JP2016085170A - Automatic analyzer - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an automatic analyzer which is capable of reducing contamination of a sample without reducing a processing speed.SOLUTION: The automatic analyzer is provided with first and second sample dispensing probes 18a and 18b which dispense a sample in a sample vessel 11 to reaction vessels 16 in first reaction vessel positions C21 and C22, and first and second moving mechanisms 19a and 19b which support the first and second sample dispensing probes 18a and 18b so as to allow them to move between the sample vessel 11 and the reaction vessels 16 in the first and second reaction vessel positions C21 and C22. One of the first and second sample dispensing probes 18a and 18b which has a longer movement distance from an upper stop position above the sample vessel 11 is lowered at a higher speed than the other having a shorter movement distance.SELECTED DRAWING: Figure 4

Description

Embodiments described herein relate generally to an automatic analyzer that dispenses a sample and a reagent into a reaction container and measures a mixed solution of the sample and the reagent dispensed into the reaction container.

The automatic analyzer is intended for biochemical test items, immunological test items, and the like, and optically measures changes in color tone and turbidity caused by the reaction of a mixture of a sample collected from a specimen and a reagent for each test item. Thereby, the analysis data represented by the concentration of each test item component contained in the sample, the activity of the enzyme, and the like are generated.

In this automatic analyzer, there is a random access method in which a sample in a sample container is dispensed into a reaction container of one line for each inspection item set in the sample using one dispensing probe. In addition, there is a semi-random access method in which a sample in a sample container can be simultaneously dispensed into two lines of reaction containers for each of two inspection items set in the sample using two dispensing probes. These sample dispensing probes are cleaned every time the same sample is dispensed.

JP-A-9-101313

However, although the semi-random access method can increase the processing speed,
Even if one sample dispensing probe does not dispense the sample, the two sample dispensing probes come into contact with the sample in the sample container, so that the sample in the sample container to be dispensed next is likely to be contaminated. There is.

Embodiments have been made to solve the above-described problems, and an object thereof is to provide an automatic analyzer that can reduce contamination of a sample without reducing the processing speed.

In order to achieve the above object, an automatic analyzer according to an embodiment includes a first dispensing probe that performs dispensing to suck a sample in a sample container and discharge it to a reaction container at a first position, and the sample container. A second dispensing probe that dispenses the sample in the container and sucks it into the reaction container at the second position; and the first dispensing probe is connected to the sample container and the reaction container at the first position. A second moving mechanism that supports the second dispensing probe so as to be movable between the sample container and the reaction container at the second position; Analysis in which one of the first and second dispensing probes having a long moving distance is lowered from the upper stop position above the sample in the sample container at a higher speed than the other dispensing probe having a short moving distance. And a control unit.

The block diagram which shows the structure of the automatic analyzer which concerns on embodiment. The figure which shows the structure of the analysis part which concerns on embodiment. The side view which shows an example of a structure of the 1st and 2nd moving mechanism which concerns on embodiment. First and second sample dispensing probes, first and second movement mechanisms, sample containers held by a sampler, sample containers held by a sample rack on the sampler, and a reaction disk FIG. The figure for demonstrating operation | movement when the 1st and 2nd sample dispensing probe which concerns on embodiment dispenses the sample in the sample container which stops at the 2nd sample container position. The figure which shows the 1st dispensing operation | movement of the 1st sample dispensing probe when the 1st dispensing of the same sample in the sample container stopped at the 1st sample container position which concerns on embodiment is performed. The figure which shows the 1st dispensing operation | movement of the 2nd sample dispensing probe when the 2nd dispensing of the same sample in the sample container stopped at the 1st sample container position which concerns on embodiment is performed. The figure for demonstrating the 1st deceleration position of the 2nd sample dispensing probe when the 2nd time dispensing of the same sample in the sample container stopped at the 1st sample container position which concerns on embodiment is performed. The figure which shows the 2nd dispensing operation | movement of the 1st sample dispensing probe when the 3rd dispensing of the same sample in the sample container stopped at the 1st sample container position which concerns on embodiment is performed. The figure which shows the 2nd dispensing operation | movement of the 2nd sample dispensing probe when the 4th dispensing of the same sample in the sample container stopped at the 1st sample container position which concerns on embodiment is performed. The figure which shows the 1st dispensing operation | movement of the 2nd sample dispensing probe when the 1st dispensing of the same sample in the sample container stopped at the 2nd sample container position which concerns on embodiment is performed. The figure which shows the 1st dispensing operation | movement of the 1st sample dispensing probe when the 2nd dispensing of the same sample in the sample container stopped at the 2nd sample container position which concerns on embodiment is performed. The figure which shows the 2nd dispensing operation | movement of the 2nd sample dispensing probe when the 3rd dispensing of the same sample in the sample container stopped at the 2nd sample container position which concerns on embodiment is performed. The figure which shows the 2nd dispensing operation | movement of the 1st sample dispensing probe when the 4th dispensing of the same sample in the sample container stopped at the 2nd sample container position which concerns on embodiment is performed.

  Hereinafter, embodiments will be described with reference to the drawings.

FIG. 1 is a block diagram illustrating a configuration of an automatic analyzer according to the embodiment. This automatic analyzer 100 dispenses each sample such as a standard sample or test sample for each test item and a reagent used for analysis of each test item, measures a mixed solution of the sample and the reagent, and compares the standard data and the test sample. An analysis unit 10 for generating inspection data is provided. Moreover, the drive part 31 which drives the various units of the analysis part 10 and the analysis control part 32 which controls the drive part 31 and operates the various units of the analysis part 10 are provided.

Further, the automatic analyzer 100 processes the standard data and test data generated by the analysis unit 10 to generate calibration data and analysis data, and the calibration data generated by the data processing unit 40. And an output unit 50 for outputting analysis data. In addition, input of analysis parameters such as amount of sample used for analysis of each inspection item, amount of reagent, input for setting A line or B line for each inspection item, inspection of this test sample for each test sample An operation unit 60 is provided for performing input or the like for setting a target inspection item. In addition, a system control unit 70 that controls the analysis control unit 32, the data processing unit 40, and the output unit 50 in an integrated manner is provided.

FIG. 2 is a diagram illustrating a configuration of the analysis unit 10. The analysis unit 10 includes a sample container 11 that accommodates each sample such as a standard sample, a management sample, and a test sample. In addition, a sampler 12a that rotatably holds a sample container 11 in which a standard sample and a management sample are stored, and a sample rack 13 that holds a sample container 11 in which a sample such as a test sample is stored are provided. . In addition, a sampler 12b that holds a plurality of sample racks 13 in the direction of the arrow L2 in the longitudinal direction and the arrow L3 in the direction opposite to the L2 direction at the retracted position moved in the short direction L1 and L1 directions. I have.

In addition, a reagent container 13a that accommodates, for example, a first reagent and a two reagent system, which are reagents that react with the components of the test item included in each sample, and a first reagent in the reagent container 13a are paired with 2
And a reagent container 13b for storing a reagent-based second reagent. In addition, a reagent rack 14a that holds the reagent container 13a in a movable manner and a reagent rack 14b that holds the reagent container 13b in a movable manner are provided.

In addition, the reagent storage 1 that keeps the first reagent in the reagent container 13a held in the reagent rack 14a cold.
5a and a reagent container 1 for keeping the second reagent in the reagent container 13b held in the reagent rack 14b cold.
5b. In addition, a plurality of reaction vessels 16 arranged alternately on the circumference for the A line and the B line, and a reaction disk 17 for holding the reaction vessel 16 so as to be rotatable are provided.

Further, for analysis of the inspection item (A line inspection item) in which the A line is set, each sample in the sample container 11 held by each of the samplers 12a and 12b is sucked into the reaction container 16 for A line. A first sample dispensing probe 18a that performs dispensing to be discharged is provided. Moreover, the 1st moving mechanism 19a which supports the 1st sample dispensing probe 18a so that a movement is possible is provided.

