JP2016144690A - 中空のマイクロニードルアレイ及び方法 - Google Patents
中空のマイクロニードルアレイ及び方法 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
- A61B17/205—Vaccinating by means of needles or other puncturing devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150022—Source of blood for capillary blood or interstitial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
- A61B5/150106—Means for reducing pain or discomfort applied before puncturing; desensitising the skin at the location where body is to be pierced
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150381—Design of piercing elements
- A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
- A61B5/150396—Specific tip design, e.g. for improved penetration characteristics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150969—Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150977—Arrays of piercing elements for simultaneous piercing
- A61B5/150984—Microneedles or microblades
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/04—Skin
Abstract
Description
マイクロニードルデバイス10は、複数の18個のマイクロニードル14がそこから延在する基材12を備えるマイクロニードルアレイ11を有する。それぞれのマイクロニードル14は、基部16から先端18までおよそ500μmの高さを有する。中空のチャネル(図示せず)は、基材12及びマイクロニードル14を通して延在し、マイクロニードルの先端近くにおいてチャネル開口部20で抜ける。これによって、アレイの後部から(例えばリザーバ(図示せず)から)それぞれのマイクロニードル14を通って、流体連通が可能である。チャネルは、マイクロニードル14の中心軸線に沿って伸びるが、皮下注射針と同様に、マイクロニードルの勾配のある側壁で抜けて、挿入時の組織による閉塞を防ぐのに役立つ。チャネルは、約20〜50平方μmの平均断面積を有する。
図1Aに関連して上述のマイクロニードルアレイデバイスが、次の実験及び実施例に使用された。
無毛モルモット(HGP)
オスのHGPを、IACUC承認の3M動物使用の適用に準拠して、Charles River Laboratories(Wilmington,MA)から注文し、そのプロトコルに基づいて使用した。本試験で使用した動物はすべて、体重が0.8〜1kgであった。
試験は、IACUC承認の3M動物使用の適用に準拠して取得した、体重がおよそ10〜30kgである、生後およそ6〜18週のメスの家畜ブタに行った。注入中、及び本試験全体を通して、ブタは、イソフルラン(2〜5%)と酸素との混合の麻酔下に維持された。ブタの上臀部を、最初に手術用クリッパー(クリップ刃#50)を使用して剃毛し、次に少量のGillette Foamシェービングクリームを使用して、Schick3かみそりで剃毛した。剃毛後、部位を水で濯ぎ、軽くたたいて水気を拭き取ってから、イソプロピルアルコール(Phoenix Pharmaceutical,Inc.,St.Joseph,MO)で拭いた。
それぞれの時点で、Vacutainer Collections Set(Becton Dickenson & Co.,Franklin Lakes,NJ)を使用して、ブタの耳静脈から1.5〜2mLの全血を採取した。血液は、少なくとも30分間室温で放置した後、1500rpmで10分間遠心分離した。遠心分離後、血清は全血から分離されて、抽出まで冷所に保管された。
技術文献に基づき、かつミクロ構造の寸法を考慮して、角質層を貫通するために1ミクロ構造当たり0.004〜0.16Nの力が必要であると推定された。S.P.David,B.J.Landis,Z.H.Adams,M.G.Allen,M.R.Prausnitz.Insertion of microneedles into skin:measurement and prediction of insertion force and needle fracture force.Journal of Biomechanics.37:115〜116(2004)。本明細書で用いられるミクロ構造の十分な耐久性を確実にするために、アレイは非弾性表面に接して押され、およそ245Nの力がアレイに加えられたとき、先端に曲げが生じた。
大量注入が家畜ブタに実証された。ブタに使用した注入システムは、貼付後に中空のマイクロニードルアレイ貼付剤に接続されて、標準医療用具を用いて、配合物の送達を提供する。中空のマイクロニードル貼付用貼付剤は、インライン滅菌済みDTX Plus TNF−R圧変換器(BD Infusion Therapy Systems,Inc,Sandy,UT)を含む、市販の滅菌済みPolyethylene IV Extension Set(Vygon Corporation,Ecouen,France)を経由して、Medfusion 3500シリンジポンプ(Smiths Medical,St.Paul,MN)につながれる。Medfusion 3500ポンプは、病院現場で一般に使用され、あらかじめ設定された安全停止機能有する。圧力数値を、2秒ごとにおよそ1測定の速度で記録した。5%デキストロースUSP注射剤液(Baxter Healthcare,Deerfield,IL)をそのまま注入に使用した。0.001%メチレンブルー溶液を滅菌水で調製して、投与前にろ過した。
注入の定量化を改善させるために、中空のマイクロニードルPOCデバイスを使用して、ナロキソンの1mg/mLの市販配合物をブタに注入した。ナロキソンは、μ−オピオイドレセプター競合拮抗薬で、ヘロイン等の薬物の過剰投与を抑制するために主に使用される。ナロキソンは、速く反応させるために通常は静脈内に投与され、経口投与の場合、約2%のみ生体に作用する。ナロキソンは吸収性が良いが、初回通過中にほぼ90%が除去される。文献レビューによると、ナロキソンの半減期は成人の場合30〜81分で、小児の場合はそれより相当長い(およそ3時間)。ナロキソンは代謝産物として尿に排泄される。
