JP6656902B2 - Automatic analyzer - Google Patents

Description

  An embodiment of the present invention relates to an automatic analyzer that dispenses a sample and a reagent into a reaction container and measures a mixture of the sample and the reagent dispensed into the reaction container.

  The automatic analyzer targets a biochemical test item, an immunological test item, and the like, and optically measures a change in color tone and turbidity caused by a reaction of a mixed solution of a sample collected from a subject and a reagent of each test item. As a result of this measurement, analysis data represented by the concentration of each test item component contained in the sample, the activity of the enzyme, and the like is generated.

  Some automatic analyzers have a semi-random access method that can simultaneously dispense two samples of two test items set for the sample into two reaction containers using two dispensing probes. . In this semi-random access method, each inspection item is divided into A line and B line in advance, and a sample of the inspection item of A line is dispensed to a reaction container of A line using a dispensing probe of A line. Further, the sample of the inspection item of the B line is dispensed to the reaction container of the B line using the dispensing probe of the B line. Then, the dispensing probes of the A line and the B line are usually washed with washing water as washing every time dispensing of the sample is completed.

  Also, in the automatic analyzer, when a test item that is set to be affected beforehand is included in the test items set for the sample, dispensing is performed before the sample via the dispensing probe. In order to avoid the influence of carry-over from the sample, special cleaning stronger than cleaning water is performed using a cleaning liquid containing a detergent.

JP 2009-216594 A

  However, in the semi-random access method, if the inspection items set on the sample include the inspection items of the A-line and the B-line as the affected inspection items, special inspection of the dispensing probe of the A-line and the B-line is performed. Since cleaning is required, there is a problem that the amount of the cleaning liquid used increases.

  Embodiments have been made to solve the above problems, and an object of the present invention is to provide an automatic analyzer that can reduce the amount of a cleaning solution used.

In order to achieve the above object, the automatic analyzer according to the embodiment dispenses a sample and a reagent of each test item set in the sample into a reaction container, and mixes the mixed solution of the sample and the reagent in the reaction container. the automatic analyzer for performing a measurement, the sample in the sample container, the reaction container of the first dispensing position corresponding to the first line, and, dispensable in the reaction vessel of the second dispensing position corresponding to the second line A first dispensing probe, which is normally washed when dispensing of the sample is completed, and a sample in the sample container , a reaction container at the first dispensing position corresponding to the first line , and, the second is dispensable configured into a reaction vessel corresponding to the line the second dispensing position, and a second dispensing probe the dispensing of the sample is completed normally washed performed, before Symbol sample Some test item set in the sample in the container, the normal washing If certain tests that require strong special cleaning than is contained more, then the dispensing of those sample to be performed by the one of the dispensing probe of the first or second dispensing probe, An analysis control unit that performs the special washing of the one dispensing probe before the dispensing of the sample is started by the one dispensing probe.

FIG. 1 is a block diagram showing a configuration of an automatic analyzer according to an embodiment. FIG. 2 is a diagram illustrating a configuration of an analysis unit according to the embodiment. FIG. 4 is a side view showing an example of the configuration of the first and second moving mechanisms according to the embodiment. FIG. 2 is a plan view showing the arrangement of first and second sample dispensing probes, first and second moving mechanisms, a sample container held on a sample rack, and a reaction container held on a reaction disk according to the embodiment. FIG. 4 is a diagram showing first and second trajectories on which first and second sample dispensing probes according to the embodiment rotate. 5 is a timing chart showing the timing of movement of the first and second sample dispensing probes according to the embodiment. The figure which shows an example of dispensing when the test item which is affected is not included in the test item set to the sample which concerns on embodiment. The figure which shows an example of dispensing when either the first or the second inspection item is included as the inspection item affected among the inspection items set to the sample which concerns on embodiment. FIG. 4 is a diagram illustrating an example of a sample in which first and second inspection items that are affected by the embodiment are set. The figure which shows an example of dispensing when the 1st and 2nd test item affected is included in the test item set to the sample which concerns on embodiment. The figure which shows the other example of dispensing when the 1st and 2nd inspection item affected is included in the inspection item set to the sample which concerns on embodiment. The figure which shows the other example of dispensing when the 1st and 2nd inspection item affected is included in the inspection item set to the sample which concerns on embodiment.

  Hereinafter, embodiments will be described with reference to the drawings.

  FIG. 1 is a block diagram showing a configuration of the automatic analyzer according to the embodiment. The automatic analyzer 100 dispenses a sample such as a standard sample or a test sample of each test item and a reagent of each test item, measures a mixture of the sample and the reagent, and generates standard data and test data. An analysis unit 10 is provided. Further, a driving unit 31 that drives various units of the analysis unit 10 is provided. Further, an analysis control unit 32 that controls the driving unit 31 to operate various units of the analysis unit 10 is provided. Further, a data processing unit 40 is provided which processes the standard data and test data generated by the analysis unit 10 and generates calibration data and analysis data of each inspection item.

  In addition, the automatic analyzer 100 includes an output unit 50 that outputs the calibration data and the analysis data generated by the data processing unit 40. In addition, input of analysis parameters such as the sample and reagent dispensed volume of each test item, input of sort information to classify the test item into either the first or second line, and the next step from the sample that has been dispensed. An operation unit 60 for inputting an avoidance parameter for setting an inspection item affected by carryover to a sample to be dispensed, inputting inspection item information for setting an inspection item for each sample, and the like. I have. In addition, a system control unit 70 that controls the analysis control unit 32, the data processing unit 40, and the output unit 50 based on input information input from the operation unit 60 is provided.

  FIG. 2 is a diagram illustrating a configuration of the analysis unit 10. The analysis unit 10 includes a sample container 11 for storing samples such as a standard sample and a test sample for each inspection item. Further, the apparatus includes a sample rack 12a holding a sample container 11 containing a sample, and a sampler 12b on which the sample rack 12a holding the sample container 11 is placed. In addition, a reagent container 13a containing, for example, a 1-reagent system and a 2-reagent system first reagent which is a reagent that reacts with a component of each test item included in the sample, and a second reagent system paired with the 2-reagent system first reagent And a reagent container 13b for storing a reagent.