Further, for analysis of the inspection item (B line inspection item) in which the B line is set, each sample in the sample container 11 held in each sampler 12a, 12b is sucked into the reaction container 16 for B line. A second sample dispensing probe 18b that performs dispensing dispensing is provided. Moreover, the 2nd moving mechanism 19b which supports the 2nd sample dispensing probe 18b so that a movement is possible is provided.

In addition, the first reagent in the reagent container 13a of the A-line inspection item held in the reagent rack 14a is sucked and dispensed into the reaction container 16 into which the sample has been dispensed by the first sample dispensing probe 18a. A first reagent dispensing probe 20a is provided. In addition, the first reagent in the reagent container 13a of the B line inspection item held in the reagent rack 14a is aspirated and dispensed into the reaction container 16 into which the sample has been dispensed by the second sample dispensing probe 18b. The first reagent dispensing probe 20b is provided.

In addition, first reagent dispensing arms 21a and 21b that movably support the first reagent dispensing probes 20a and 20b are provided. Moreover, the 1st stirring unit 22 which stirs the liquid mixture of the sample and the 1st reagent dispensed to the reaction container 16 is provided. Further, the second reagent in the reagent container 13b of the A-line inspection item held in the reagent rack 14b is aspirated and the first reagent dispensing probe 20 is sucked.
A second reagent dispensing probe 23a is provided for dispensing into the reaction container 16 into which the first reagent has been dispensed by a.

In addition, the second reagent in the reagent container 13b of the B line inspection item held in the reagent rack 14b is sucked and discharged to the reaction container 16 into which the first reagent has been dispensed by the first reagent dispensing probe 20b. A second reagent dispensing probe 23b for performing the injection is provided. Also, second reagent dispensing arms 24a and 24b that hold the second reagent dispensing probes 23a and 23b in a movable manner are provided. Moreover, the 2nd stirring unit 25 which stirs each sample dispensed to the reaction container 16, and the liquid mixture of a 1st reagent and a 2nd reagent is provided.

In addition, the reaction container 16 containing the mixed liquid stirred by the first stirring unit 22 and the second stirring unit 25 is irradiated with light, and the mixed liquid containing the standard sample and the test sample in the reaction container 16 is transmitted. A measuring unit 26 is provided for detecting the generated light and generating standard data and test data. Further, a cleaning nozzle 27 is provided for cleaning the inside of the reaction vessel 16 after the measurement. Then, the reaction vessel 16 cleaned by the cleaning nozzle 27 is used again for measurement.

The drive unit 31 illustrated in FIG. 1 includes various units of the analysis unit 10 and motors that drive mechanisms provided in the units. Then, the sampler 12a, the reagent rack 14a, and the reagent rack 14b are driven to rotate, and the sample container 11 and the reagent containers 13a and 13b are moved. Further, the sample rack 13 on the sampler 12b is moved. In addition, the reaction disk 17 is rotated to move the reaction vessel 16.

The drive unit 31 includes the first and second moving mechanisms 19a and 19b and the first reagent dispensing arm 2.
1a, 21b and second reagent dispensing arms 24a, 24b are driven up and down and rotated respectively to be first
The second sample dispensing probes 18a and 18b, the first reagent dispensing probes 20a and 20b, and the second reagent dispensing probes 23a and 23b are moved. Also, the first and second stirring units 2
2 and 25 and the cleaning nozzle 27 are moved up and down, respectively.

The data processing unit 40 includes a calculation unit 41 and a data storage unit 42. And the calculating part 41 produces | generates calibration data from the standard data of each test | inspection item produced | generated by the analysis part 10, The analysis data is produced | generated for the test data produced | generated by the analysis part 10 using the calibration data of this test | inspection item. Generate. The data storage unit 42 stores the calibration data generated by the calculation unit 41 for each inspection item, and stores the analysis data of each inspection item generated by the calculation unit 41 for each test sample.

The output unit 50 includes a printing unit 51 that prints out the standard data and analysis data generated by the data processing unit 40, and a display unit 52 that displays the data. The printing unit 51 includes a printer or the like, and prints out calibration data and analysis data on printer paper or the like according to a preset format. The display unit 52 includes a monitor such as a CRT or a liquid crystal panel. A screen for setting an analysis parameter of the inspection item for each inspection item, and an A for each inspection item.
A screen for setting a line or a B line, a screen for setting an inspection item to be inspected for the test sample for each test sample, and the like are displayed.

The operation unit 60 includes input devices such as a keyboard, a mouse, a button, and a touch key panel, and inputs for setting analysis parameters and A or B lines for each inspection item, and for setting inspection items for each test sample. Input.

The system control unit 70 includes a CPU and a storage circuit (not shown). And the operation part 6
After storing input information such as command signals, analysis parameters, and inspection item information input from 0, the analysis control unit 32, data processing unit 40, and output unit 50 are based on these input information.
To control.

Next, referring to FIG. 2 and FIG. 3, the first and second moving mechanisms 19a and 19b of the analysis unit 10 are used.
Details of the configuration will be described.

FIG. 3 is a side view showing an example of the configuration of the first and second moving mechanisms 19a and 19b.

The first moving mechanism 19a includes a first probe support 191a that supports the first sample dispensing probe 18a, and a first vertical movement support that supports the first probe support 191a so as to be movable up and down. 192a. In addition, a first rotation shaft 193a that rotatably supports the first vertical support 192a is provided. And the 1st sample dispensing probe 18a is arrange | positioned in the position away from the axial center 19 of the 1st rotation axis | shaft 193a by the distance r.

The first probe support 191a is the drive unit 3 disposed on the first vertical movement support 192a.
It is driven up and down by one stepping motor, for example. Thereby, the first sample dispensing probe 18a is lowered and raised. The first vertical support 192a is rotated by driving the first rotation shaft 193a in the R1 direction and the R2 direction by the motor of the drive unit 31. As a result, the first sample dispensing probe 18a moves in the R1 direction and the R2 direction while drawing a circular arc trajectory centered on the axis center 19 and having a radius of the distance r.

The second moving mechanism 19b includes a second probe support 191b that supports the second sample dispensing probe 18b, and a second vertical movement support that supports the second probe support 191b so as to be movable up and down. 192b. Further, the first rotating shaft 193 of the first moving mechanism 19a.
a first pivot shaft 193a penetrating through a and supporting the second vertical support 192b in a pivotable manner.
And a second rotating shaft 193b disposed on the same axis. Then, the second rotation shaft 193
The second sample dispensing probe 18b is disposed at a position r away from the axis center 19 common to the first rotation shaft 193a of b.

In this way, the first sample dispensing probe 18a is supported by the first moving mechanism 19a and the second sample dispensing probe 18b is supported by the second moving mechanism 19b, so that the first and second moving mechanisms are supported. By driving 19a and 19b independently, the first sample dispensing probe 18a and the second sample dispensing probe 18b can be moved at high speed.
Further, the first and second moving mechanisms 19a and 19b are made coaxial by making the first rotating shaft 193a of the first moving mechanism 19a and the second rotating shaft 193b of the second moving mechanism 19b coaxial. It can be downsized.

The second probe support 191b is a drive unit 3 disposed on the second vertical support 192b.
It is driven up and down by one stepping motor. Thereby, the second sample dispensing probe 1
8b descends and rises. The second vertical support 192b is rotated by driving the second rotation shaft 193b in the R1 direction and the R2 direction by the motor of the drive unit 31. As a result, the second sample dispensing probe 18b moves in the R1 direction and the R2 direction while drawing a circular arc trajectory centered on the axial center 19 and having a radius of the distance r.

