JP2015536954A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015536954A5 JP2015536954A5 JP2015540915A JP2015540915A JP2015536954A5 JP 2015536954 A5 JP2015536954 A5 JP 2015536954A5 JP 2015540915 A JP2015540915 A JP 2015540915A JP 2015540915 A JP2015540915 A JP 2015540915A JP 2015536954 A5 JP2015536954 A5 JP 2015536954A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- hydrogen
- optionally substituted
- butyl
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 chloro, bromo, iodo, methyl Chemical group 0.000 claims description 162
- 229910052739 hydrogen Inorganic materials 0.000 claims description 106
- 239000001257 hydrogen Substances 0.000 claims description 106
- 150000001875 compounds Chemical class 0.000 claims description 102
- 150000002431 hydrogen Chemical class 0.000 claims description 68
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 38
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 30
- 125000001153 fluoro group Chemical group F* 0.000 claims description 30
- 150000001356 alkyl thiols Chemical class 0.000 claims description 26
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 claims description 26
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims description 26
- 125000004785 fluoromethoxy group Chemical group [H]C([H])(F)O* 0.000 claims description 26
- 150000003573 thiols Chemical class 0.000 claims description 26
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 26
- 125000004106 butoxy group Chemical group [*]OC([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims description 25
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 25
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 22
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 21
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 21
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 20
- 125000004663 dialkyl amino group Chemical group 0.000 claims description 19
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 19
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 19
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 18
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 12
- 208000035475 disorder Diseases 0.000 claims description 12
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 10
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 208000036142 Viral infection Diseases 0.000 claims description 9
- 125000006242 amine protecting group Chemical group 0.000 claims description 9
- 230000009385 viral infection Effects 0.000 claims description 9
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 7
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 7
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 7
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 6
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 6
- 206010028980 Neoplasm Diseases 0.000 claims description 6
- 125000001246 bromo group Chemical group Br* 0.000 claims description 6
- 201000011510 cancer Diseases 0.000 claims description 6
- 125000002346 iodo group Chemical group I* 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 5
- 239000012453 solvate Substances 0.000 claims description 5
- ATVJXMYDOSMEPO-UHFFFAOYSA-N 3-prop-2-enoxyprop-1-ene Chemical compound C=CCOCC=C ATVJXMYDOSMEPO-UHFFFAOYSA-N 0.000 claims description 3
- 206010005003 Bladder cancer Diseases 0.000 claims description 3
- 206010006187 Breast cancer Diseases 0.000 claims description 3
- 208000026310 Breast neoplasm Diseases 0.000 claims description 3
- QWOJMRHUQHTCJG-UHFFFAOYSA-N CC([CH2-])=O Chemical compound CC([CH2-])=O QWOJMRHUQHTCJG-UHFFFAOYSA-N 0.000 claims description 3
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 3
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 3
- DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 claims description 3
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 3
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 3
- AQEFLFZSWDEAIP-UHFFFAOYSA-N di-tert-butyl ether Chemical compound CC(C)(C)OC(C)(C)C AQEFLFZSWDEAIP-UHFFFAOYSA-N 0.000 claims description 3
- 201000004101 esophageal cancer Diseases 0.000 claims description 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 3
- GQNZGCARKRHPOH-RQIKCTSVSA-N miocamycin Chemical compound C1[C@](OC(C)=O)(C)[C@@H](OC(=O)CC)[C@H](C)O[C@H]1O[C@H]1[C@H](N(C)C)[C@@H](O)[C@H](O[C@@H]2[C@H]([C@H](OC(=O)CC)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]2CC=O)OC)O[C@@H]1C GQNZGCARKRHPOH-RQIKCTSVSA-N 0.000 claims description 3