  In addition, a reagent rack 14a1 that rotatably holds a reagent container 13a that contains a first reagent of a first test item, which is divided into a first line among the test items, is provided. A reagent rack 14a2, which is arranged inside the reagent rack 14a1 and rotatably holds a reagent container 13a containing a first reagent of a second test item divided into a second line of the test items, is provided. Have. Further, a reagent storage 15a for keeping the first reagent in the reagent container 13a held by the reagent racks 14a1 and 14a2 is provided.

  In addition, there is provided a reagent rack 14b1 for rotatably holding a reagent container 13b containing the second reagent of the first test item. Further, a reagent rack 14b2 is provided inside the reagent rack 14b1 and rotatably holds a reagent container 13b containing a second reagent of the second test item. Further, a reagent storage 15b for keeping the second reagent in the reagent container 13b held by the reagent racks 14b1 and 14b2 cool is provided.

  Further, a plurality of reaction vessels 16 divided into a first line and a second line are provided. In addition, there is provided a reaction disk 17 for rotatably holding a reaction vessel 16 divided into a first line and a second line arranged at positions adjacent to each other on the circumference.

  When the inspection item set for the sample in the sample container 11 held in the sample rack 12a is the first inspection item, the sample of the first inspection item is sucked and divided into the first line. Is dispensed into the reaction vessel 16 of the first line stopped at the set first dispensing position, and when the test item set for the sample is the second test item, the second test is performed. A first sample dispensing probe 18a for dispensing by dispensing the sample of the item into the reaction container 16 of the second line stopped at the second dispensing position divided into the second line is provided. Further, a first moving mechanism for movably supporting the first sample dispensing probe 18a between the sample container 11 held on the sample rack 12a and the reaction container 16 at the first dispensing position or the second dispensing position. 19a.

  When the inspection item set for the sample in the sample container 11 held in the sample rack 12a is the first inspection item, the sample of the first inspection item is sucked and divided into the first line. Is dispensed into the reaction vessel 16 of the first line stopped at the set first dispensing position, and when the test item set for the sample is the second test item, the second test is performed. There is provided a second sample dispensing probe 18b for dispensing by discharging the sample of the item and discharging it to the reaction container 16 of the second line stopped at the second dispensing position divided into the second line. Also, a second moving mechanism for movably supporting the second sample dispensing probe 18b between the sample container 11 held on the sample rack 12a and the reaction container 16 at the first dispensing position or the second dispensing position. 19b.

  Further, the first reagent of the first test item in the reagent container 13a held in the reagent rack 14a1 is sucked, and the first or second sample dispensing probe 18a, 18b dispenses the first sample. A first first reagent dispensing probe 20a for dispensing to be discharged to the reaction container 16 in the line is provided. Further, the first reagent of the second test item in the reagent container 13a held in the reagent rack 14a2 is sucked, and the second or third sample dispensed by the first or second sample dispensing probe 18a or 18b. A second first reagent dispensing probe 20b that performs dispensing to be discharged to the reaction container 16 in the line is provided.

  Also, a first first reagent dispensing arm 21a that movably supports the first first reagent dispensing probe 20a, and a second second reagent that movably supports the second first reagent dispensing probe 20b. And one reagent dispensing arm 21b. Further, a first stirring unit 22 for stirring a mixture of the sample and the first reagent dispensed into the reaction container 16 is provided. Further, the second reagent of the first test item in the reagent container 13b held in the reagent rack 14b1 is sucked, and the reaction container 16 in which the first reagent is dispensed by the first first reagent dispensing probe 20a. A first and second reagent dispensing probe 23a for performing dispensing to be discharged to the apparatus is provided.

  Further, the second reagent of the second test item in the reagent container 13b held in the reagent rack 14b2 is sucked, and the reaction container 16 in which the first reagent is dispensed by the second first reagent dispensing probe 20b. And a second reagent dispensing probe 23b for dispensing the liquid to be discharged. In addition, a first second reagent dispensing arm 24a that movably holds the first second reagent dispensing probe 23a, and a second second arm that movably holds the second second reagent dispensing probe 23b. And a two-reagent dispensing arm 24b. Further, a second stirring unit 25 for stirring a mixture of the sample, the first reagent, and the second reagent dispensed into the reaction vessel 16 is provided.

  The reaction vessel 16 containing the mixed solution stirred by the first stirring unit 22 and the second stirring unit 25 is irradiated with light, and the mixed solution containing the standard sample and the test sample in the reaction vessel 16 is transmitted. And a measuring unit 26 for detecting standard light and generating standard data and test data. Further, a washing nozzle 27 for washing the inside of the reaction vessel 16 every time the measurement is completed is provided. Then, the reaction container 16 cleaned by the cleaning nozzle 27 is used again for dispensing a sample, dispensing a reagent, and measuring.

  Although not shown, a washing tank is provided for washing the first and second first reagent dispensing probes 20a and 20b and the first and second second reagent dispensing probes 23a and 23b, respectively. ing. Then, each time the dispensing of the first reagent of the first test item is completed, the first first reagent dispensing probe 20a is washed. Further, each time the dispensing of the first reagent of the second test item is completed, the second first reagent dispensing probe 20b is washed. Further, each time the dispensing of the second reagent of the first inspection item is completed, the first second reagent dispensing probe 23a is washed. Further, every time the dispensing of the second reagent of the second inspection item is completed, the second second reagent dispensing probe 23b is washed.

  The drive unit 31 shown in FIG. 1 includes various units of the analysis unit 10 and a mechanism for driving the units. Then, as shown in FIG. 2, the sample rack 12a placed on the sampler 12b is moved in the directions of the arrows L1, L2 and L3. In addition, the reagent racks 14a1 and 14a2 are driven for each cycle to rotate the reagent container 13a. In addition, the reagent racks 14b1 and 14b2 are driven for each cycle to rotate the reagent container 13b. Further, the reaction disk 17 is driven every cycle, and each reaction vessel 16 is rotated.