Thus, since the first sample dispensing probe 18a and the second sample dispensing probe 18b can be moved while drawing a circular orbit on the same circumference, the first and second sample dispensing probes can be moved. Since the sample containers 11 that contain samples to be dispensed by the probes 18a and 18b can be arranged at a plurality of positions with a high degree of freedom, the analysis unit 10 can be downsized.

  Next, dispensing of the sample in the sample container 11 will be described with reference to FIGS.

FIG. 4 shows the first and second sample dispensing probes 18a and 18b, the first and second moving mechanisms 1.
9A and 19B are plan views showing the arrangement of the sample container 11 held by the sampler 12a, the sample container 11 held by the sample rack 13 on the sampler 12b, and the reaction container 16 held by the reaction disk 17. FIG.

First and second sample dispensing probes 18a and 18b and first and second moving mechanisms 19a
, 19b, a sampler 12a, a sampler 12b, and a reaction disk 17 are arranged. A first cleaning tank 28a for cleaning the first sample dispensing probe 18a is disposed between the sampler 12b and the reaction disk 17. Further, a second cleaning tank 28b in which the second sample dispensing probe 18b is cleaned is disposed between the sampler 12a and the reaction disk 17.

The sample rack 13 on the sampler 12b is moved in the L1 direction by the driving unit 31, and then moved in the L2 direction at the retracted position. The first and second sample dispensing probes 18a,
The first sample container position P at which the sample in the held sample container 11 can be sucked by 18b.
Stop at 11.

The sample container 11 held by the sampler 12a includes first and second sample dispensing probes 18a.
, 18b stops at the second sample container position P31 where the sample can be sucked. In addition, the reaction vessels 16 for the A and B lines that have been cleaned by the cleaning nozzle 27 rotate and move every analysis cycle time, and are different from those before the movement, and the first and second sample dispensing probes 18a and 18b. Stops at the first and second reaction vessel positions C21 and C22 where the sample can be discharged. While the reaction vessel 16 is stopped at the first and second reaction vessel positions C21 and C22, the first reaction vessel 16 is stopped.
The sample is dispensed to the reaction container 16 at the first reaction container position C21 by the sample dispensing probe 18a and the sample is ejected to the reaction container 16 at the second reaction container position C22 by the second sample dispensing probe 18b. Can do.

The first sample dispensing probe 18a has a first sample container position P11 at a timing different from that of the second sample dispensing probe 18b in order to avoid collision with the second sample dispensing probe 18b.
Stop at the upper stop position. Moreover, it stops at the upper stop position above the first reaction vessel position C21. In addition, the distance between the upper stop position of the first sample container position P11 and the upper stop position of the first reaction container position C21 is horizontal along the arc-shaped first trajectory T1 having the first distance D11. It moves in the direction R1 and R2.

Then, the first sample dispensing probe 18a descends from the upper stop position of the first sample container position P11 and sucks the sample in the sample container 11 that stops at the first sample container position P11, and then the above-mentioned. Ascend to the upper stop position. Further, the sample descends from the upper stop position of the first reaction container position C21, and then rises to the upper stop position after the sample is discharged into the reaction container 16 at the first reaction container position C21.

The second sample dispensing probe 18b has a first sample container position P11 at a timing different from that of the first sample dispensing probe 18a in order to avoid collision with the first sample dispensing probe 18a.
Stop at the top stop position. Moreover, it stops at the upper stop position above the second reaction vessel position C22. In addition, the first arc-shaped first distance between the upper stop position of the first sample container position P11 and the upper stop position of the second reaction container position C22 is a second distance D12 that is longer than the first distance D11. Orbit T1
The first sample dispensing probe 18a moves in the R1 direction and the R2 direction at the same speed as when the first sample dispensing probe 18a moves along the first trajectory T1 along the second trajectory T2 on the extension line.

Then, the second sample dispensing probe 18b descends from the upper stop position of the first sample container position P11 and sucks the sample in the sample container 11 that stops at the first sample container position P11, and then the above-mentioned. Ascend to the upper stop position. In addition, the sample descends from the upper stop position of the second reaction container position C22, and then rises to the upper stop position after the sample is discharged into the reaction container 16 at the second reaction container position C22.

FIG. 5 shows that the first and second sample dispensing probes 18a and 18b are in the second sample container position P31.
It is a figure for demonstrating the operation | movement when dispensing the sample in the sample container 11 stopped by.

The second sample dispensing probe 18b has a second sample container position P31 at a timing different from that of the first sample dispensing probe 18a in order to avoid a collision with the first sample dispensing probe 18a.
Stop at the upper stop position. Moreover, it stops at the upper stop position of the second reaction vessel position C22. In addition, the third between the upper stop position of the second sample container position P31 and the upper stop position of the second reaction container position C22 is included in the arc-shaped second trajectory T2 having the third distance D13. Orbit T3
Along the R1 direction and the R2 direction.

The second sample dispensing probe 18b descends from the upper stop position of the second sample container position P31 and sucks the sample in the sample container 11 that stops at the second sample container position P31. Ascend to the upper stop position. In addition, the sample descends from the upper stop position of the second reaction container position C22, and then rises to the upper stop position after the sample is discharged into the reaction container 16 at the second reaction container position C22.

The first sample dispensing probe 18a has a second sample container position P31 at a timing different from that of the second sample dispensing probe 18b in order to avoid collision with the second sample dispensing probe 18b.
Stop at the top stop position. Moreover, it stops at the upper stop position of the first reaction vessel position C21. In addition, the third arc-shaped third distance between the upper stop position of the second sample container position P31 and the upper stop position of the first reaction container position C21 is a fourth distance D14 longer than the third distance D13. The second sample dispensing probe 18b moves along the fourth trajectory T4 along the fourth trajectory T4 on the extension line of the trajectory T3.
3 move in the R1 direction and the R2 direction at the same speed as when moving along 3.

The first sample dispensing probe 18a descends from the upper stop position of the second sample container position P31 and sucks the sample in the sample container 11 that stops at the second sample container position P31. Ascend to the upper stop position. Further, the sample descends from the upper stop position of the first reaction container position C21, and then rises to the upper stop position after the sample is discharged into the reaction container 16 at the first reaction container position C21.

When the sample in the sample container 11 is dispensed into the reaction container 16, the analysis control unit 32 is based on the moving distance of the first or second sample dispensing probes 18 a and 18 b between the sample and the reaction container 16. Thus, the first or second sample dispensing probe 18a, 18b moves one dispensing probe with a longer moving distance at a higher speed than the other sample dispensing probe with a shorter moving distance.
Lower from the upper stop position.

Hereinafter, with reference to FIG. 1 to FIG. 14, an operation in the dispensing of the sample of the automatic analyzer 100 will be described.

First, the dispensing when a plurality of A line inspection items and the same number of B line inspection items as the A line inspection items are set in the sample in the sample container 11 stopped at the first sample container position P11 will be described.

When the A line inspection item and the B line inspection item are set, the analysis control unit 32 causes the first sample dispensing probe 18a having a short moving distance to perform the first dispensing of the same sample. The (2n-1) -th time of the same sample by the first sample dispensing probe 18a (n is a positive integer)
And the 2n-th dispensing by the second sample dispensing probe 18b are performed during one analysis cycle time.

The first and second sample dispensing probes 18a and 18b are adjusted so that the lower ends thereof are at the same height at the upper stop position above the first sample container position P11.

FIG. 6 shows the first dispensing operation of the first sample dispensing probe 18a when the first dispensing of the same sample in the sample container 11 stopped at the first sample container position P11 is performed. FIG. The first sample dispensing probe 18a comes into contact with the sample in the sample container 11 that stops at the first sample container position P11, thereby detecting the liquid level of the sample.
Is electrically connected.