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 3
- 201000002528 pancreatic cancer Diseases 0.000 claims description 3
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 3
- 229950010765 pivalate Drugs 0.000 claims description 3
- IUGYQRQAERSCNH-UHFFFAOYSA-N pivalic acid Chemical compound CC(C)(C)C(O)=O IUGYQRQAERSCNH-UHFFFAOYSA-N 0.000 claims description 3
- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 3
- 125000000037 tert-butyldiphenylsilyl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1[Si]([H])([*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 3
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 3
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 3
- 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 claims description 2
- NRKYWOKHZRQRJR-UHFFFAOYSA-N 2,2,2-trifluoroacetamide Chemical compound NC(=O)C(F)(F)F NRKYWOKHZRQRJR-UHFFFAOYSA-N 0.000 claims description 2
- 241000701022 Cytomegalovirus Species 0.000 claims description 2
- 241000725619 Dengue virus Species 0.000 claims description 2
- 208000005176 Hepatitis C Diseases 0.000 claims description 2
- 208000009889 Herpes Simplex Diseases 0.000 claims description 2
- 241000701044 Human gammaherpesvirus 4 Species 0.000 claims description 2
- 241000725303 Human immunodeficiency virus Species 0.000 claims description 2
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims description 2
- LHHCSNFAOIFYRV-DOVBMPENSA-N boceprevir Chemical compound O=C([C@@H]1[C@@H]2[C@@H](C2(C)C)CN1C(=O)[C@@H](NC(=O)NC(C)(C)C)C(C)(C)C)NC(C(=O)C(N)=O)CC1CCC1 LHHCSNFAOIFYRV-DOVBMPENSA-N 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 208000005252 hepatitis A Diseases 0.000 claims description 2
- 208000002672 hepatitis B Diseases 0.000 claims description 2
- AFDMODCXODAXLC-UHFFFAOYSA-N phenylmethanimine Chemical compound N=CC1=CC=CC=C1 AFDMODCXODAXLC-UHFFFAOYSA-N 0.000 claims description 2
- XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical compound C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 claims description 2
- LMYRWZFENFIFIT-UHFFFAOYSA-N toluene-4-sulfonamide Chemical compound CC1=CC=C(S(N)(=O)=O)C=C1 LMYRWZFENFIFIT-UHFFFAOYSA-N 0.000 claims description 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 2
- 101100516554 Caenorhabditis elegans nhr-5 gene Proteins 0.000 claims 1
- JJWSNOOGIUMOEE-UHFFFAOYSA-N Monomethylmercury Chemical compound [Hg]C JJWSNOOGIUMOEE-UHFFFAOYSA-N 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims 1
- 241000710772 Yellow fever virus Species 0.000 claims 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims 1
- 201000005621 esophagus lymphoma Diseases 0.000 claims 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 229940051021 yellow-fever virus Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 description 46
- 208000035269 cancer or benign tumor Diseases 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 125000004093 cyano group Chemical group *C#N 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000004614 tumor growth Effects 0.000 description 3
- HEVMDQBCAHEHDY-UHFFFAOYSA-N (Dimethoxymethyl)benzene Chemical group COC(OC)C1=CC=CC=C1 HEVMDQBCAHEHDY-UHFFFAOYSA-N 0.000 description 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 2
- 201000009030 Carcinoma Diseases 0.000 description 2
- 206010025323 Lymphomas Diseases 0.000 description 2
- 0 OC[C@]([C@](C1(F)F)O)O*1N(C=CC(NC(c1cc(Cl)cc(Cl)c1)=O)=N1)C1=O Chemical compound OC[C@]([C@](C1(F)F)O)O*1N(C=CC(NC(c1cc(Cl)cc(Cl)c1)=O)=N1)C1=O 0.000 description 2
- 239000003443 antiviral agent Substances 0.000 description 2
- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 description 2
- 229960004562 carboplatin Drugs 0.000 description 2
- 230000010261 cell growth Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- KKMXRZRAIUFWOH-VEWSYLICSA-N CC[C@H]([C@H]1O)O[C@@](C)(CN2C=CC(NC(c(c(OC)ccc3)c3OC)=O)=NC2O)C1(F)F Chemical compound CC[C@H]([C@H]1O)O[C@@](C)(CN2C=CC(NC(c(c(OC)ccc3)c3OC)=O)=NC2O)C1(F)F KKMXRZRAIUFWOH-VEWSYLICSA-N 0.000 description 1
- OSKQLTHIMAVQNG-VQIVBJKUSA-N C[C@](C(COC1CO)N(C=CC(NC(c2cc(OC)cc(OC)c2)=O)=N2)C2=O)([C@@H]1O)F Chemical compound C[C@](C(COC1CO)N(C=CC(NC(c2cc(OC)cc(OC)c2)=O)=N2)C2=O)([C@@H]1O)F OSKQLTHIMAVQNG-VQIVBJKUSA-N 0.000 description 1
- 206010019799 Hepatitis viral Diseases 0.000 description 1
- 208000003152 Yellow Fever Diseases 0.000 description 1
