JP2016105795A - 経皮投薬装置 - Google Patents
経皮投薬装置 Download PDFInfo
- Publication number
- JP2016105795A JP2016105795A JP2016008439A JP2016008439A JP2016105795A JP 2016105795 A JP2016105795 A JP 2016105795A JP 2016008439 A JP2016008439 A JP 2016008439A JP 2016008439 A JP2016008439 A JP 2016008439A JP 2016105795 A JP2016105795 A JP 2016105795A
- Authority
- JP
- Japan
- Prior art keywords
- skin
- channel
- carrier
- transdermal administration
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims abstract description 56
- 229940079593 drug Drugs 0.000 claims abstract description 43
- 239000000969 carrier Substances 0.000 claims abstract 6
- 238000003780 insertion Methods 0.000 claims description 9
- 230000037431 insertion Effects 0.000 claims description 9
- 230000000149 penetrating effect Effects 0.000 claims description 2
- 239000011148 porous material Substances 0.000 abstract description 5
- 210000003491 skin Anatomy 0.000 description 44
- 230000006835 compression Effects 0.000 description 12
- 238000007906 compression Methods 0.000 description 12
- 210000000434 stratum corneum Anatomy 0.000 description 10
- 238000000034 method Methods 0.000 description 7
- 239000002245 particle Substances 0.000 description 6
- 239000007787 solid Substances 0.000 description 5
- 238000013459 approach Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 239000003937 drug carrier Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000010419 fine particle Substances 0.000 description 2
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 239000013543 active substance Substances 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000013528 metallic particle Substances 0.000 description 1
- 238000005459 micromachining Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000001640 nerve ending Anatomy 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (12)
- 患者の皮膚(4)を貫通する多数の針(46,62)を含み、該皮膚(4)に多数の小孔(44)を形成する手段(46,62)と、
投与する薬剤(42)が装填され、前記針(46,62)とは別体で、それぞれ先端部(48,84)を有する長手状の部材である多数の担持体(40,82)と、
前記針(46,62)が前記皮膚(4)に留まっている状態で操作可能とされており、各前記担持体(40,82)を前記針(46,62)の外部に配設させて各前記小孔(44)に作用させて前記薬剤(42)を該小孔(44)へ投与する手段と
を備えたことを特徴とする経皮投薬装置。 - 各前記担持体(40)が、対応する前記針(46)に隣接して前記小孔(44)に導入されるように配設されている請求項1に記載の経皮投薬装置。
- 前記薬剤(42)が前記担持体(40,82)の前記先端部(48,84)に装填されている請求項1又は2に記載の経皮投薬装置。
- 前記薬剤(42)が前記担持体(40,82)の前記先端部(48,84)に付着されている請求項3に記載の経皮投薬装置。
- 各前記担持体(82)に対応するチャネル(74)が設けられており、該担持体(82)が該チャネル(74)に沿って摺動可能であり、前記薬剤が前記担持体(82)の前記先端部(84)によって前記チャネル(74)内に保持されている請求項3に記載の経皮投薬装置。
- 各前記担持体(40,82)が、対応する一つの前記針(46,62)に対して移動可能である請求項1〜5の何れか1項に記載の経皮投薬装置。
- 各前記担持体に対応するチャネルが設けられており、該担持体が該チャネルに沿って摺動可能である請求項6に記載の経皮投薬装置。
- 前記チャネル(74)が対応する前記針(62)の位置に配設されている請求項7に記載の経皮投薬装置。
- 前記チャネル(74)の第一の部位(76)が形成された第一挿入部(64)と、前記チャネル(74)の第二の部位(78)が形成された第二挿入部(66)を含んでおり、前記第一および第二挿入部(64,66)は、前記チャネル(74)の前記第一および第二の部位(76,78)が位置合わせされていない静止状態と、前記第一および第二の部位(76,78)が位置合わせされている作動状態との間で相対移動可能とされている請求項7に記載の経皮投薬装置。
- 前記静止状態では、前記チャネル(74)の前記第一の部位(76)が、前記第二挿入部(66)の対向する壁部によって覆蓋されている請求項9に記載の経皮投薬装置。
- 各前記担持体(40,82)の前記先端部が鈍端とされている請求項1〜10の何れか1項に記載の経皮投薬装置。
- 各前記担持体(40,82)が棒状、柱状又はピストン状である請求項1〜11の何れか1項に記載の経皮投薬装置。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1015164.5 | 2010-09-13 | ||