The first sample dispensing probe 18a is moved along the first trajectory T1 from the first cleaning tank 28a.
After moving in one direction, as shown in FIG. 6 (a), it stops at the upper stop position P12 above the sample container 11 stopped at the first sample container position P11. Next, as shown in FIGS. 6B and 6C, the first liquid level detector 29a detects the liquid level of the sample in the sample container 11 for the first time from the upper stop position P12. To the detection position P13 at the first speed V1.

The analysis control unit 32 supplies the pulse supplied to the stepping motor that drives the first moving mechanism 19a of the drive unit 31 in order to lower the first sample dispensing probe 18a from the upper stop position P12 to the first detection position P13. Based on the number, the distance D21 between the upper stop position P12 where the first sample dispensing probe 18a is lowered and the first detection position P13 is calculated.

As shown in FIG. 6D, the first sample dispensing probe 18a is stopped at the first suction position P14 that can suck the first sample below the distance D22 from the first detection position P13. The sample in the sample container 11 is sucked.

Here, the first speed V1 when the first sample dispensing probe 18a is lowered is due to an impact when the liquid level of the sample in the sample container 11 is detected and stopped at the first suction position P14. The sample dispensing accuracy of the first sample dispensing probe 18a is set to a speed that can be maintained within an allowable range.

Thus, since only the first sample dispensing probe 18a enters the sample container 11 and the sample is sucked, the sample container 11 having a small opening area capable of accommodating a small amount of sample such as a child specimen.
Even in this case, the sample can be sucked by entering the first sample dispensing probe 18a.

The first sample dispensing probe 18a ascends to the upper stop position P12 after sucking the sample.
Subsequently, it moves in the R2 direction along the first trajectory T1 from the upper stop position P12, and stops at the upper stop position above the first reaction vessel position C21. And it descends from the upper stop position and the first
After the sample is discharged into the reaction container 16 at the reaction container position C21, it rises to the upper stop position. Then, it moves to the 1st washing tank 28a along the 1st track T1.

FIG. 7 shows the first dispensing operation of the second sample dispensing probe 18b when the second dispensing of the same sample in the sample container 11 stopped at the first sample container position P11 is performed. FIG. The second sample dispensing probe 18b is connected to the sample container 1 at the first sample container position P11.
By being in contact with the sample in 1, it is electrically connected to a second liquid level detector 29 b that detects the liquid level of the sample.

The second sample dispensing probe 18b is moved along the second trajectory T2 from the second cleaning tank 28b.
Move in two directions. Then, after the first sample dispensing probe 18a that has sucked the sample to perform the first dispensing of the same sample moves in the R2 direction from the upper stop position P12, as shown in FIG. Stop at stop position P12. Next, as shown in FIG. 7B, the vehicle descends from the upper stop position P12 at a second speed V2 that is higher than the first speed V1.

Thus, in order to cause the sample in the sample container 11 stopped at the first sample container position P11 to be dispensed, the second sample dispensing probe 18b having the longer moving distance is moved to the one having the shorter moving distance. By lowering the sample at a higher speed than the first sample dispensing probe 18a, the sample dispensing time can be extended by causing the first and second sample dispensing probes 18a and 18b to suck the sample at different timings. Can be prevented.

As shown in FIG. 8, the analysis control unit 32 subtracts the distance 23 from the distance D21 calculated in the first detection of the liquid level of the same sample, thereby making the second before contacting the sample in the sample container 11. A distance D24 that is a first deceleration position P15 for decelerating the sample dispensing probe 18b from the second speed V2 is calculated.

Thus, by obtaining the first deceleration position P15 based on the first detection position P13, the second sample dispensing probe 18b descending at a high speed before contacting the sample in the sample container 11 is obtained. Can be decelerated.

Before the sample is dispensed, the sample container 11 is arranged at the first sample container position P11, and the first and second liquid level detectors 29a and 29b are used to move the sample container 11 from the upper stop position P12. The first and second sample dispensing probes 18a, 18 are detected by the detection position where the liquid level of the sample is detected.
b is lowered. Then, the first detection distance between the upper stop position P12 calculated by lowering the first sample dispensing probe 18a and the detection position, and the upper stop calculated by lowering the second sample dispensing probe 18b. When the second detection distance between the position P12 and the detection position is different, it is determined that the lower ends of the first and second sample dispensing probes 18a and 18b at the upper stop position P12 are different from each other. The first deceleration position P15 may be corrected based on the difference between the detection distance and the second detection distance.

As shown in FIG. 7C, the second sample dispensing probe 18b descends at the second speed V2 from the upper stop position P12 to the first deceleration position P15 below the distance D24. Next, after decelerating at the first deceleration position P15, as shown in FIGS. 7D and 7E, the liquid level of the sample in the sample container 11 is set for the second time by the second liquid level detector 29b. The vehicle descends at a speed VL equal to or lower than the first speed V1 to the second detection position P16 detected at the first time. Then, as shown in FIG. 7 (f), the second suction position P17 capable of sucking the second sample below the distance D22 from the second detection position P16.
Then, the sample in the sample container 11 is sucked.

In this way, since only the second sample dispensing probe 18b enters the sample container 11 to suck the sample, the sample container 11 having a small opening area capable of accommodating a small amount of sample like a child specimen.
Even in this case, the second sample dispensing probe 18b can be advanced to suck the sample.

Here, the second speed V2 when the second sample dispensing probe 18b is lowered is, when the liquid level is detected at this speed, the second suction is performed after the liquid level of the sample in the sample container 11 is detected. Position P1
7 is set at such a high speed as to cause a drop in the sample dispensing accuracy of the second sample dispensing probe 18b due to an impact when stopped at 7.

In this way, the second sample dispensing probe 18b lowered at a high speed is moved to the first deceleration position P.
By decelerating at 15 and then contacting with the liquid level of the sample in the sample container 11, the impact when stopped at the second suction position P17 can be reduced. Thereby, the fall of the dispensing precision of the sample of the 2nd sample dispensing probe 18b by the impact when it stops can be prevented.

The analysis control unit 32 supplies the pulse supplied to the stepping motor that drives the second moving mechanism 19b of the drive unit 31 in order to lower the second sample dispensing probe 18b from the upper stop position P12 to the second detection position P16. Based on the number, the distance D25 between the upper stop position P12 where the second sample dispensing probe 18b is lowered and the second detection position P16 is calculated.

The second sample dispensing probe 18b ascends to the upper stop position P12 after sucking the sample.
Subsequently, it moves in the R1 direction along the second trajectory T2 from the upper stop position P12, and stops at the upper stop position of the second reaction vessel position C22. Then, the second sample descends from the upper stop position and is adjacent to the reaction vessel 16 at the first reaction vessel position C21 where the sample is discharged by the first dispensing of the same sample by the first sample dispensing probe 18a. The sample is discharged into the reaction container 16 at the reaction container position C22.

After discharging the sample, the second sample dispensing probe 18b rises to the upper stop position of the second reaction container position C22. Next, the second cleaning tank 28b is moved along the second trajectory T2 from the upper stop position.

When the B line inspection item is set for the sample in the sample container 11 that stops at the first sample container position P11 and the A line inspection item is not set, the first sample dispensing probe 18a.
Is the first speed V1 from the upper stop position P12 to the first detection position P13 shown in FIG.
To descend. Then, after descending to the first detection position P13, it rises without descending to the first suction position P14, moves to the first cleaning tank 28a, and waits. On the other hand, the second sample dispensing probe 18b performs the first dispensing of the same sample by the dispensing operation shown in FIG.
The liquid level detection operation of the sample by the first sample dispensing probe 18a and the first dispensing operation of the sample by the second sample dispensing probe 18b are performed during one analysis cycle time. And B
When a plurality of line inspection items are set, the second sample dispensing probe 18b dispenses a sample every analysis cycle time. On the other hand, the first sample dispensing probe 18a is washed in the first washing tank 28a until the dispensing of the same sample by the second sample dispensing probe 18b is completed.

