BR112012007557A2 - alterações anormais de processamento de isozimas de pkc em células periféricas da doença de alzheimer - Google Patents
alterações anormais de processamento de isozimas de pkc em células periféricas da doença de alzheimerInfo
- Publication number
- BR112012007557A2 BR112012007557A2 BR112012007557A BR112012007557A BR112012007557A2 BR 112012007557 A2 BR112012007557 A2 BR 112012007557A2 BR 112012007557 A BR112012007557 A BR 112012007557A BR 112012007557 A BR112012007557 A BR 112012007557A BR 112012007557 A2 BR112012007557 A2 BR 112012007557A2
- Authority
- BR
- Brazil
- Prior art keywords
- peripheral cells
- alzheimer
- disease
- processing
- pkc
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
- G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
alterações anormais de processamento de isizimas de pkc em células periféricas da doença de alzheimer. a presente invenção refere-se a um método para o diagnóstico de ad de condições não ad usando um índice de isozima de pkc obtido por determinação das razões de isozimas de okc diferentes em células periféricas de um indivíduo teste na ausência e presença de um peptídeo beta-amiloide, e opcionalmente, na presença de um ativador de pkc.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24836109P | 2009-10-02 | 2009-10-02 | |
PCT/US2010/051112 WO2011041670A2 (en) | 2009-10-02 | 2010-10-01 | Abnormal alterations of pkc isozymes processing in alzheimer's disease peripheral cells |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112012007557A2 true BR112012007557A2 (pt) | 2017-05-02 |
Family
ID=43302691
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012007557A BR112012007557A2 (pt) | 2009-10-02 | 2010-10-01 | alterações anormais de processamento de isozimas de pkc em células periféricas da doença de alzheimer |
Country Status (7)
Country | Link |
---|---|
US (1) | US20110212474A1 (pt) |
EP (1) | EP2483695A2 (pt) |
JP (2) | JP6013184B2 (pt) |
CN (1) | CN102741696A (pt) |
BR (1) | BR112012007557A2 (pt) |
CA (1) | CA2776498A1 (pt) |
WO (1) | WO2011041670A2 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2016516201A (ja) * | 2013-03-15 | 2016-06-02 | ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート | 神経保護性pkc活性化因子を特定する方法 |
EP3265810A1 (en) | 2015-03-06 | 2018-01-10 | Blanchette Rockefeller Neurosciences, Institute | Methods for classifying populations including alzheimer's disease populations |
WO2017147114A1 (en) * | 2016-02-22 | 2017-08-31 | Blanchette Rockefeller Neurosciences Institute | Diagnosing mild cognitive impairment (mci), predicting alzheimer's disease (ad) dementia onset, and screening and monitoring agents for treating mci or preventing dementia onset |
EP3601601A4 (en) * | 2017-03-31 | 2020-12-23 | Neurodiagnostics LLC | LYMPHOCYTE-BASED PKCEPSILON TEST FOR ALZHEIMER'S DISEASE |
CN115078570B (zh) * | 2022-05-30 | 2024-05-28 | 郑州大学第一附属医院 | Tau蛋白639位硫氰酸氨基酸修饰在快速质谱法检测阿尔茨海默症中的应用 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6080784A (en) * | 1986-06-11 | 2000-06-27 | Procyon Pharmaceuticals, Inc. | Protein kinase C modulators N |
US5242932A (en) * | 1991-12-17 | 1993-09-07 | The Rockefeller University | Treatment of amyloidosis associated with alzheimer disease |
US5385915A (en) * | 1990-05-16 | 1995-01-31 | The Rockefeller University | Treatment of amyloidosis associated with Alzheimer disease using modulators of protein phosphorylation |
US6107050A (en) * | 1993-05-03 | 2000-08-22 | The United States Of America As Represented By The Department Of Health And Human Services | Diagnostic test for alzheimers disease |
US20030108956A1 (en) * | 1993-05-03 | 2003-06-12 | Alkon Daniel L. | Cell tests for Alzheimer's disease |
US5976816A (en) * | 1993-05-03 | 1999-11-02 | The United States Of America As Represented By The Department Of Health And Human Services | Cell tests for alzheimer's disease |