GB1015164.5A GB2483505B (en) | 2010-09-13 | 2010-09-13 | Devices for transdermal drug delivery |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013527686A Division JP6034290B2 (ja) | 2010-09-13 | 2011-09-13 | 経皮投薬装置 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2016105795A true JP2016105795A (ja) | 2016-06-16 |
JP6182227B2 JP6182227B2 (ja) | 2017-08-16 |
Family
ID=43065047
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013527686A Active JP6034290B2 (ja) | 2010-09-13 | 2011-09-13 | 経皮投薬装置 |
JP2016008439A Active JP6182227B2 (ja) | 2010-09-13 | 2016-01-20 | 経皮投薬装置 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013527686A Active JP6034290B2 (ja) | 2010-09-13 | 2011-09-13 | 経皮投薬装置 |
Country Status (11)
Country | Link |
---|---|
US (2) | US9770578B2 (ja) |
EP (3) | EP2878330B1 (ja) |
JP (2) | JP6034290B2 (ja) |
CN (1) | CN103153387B (ja) |
AU (1) | AU2011303676B2 (ja) |
BR (1) | BR112013005891B1 (ja) |
CA (2) | CA2810800C (ja) |
ES (3) | ES2609829T3 (ja) |
GB (1) | GB2483505B (ja) |
PL (3) | PL3023120T3 (ja) |
WO (1) | WO2012035334A1 (ja) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201307262D0 (en) | 2013-04-23 | 2013-05-29 | Chowdhury Dewan F H | Device for containment and release of drug formulation |
US11413092B2 (en) | 2016-01-13 | 2022-08-16 | The General Hospital Corporation | Systems and methods to facilitate delivery of a therapeutic agent into the skin of a subject |
GB2550924A (en) | 2016-05-31 | 2017-12-06 | Ndm Technologies Ltd | Improvements in or relating to transdermal delivery |
USD819197S1 (en) | 2016-12-16 | 2018-05-29 | Kimberly-Clark Worldwide, Inc. | Fluid delivery apparatus |
WO2018111620A2 (en) | 2016-12-16 | 2018-06-21 | Kimberly-Clark Worldwide, Inc. | Method for administering a medicament suitable for treating a migraine or cluster headache |
CN114681787A (zh) | 2016-12-16 | 2022-07-01 | 索伦托治疗有限公司 | 具有控制器组件的流体递送装置及其使用方法 |
USD836774S1 (en) | 2016-12-16 | 2018-12-25 | Sorrento Therapeutics, Inc. | Cartridge for a fluid delivery apparatus |
CA3172933A1 (en) | 2017-04-28 | 2018-11-01 | Lutron Technology Company Llc | Window treatment hembar |
US20220330860A1 (en) | 2021-04-14 | 2022-10-20 | Neoenta LLC | Dermal patch system |
US11877848B2 (en) | 2021-11-08 | 2024-01-23 | Satio, Inc. | Dermal patch for collecting a physiological sample |
US11964121B2 (en) | 2021-10-13 | 2024-04-23 | Satio, Inc. | Mono dose dermal patch for pharmaceutical delivery |
US11510602B1 (en) | 2021-11-08 | 2022-11-29 | Satio, Inc. | Dermal patch for collecting a physiological sample |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60129057A (ja) * | 1983-12-14 | 1985-07-10 | 住友化学工業株式会社 | 針状固形製剤投与針 |
WO2001049346A2 (en) * | 1999-12-30 | 2001-07-12 | Redeon, Inc. | Stacked microneedle systems |
WO2008062832A1 (fr) * | 2006-11-22 | 2008-05-29 | Toppan Printing Co., Ltd. | Matrice à micro-aiguilles et son procédé de production |
Family Cites Families (14)
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US1699012A (en) * | 1927-11-22 | 1929-01-15 | Joseph S Naylor | Stock and poultry marker |
US6611707B1 (en) * | 1999-06-04 | 2003-08-26 | Georgia Tech Research Corporation | Microneedle drug delivery device |
US6589202B1 (en) * | 2000-06-29 | 2003-07-08 | Becton Dickinson And Company | Method and apparatus for transdermally sampling or administering a substance to a patient |