In this manner, the first sample dispensing probe 18a can be washed in the first washing tank 28a until the dispensing of the same sample by the second sample dispensing probe 18b is completed. Thereby, contamination of the sample in the sample container 11 to be dispensed next can be reduced.

FIG. 9 shows the second dispensing operation of the first sample dispensing probe 18a when the third dispensing of the same sample in the sample container 11 stopped at the first sample container position P11 is performed. FIG.

The first sample dispensing probe 18a is moved along the first trajectory T1 from the first cleaning tank 28a.
Move in one direction. Then, after the second sample dispensing probe 18b that has sucked the sample to perform the second dispensing of the same sample moves in the R1 direction from the upper stop position P12, as shown in FIG. Stop at stop position P12. Next, as shown in FIG. 9B, the vehicle descends from the upper stop position P12 at the second speed V2.

The analysis control unit 32 calculates the distance 23 from the distance D25 calculated by the second liquid level detection of the same sample.
Is subtracted to calculate a distance D26 from the upper stop position P12, which is the second deceleration position P18 for decelerating the first sample dispensing probe 18a from the second speed V2.

Thus, by obtaining the second deceleration position P18 based on the second detection position P16, the first sample dispensing probe 18a can be decelerated before contacting the sample in the sample container 11. .

As shown in FIG. 9C, the first sample dispensing probe 18a descends at the second speed V2 from the upper stop position P12 to the second deceleration position P18 below the distance D26. Next, after decelerating at the second deceleration position P18, as shown in FIGS. 9D and 9E, the liquid level of the sample in the sample container 11 is 3 by the first liquid level detector 29a. Third detection position P19 detected for the second time
Descends at a speed VL. Then, as shown in FIG. 9 (f), after stopping at the third suction position P20 where the sample can be sucked for the third time below the distance D22 from the third detection position P19, the sample in the sample container 11 is removed. Aspirate.

In this way, the first sample dispensing probe 18a lowered at a high speed is moved to the second deceleration position P.
After decelerating at 18, the impact when stopped at the third suction position 20 can be reduced by bringing the sample into contact with the liquid level of the sample in the sample container 11. Thereby, the fall of the sample dispensing precision of the 1st sample dispensing probe 18a by the impact when it stops can be prevented.

The first sample dispensing probe 1 having a shorter moving distance in the third dispensing of the same sample.
By lowering 8a at a speed higher than the speed in the first dispensing, the third detection position P
The sample may be lowered to 19 at a lower speed than the speed VL so as to improve the sample dispensing accuracy.

The analysis control unit 32 supplies the pulse supplied to the stepping motor that drives the first moving mechanism 19a of the driving unit 31 in order to lower the first sample dispensing probe 18a from the upper stop position P12 to the third detection position P19. Based on the number, a distance D27 between the upper stop position P12 where the first sample dispensing probe 18a is lowered and the third detection position P19 is calculated.

The first sample dispensing probe 18a ascends to the upper stop position P12 after sucking the sample.
Next, after moving from the upper stop position P12 along the first trajectory T1 to the upper stop position of the second reaction container position C22, it descends and after the first and second dispensing of the same sample has been performed The sample is discharged into the reaction container 16 that rotates and stops at the first reaction container position C21. After the sample is discharged, the sample moves up to the upper stop position of the first reaction container position C21 and then moves to the first cleaning tank 28a.

FIG. 10 shows the second dispensing operation of the second sample dispensing probe 18b when the fourth dispensing of the same sample in the sample container 11 stopped at the first sample container position P11 is performed. FIG.

The second sample dispensing probe 18b is moved along the second trajectory T2 from the second cleaning tank 28b.
Move in two directions. Then, after the first sample dispensing probe 18a that sucked the sample to perform the third dispensing of the same sample moves in the R2 direction from the upper stop position P12, as shown in FIG. Stop at stop position P12. Next, as shown in FIG. 10B, the vehicle descends at the second speed V2.

Thus, in order to cause the sample in the sample container 11 stopped at the first sample container position P11 to be dispensed, the second sample dispensing probe 18b having the longer moving distance is moved to the one having the shorter moving distance. 1
By descending at a higher speed than the first sample dispensing probe 18a in the second dispensing,
It is possible to prevent the sample dispensing time from being extended by causing the first and second sample dispensing probes 18a and 18b to suck the sample at different timings.

The analysis control unit 32 calculates the distance 23 from the distance D27 calculated by the third liquid level detection of the same sample.
Is subtracted to calculate the distance D28 from the upper stop position P12, which is the third deceleration position P21 for decelerating the second sample dispensing probe 18b from the second speed V2.

Thus, by obtaining the third deceleration position P21 based on the third detection position P19, the second sample dispensing probe 18b can be decelerated before coming into contact with the sample in the sample container 11. .

As shown in FIG. 10C, the second sample dispensing probe 18b descends at the second speed V2 from the upper stop position P12 to the third deceleration position P21 below the distance D28. Next, after decelerating at the third deceleration position P21, as shown in FIGS. 10D and 10E, the liquid level of the sample in the sample container 11 is set to 4 by the second liquid level detector 29b. It descends at a speed VL to the fourth detection position P22 detected for the second time. Then, as shown in FIG. 10 (f), the fourth detection position P
After stopping at the fourth suction position P23 below the distance D22 from 22, the sample in the sample container 11 is sucked.

In this way, the second sample dispensing probe 18b that is lowered at a high speed is moved to the third deceleration position P.
By decelerating at 21 and then contacting with the liquid level of the sample in the sample container 11, the impact when stopped at the fourth suction position 23 can be reduced. Thereby, the fall of the dispensing precision of the sample of the 2nd sample dispensing probe 18b by the impact when it stops can be prevented.

The analysis control unit 32 calculates a distance D29 from the upper stop position P12 where the second sample dispensing probe 18b is lowered to the fourth detection position P22.

The second sample dispensing probe 18b ascends to the upper stop position P12 after sucking the sample.
Subsequently, after moving from the upper stop position P12 to the upper stop position of the second reaction container position C22, the second reaction is performed after the first and second dispensing of the same sample has been performed and the second reaction is performed. The sample is discharged into the reaction container 16 that stops at the container position C22. After the sample is discharged, the sample moves up to the upper stop position of the second reaction container position C22 and then moves to the second cleaning tank 28b.

After the fourth dispensing of the same sample is performed, when the (2m-1) th dispensing (m is an integer of 3 or more) of the same sample is performed, the first sample dispensing probe 18a is the first R from washing tank 28a
Move in one direction. Then, after the second sample dispensing probe 18b that has sucked the sample in order to perform the 2 (m-1) th dispensing of the same sample moves in the R1 direction from the upper stop position P12, the second sample dispensing probe 18b stops at the upper stop position P12 To do. Next, the vehicle descends from the upper stop position P12 at the second speed V2.

The analysis control unit 32 calculates the upper stop position P calculated by detecting the 2 (m-1) th liquid level of the same sample.
Subtracting the distance 23 from the distance between the 12th and the second (m−1) detection positions, the upper is the (m + 1) th deceleration position for decelerating the first sample dispensing probe 18a from the second velocity V2. The distance from the stop position P12 is calculated.

The first sample dispensing probe 18a has a first (m) lower than the distance calculated from the upper stop position P12.
(2) The liquid level of the sample in the sample container 11 is detected at the (2m-1) th time after decelerating at the second speed V2 to the deceleration position (+1) and decelerating at the (m + 1) th deceleration position. 2m-1) descends at a speed VL to the detection position. Then, the sample in the sample container 11 is sucked at the (2m−1) suction position below the distance D22 from the (2m−1) detection position.