上述した用具と同じものを使用して、大量、高速注入をヒトで実証した。ヒト臨床試験において、28人の被験者に、4〜6回連続の中空のマイクロニードルによるプラセボ注入が、上腕、及び/又は大腿部に投与された。背圧は、注入全体を通して、連続的にモニタされた。10点の痛みの尺度(図4を参照)を使用して、被験者はそれぞれ、中空のマイクロニードル貼付剤の貼付、及び除去に関連する痛みを評価することを求められた。被験者は、注入中10分ごとに、又は注入が10分未満で終了した場合は注入の終了時に、注入に関連した痛みを評価することも求められた。
Claims (5)
- 中空のマイクロニードルのアレイであって、
基材と、
該基材から突出するように配置され、100μm超〜1mm未満の長さを有する10〜30個の中空のマイクロニードルであって、1個の前記マイクロニードルは、隣接する他の前記マイクロニードルと平均1.5mm以上の間隔を持つ、中空のマイクロニードルと、を備え、
20μL/分超の速度で、前記中空のマイクロニードルを通して200μL超の流体を注入することができ、
前記マイクロニードルのうちの少なくとも一部は、勾配のある側壁を有し、該勾配のある側壁は、チャネルの出口孔を含む、中空のマイクロニードルのアレイ。 - 13〜20個の前記マイクロニードルを有する、請求項1に記載の中空のマイクロニードルのアレイ。
- 注入中の背圧は、25psi(172.4kPa)以下である、請求項1又は2に記載の中空のマイクロニードルのアレイ。
- 前記マイクロニードルは、各々の前記マイクロニードルの一側壁に設置された出口孔を有する、請求項1〜3のいずれか一項に記載の中空のマイクロニードルのアレイ。
- 前記マイクロニードルは、互いに平均少なくとも2mmの間隔を空けて配置される、請求項1〜4のいずれか一項に記載の中空のマイクロニードルのアレイ。
Applications Claiming Priority (2)
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US11584008P | 2008-11-18 | 2008-11-18 | |
US61/115,840 | 2008-11-18 |
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JP2011536589A Division JP2012509106A (ja) | 2008-11-18 | 2009-11-17 | 中空のマイクロニードルアレイ及び方法 |
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JP2016144690A true JP2016144690A (ja) | 2016-08-12 |
JP6334592B2 JP6334592B2 (ja) | 2018-05-30 |
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JP2011536589A Pending JP2012509106A (ja) | 2008-11-18 | 2009-11-17 | 中空のマイクロニードルアレイ及び方法 |
JP2016077924A Active JP6334592B2 (ja) | 2008-11-18 | 2016-04-08 | 中空のマイクロニードルアレイ及び方法 |
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US (1) | US20110213335A1 (ja) |
EP (2) | EP3300765A1 (ja) |
JP (2) | JP2012509106A (ja) |
KR (3) | KR20190064676A (ja) |
CN (2) | CN105999538A (ja) |
AU (1) | AU2009316789B2 (ja) |
BR (1) | BRPI0916150B1 (ja) |
CA (1) | CA2742853C (ja) |
ES (1) | ES2643606T3 (ja) |
MX (1) | MX349292B (ja) |
RU (1) | RU2494769C2 (ja) |
SG (1) | SG10201500415VA (ja) |
WO (1) | WO2010059605A2 (ja) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112012001685B8 (pt) | 2009-07-31 | 2021-06-22 | 3M Innovative Properties Co | conjuntos de microagulhas ocas |
EP3225247B1 (en) | 2010-05-28 | 2020-09-02 | 3M Innovative Properties Company | Aqueous formulations for coating microneedle arrays |
WO2012074721A2 (en) * | 2010-12-02 | 2012-06-07 | Lanco Biosciences, Inc. | Delivery of serotonin receptor antagonists by microinjection systems |
WO2012098503A1 (en) * | 2011-01-18 | 2012-07-26 | Nanopass Technologies Ltd. | Medication delivery assembly |
CN103764197B (zh) | 2011-09-07 | 2017-03-15 | 3M创新有限公司 | 用于中空微针阵列的递送系统 |
CA2850952A1 (en) * | 2011-10-28 | 2013-05-02 | Sung-Yun Kwon | Dissolving solid solution perforator patch for migraine treatment |
CA2857501C (en) | 2011-11-30 | 2020-06-23 | 3M Innovative Properties Company | Microneedle device having a peptide therapeutic agent and an amino acid, methods of making and using the same |
EP2906285B1 (en) | 2012-10-10 | 2019-06-12 | 3M Innovative Properties Company | Applicator for applying a microneedle device to skin |
