated with alzheimer disease |
| US5976816A (en) * | 1993-05-03 | 1999-11-02 | The United States Of America As Represented By The Department Of Health And Human Services | Cell tests for alzheimer's disease |
| US20030108956A1 (en) * | 1993-05-03 | 2003-06-12 | Alkon Daniel L. | Cell tests for Alzheimer's disease |
| US6107050A (en) * | 1993-05-03 | 2000-08-22 | The United States Of America As Represented By The Department Of Health And Human Services | Diagnostic test for alzheimers disease |
| US7625697B2 (en) * | 1994-06-17 | 2009-12-01 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for constructing subarrays and subarrays made thereby |
| WO1997032020A2 (en) * | 1996-02-29 | 1997-09-04 | Mount Sinai Hospital Corporation | Shc proteins |
| WO2001027624A2 (en) * | 1999-10-08 | 2001-04-19 | Superarray, Inc. | Compositions and methods for detecting protein modification and enzymatic activity |
| AUPR215700A0 (en) * | 2000-12-19 | 2001-01-25 | Fujisawa Pharmaceutical Co., Ltd. | Carboxylic acid compound having cyclopropane ring |
| CA2437497A1 (en) * | 2001-02-06 | 2002-08-15 | Incyte Genomics, Inc. | Lipid-associated molecules |
| ATE394115T1 (de) | 2001-02-27 | 2008-05-15 | Brni Neurosciences Inst | Diagnose der alzheimer-krankheit auf basis von mitogenaktivierter proteinkinase-phosphorylierung |
| US20040014678A1 (en) * | 2001-08-08 | 2004-01-22 | Antonella Favit | Prevention of beta-amyloid neurotoxicity by blockade of the ubiquitin-proteasome proteolytoc pathway |
| US7608406B2 (en) * | 2001-08-20 | 2009-10-27 | Biosite, Inc. | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
| US6897014B2 (en) | 2002-02-15 | 2005-05-24 | Fuji Photo Film Co., Ltd. | Silver halide photographic light-sensitive material, photographic emulsion, and mercapto group-containing polymer compound used for them |
| ITMI20031098A1 (it) * | 2003-05-30 | 2004-11-30 | Indena Spa | Composti utili nella terapia del morbo di alzheimer e formulazioni che li contengono |
| KR100574017B1 (ko) | 2003-08-11 | 2006-04-26 | 삼성전자주식회사 | 잉크젯 프린터의 잉크 카트리지 |
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| US20070054890A1 (en) * | 2005-07-29 | 2007-03-08 | Alkon Daniel L | Protein synthesis required for long-term memory is induced by PKC activation on days preceding associative learning |
| US7595167B2 (en) * | 2005-10-11 | 2009-09-29 | Blanchette Rockefeller Neurosciences Institute | Alzheimer's disease-specific alterations of the Erk1/Erk2 phosphorylation ratio |
| US20090029873A1 (en) * | 2005-10-11 | 2009-01-29 | Blanchette Rockefeller Neurosciences Institute | Alzheimer's Disease-Specific Alterations of the Erk1/Erk2 Phosphorylation Ratio-Alzheimer's Disease-Specific Molecular Biomarkers (Adsmb) |
| WO2007044094A1 (en) * | 2005-10-11 | 2007-04-19 | Blanchette Rockefeller Neurosciences Institute | Alzheimer's disease-specific alterations of the erk1/erk2 phosphorylation ratio as alzheimer's disease-specific molecular biomarkers (adsmb) |
| KR20140049054A (ko) | 2007-02-09 | 2014-04-24 | 블랜체트 록펠러 뉴로사이언시즈 인스티튜트 | 두부 외상으로 유발된 기억 장애 및 뇌 손상에 대한 브리오스타틴, 브리오로그 및 기타 관련 물질의 치료학적 효과 |
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| Publication number | Publication date |
|---|---|
| US20110212474A1 (en) | 2011-09-01 |
| JP2013506844A (ja) | 2013-02-28 |
| CN102741696A (zh) | 2012-10-17 |
| WO2011041670A2 (en) | 2011-04-07 |
| BR112012007557A2 (pt) | 2017-05-02 |
| EP2483695A2 (en) | 2012-08-08 |
| JP6013184B2 (ja) | 2016-10-25 |
| WO2011041670A3 (en) | 2011-06-30 |
| JP2016197112A (ja) | 2016-11-24 |
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