The first sample dispensing probe 18a moves up to the upper stop position P12 and moves to the second reaction container position C.
After moving to the upper stop position of 22 and descending, (2m-3) th and 2 (m-
1) The sample is discharged into the reaction container 16 that rotates and stops at the first reaction container position C21 after the first dispensing. And after discharging a sample, after raising to the upper stop position of the 1st reaction container position C21, it moves to the 1st washing tank 28a.

When the first sample dispensing probe 18a continues to dispense the sample in the sample container 11 stopped at the first sample container position P11, the first sample dispensing probe 18a starts from the first washing tank 28a to the upper stop position P12.
Move up. In addition, when the dispensing of the sample in the sample container 11 stopped at the first sample container position P11 is finished, the cleaning is performed in the first cleaning tank 28a.

In the second dispensing of the same sample, the second sample dispensing probe 18b moves in the R2 direction from the second cleaning tank 28b. Then, after the first sample dispensing probe 18a that sucked the sample in order to perform the (2m-1) th dispensing of the same sample moves in the R2 direction from the upper stop position P12, it stops at the upper stop position P12. . Next, the vehicle descends from the upper stop position P12 at the second speed V2.

The analysis control unit 32 calculates the upper stop position P calculated by the (2m-1) th liquid level detection of the same sample.
By subtracting the distance 23 from the distance between the 12th and (2m-1) detection positions, the distance to be the (m + 2) deceleration position for decelerating the second sample dispensing probe 18b from the second speed V2 is calculated. To do.

The second sample dispensing probe 18b has a second (m) below the distance calculated from the upper stop position P12.
+2) Decrease at the second speed V2 to the deceleration position, decelerate at the (m + 2) deceleration position, and then to the 2m detection position where the liquid level of the sample in the sample container 11 is detected for the 2mth time. Decrease at speed VL. Then, the sample in the sample container 11 is sucked at the second m suction position below the distance D22 from the second m detection position.

After sucking the sample, the second sample dispensing probe 18b moves up to the upper stop position P12 and moves to the upper stop position of the second reaction container position C22. Next, it descends from the upper stop position, and after the (2m-3) th and 2 (m-1) th dispensing of the same sample is performed, it rotates and stops at the second reaction vessel position C22. A sample is discharged into the reaction vessel 16. And after discharging a sample, after raising to the upper stop position above the 2nd reaction container position C22, it moves to the 2nd washing tank 28b.

When the second sample dispensing probe 18b continues to dispense the sample in the sample container 11 stopped at the first sample container position P11, the second sample dispensing probe 18b moves from the second cleaning tank 28b to the upper stop position P12.
Move up. In addition, when the dispensing of the sample in the sample container 11 stopped at the first sample container position P11 is finished, the cleaning is performed in the second cleaning tank 28b.

Next, when a plurality of A-line inspection items and B-line inspection items are set for the sample in the sample container 11 that stops at the first sample container position P11, and the number of A-line inspection items and B-line inspection items is different. Dispensing will be described.

The analysis control unit 32 sets the number of one inspection item with a small number of set A line inspection items or B line inspection items to c (c is an integer of 2 or more), and sets the other inspection item with a large number. When the number is d (d is an integer of 3 or more), the first and second sample dispensing probes 18a and 18b
The same sample is dispensed c times alternately by c times. Thereafter, (dc) times of dispensing by one sample dispensing probe of the first or second sample dispensing probe 18a, 18b corresponding to the other inspection item line is performed at every analysis cycle time.

In (2c + 1) dispensing of the same sample, one sample dispensing probe moves from one of the first or second washing tanks 28a, 28b where the one sample dispensing probe is washed, Stop at stop position P12. Next, the vehicle descends from the upper stop position P12 at the second speed V2.

The analysis control unit 32 subtracts the distance 23 from the distance between the upper stop position P12 and the second c detection position calculated in the second c level detection of the same sample, and moves one sample dispensing probe to the second speed. The distance from the upper stop position P12, which is the 2c deceleration position to be decelerated from V2, is calculated.

One sample dispensing probe descends at the second speed V2 to the 2c decelerating position below the calculated distance from the upper stop position P12, decelerates at the 2c decelerating position, and then in the sample container 11 The liquid level of the sample is lowered at the speed VL to the (2c + 1) th detection position detected at the (2c + 1) th time. Then, the sample in the sample container 11 is sucked at the (2c + 1) th suction position below the (2c + 1) th detection position by the distance D22.

One sample dispensing probe moves up to the upper stop position P12 and moves to the upper stop position above one of the reaction container positions C21 and C22 corresponding to the one sample dispensing probe. After the second sample is dispensed, the sample is discharged into the reaction vessel 16 that rotates and stops at one reaction vessel position after the (2c-1) th and 2cth dispensing of the same sample is performed.
And after discharging a sample, after raising to the upper stop position above one reaction container position, it moves to one washing tank.

And one sample dispensing probe is the sample container 1 stopped at the first sample container position P11.
When the dispensing of the sample in 1 is continued, the sample moves from one washing tank to the upper stop position P12. When the dispensing of the sample in the sample container 11 stopped at the first sample container position P11 is finished, the cleaning is performed in one of the cleaning tanks.

The other sample dispensing probe is cleaned by stopping in the other washing tank until the dispensing of the same sample by one sample dispensing probe is completed.

In this way, until the dispensing of the same sample by one sample dispensing probe is completed, the other sample dispensing probe is washed in the other washing tank without contacting the sample in the sample container 11. Can do. Thereby, contamination of the sample in the sample container 11 to be dispensed next can be reduced.

Next, dispensing when a plurality of A line inspection items and the same number of B line inspection items as the A line inspection items are set in the sample in the sample container 11 stopped at the second sample container position P31 will be described. .

When the A line inspection item and the B line inspection item are set, the analysis control unit 32 causes the second sample dispensing probe 18b having a short moving distance to dispense a sample. Then, the (2n-1) th (n is a positive integer) dispensing of the same sample by the first sample dispensing probe 18a and the 2nth dispensing by the second sample dispensing probe 18b are performed in one analysis cycle. Let it happen during the time.

The first and second sample dispensing probes 18a and 18b are adjusted so that their lower ends are at the same height at the upper stop position above the second sample container position P31.

FIG. 11 shows the first dispensing operation of the second sample dispensing probe 18b when the first dispensing of the same sample in the sample container 11 stopped at the second sample container position P31 is performed. FIG.

The second sample dispensing probe 18b is moved along the third trajectory T3 from the second cleaning tank 28b.
After moving in two directions, it stops at the upper stop position P32 above the sample container 11 at the second sample container position P31. Next, the liquid level of the sample in the sample container 11 is lowered at the first speed V3 from the upper stop position P32 to the first detection position P33 where the liquid level of the sample in the sample container 11 is detected for the first time. The analysis control unit 32 moves the upper stop position P3 where the second sample dispensing probe 18b is lowered.
A distance D31 between 2 and the first detection position P33 is calculated.

The second sample dispensing probe 18b stops at the first suction position P34 where the first sample can be sucked below the distance D22 from the first detection position P33, and then sucks the sample in the sample container 11. Do.

Here, the third speed V3 when lowering the second sample dispensing probe 18b is due to an impact when the liquid level of the sample in the sample container 11 is detected and stopped at the first suction position P34. The second sample dispensing probe 18b is set at a speed that does not cause a decrease in the dispensing accuracy of the sample.

The second sample dispensing probe 18b ascends to the upper stop position P32 after sucking the sample.
Subsequently, it moves from the upper stop position P32 and stops at the upper stop position of the second reaction vessel position C22. Then, the sample descends from the upper stop position, discharges the sample into the reaction container 16 at the second reaction container position C22, and then rises to the upper stop position. Then, it moves to the 2nd washing tank 28b.