WO2014058746A1 (en) | 2012-10-10 | 2014-04-17 | 3M Innovative Properties Company | Force-controlled applicator for applying a microneedle device to skin |
WO2014061339A1 (ja) * | 2012-10-17 | 2014-04-24 | 凸版印刷株式会社 | マルチマイクロニードルデバイス使用流体注入器操作器具 |
CN104797287B (zh) | 2012-11-16 | 2017-12-26 | 3M创新有限公司 | 力控施用装置 |
KR102236575B1 (ko) | 2012-12-21 | 2021-04-05 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 접착제 조립체 및 이를 포함하는 마이크로니들 주사 장치 |
US10105524B2 (en) | 2012-12-27 | 2018-10-23 | 3M Innovative Properties Company | Article with hollow microneedles and method of making |
CN104902943B (zh) | 2013-01-08 | 2017-10-31 | 3M创新有限公司 | 用于向皮肤施用微针装置的施用装置 |
EP2968162B1 (en) | 2013-03-15 | 2020-12-02 | Incube Labs, Llc | Multi-stage biodegradable drug delivery platform |
CN105073180B (zh) | 2013-03-22 | 2016-08-10 | 3M创新有限公司 | 包括计数器组件的微针施用装置 |
US20140350514A1 (en) * | 2013-05-22 | 2014-11-27 | Nanopass Technologies Ltd. | Systems and methods for intradermal delivery of therapeutics using microneedles |
BR112015027608A2 (pt) | 2013-05-23 | 2017-07-25 | Kimberly Clark Co | microagulhas com geometrias transversais de canal aberto melhoradas |
SG11201509722PA (en) | 2013-05-31 | 2015-12-30 | 3M Innovative Properties Co | Microneedle injection apparatus comprising a dual cover |
JP6494601B2 (ja) | 2013-05-31 | 2019-04-03 | スリーエム イノベイティブ プロパティズ カンパニー | マイクロニードル注射及び注入装置並びにその使用方法 |
WO2014193729A1 (en) | 2013-05-31 | 2014-12-04 | 3M Innovative Properties Company | Microneedle injection apparatus comprising an inverted actuator |
JP6430501B2 (ja) | 2013-07-16 | 2018-11-28 | スリーエム イノベイティブ プロパティズ カンパニー | 斜角開口部を有する中空マイクロニードル |
CN105407957A (zh) | 2013-07-16 | 2016-03-16 | 3M创新有限公司 | 一种包括微针的制品 |
US10099043B2 (en) | 2013-07-16 | 2018-10-16 | 3M Innovative Properties Company | Hollow microneedle array article |
WO2015009524A1 (en) | 2013-07-16 | 2015-01-22 | 3M Innovative Properties Company | Hollow microneedle with beveled tip |
WO2015034807A2 (en) * | 2013-09-05 | 2015-03-12 | Merck Sharp & Dohme Corp. | Methods of immunization with varicella zoster virus antigen |
DE102013219432A1 (de) * | 2013-09-26 | 2015-03-26 | Peter Röhr | Blutentnahmevorrichtung und Verfahren zum Entnehmen von Blut |
GB201403773D0 (en) | 2014-03-04 | 2014-04-16 | Univ Cardiff | Microneedle based cell delivery |
CN106573135B (zh) | 2014-03-12 | 2020-03-17 | 株式会社培旺精廉宅 | 真皮内目标物质留置用微针制剂给药部件和微针制剂迅速给药器具 |
RU2719937C1 (ru) * | 2014-04-24 | 2020-04-23 | Джорджия Тек Рисёч Корпорейшн | Микроиглы и способы их изготовления |
EP3247449B1 (en) | 2015-01-21 | 2021-01-06 | Kindeva Drug Delivery L.P. | Microneedle array |
KR20170105105A (ko) | 2015-01-27 | 2017-09-18 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 마이크로니들 백신 패치를 위한 명반-함유 코팅 제형 |
US11241505B2 (en) | 2015-02-13 | 2022-02-08 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
IL307981A (en) | 2015-04-29 | 2023-12-01 | Radius Pharmaceuticals Inc | Cancer treatment methods |
CN108135837B (zh) | 2015-10-09 | 2022-05-31 | 3M创新有限公司 | 用于涂布微针阵列的锌组合物 |