  The drive unit 31 drives the first and second moving mechanisms 19a and 19b, respectively, to rotate and vertically move the first and second sample dispensing probes 18a and 18b. Further, the first and second first reagent dispensing arms 21a and 21b are respectively driven to rotate and vertically move the first and second first reagent dispensing probes 20a and 20b. Further, the first and second second reagent dispensing arms 24a and 24b are respectively driven to rotate and vertically move the first and second second reagent dispensing probes 23a and 23b. Further, the first stirring unit 22, the second stirring unit 25, and the cleaning nozzle 27 are moved up and down, respectively.

  The analysis control unit 32 controls the drive unit 31 based on input information such as analysis parameters, classification information, avoidance parameters, and inspection item information input from the operation unit 60 to operate various units of the analysis unit 10. Then, dispensing of a sample, dispensing of a reagent, stirring of a mixed solution, measurement, washing to avoid various units, and the like are executed.

  The data processing unit 40 includes a calculation unit 41 and a data storage unit 42. Then, the calculation unit 41 generates calibration data from the standard data of each test item generated by the analysis unit 10 and converts the test data generated by the analysis unit 10 using the calibration data of this test item into analysis data. Generate. The data storage unit 42 stores the calibration data generated by the calculation unit 41 for each test item, and stores the analysis data of each test item generated by the calculation unit 41 for each test sample.

  The output unit 50 includes a printing unit 51 that prints out the standard data and the analysis data generated by the data processing unit 40 and a display unit 52 that displays and outputs the data. The printing unit 51 includes a printer or the like, and prints calibration data and analysis data on printer paper or the like in accordance with a preset format.

  Further, the display unit 52 includes a monitor such as a CRT and a liquid crystal panel. Then, an analysis parameter setting screen for setting an analysis parameter of the inspection item is displayed for each inspection item. Also, a section information setting screen for setting the first line and the second line for each inspection item is displayed. Further, an avoidance parameter setting screen is displayed to set an inspection item affected by carry-over of the sample via each of the first and second sample dispensing probes 18a and 18b. Further, an inspection item information setting screen for setting an inspection item to be inspected for this sample is displayed for each sample.

  The operation unit 60 includes input devices such as a keyboard, a mouse, buttons, and a touch key panel. Then, input of analysis parameters, input of classification information, input of avoidance parameters, input of inspection item information, and the like are performed. Further, the system control unit 70 includes a CPU and a storage circuit (not shown). Then, after storing the input information input from the operation unit 60, the analysis control unit 32, the data processing unit 40, and the output unit 50 are controlled based on the input information.

  Next, the configuration of the first and second moving mechanisms 19a and 19b of the analyzer 10 will be described in detail with reference to FIGS.

FIG. 3 is a side view showing an example of the configuration of the first and second moving mechanisms 19a and 19b.
The first moving mechanism 19a includes a first probe support 191a that supports the first sample dispensing probe 18a, and a first vertical support that supports the first probe support 191a so as to be vertically movable. 192a. In addition, a first rotation shaft 193a that rotatably supports the first vertically movable support 192a is provided. The first sample dispensing probe 18a, which is disposed at a position separated by a distance r from the axis center 19 of the first rotation shaft 193a, is movably supported.

  The first probe support 191a is driven up and down by, for example, a stepping motor of the drive unit 31 arranged on the first vertically movable support 192a. As a result, the first sample dispensing probe 18a moves down and up. The first vertically movable support 192a is rotated by the motor of the drive unit 31 driven by the first rotating shaft 193a in the direction of arrow R1 and in the direction of arrow R2 opposite to the direction R1. As a result, the first sample dispensing probe 18a pivotally moves in the R1 direction and the R2 direction on an orbit of an arc having the radius of the distance r around the axis center 19.

  The second moving mechanism 19b includes a second probe support 191b that supports the second sample dispensing probe 18b, and a second vertical support that supports the second probe support 191b so as to be vertically movable. 192b. Further, a first rotating shaft 193a of the first moving mechanism 19a is penetrated, and is arranged coaxially with the first rotating shaft 193a rotatably supporting the second vertically movable support 192b. A second rotary shaft 193b having a tubular shape is provided. The second sample dispensing probe 18b, which is located at a distance r from the axis center 19 common to the first rotation axis 193a of the second rotation axis 193b, is movably supported.

  The second probe support 191b is driven up and down by a stepping motor of a driving unit 31 arranged on the second vertical support 192b. As a result, the second sample dispensing probe 18b moves down and up. Further, the second vertically moving support 192b is rotated by driving the second rotation shaft 193b in the R1 and R2 directions by the motor of the drive unit 31. Accordingly, the second sample dispensing probe 18b moves in the R1 direction and the R2 direction on an orbit of an arc whose radius is the distance r around the axis center 19.

  As described above, the first sample dispensing probe 18a is supported by the first moving mechanism 19a, and the second sample dispensing probe 18b is supported by the second moving mechanism 19b. The first sample dispensing probe 18a and the second sample dispensing probe 18b can be moved at high speed by independently driving the 19a and 19b, respectively. The first and second moving mechanisms 19a and 19b are made coaxial with the first rotating shaft 193a of the first moving mechanism 19a and the second rotating shaft 193b of the second moving mechanism 19b. The size can be reduced. Further, since the first sample dispensing probe 18a and the second sample dispensing probe 18b can be moved on an orbit of an arc on the same circumference, the first and second sample dispensing probes 18a, 18a, The same sample can be dispensed into the same reaction container 16 by 18b.

  Next, dispensing of a sample in the analysis unit 10 will be described with reference to FIGS.

  FIG. 4 shows the first and second sample dispensing probes 18a and 18b, the first and second moving mechanisms 19a and 19b, the sample container 11 held on the sample rack 12a, and the reaction held on the reaction disk 17. FIG. 3 is a plan view showing an arrangement of a container 16.

  The sample rack 12a is moved on the sampler 12b by the drive unit 31, and stops at the sample position S1 where the sample in the sample container 11 can be sucked by the first and second sample dispensing probes 18a and 18b.