US7625697B2 (en) * | 1994-06-17 | 2009-12-01 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for constructing subarrays and subarrays made thereby |
AU2316797A (en) * | 1996-02-29 | 1997-09-16 | Mount Sinai Hospital Corporation | Shc proteins |
EP1224463A2 (en) * | 1999-10-08 | 2002-07-24 | Superarray, Inc. | Compositions and methods for detecting protein modification and enzymatic activity |
AUPR215700A0 (en) * | 2000-12-19 | 2001-01-25 | Fujisawa Pharmaceutical Co., Ltd. | Carboxylic acid compound having cyclopropane ring |
JP2005503112A (ja) * | 2001-02-06 | 2005-02-03 | インサイト・ゲノミックス・インコーポレイテッド | 脂質結合分子 |
DE08002964T1 (de) * | 2001-02-27 | 2009-09-03 | Blanchette Rockefeller Neurosciences Institute | Alzheimer-Diagnose auf Basis von mitogenaktivierter Proteinkinasephosphorylierung |
US20040014678A1 (en) * | 2001-08-08 | 2004-01-22 | Antonella Favit | Prevention of beta-amyloid neurotoxicity by blockade of the ubiquitin-proteasome proteolytoc pathway |
US7608406B2 (en) * | 2001-08-20 | 2009-10-27 | Biosite, Inc. | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
US6897014B2 (en) | 2002-02-15 | 2005-05-24 | Fuji Photo Film Co., Ltd. | Silver halide photographic light-sensitive material, photographic emulsion, and mercapto group-containing polymer compound used for them |
ITMI20031098A1 (it) * | 2003-05-30 | 2004-11-30 | Indena Spa | Composti utili nella terapia del morbo di alzheimer e formulazioni che li contengono |
KR100574017B1 (ko) | 2003-08-11 | 2006-04-26 | 삼성전자주식회사 | 잉크젯 프린터의 잉크 카트리지 |
US8199333B2 (en) | 2005-05-27 | 2012-06-12 | Carl Zeiss Smt Gmbh | Optical scattering disk, use thereof, and wavefront measuring apparatus |
WO2007016202A1 (en) * | 2005-07-29 | 2007-02-08 | Blanchette Rockefeller Neurosciences Institute | Use of a pkc activator, alone or combined with a pkc inhibitor to enhance long term memory |
US20090029873A1 (en) * | 2005-10-11 | 2009-01-29 | Blanchette Rockefeller Neurosciences Institute | Alzheimer's Disease-Specific Alterations of the Erk1/Erk2 Phosphorylation Ratio-Alzheimer's Disease-Specific Molecular Biomarkers (Adsmb) |
WO2007044094A1 (en) * | 2005-10-11 | 2007-04-19 | Blanchette Rockefeller Neurosciences Institute | Alzheimer's disease-specific alterations of the erk1/erk2 phosphorylation ratio as alzheimer's disease-specific molecular biomarkers (adsmb) |
US7595167B2 (en) | 2005-10-11 | 2009-09-29 | Blanchette Rockefeller Neurosciences Institute | Alzheimer's disease-specific alterations of the Erk1/Erk2 phosphorylation ratio |
CA2873179A1 (en) | 2007-02-09 | 2008-08-21 | Blanchette Rockefeller Neurosciences Institute | Use of bryostatins and neristatins in the treatment of cognitive impairment due to head trauma |
-
2010
- 2010-10-01 CA CA2776498A patent/CA2776498A1/en not_active Abandoned
- 2010-10-01 EP EP10821325A patent/EP2483695A2/en not_active Withdrawn
- 2010-10-01 WO PCT/US2010/051112 patent/WO2011041670A2/en active Application Filing
- 2010-10-01 JP JP2012532353A patent/JP6013184B2/ja active Active
- 2010-10-01 CN CN2010800551432A patent/CN102741696A/zh active Pending
- 2010-10-01 US US12/895,957 patent/US20110212474A1/en not_active Abandoned
- 2010-10-01 BR BR112012007557A patent/BR112012007557A2/pt not_active Application Discontinuation
-
2016
- 2016-06-15 JP JP2016118888A patent/JP2016197112A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP2483695A2 (en) | 2012-08-08 |
JP6013184B2 (ja) | 2016-10-25 |
CN102741696A (zh) | 2012-10-17 |
JP2013506844A (ja) | 2013-02-28 |
WO2011041670A2 (en) | 2011-04-07 |
WO2011041670A3 (en) | 2011-06-30 |
JP2016197112A (ja) | 2016-11-24 |
US20110212474A1 (en) | 2011-09-01 |
CA2776498A1 (en) | 2011-04-07 |
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Legal Events
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B07A | Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL |
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B350 | Update of information on the portal [chapter 15.35 patent gazette] |