US10287543B2 (en) | 2015-11-19 | 2019-05-14 | Miltenyi Biotec, Gmbh | Process and device for isolating cells from biological tissue |
JP2017176652A (ja) | 2016-03-31 | 2017-10-05 | 花王株式会社 | 微細中空突起具 |
JP6732373B2 (ja) | 2016-03-31 | 2020-07-29 | 花王株式会社 | 微細中空突起具の製造方法、及び微細中空突起具 |
AU2017253674B2 (en) | 2016-04-18 | 2021-07-29 | Kindeva Drug Delivery L.P. | Formulations of abaloparatide, transdermal patches thereof, and uses thereof |
CN107569238A (zh) * | 2016-07-04 | 2018-01-12 | 中山大学 | 一种粘贴式烟囱型微针阵列及其制造方法 |
FR3054137B1 (fr) * | 2016-07-21 | 2021-08-27 | Univ Angers | Dispositif medical implantable d’injection locoregionale |
CA3033788A1 (en) | 2016-08-17 | 2018-02-22 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
US11266344B2 (en) | 2016-09-21 | 2022-03-08 | Samsung Electronics Co., Ltd. | Method for measuring skin condition and electronic device therefor |
EP3318300A1 (en) | 2016-11-02 | 2018-05-09 | Miltenyi Biotec GmbH | Perfusion device for biological tissue |
MX2019002993A (es) * | 2016-12-29 | 2019-07-01 | Labnpeople Co Ltd | Arreglo de microagujas. |
JP7481115B2 (ja) | 2017-01-05 | 2024-05-10 | ラジウス ファーマシューティカルズ,インコーポレイテッド | Rad1901-2hclの多形性形態 |
US11642453B2 (en) | 2017-01-10 | 2023-05-09 | A.T. Still University | Fluid infusion system |
EP3586906A4 (en) * | 2017-02-24 | 2020-12-30 | Hisamitsu Pharmaceutical Co., Inc. | MICRO-NEEDLE DEVICE |
EP3603731A4 (en) * | 2017-03-31 | 2020-07-15 | Toppan Printing Co., Ltd. | DEVICE FOR PERCUTANEOUS ADMINISTRATION |
FR3065648B1 (fr) * | 2017-04-28 | 2020-08-21 | Line Paradis | Applicateur d'un produit de traitement cosmetique de la peau ou des levres |
CN109394236B (zh) * | 2017-08-17 | 2022-04-01 | 李泉 | 一种采血装置及其控制设备 |
JP7284748B2 (ja) | 2017-10-17 | 2023-05-31 | キンデーバ ドラッグ デリバリー リミティド パートナーシップ | マイクロニードルアレイを皮膚に適用するためのアプリケータ |
WO2019166572A1 (en) | 2018-02-28 | 2019-09-06 | Pharming Intellectual Property B.V. | Pharmaceutical system for transdermal administration of a c1 -esterase inhibitor |
KR102137760B1 (ko) | 2018-03-23 | 2020-07-24 | (주)지엘캄퍼니 | 주사기용 마이크로 니들 어레이 및 이를 포함하는 주사기 및 주사기용 마이크로 니들 어레이의 제조 방법 |
KR102146704B1 (ko) | 2018-04-13 | 2020-08-21 | 가천대학교 산학협력단 | 사이클로스포린 A (CsA) 경피 및 피내 약물전달용 마이크로구조체 |
US20210228119A1 (en) | 2018-05-16 | 2021-07-29 | Kindeva Drug Delivery L.P. | Microneedle biosensor |
SG11202013177WA (en) | 2018-07-04 | 2021-01-28 | Radius Pharmaceuticals Inc | Polymorphic forms of rad 1901-2hcl |
CN112752590A (zh) | 2018-09-24 | 2021-05-04 | 欧莱雅 | 包含用于皮肤原位反应的微针的装置 |
US20210308440A1 (en) | 2018-09-24 | 2021-10-07 | L'oreal | Device comprising microneedles for skin-coloring |
EP3856323A1 (en) | 2018-09-24 | 2021-08-04 | L'oreal | Device comprising microneedles for cosmetic fillers delivery |
JP7385352B2 (ja) * | 2018-11-30 | 2023-11-22 | 花王株式会社 | 微細突起具の検査方法及び製造方法 |
KR20200120231A (ko) | 2019-04-12 | 2020-10-21 | 연세대학교 산학협력단 | 신부전증 치료를 위한 동정맥루 마이크로 니들 |
US10501404B1 (en) | 2019-07-30 | 2019-12-10 | Factor Bioscience Inc. | Cationic lipids and transfection methods |
CN111803278A (zh) * | 2020-07-20 | 2020-10-23 | 中国人民解放军陆军军医大学 | 一种内置装载微囊和微针注射功能的复合式创伤急救敷料 |
KR102297883B1 (ko) | 2021-02-17 | 2021-09-03 | 주식회사 지엘캄퍼니 | 마이크로 니들조립체 |