  As shown in FIG. 5A, the first sample dispensing probe 18a is driven by the first moving mechanism 19a by the driving unit 31 to stop the first sample dispensing probe 18a at the upper stop position above the sample container 11 at the sample position S1, the first line. The upper stop position above the reaction vessel 16 of the first line, which stops at the first dispensing position C1, which is divided into the first line, and the reaction vessel 16 which stops at the second dispensing position C2, which is divided into the second line. It rotates and moves on the first arc-shaped orbit TR1 including the upper upper stop position. And, on the first track TR1, two first cleaning tanks 28a and 28b for cleaning the first sample dispensing probe 18a are arranged.

  Further, the first sample dispensing probe 18a is lowered from the upper stop position of the sample container 11 at the sample position S1 by the driving of the first moving mechanism 19a by the driving unit 31, and the sample in the sample container 11 is sucked. Stop at the available suction position. Further, it rises from the suction position to the upper stop position. Further, it descends from the upper stop position of the reaction container 16 at one of the first and second dispensing positions C1 and C2, and stops at the discharge position where the sample can be discharged into the reaction container 16. Further, it rises from the discharge position to the upper stop position.

  Then, the first sample dispensing probe 18a dispenses the sample of the first inspection item set for the sample in the sample container 11 at the sample position S1 to the reaction container 16 at the first dispensing position C1. Further, the sample of the second inspection item set for the sample in the sample container 11 at the sample position S1 is dispensed to the reaction container 16 at the second dispensing position C2. Then, each time the dispensing of the same sample is completed, normal cleaning is performed in the first cleaning tank 28a using the cleaning water supplied to the first cleaning tank 28a.

  In addition, the first sample dispensing probe 18a dispenses a sample of the affected first inspection item or the affected second inspection item based on the avoidance parameter. In this case, before starting dispensing of the sample, special cleaning stronger than normal cleaning is performed. The special cleaning is performed in the first cleaning tank 28b using a cleaning liquid containing an alkaline, acidic, or neutral detergent supplied to the first cleaning tank 28b, and the cleaning water performed after the cleaning. The cleaning is performed in the first cleaning tank 28a by using.

  As shown in FIG. 5B, the second sample dispensing probe 18b is driven by the second moving mechanism 19b by the drive unit 31 to move the second sample dispensing probe 18b to the upper stop position above the sample container 11 at the sample position S1, and the second dispensing probe 18b. It rotates on an arc-shaped second trajectory TR2 including an upper stop position above the reaction container 16 at the pouring position C2 and an upper stop position above the reaction container 16 at the first dispensing position C1.

  The second trajectory TR2 is located on an extension of the first trajectory TR1, and overlaps the first trajectory TR1 between the upper stop position of the first dispensing position C1 and the upper stop position of the second dispensing position C2. Have overlapping orbits. And, on the second trajectory TR2, two second cleaning tanks 29a and 29b for cleaning the second sample dispensing probe 18b are arranged.

  Further, the second sample dispensing probe 18b is lowered from the upper stop position of the sample container 11 at the sample position S1 by the driving of the second moving mechanism 19b by the driving unit 31, and the sample in the sample container 11 is sucked. Stop at the available suction position. Further, it rises from the suction position to the upper stop position. Further, it descends from the upper stop position of the reaction container 16 at one of the first and second dispensing positions C1 and C2, and stops at the discharge position where the sample can be discharged into the reaction container 16. Further, it rises from the discharge position to the upper stop position.

  Then, the second sample dispensing probe 18b dispenses the sample of the first inspection item set for the sample in the sample container 11 at the sample position S1 to the reaction container 16 at the first dispensing position C1. Further, the sample of the second inspection item set for the sample in the sample container 11 at the sample position S1 is dispensed to the reaction container 16 at the second dispensing position C2. Then, each time the dispensing of the same sample is completed, normal cleaning is performed using the cleaning water supplied to the second cleaning tank 29a.

  Further, the second sample dispensing probe 18b dispenses a sample of the affected first inspection item or the affected second inspection item based on the avoidance parameter. In this case, before starting dispensing of the sample, special cleaning stronger than normal cleaning is performed. The special cleaning is performed in the second cleaning tank 29b using a cleaning liquid containing an alkaline, acidic, neutral, etc. detergent supplied to the second cleaning tank 29b, and cleaning water performed after this cleaning. The cleaning is performed in the second cleaning tank 29a using

  As described above, by moving the first sample dispensing probe 18a and the second sample dispensing probe 18b on the orbit of an arc on the same circumference, each of the first and second sample dispensing probes 18a and 18b is moved. The tubes 18a and 18b allow the sample in the sample container 11 at the sample position S1 to be dispensed to the reaction containers 16 at the first and second dispensing positions C1 and C2.

  Next, the movement timing of each of the first and second sample dispensing probes 18a and 18b for dispensing a sample will be described.

  FIG. 6 is a timing chart showing the movement timing of the first and second sample dispensing probes 18a and 18b. In this timing chart, the time zones allocated to the movement of each of the first and second sample dispensing probes 18a and 18b for dispensing a sample in each cycle are shown by convexes, and each of the first and second sample dispensing is performed. The time zone allocated to the stop of the probes 18a and 18b is indicated by a concave.

  The first sample dispensing probe 18a pivotally moves from, for example, the first cleaning tank 28a to the upper stop position of the sample position S1 during the time period of the timing T1, with the rising of the timing T1 as the start of the sample dispensing. After stopping at the upper stop position, it descends to the suction position in the sample container 11 at the sample position S1 during the time period of the timing T2. After the sample is sucked at the suction position, the sample position S1 rises to the upper stop position in the time zone of the timing T3.

  After stopping at the upper stop position of the sample position S1, the first sample dispensing probe 18a reaches the upper stop position of one of the first or second dispensing positions C1 and C2 in the time zone of the timing T4. Rotate and move. After stopping at the upper stop position, it descends to the discharge position of the reaction container 16 at one of the dispensing positions during the time period of the timing T5. After the sample is discharged into the reaction vessel 16 at the discharge position, it rises to the upper stop position of one of the dispensing positions during the time period of timing T6.

  After stopping at the upper stop position of one dispensing position, the first sample dispensing probe 18a pivotally moves to the first washing tank 28a during the time period of the timing T7. When the same sample is continuously dispensed, the operation is stopped in the first washing tank 28a until the end of the cycle. In the case of the last dispensing of the same sample, normal cleaning is performed in the first cleaning tank 28a.