US7315758B2 (en) * | 2004-06-03 | 2008-01-01 | Lynntech, Inc. | Transdermal delivery of therapeutic agent |
US7713266B2 (en) * | 2005-05-20 | 2010-05-11 | Myoscience, Inc. | Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat) |
US20070106207A1 (en) * | 2005-11-04 | 2007-05-10 | Withey Edward L | High-speed vaccination device |
EP2005990B1 (en) * | 2006-04-07 | 2013-08-28 | Hisamitsu Pharmaceutical Co., Inc. | Microneedle device and transdermal administration device provided with microneedles |
US9987475B2 (en) * | 2006-07-03 | 2018-06-05 | Lotte Chemical Corporation | Micro needle roller assembly |
AU2008208009B2 (en) * | 2007-01-22 | 2013-08-15 | Passport Technologies, Inc. | Transdermal porator and patch system and method for using same |
US7713196B2 (en) * | 2007-03-09 | 2010-05-11 | Nellcor Puritan Bennett Llc | Method for evaluating skin hydration and fluid compartmentalization |
GB2448493B (en) * | 2007-04-16 | 2009-10-14 | Dewan Fazlul Hoque Chowdhury | Microneedle transdermal delivery device |
KR20090058077A (ko) * | 2007-12-04 | 2009-06-09 | 충북대학교 산학협력단 | 생물체 정보의 염색체 내 표지 방법 및 그 정보가 표지된생물체 |
KR101039078B1 (ko) * | 2009-08-04 | 2011-06-07 | (주)마이티시스템 | 이동되는 약물 저장 캡슐이 있는 미세바늘 약물 전달 시스템 |
CN102497909B (zh) * | 2009-07-31 | 2014-10-29 | 3M创新有限公司 | 中空微针阵列 |
-
2010
- 2010-09-13 GB GB1015164.5A patent/GB2483505B/en not_active Expired - Fee Related
-
2011
- 2011-09-13 ES ES15152177.0T patent/ES2609829T3/es active Active
- 2011-09-13 ES ES16150262.0T patent/ES2642152T3/es active Active
- 2011-09-13 CN CN201180044042.XA patent/CN103153387B/zh active Active
- 2011-09-13 PL PL16150262T patent/PL3023120T3/pl unknown
- 2011-09-13 EP EP15152177.0A patent/EP2878330B1/en active Active
- 2011-09-13 EP EP11773515.9A patent/EP2616133B1/en active Active
- 2011-09-13 AU AU2011303676A patent/AU2011303676B2/en active Active
- 2011-09-13 PL PL15152177T patent/PL2878330T3/pl unknown
- 2011-09-13 BR BR112013005891-9A patent/BR112013005891B1/pt active IP Right Grant
- 2011-09-13 PL PL11773515T patent/PL2616133T3/pl unknown
- 2011-09-13 JP JP2013527686A patent/JP6034290B2/ja active Active
- 2011-09-13 WO PCT/GB2011/051716 patent/WO2012035334A1/en active Application Filing
- 2011-09-13 EP EP16150262.0A patent/EP3023120B1/en active Active
- 2011-09-13 CA CA2810800A patent/CA2810800C/en active Active
- 2011-09-13 US US13/822,554 patent/US9770578B2/en active Active
- 2011-09-13 ES ES11773515.9T patent/ES2633137T3/es active Active
- 2011-09-13 CA CA3085890A patent/CA3085890C/en active Active
-
2016
- 2016-01-20 JP JP2016008439A patent/JP6182227B2/ja active Active
-
2017
- 2017-09-20 US US15/710,309 patent/US10675453B2/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60129057A (ja) * | 1983-12-14 | 1985-07-10 | 住友化学工業株式会社 | 針状固形製剤投与針 |
WO2001049346A2 (en) * | 1999-12-30 | 2001-07-12 | Redeon, Inc. | Stacked microneedle systems |
WO2008062832A1 (fr) * | 2006-11-22 | 2008-05-29 | Toppan Printing Co., Ltd. | Matrice à micro-aiguilles et son procédé de production |
US20090234301A1 (en) * | 2006-11-22 | 2009-09-17 | Toppan Printing Co., Ltd. | Microneedle array and method for producing microneedle array |
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