US20220273924A1 (en) * | 2021-03-01 | 2022-09-01 | Deka Products Limited Partnership | Medical Agent Dispensing Systems, Methods, and Apparatuses |
US11877848B2 (en) | 2021-11-08 | 2024-01-23 | Satio, Inc. | Dermal patch for collecting a physiological sample |
US11964121B2 (en) | 2021-10-13 | 2024-04-23 | Satio, Inc. | Mono dose dermal patch for pharmaceutical delivery |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050256499A1 (en) * | 2004-03-03 | 2005-11-17 | Pettis Ronald J | Methods and devices for improving delivery of a substance to skin |
US7285113B2 (en) * | 2000-03-09 | 2007-10-23 | Nanopass Technologies Ltd. | Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems |
Family Cites Families (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5457A (en) * | 1848-02-22 | Behch-vise | ||
JP4118356B2 (ja) * | 1996-12-12 | 2008-07-16 | 日本ペイント株式会社 | 防汚塗料組成物 |
US6200289B1 (en) * | 1998-04-10 | 2001-03-13 | Milestone Scientific, Inc. | Pressure/force computer controlled drug delivery system and the like |
US6503231B1 (en) * | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
GB9815820D0 (en) * | 1998-07-22 | 1998-09-16 | Secr Defence | Improvements relating to micro-machining |
US7048723B1 (en) * | 1998-09-18 | 2006-05-23 | The University Of Utah Research Foundation | Surface micromachined microneedles |
US6611707B1 (en) * | 1999-06-04 | 2003-08-26 | Georgia Tech Research Corporation | Microneedle drug delivery device |
US6256533B1 (en) * | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
US6623457B1 (en) * | 1999-09-22 | 2003-09-23 | Becton, Dickinson And Company | Method and apparatus for the transdermal administration of a substance |
US8465468B1 (en) * | 2000-06-29 | 2013-06-18 | Becton, Dickinson And Company | Intradermal delivery of substances |
US6558361B1 (en) * | 2000-03-09 | 2003-05-06 | Nanopass Ltd. | Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems |
PL360998A1 (en) * | 2000-10-13 | 2004-09-20 | Alza Corporation | Apparatus and method for piercing skin with microprotrusions |
US6881203B2 (en) | 2001-09-05 | 2005-04-19 | 3M Innovative Properties Company | Microneedle arrays and methods of manufacturing the same |
US6908453B2 (en) * | 2002-01-15 | 2005-06-21 | 3M Innovative Properties Company | Microneedle devices and methods of manufacture |
US20070005017A1 (en) * | 2002-02-04 | 2007-01-04 | Becton, Dickinson And Company | Intradermal delivery device with crenellated skin engaging surface geometry |
AU2003209645A1 (en) * | 2002-03-04 | 2003-09-16 | Nano Pass Technologies Ltd. | Devices and methods for transporting fluid across a biological barrier |
AU2003251831B2 (en) | 2002-07-19 | 2009-06-11 | 3M Innovative Properties Company | Microneedle devices and microneedle delivery apparatus |
US7913611B2 (en) * | 2002-09-03 | 2011-03-29 | University Of Virginia Patent Foundation | Blast and ballistic protection systems and method of making the same |
EP1575656B1 (en) * | 2002-10-11 | 2009-06-17 | Becton, Dickinson and Company | Insulin delivery system with sensor |