  The second sample dispensing probe 18b overlaps a part of the timing T4 and a part of the timing T5 after the first sample dispensing probe 18a pivots and moves away from the upper stop position of the sample position S1. The rising of the timing T11 to be performed is defined as the start of sample dispensing. Then, during the time period of the timing T11, the rotation movement is performed from the second cleaning tank 29a to the upper stop position of the sample position S1.

  After stopping at the upper stop position of the sample position S1, the second sample dispensing probe 18b moves to the suction position of the sample in the sample container 11 at the sample position S1 in the time zone of the timing T12 overlapping part of the timing T5. Descend. After aspirating the sample at the aspiration position, it rises to the upper stop position in the time zone of timing T13 overlapping part of timing T6.

  After the second sample dispensing probe 18b stops at the upper stop position of the sample position S1, the first sample dispensing probe 18a pivotally moves to move the overlapping trajectory of the first and second trajectories TR1 and TR2. During the time period of the timing T14 that overlaps with a part of the timing chart T7 after the separation, the rotation is moved to the upper stop position of the other dispensing position of the first or second dispensing position C1, C2. After stopping at the upper stop position, the other dispenser adjacent to the reaction container 16 from which the sample has been discharged from the first sample dispensing probe 18a during the time period between the timing T5 and the timing T6 during the time period of the timing T15. It descends to the discharge position of the reaction container 16 at the position. After the sample is discharged into the reaction vessel 16 at the discharge position, it rises to the upper stop position at the other dispensing position during the time period of timing T16.

  After stopping at the upper stop position of the other dispensing position, the second sample dispensing probe 18b pivotally moves to the second washing tank 29a during the time period of the timing T17. When the same sample is continuously dispensed, the operation is stopped in the second washing tank 29a until the end of the cycle. In the case of the last dispensing of the same sample, normal washing is performed in the second washing tank 29a.

  The analysis control unit 32 dispenses first and second samples based on the analysis parameters input from the operation unit 60, the inspection items and avoidance parameters set for each sample, and the timing chart shown in FIG. The dispensing of the sample by the probes 18a and 18b is controlled. When the first and second inspection items are set for the sample in the sample container 11 at the sample position S1, one of the first and second sample dispensing probes 18a and 18b is provided during one cycle. A sample dispensing probe dispenses a sample of one of the first or second inspection items, and a sample dispensing probe dispenses a sample of one inspection item. During the same cycle as the cycle in which the sample of one inspection item is dispensed, the sample of the other inspection item is dispensed by the other sample dispensing probe.

  In addition, the analysis control unit 32 includes the first or second inspection item as an affected inspection item set as the avoidance parameter among the inspection items set for the sample in the sample container 11 at the sample position S1. In this case, when the affected test item is the first test item, the first sample dispensing probe 18a is caused to perform the dispensing of the sample of the first test item. Then, the special cleaning of the first sample dispensing probe 18a is performed during one cycle before the cycle in which dispensing of the sample is started by the first sample dispensing probe 18a. When the affected inspection item is the second inspection item, the second sample dispensing probe 18b is caused to perform the dispensing of the sample of the second inspection item. Then, the special cleaning of the second sample dispensing probe 18b is performed during one cycle before the cycle in which the dispensing of the sample is started from the second sample dispensing probe 18b.

  In addition, the analysis control unit 32 determines the influence when the first and second test items are included as the test items affected by the test items set for the sample in the sample container 11 at the sample position S1. One of the first and second sample dispensing probes 18a and 18b is caused to perform dispensing of the sample of the first and second inspection items to be received. Then, special cleaning of one sample dispensing probe is performed during one cycle before the cycle in which dispensing of the sample is started by one sample dispensing probe.

  Hereinafter, the dispensing of a sample in the automatic analyzer 100 will be described with reference to FIGS.

The analysis control unit 32 causes the sample to be dispensed based on the inspection items set for the sample in the sample container 11 stopped at the sample position S1 of the analysis unit 10.
First, with reference to FIG. 7, a description will be given of dispensing in a case where the inspection item set for the sample does not include the affected inspection item set as the avoidance parameter.

  FIG. 7 is a diagram illustrating an example of dispensing when the affected inspection item is not included in the inspection items set for the sample. In this sample P1, three first inspection items A1 to A3 and two second inspection items B1 and B2 are set.

  When the affected test item is not set, the analysis control unit 32 causes the first sample dispensing probe 18a to dispense the sample P1 of each of the first test items A1 to A3, and causes the second sample dispensing probe 18a to perform dispensing. The second sample dispensing probe 18b performs dispensing of the sample P1 of the inspection items B1 and B2.

  In the first cycle, the reaction vessels 16 of the first and second lines cleaned by the cleaning nozzle 27 stop at the first and second dispensing positions C1 and C2. The first sample dispensing probe 18a dispenses the sample P1 of the first inspection item A1 to the reaction container 16 at the first dispensing position C1. The second sample dispensing probe 18b dispenses the sample P1 of the second inspection item B1 to the reaction container 16 at the second dispensing position C2.

  In the second cycle, the reaction vessels 16 of the first and second lines cleaned by the cleaning nozzle 27 stop at the first and second dispensing positions C1 and C2. The first sample dispensing probe 18a dispenses the sample P1 of the first inspection item A2 to the reaction container 16 at the first dispensing position C1. The second sample dispensing probe 18b dispenses the sample P1 of the second inspection item B2 to the reaction container 16 at the second dispensing position C2. Thereafter, the second sample dispensing probe 18b is normally cleaned by the end of dispensing of the same sample P1.

  In the third cycle, the reaction vessels 16 of the first and second lines cleaned by the cleaning nozzle 27 stop at the first and second dispensing positions C1 and C2. The first sample dispensing probe 18a dispenses the sample P1 of the first inspection item A3 to the reaction container 16 at the first dispensing position C1. Thereafter, the first sample dispensing probe 18a is normally cleaned by the end of dispensing of the same sample P1.