FIG. 12 shows the first dispensing operation of the first sample dispensing probe 18a when the second dispensing of the same sample in the sample container 11 stopped at the second sample container position P31 is performed. FIG.

The first sample dispensing probe 18a is moved along the fourth trajectory T4 from the first cleaning tank 28a.
Move in one direction. Then, after the second sample dispensing probe 18b that sucked the sample to perform the first dispensing of the same sample moves in the R1 direction from the upper stop position P32, the upper stop position P3.
Stop at 2. Next, a second speed V that is higher than the first speed V3 from the upper stop position P32.
Move down at 4.

Thus, in order to cause the sample in the sample container 11 stopped at the second sample container position P31 to be dispensed, the first sample dispensing probe 18a having the longer moving distance is moved to the one having the shorter moving distance. By lowering the sample at a higher speed than the second sample dispensing probe 18b, the sample dispensing time can be extended by causing the first and second sample dispensing probes 18a and 18b to suck the sample at different timings. Can be prevented.

The analysis control unit 32 determines the distance 23 from the distance D31 calculated in the first liquid level detection of the same sample.
Is subtracted to calculate a distance D34 from the upper stop position P12, which is the first deceleration position P35 for decelerating the first sample dispensing probe 18a from the second speed V4.

Thus, by obtaining the first deceleration position P35 based on the first detection position P33, the first sample dispensing probe 18a can be decelerated before contacting the sample in the sample container 11. .

The first sample dispensing probe 18a descends at the second speed V4 from the upper stop position P32 to the first deceleration position P35 below the distance D34. Next, after decelerating at the first deceleration position P35, the second speed is reached to the second detection position P36 where the liquid level of the sample in the sample container 11 is detected a second time by the first liquid level detector 29a. The vehicle descends at a speed VL equal to or lower than V3. Then, after stopping at the second suction position P37 where the sample can be sucked a second time below the distance D22 from the second detection position P36, the sample in the sample container 11 is sucked.

Here, the fourth speed V4 when the first sample dispensing probe 18a is lowered is, when the liquid level is detected at this speed, the second suction is performed after the liquid level of the sample in the sample container 11 is detected. Position P3
7 is set at such a high speed as to cause a drop in the dispensing accuracy of the sample of the first sample dispensing probe 18a due to an impact when stopped at 7.

In this way, the first sample dispensing probe 18a lowered at a high speed is moved to the first deceleration position P.
By decelerating at 35 and then contacting with the liquid level of the sample in the sample container 11, the impact when stopped at the second suction position 37 can be reduced. Thereby, the fall of the sample dispensing precision of the 1st sample dispensing probe 18a by the impact when it stops can be prevented.

The analysis control unit 32 supplies the pulse supplied to the stepping motor that drives the first moving mechanism 19a of the drive unit 31 in order to lower the first sample dispensing probe 18a from the upper stop position P32 to the second detection position P36. Based on the number, a distance D35 between the upper stop position P32 and the second detection position P36 is calculated.

The first sample dispensing probe 18a ascends to the upper stop position P32 after sucking the sample.
Next, the first reaction container position C2 moves from the upper stop position P32 along the fourth trajectory T4.
Stop at the top stop position. Then, the second reaction container position C is lowered from the upper stop position and the second sample dispensing probe 18b discharges the sample by the first dispensing of the same sample.
The sample is discharged into the reaction container 16 at the first reaction container position C21 adjacent to the 22 reaction containers 16. After the sample is discharged, the first reaction container position C21 rises to the upper stop position, and then the first
It moves to the washing tank 28a.

FIG. 13 shows the second dispensing operation of the second sample dispensing probe 18b when the third dispensing of the same sample in the sample container 11 stopped at the second sample container position P31 is performed. FIG.

The second sample dispensing probe 18b moves in the R2 direction from the second cleaning tank 28b. Then, the first sample dispensing probe 18a that sucks the sample in order to perform the second dispensing of the same sample.
Moves in the R2 direction from the upper stop position P32, and then stops at the upper stop position P32. Then
The vehicle descends at the second speed V4 from the upper stop position P32.

The analysis control unit 32 calculates the distance 23 from the distance D35 calculated in the second liquid level detection of the same sample.
Is subtracted to calculate the distance D36 from the upper stop position P32, which is the second deceleration position P38 for decelerating the second sample dispensing probe 18b from the second speed V4.

The first sample dispensing probe 18a descends at the second speed V4 from the upper stop position P32 to the second deceleration position P38 below the distance D36. Next, after decelerating at the second deceleration position P38, the second liquid level detector 29b descends at a speed VL to the third detection position P39 where the liquid level of the sample in the sample container 11 is detected for the third time. To do. Then, the distance D from the third detection position P39
22 After stopping at the third suction position P40 where the sample can be sucked for the third time, the sample container 1
The sample in 1 is aspirated.

In this way, the second sample dispensing probe 18b that is lowered at a high speed is moved to the second deceleration position P.
By decelerating at 38 and then bringing into contact with the liquid level of the sample in the sample container 11, the impact when stopped at the third suction position 40 can be reduced. Thereby, the fall of the dispensing precision of the sample of the 2nd sample dispensing probe 18b by the impact when it stops can be prevented.

The analysis control unit 32 supplies the pulse supplied to the stepping motor that drives the second moving mechanism 19b of the driving unit 31 in order to lower the second sample dispensing probe 18b from the upper stop position P32 to the third detection position P39. Based on the number, a distance D37 between the upper stop position P32 and the third detection position P39 is calculated.

Thus, by obtaining the second deceleration position P38 based on the second detection position P36, the second sample dispensing probe 18b can be decelerated before coming into contact with the sample in the sample container 11. .

The second sample dispensing probe 18b ascends to the upper stop position P32 after sucking the sample.
Subsequently, after moving from the upper stop position P32 to the upper stop position of the second reaction vessel position C22, the second reaction is performed after the first and second dispensing of the same sample is performed and the second reaction is performed. The sample is discharged into the reaction container 16 that stops at the container position C22.

The second sample dispensing probe 18b discharges the sample, moves up to the upper stop position of the second reaction container position C22, and then moves to the second cleaning tank 28b. When the dispensing of the sample in the sample container 11 stopped at the second sample container position P31 is continued, the second cleaning tank 28
It moves from b to the upper stop position P32. Further, when the dispensing of the sample in the sample container 11 stopped at the second sample container position P31 is finished, the cleaning is performed in the second cleaning tank 28b.

FIG. 14 shows the second dispensing operation of the first sample dispensing probe 18a when the fourth dispensing of the same sample in the sample container 11 stopped at the second sample container position P31 is performed. FIG.

The first sample dispensing probe 18a moves in the R1 direction from the first cleaning tank 28a. Then, the second sample dispensing probe 18b that sucks the sample in order to perform the third dispensing of the same sample.
Moves from the upper stop position P32 in the R1 direction, then stops at the upper stop position P32 and then descends at the second speed V4.

Thus, in order to cause the sample in the sample container 11 stopped at the second sample container position P31 to be dispensed, the first sample dispensing probe 18a having the longer moving distance is moved to the one having the shorter moving distance. 1
By lowering at a higher speed than the second sample dispensing probe 18b in the second dispensing,
It is possible to prevent the sample dispensing time from being extended by causing the first and second sample dispensing probes 18a and 18b to suck the sample at different timings.

The analysis control unit 32 calculates the distance 23 from the distance D37 calculated by the third liquid level detection of the same sample.
Is calculated, and a distance D38 from the upper stop position P32, which is a third deceleration position P41 for decelerating the first sample dispensing probe 18a from the second speed V4, is calculated.

Thus, by obtaining the third deceleration position P41 based on the third detection position P39, the first sample dispensing probe 18a can be decelerated before coming into contact with the sample in the sample container 11. .