US20060184101A1 (en) * | 2003-04-21 | 2006-08-17 | Ravi Srinivasan | Microjet devices and methods for drug delivery |
EP1632263A4 (en) * | 2003-06-10 | 2008-04-30 | Medrx Co Ltd | METHOD FOR THE PRODUCTION OF A REFERENCE BASIS FOR TRANSDERMAL MEDICINAL ADMINISTRATION, BASIC BASIS FOR TRANSDERMAL ADMINISTRATIVE ADMINISTRATION AND NEEDLE |
JP2005021677A (ja) * | 2003-06-10 | 2005-01-27 | Medorekkusu:Kk | 経皮投薬用パッドベース、及び注射針 |
GB2416203B (en) | 2004-07-13 | 2007-03-07 | Microsulis Ltd | Motion rate sensor |
US8016811B2 (en) * | 2003-10-24 | 2011-09-13 | Altea Therapeutics Corporation | Method for transdermal delivery of permeant substances |
CA2552385C (en) | 2003-12-29 | 2013-07-23 | 3M Innovative Properties Company | Medical devices and kits including same |
WO2005082596A1 (en) * | 2004-02-23 | 2005-09-09 | 3M Innovative Properties Company | Method of molding for microneedle arrays |
RU2334507C2 (ru) * | 2004-03-19 | 2008-09-27 | Макнейл Аб | Средство для чрескожного введения никотина |
ES2650188T3 (es) | 2004-06-10 | 2018-01-17 | 3M Innovative Properties Company | Dispositivo y kit de aplicación de parches |
GB0427762D0 (en) * | 2004-12-17 | 2005-01-19 | Functional Microstructures Ltd | Device and method for transport across barrier |
EP1845870A1 (en) | 2004-11-18 | 2007-10-24 | 3M Innovative Properties Company | Non-skin-contacting microneedle array applicator |
WO2006055802A1 (en) | 2004-11-18 | 2006-05-26 | 3M Innovative Properties Company | Microneedle array applicator and retainer |
WO2006062974A2 (en) | 2004-12-07 | 2006-06-15 | 3M Innovative Properties Company | Method of molding a microneedle |
ATE483493T1 (de) | 2004-12-10 | 2010-10-15 | 3M Innovative Properties Co | Medizinische vorrichtung |
WO2006101459A1 (en) * | 2005-03-23 | 2006-09-28 | Agency For Science, Technology And Research | Microneedles |
WO2006108185A1 (en) | 2005-04-07 | 2006-10-12 | 3M Innovative Properties Company | System and method for tool feedback sensing |
US20080269666A1 (en) * | 2005-05-25 | 2008-10-30 | Georgia Tech Research Corporation | Microneedles and Methods for Microinfusion |
US20100193997A1 (en) | 2005-06-10 | 2010-08-05 | Frederickson Franklyn L | Method of making a mold and molded article |
WO2007002523A2 (en) | 2005-06-24 | 2007-01-04 | 3M Innovative Properties Company | Collapsible patch with microneedle array |
AU2006261898B2 (en) | 2005-06-27 | 2011-11-03 | 3M Innovative Properties Company | Microneedle array applicator device |
EP1896115B2 (en) | 2005-06-27 | 2020-01-22 | 3M Innovative Properties Company | Microneedle cartridge assembly |
US20070185432A1 (en) * | 2005-09-19 | 2007-08-09 | Transport Pharmaceuticals, Inc. | Electrokinetic system and method for delivering methotrexate |
AU2007288442A1 (en) * | 2006-05-09 | 2008-02-28 | Apogee Technology, Inc. | Nanofiber structures on asperities for sequestering, carrying and transferring substances |
US20080008745A1 (en) * | 2006-06-21 | 2008-01-10 | University Of Kentucky Research Foundation | Transdermal delivery of naltrexone hydrochloride, naltrexol hydrochloride, and bis(hydroxy-methyl)propionyl-3-0 ester naltrexone using microneedles |