  Next, with reference to FIG. 8, dispensing in a case where any one of the first and second inspection items is included as an affected inspection item among the inspection items set for the sample. Will be described.

  FIG. 8 is a diagram illustrating an example of dispensing when one of the first and second inspection items is included as an affected inspection item among the inspection items set for the sample. It is. In this sample P2, three first inspection items A1, A2, A3 and two second inspection items B1, B3 are set. The second inspection item B3 is included as an inspection item affected among the inspection items set for the sample P2.

  The analysis control unit 32 causes the first sample dispensing probe 18a to dispense the sample P2 of each of the first inspection items A1 to A3, and dispenses the sample P2 of each of the second inspection items B1 and B3. The second sample dispensing probe 18b is caused to perform this. Then, before starting the dispensing of the sample P2, the special cleaning of the second sample dispensing probe 18b is performed.

  In the first cycle, the reaction vessels 16 of the first and second lines cleaned by the cleaning nozzle 27 stop at the first and second dispensing positions C1 and C2. The first sample dispensing probe 18a is stopped in the first washing tank 28a. The special cleaning is performed on the second sample dispensing probe 18b.

  In the second cycle, the reaction vessels 16 of the first and second lines cleaned by the cleaning nozzle 27 stop at the first and second dispensing positions C1 and C2. The first sample dispensing probe 18a dispenses the sample P2 of the first inspection item A1 to the reaction container 16 at the first dispensing position C1. The second sample dispensing probe 18b dispenses the sample P2 of the second inspection item B1 to the reaction container 16 at the second dispensing position C2.

  In the third cycle, the reaction vessels 16 of the first and second lines cleaned by the cleaning nozzle 27 stop at the first and second dispensing positions C1 and C2. The first sample dispensing probe 18a dispenses the sample P2 of the first inspection item A2 to the reaction container 16 at the first dispensing position C1. The second sample dispensing probe 18b dispenses the sample P2 of the second inspection item B3 to the reaction container 16 at the second dispensing position C2. The second sample dispensing probe 18b is normally washed after dispensing the same sample P2.

  In the fourth cycle, the reaction vessels 16 of the first and second lines cleaned by the cleaning nozzle 27 stop at the first and second dispensing positions C1 and C2. The first sample dispensing probe 18a dispenses the sample P2 of the first inspection item A3 to the reaction container 16 at the first dispensing position C1. Thereafter, the first sample dispensing probe 18a is normally cleaned by the end of dispensing of the same sample P2.

  Next, with reference to FIG. 9 and FIG. 10, dispensing in a case where the first and second inspection items are included as the inspection items affected among the inspection items set for the sample will be described.

  When the first and second test items are included as the test items affected by the test items set in the sample, the first test item other than the first test item affected by the first test item is not affected. Dispensing is performed by the first sample dispensing probe 18a and dispensing of the sample of the second test item other than the affected second test item is performed by the second sample dispensing probe 18b. I do. Then, one of the first or second sample dispensing probes 18a and 18b is caused to perform dispensing of the sample of the affected first and second inspection items. A method of determining one of the sample dispensing probes as one of the first and second sample dispensing probes 18a and 18b will be described.

  The analysis control unit 32 determines the number of dispensing of the sample assuming that the dispensing of the sample of the affected first and second inspection items is performed by the first sample dispensing probe 18a. A first dispensing count is obtained by adding the number of affected second inspection items set for the sample and the number of all first inspection items set for the setting. Also, the number of dispensing of the sample, which is the number of dispensing of the sample under the assumption that the dispensing of the sample of the affected first and second inspection items is performed by the second sample dispensing probe 18b, is set in the sample. A second dispensing count is obtained by summing the number of affected first test items and the number of all second test items set for the sample. Then, it is determined to be one of the first and second sample dispensing probes 18a and 18b in which the number of dispensing operations having a small first or second dispensing frequency is assumed.

  FIG. 9 is a diagram illustrating an example of a sample in which first and second inspection items that are affected are set. In this sample P3, three first inspection items A1, A2, A4 and two second inspection items B1, B3 are set. The first and second inspection items A4 and B3 which are affected are included in the inspection items set for the sample P3.

  Here, assuming that the sample P3 of the first and second inspection items A4 and B3 is dispensed by the first sample dispensing probe 18a, the second inspection item B3 and the sample P3 are set. Four times, which is the first number of dispensing times, in which all the first inspection items A1, A2, and A4 are obtained. Further, when it is assumed that the sample P3 of the first and second inspection items A4 and B3 is dispensed by the second sample dispensing probe 18b, all the second inspection items B1 and P1 that are set to P3 are set. A third number of dispensing times, ie, three times, in which the number of B3 and the number of first inspection items A4 are totaled is determined. Then, the second sample dispensing probe 18b is assumed to have a small number of dispensing times of three.

  FIG. 10 is a diagram illustrating an example of dispensing when the first and second inspection items that are affected are included in the inspection items set for the sample.

  When the sample P3 is the sample P3 shown in FIG. 9, the analysis control unit 32 dispenses the sample P3 of the first and second inspection items A4 and B3 affected by the sample P3 to the second sample dispensing. The probe 18b is caused to perform this. Further, among the inspection items other than the first and second inspection items A4 and B3 which are set to be affected by the sample P3, the dispensing of the sample P3 of each of the first inspection items A1 and A2 is performed by the first sample dispensing. The second sample dispensing probe 18b performs dispensing of the sample P3 of the second inspection item B1. Further, the sample P3 of the first inspection item A4 is dispensed after the second inspection items B1 and B3 by the second sample dispensing probe 18b. Then, before the second sample dispensing probe 18b starts dispensing the sample P3, the second sample dispensing probe 18b is specially cleaned.

  In the first cycle, the reaction vessels 16 of the first and second lines cleaned by the cleaning nozzle 27 stop at the first and second dispensing positions C1 and C2. The first sample dispensing probe 18a is stopped in the first washing tank 28a. The special cleaning is performed on the second sample dispensing probe 18b.