The first sample dispensing probe 18a descends at the second speed V4 from the upper stop position P32 to the third deceleration position P41 below the distance D38. Next, after decelerating at the third deceleration position P41, the first liquid level detector 29a descends at a speed VL to a fourth detection position P42 where the liquid level of the sample in the sample container 11 is detected for the fourth time. To do. The distance D from the fourth detection position P42
After stopping at the fourth suction position P43 below 22, the sample in the sample container 11 is sucked.

In this way, the first sample dispensing probe 18a lowered at a high speed is moved to the third deceleration position P.
By decelerating at 41 and bringing it into contact with the liquid level of the sample in the sample container 11, the impact when stopped at the fourth suction position 43 can be reduced. Thereby, the fall of the sample dispensing precision of the 1st sample dispensing probe 18a by the impact when it stops can be prevented.

The analysis control unit 32 supplies the pulse supplied to the stepping motor that drives the first moving mechanism 19a of the driving unit 31 to lower the first sample dispensing probe 18a from the upper stop position P32 to the fourth detection position P42. Based on the number, a distance D39 between the upper stop position P32 and the fourth detection position P42 is calculated.

The first sample dispensing probe 18a ascends to the upper stop position P32 after sucking the sample.
Next, after moving from the upper stop position P32 to the upper stop position of the first reaction container position C21, the first reaction is performed after the first and second dispensing of the same sample is performed and the first reaction is performed. The sample is discharged into the reaction container 16 that stops at the container position C21.

After discharging the sample, the first sample dispensing probe 18a moves up to the upper stop position of the first reaction container position C21 and then moves to the first cleaning tank 28a. When the dispensing of the sample in the sample container 11 stopped at the second sample container position P31 is continued, the first cleaning tank 28a
To the upper stop position P32. When the dispensing of the sample in the sample container 11 stopped at the second sample container position P31 is finished, the cleaning is performed in the first cleaning tank 28a.

According to the embodiment described above, the first and second moving mechanisms 19a and 19b for supporting the first and second sample dispensing probes 18a and 18b so as to be independently movable are provided, and the first or second moving mechanism 19a or 19b is provided. The first and second sample dispensing probes 18a and 18b are moved at a higher speed than the other sample dispensing probe in the first dispensing with a short moving distance by moving one sample dispensing probe having a long moving distance. It is possible to prevent the sample dispensing time from being extended by causing the two sample dispensing probes 18a and 18b to suck the sample at different timings.

Then, the sample container 11 is decelerated after the one sample dispensing probe being lowered at high speed is decelerated.
By bringing the sample in the sample container 11 into contact with the liquid surface, the impact when the sample in the sample container 11 is stopped at a position where it can be sucked can be reduced. Thereby, the fall of the sample dispensing precision of one sample dispensing probe by the impact when it stops can be prevented.

When one sample dispensing probe of the first or second sample dispensing probe 18a, 18b dispenses a sample and the other sample dispensing probe is waiting, one sample dispensing probe While the sample is being dispensed, the other sample dispensing probe can be washed.

  As described above, contamination of the sample can be reduced without reducing the processing speed.

Although several embodiments of the present invention have been described, these embodiments are presented by way of example and are not intended to limit the scope of the invention. These novel embodiments can be implemented in various other forms, and various omissions, replacements, and changes can be made without departing from the scope of the invention. These embodiments and modifications thereof are included in the scope and gist of the invention, and are included in the invention described in the claims and the equivalents thereof.

D11 1st distance D12 2nd distance D13 3rd distance D14 4th distance P11 1st sample container position C21 1st reaction container position C22 2nd reaction container position P31 2nd sample container position T1 1st 1 trajectory T2 2nd trajectory T3 3rd trajectory T4 4th trajectory 11 sample container 16 reaction vessel 18a first sample dispensing probe 18b second sample dispensing probe 19a first moving mechanism 19b second Moving mechanism 32 Analysis control unit

Claims (9)

A first dispensing probe for performing dispensing to suck the sample in the sample container and discharge it to the reaction container at the first position;
A second dispensing probe for performing dispensing to suck the sample in the sample container and discharge it to the reaction container at the second position;
A first moving mechanism for movably supporting the first dispensing probe between the sample container and the reaction container at the first position;
A second moving mechanism for supporting the second dispensing probe movably between the sample container and the reaction container at the second position;
Either one of the dispensing probes having a long moving distance of the first or second dispensing probe is lowered from the upper stop position above the sample in the sample container at a higher speed than the other dispensing probe having a short moving distance. An automatic analyzer comprising an analysis control unit. A liquid level detector for detecting the liquid level of the sample by contacting the other dispensing probe with the sample in the sample container;
The analysis control unit
Lowering the other dispensing probe from the upper stop position to a first detection position where the liquid level of the sample is detected by the liquid level detector at a first speed;
From the upper stop position of the one dispensing probe to a deceleration position below a distance obtained by subtracting a predetermined distance from the distance between the upper stop position where the other dispensing probe is lowered and the first detection position 2. The vehicle is lowered at a second speed higher than the first speed.
Automatic analyzer described in 1. A liquid level detector that detects the liquid level of the sample by contacting the one dispensing probe with the sample in the sample container;
The analysis control unit
In the first dispensing of the sample, the other dispensing probe is lowered from the upper stop position to the first detection position at the first speed,
In the second dispensing of the sample, the one dispensing probe is lowered from the upper stop position to the deceleration position at the second speed, decelerated at the deceleration position, and then the one dispensing probe and The automatic analyzer according to claim 2, wherein the automatic analyzer is lowered to a second detection position where the liquid level of the sample is detected by the contact at a speed equal to or lower than the first speed. In the third dispensing of the sample, the analysis control unit moves the other dispensing probe between the upper stop position where the one dispensing probe is lowered from the upper stop position and the second detection position. The liquid level of the sample is detected by contact with the other dispensing probe after being lowered at the second speed to a deceleration position below a distance obtained by subtracting a predetermined distance from the distance between the two, and decelerating at the deceleration position. 4. The automatic analyzer according to claim 3, wherein the automatic analyzer is moved down to a third detection position at a speed equal to or lower than the first speed. A liquid level detector for detecting the liquid level of the sample by contacting the one dispensing probe with the sample;
In the first dispensing of the sample, the analysis control unit lowers the one dispensing probe from the upper stop position to the deceleration position at the second speed, decelerates at the deceleration position, and then The automatic analyzer according to claim 2, wherein the automatic analyzer is lowered at a speed equal to or lower than the first speed to a second detection position where the liquid level of the sample is detected by contact with one of the dispensing probes. The first moving mechanism includes a first probe support that supports the first dispensing probe, a first vertical movement support that supports the first probe support so as to move up and down, and a first A first rotation shaft that rotatably supports one vertical movement support;
The second moving mechanism includes a second probe support that supports the second dispensing probe, a second vertical movement support that supports the second probe support so as to move up and down, and a second 6. A second rotating shaft arranged coaxially with the first rotating shaft for rotatably supporting two vertical movement supports. Automatic analyzer described in 1. The distance between the first dispensing probe and the center of the first rotating shaft, and the first rotating shaft of the second dispensing probe and the second rotating shaft are common. The automatic analyzer according to claim 6, wherein the distance between the axis centers is the same. 8. The automatic according to claim 1, wherein the analysis control unit stops the first dispensing probe and the second dispensing probe at the upper stop position at different timings. Analysis equipment. While the reaction vessel is stopped at the first and second positions, the analysis control unit
The sample is discharged into the reaction container at the first position by the dispensing probe, and the second
The automatic analyzer according to any one of claims 1 to 3, wherein the sample is discharged into the reaction container at the second position by the dispensing probe.

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