WO2008020632A1 (fr) * | 2006-08-18 | 2008-02-21 | Toppan Printing Co., Ltd. | Micro-aiguille et timbre à micro-aiguilles |
DE102006040642A1 (de) * | 2006-08-30 | 2008-03-13 | Robert Bosch Gmbh | Mikronadeln zur Platzierung in der Haut zwecks transdermaler Applikation von Pharmazeutika |
WO2008053481A1 (en) * | 2006-11-01 | 2008-05-08 | Svip 6 Llc | Microneedle arrays |
US20090082713A1 (en) * | 2007-09-20 | 2009-03-26 | Friden Phillip M | Method of enhancing iontophoretic delivery of a peptide |
-
2009
- 2009-11-17 KR KR1020197015594A patent/KR20190064676A/ko not_active Application Discontinuation
- 2009-11-17 KR KR1020117013673A patent/KR20110086854A/ko active Application Filing
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- 2009-11-17 ES ES09828101.7T patent/ES2643606T3/es active Active
- 2009-11-17 SG SG10201500415VA patent/SG10201500415VA/en unknown
- 2009-11-17 US US13/128,066 patent/US20110213335A1/en not_active Abandoned
- 2009-11-17 CN CN201610438597.7A patent/CN105999538A/zh active Pending
- 2009-11-17 CN CN2009801461498A patent/CN102215902A/zh active Pending
- 2009-11-17 CA CA2742853A patent/CA2742853C/en active Active
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- 2009-11-17 KR KR1020167035474A patent/KR20160150109A/ko not_active Application Discontinuation
- 2009-11-17 BR BRPI0916150-3A patent/BRPI0916150B1/pt not_active IP Right Cessation
- 2009-11-17 EP EP17184337.8A patent/EP3300765A1/en not_active Withdrawn
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- 2009-11-17 EP EP09828101.7A patent/EP2355887B1/en active Active
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- 2009-11-17 AU AU2009316789A patent/AU2009316789B2/en active Active
-
2016
- 2016-04-08 JP JP2016077924A patent/JP6334592B2/ja active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7285113B2 (en) * | 2000-03-09 | 2007-10-23 | Nanopass Technologies Ltd. | Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems |
US20050256499A1 (en) * | 2004-03-03 | 2005-11-17 | Pettis Ronald J | Methods and devices for improving delivery of a substance to skin |
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CA2742853A1 (en) | 2010-05-27 |
ES2643606T3 (es) | 2017-11-23 |
EP3300765A1 (en) | 2018-04-04 |
RU2494769C2 (ru) | 2013-10-10 |
EP2355887A4 (en) | 2012-04-25 |
JP6334592B2 (ja) | 2018-05-30 |
BRPI0916150B1 (pt) | 2019-09-24 |
SG10201500415VA (en) | 2015-03-30 |
EP2355887B1 (en) | 2017-08-02 |
RU2011120269A (ru) | 2012-12-27 |
KR20160150109A (ko) | 2016-12-28 |
KR20190064676A (ko) | 2019-06-10 |
MX349292B (es) | 2017-07-21 |
CN102215902A (zh) | 2011-10-12 |
MX2011005165A (es) | 2011-06-01 |
JP2012509106A (ja) | 2012-04-19 |
BRPI0916150A2 (pt) | 2015-11-03 |
CA2742853C (en) | 2019-01-08 |
US20110213335A1 (en) | 2011-09-01 |
WO2010059605A9 (en) | 2010-09-30 |
AU2009316789A1 (en) | 2010-05-27 |
EP2355887A2 (en) | 2011-08-17 |
KR20110086854A (ko) | 2011-08-01 |
CN105999538A (zh) | 2016-10-12 |
AU2009316789B2 (en) | 2013-09-19 |
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