  In the second cycle, the reaction vessels 16 of the first and second lines cleaned by the cleaning nozzle 27 stop at the first and second dispensing positions C1 and C2. The first sample dispensing probe 18a dispenses the sample P3 of the first inspection item A1 to the reaction container 16 at the first dispensing position C1. The second sample dispensing probe 18b dispenses the sample P3 of the second inspection item B1 to the reaction container 16 at the second dispensing position C2.

  In the third cycle, the reaction vessels 16 of the first and second lines cleaned by the cleaning nozzle 27 stop at the first and second dispensing positions C1 and C2. The first sample dispensing probe 18a dispenses the sample P3 of the first inspection item A2 to the reaction container 16 at the first dispensing position C1. After that, when the dispensing of the same sample P3 is completed, normal washing is performed. The second sample dispensing probe 18b dispenses the sample P3 of the second inspection item B3 to the reaction container 16 at the second dispensing position C2.

  In the fourth cycle, the reaction vessels 16 of the first and second lines cleaned by the cleaning nozzle 27 stop at the first and second dispensing positions C1 and C2. The second sample dispensing probe 18b dispenses the sample P3 of the first inspection item A4 to the reaction container 16 at the first dispensing position C1. After that, when the dispensing of the same sample P3 is completed, normal washing is performed.

  In this way, the first sample dispensing probe 18a is specially cleaned by causing the second sample dispensing probe 18b to perform dispensing of the sample P3 of the affected first and second inspection items A4 and B3. Can be stopped. Thereby, the amount of the cleaning liquid used for the special cleaning can be reduced.

  Further, the dispensing of the sample P3 of the first and second inspection items A4 and B3 is performed by the second sample dispensing probe 18b, as compared with the case where the first sample dispensing probe 18a is performed. The sample P3 can be dispensed with a small number of cycles. As a result, a decrease in throughput due to sample dispensing can be reduced.

  As another example of dispensing when the first and second inspection items that are affected are included in the inspection items set for the sample in the sample container 11 at the sample position S1, the affected portion is affected. When the first and second test items are dispensed by the first sample dispensing probe 18a, the number of affected second test items among the test items set for the sample and The second sample dispensing probe 18b may perform the dispensing of the sample of the first test item other than the first test item affected by the same number.

  In addition, the test items set for the sample in the sample container 11 include the first and second test items as the test items affected, and the test items of the first and second test items affected by the first and second test items are affected. When dispensing is performed by the second sample dispensing probe 18b, among the inspection items set for the sample, the number of affected second inspection items is the same as the number of affected first inspection items. The dispensing of the sample of the second inspection item may be performed by the first sample dispensing probe 18a.

  FIG. 11 is a diagram showing another example of dispensing when the affected first and second inspection items are included in the inspection items set for the sample. The difference between this dispensing and the dispensing shown in FIG. 10 is that, among the inspection items set for the sample P3, the number of the second inspection items B3 affected by the same number as the number of the first inspection items A4 affected. The point is that the sample P3 of the second inspection item B1 other than the above is made to be dispensed by the first sample dispensing probe 18a.

  In this case, the sample of the second inspection item B1 performed by the second sample dispensing probe 18b in the second cycle shown in FIG. 10 is dispensed, and the sample P3 of the first inspection item A4 is dispensed. The fourth sample is performed by the first sample dispensing probe 18a in the same cycle as the first cycle.

  In the case of the dispensing shown in FIG. 11, as shown in FIG. 12, the first sample dispensing probe 18a utilizes a cycle in which the special washing of the second sample dispensing probe 18b is performed, and the sample P3 is dispensed. May be carried out so as to perform the dispensing.

  FIG. 12 shows an example in which the sample is dispensed in a special cleaning cycle when the first and second inspection items A4 and B3 affected by the inspection items set in the sample P3 are included. FIG. This dispensing is different from the dispensing shown in FIG. 11 in comparison with the cycle in which the sample P3 of each of the first and second inspection items A1, A2, A4, B1, and B3 in FIG. 11 is dispensed. The point is that dispensing is performed in the previous cycle.

  The first sample dispensing probe 18a starts dispensing the sample P3 in the first cycle in which the special cleaning of the second sample dispensing probe 18b is performed. Then, the first inspection item A1 is dispensed in the first cycle, and the first inspection item A2 is dispensed in the second cycle. In the third cycle, the second inspection item B1 is dispensed.

  On the other hand, in the second sample dispensing probe 18b, the first test item A2 is dispensed by the first sample dispensing probe 18a in the second cycle, so that the second test is performed in the second cycle. Dispense item B3. In addition, since the second test item B1 is dispensed by the first sample dispensing probe 18a in the third cycle, the first test item A4 is dispensed in the third cycle.

  As described above, in the cycle in which one of the first and second sample dispensing probes 18a and 18b is specially washed, the dispensing of the sample is started by the other sample dispensing probe, and the other sample is dispensed. In a cycle in which the sample of one of the first or second inspection items is dispensed by the dispensing probe, the sample is dispensed by one of the sample dispensing probes so that the sample of the other inspection item can be dispensed. By changing the cycle of the inspection item for performing the dispensing, it is possible to reduce a decrease in throughput caused by dispensing the sample P3 when special cleaning is required.

  According to the above-described embodiment, when the inspection item set for the sample at the sample position S1 is the first inspection item, the first and second sample dispensing probes 18a and 18b set the first inspection item. Is dispensed into the reaction container 16 at the first dispensing position C1, and when the test item set for the sample is the second test item, the sample of the second test item is dispensed. Can be dispensed to the reaction container 16 at the second dispensing position C2.

  When one of the first or second inspection item is included as an affected inspection item among the inspection items set for the sample at the sample position S1, one of the inspection items is the second inspection item. When the first test item is the first test item, the first sample dispensing probe 18a causes the sample to be dispensed by the first sample dispensing probe 18a. Before the start, special cleaning of the first sample dispensing probe 18a can be performed. Further, when the one inspection item is the second inspection item, the second sample dispensing probe 18b is caused to perform the dispensing of the sample of the second inspection item, and the second sample dispensing is performed. The special cleaning of the second sample dispensing probe 18b can be performed before the dispensing of the sample is started by the probe 18b.

  Further, when the first and second inspection items are included as the inspection items affected among the inspection items set for the sample at the sample position S1, the relevant first and second inspection items are affected. Dispensing of a sample is performed by one of the first and second sample dispensing probes 18a and 18b, and before dispensing of the sample is started by one of the sample dispensing probes. Special cleaning of one sample dispensing probe can be performed. Thereby, the amount of the cleaning liquid used for the special cleaning can be reduced.

  Although several embodiments of the present invention have been described, these embodiments are provided by way of example and are not intended to limit the scope of the invention. These new embodiments can be implemented in other various forms, and various omissions, replacements, and changes can be made without departing from the spirit of the invention. These embodiments and their modifications are included in the scope and gist of the invention, and are also included in the invention described in the claims and their equivalents.

C1 First dispensing position C2 Second dispensing position S1 Sample position TR1 First trajectory TR2 Second trajectory 11 Sample container 12a Sample rack 16 Reaction container 18a First sample dispensing probe 18b Second sample dispensing probe 19a First moving mechanism 19b Second moving mechanism 28a, 28b First cleaning tank 29a, 29b Second cleaning tank 32 Analysis control unit

Claims (8)

In an automatic analyzer for dispensing a sample and a reagent of each test item set in the sample into a reaction container and measuring a mixed solution of the sample and the reagent in the reaction container,
The sample in the sample container, the reaction container of the first dispensing position corresponding to the first line, and, dispensable so configured to the reaction vessel of the second dispensing position corresponding to the second line, min the sample A first dispensing probe, which is normally cleaned when the injection is completed;
Samples of the sample vessel, wherein the reaction vessel first dispensing position corresponding to the first line, and, dispensable so configured to the reaction vessel of the second dispensing position corresponding to the second line A second dispensing probe, which is usually washed when dispensing of the sample is completed ,
Some test item set in the sample before Symbol sample container, if the normal certain tests that require strong special cleaning than cleaning contains multiple, the dispensing of those sample No. The special washing of the one dispensing probe is performed before the dispensing of the sample is started by the one dispensing probe. An analysis control unit to be performed,
Automatic analyzer, characterized in that it comprises a. The analysis control unit,
In a case where only the first inspection item classified into the first line is included as the specific inspection item in the inspection items set for the sample in the sample container, the first inspection item The first dispensing probe is caused to perform the dispensing of the sample by the first dispensing probe, and before the dispensing of the sample is started by the first dispensing probe, the special dispensing of the first dispensing probe is performed. Let them wash,
When only the second inspection item classified into the second line is included as the specific inspection item, the dispensing of the sample of the second inspection item is performed on the second dispensing probe. Before the dispensing of the sample by the second dispensing probe is started, the special washing of the second dispensing probe is performed,
When the first and second inspection items are included as the specific inspection item, the dispensing of the sample of the first and second inspection items is performed by the first or second dispensing probe. The one dispensing probe is performed, and before the dispensing of the sample is started by the one dispensing probe, the special cleaning of the one dispensing probe is performed.
The automatic analyzer according to claim 1, wherein: When the first and second inspection items are set in the sample in the sample container, the analysis control unit may perform one of the first or second inspection items during one cycle. The dispensing of the sample is performed by one dispensing probe of the first or second dispensing probe, and the same cycle as the dispensing of the sample of the one inspection item by the one dispensing probe is performed. 3. The automatic analyzer according to claim 2 , wherein during the cycle, the sample of the other test item is dispensed by the other dispensing probe. The analysis control unit, when the first and second test items are included as the specific test items in the test items set for the sample in the sample container, other than the first test item Dispensing the sample of the first test item in the first dispensing probe and dispensing the sample of the second test item other than the second test item in the second dispensing probe. One of the first or second dispensing probe for causing a probe to perform dispensing of the sample of the first and second test items as the specific test item is the dispensing probe. The number of the second test items as the specific test items, which is the number of times the sample is dispensed assuming that the probe is the first dispensing probe, and all the first test items set for the sample. The first number of dispensing times obtained by summing the number of inspection items of Is the number of times of dispensing of the sample when assuming that the dispensing probe is the second dispensing probe. all the sought and second dispensing times of the sum of the number of the second test item, the first or second low dispensing times of the first or second dispensing times are contemplated 4. The automatic analyzer according to claim 3 , wherein one of the dispensing probes dispenses the sample of the first and second test items as the specific test item. The analysis control unit includes the first and second test items as the specific test items in the test items set for the sample in the sample container, and the first and second test items when to perform the dispensing of the sample into the first dispensing probe, the second a same number of inspection items of inspection items, the first test item other than the first inspection item Dispensing the sample to the second dispensing probe, the first and second test items are included as the specific test items in the test items set for the sample in the sample container, When dispensing the sample of the first and second inspection items by the second dispensing probe, the number of the inspection items is the same as the number of the first inspection items, and the second inspection is performed. The first dispensing probe performs dispensing of the sample of the second inspection item other than the item. Automatic analyzer according to claim 3 or claim 4, wherein the door. A first probe support for supporting the first dispensing probe, a first vertically movable support for vertically supporting the first probe support, and a first vertically movable support for rotating the first vertically supported support; A first rotating shaft movably supported, and movably supports the first dispensing probe between the sample container and the reaction container at the first dispensing position or the second dispensing position. A first moving mechanism;
A second probe support supporting the second dispensing probe, a second vertical support supporting the second probe support so as to be vertically movable, and rotating the second vertical support. A second rotating shaft arranged coaxially with the first rotating shaft that movably supports the second dispensing probe, wherein the second dispensing probe is connected to the sample container and the first dispensing position or the second dispensing probe; The automatic analyzer according to any one of claims 1 to 5 , further comprising: a second moving mechanism that movably supports the reaction container between the dispensing positions. The reaction vessel divided into the first section and the reaction vessel divided into the second section are arranged at positions adjacent to each other on a circumference and are rotatably held by a reaction disk. The automatic analyzer according to any one of claims 1 to 6 . The specific inspection item is an inspection item that is set in advance as an inspection item that is affected by carry-over from a dispensed sample to a sample in the sample container to be dispensed next. An automatic analyzer according to any one of claims 1 to 7 , wherein:

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