- 125000005157 alkyl carboxy group Chemical group 0.000 description 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 1
- 229960004316 cisplatin Drugs 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 125000001072 heteroaryl group Chemical group 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 125000002577 pseudohalo group Chemical group 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- NVBFHJWHLNUMCV-UHFFFAOYSA-N sulfamide Chemical compound NS(N)(=O)=O NVBFHJWHLNUMCV-UHFFFAOYSA-N 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- BZVJOYBTLHNRDW-UHFFFAOYSA-N triphenylmethanamine Chemical group C=1C=CC=CC=1C(C=1C=CC=CC=1)(N)C1=CC=CC=C1 BZVJOYBTLHNRDW-UHFFFAOYSA-N 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 201000001862 viral hepatitis Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261723708P | 2012-11-07 | 2012-11-07 | |
| US61/723,708 | 2012-11-07 | ||
| PCT/US2013/068965 WO2014074725A1 (en) | 2012-11-07 | 2013-11-07 | Substituted gemcitabine aryl amide analogs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015536954A JP2015536954A (ja) | 2015-12-24 |
| JP2015536954A5 true JP2015536954A5 (enExample) | 2016-12-15 |
Family
ID=50685152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015540915A Pending JP2015536954A (ja) | 2012-11-07 | 2013-11-07 | 置換ゲムシタビンアリールアミド類似体 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9447137B2 (enExample) |
| EP (1) | EP2916840B1 (enExample) |
| JP (1) | JP2015536954A (enExample) |
| CN (1) | CN104955458A (enExample) |
| CA (1) | CA2890359A1 (enExample) |
| WO (1) | WO2014074725A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9447137B2 (en) | 2012-11-07 | 2016-09-20 | Nucorion Pharmaceuticals, Inc. | Substituted gemcitabine aryl amide analogs |
| WO2014145207A1 (en) | 2013-03-15 | 2014-09-18 | Ohio State Innovation Foundation | Substituted gemcitabine bicyclic amide analogs and treatment methods using same |
| WO2015134334A1 (en) * | 2014-03-03 | 2015-09-11 | Suo Zucai | Gemcitabine analogs |
| EA033046B1 (ru) * | 2014-06-25 | 2019-08-30 | НУКАНА ПиЭлСи | Состав, содержащий пролекарство гемцитабина |
| US20200069630A1 (en) * | 2016-07-11 | 2020-03-05 | Hennipen Life Sciences, Llc | Compositions for sexually transmitted diseases |
| US10435429B2 (en) | 2017-10-03 | 2019-10-08 | Nucorion Pharmaceuticals, Inc. | 5-fluorouridine monophosphate cyclic triester compounds |
| AU2019207626B2 (en) | 2018-01-10 | 2023-10-05 | Nucorion Pharmaceuticals, Inc. | Phosphor(n)amidatacetal and phosph(on)atalcetal compounds |
| US11427550B2 (en) | 2018-01-19 | 2022-08-30 | Nucorion Pharmaceuticals, Inc. | 5-fluorouracil compounds |
| KR20200118827A (ko) | 2018-02-02 | 2020-10-16 | 마베릭스 온콜로지, 잉크. | 젬시타빈 모노포스페이트의 소분자 약물 컨쥬게이트 |
| WO2021011692A1 (en) | 2019-07-17 | 2021-01-21 | Nucorion Pharmaceuticals, Inc. | Cyclic deoxyribonucleotide compounds |
| EP4143199B1 (en) | 2020-04-21 | 2025-11-19 | Ligand Pharmaceuticals, Inc. | Nucleotide prodrug compounds |
| WO2021216431A1 (en) | 2020-04-21 | 2021-10-28 | Ligand Pharmaceuticals, Inc. | Benzyloxy phosph(on)ate compounds |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61204193A (ja) * | 1985-03-05 | 1986-09-10 | Takeda Chem Ind Ltd | シトシンヌクレオシド類の製造法 |
| CA1327358C (en) * | 1987-11-17 | 1994-03-01 | Morio Fujiu | Fluoro cytidine derivatives |
| CA2416527C (en) * | 2000-08-10 | 2009-12-22 | Pharmacia Italia S.P.A. | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
| KR20050035194A (ko) * | 2002-06-28 | 2005-04-15 | 이데닉스 (케이만) 리미티드 | 플라비비리다에 감염 치료용 2'-ｃ-메틸-3'-ｏ-ｌ-발린에스테르 리보푸라노실 사이티딘 |
| ES2310860T3 (es) | 2004-12-17 | 2009-01-16 | Eli Lilly And Company | Profarmaco amida de gemcitabina, composiciones y uso del mismo. |
| ES2436404T3 (es) * | 2005-10-03 | 2013-12-30 | University Health Network | Inhibidores ODCasa para el tratamiento de malaria |
| JP2009531284A (ja) * | 2006-02-06 | 2009-09-03 | ドクター レディズ ラボラトリーズ リミテッド | ゲムシタビンの調製 |
| FR2907786B1 (fr) * | 2006-10-27 | 2009-09-18 | Univ Grenoble 1 | Thionucleosides et applications pharmaceutiques |
| WO2008030373A2 (en) | 2006-09-01 | 2008-03-13 | University Of Georgia Research Foundation, Inc. | L- oddc prodrugs for cancer |
| US8741858B2 (en) * | 2007-09-21 | 2014-06-03 | Zhongxu Ren | Oligomer-nucleoside phosphate conjugates |
| WO2009061781A1 (en) * | 2007-11-07 | 2009-05-14 | Schering Corporation | Novel modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors |
| WO2010027326A1 (en) * | 2008-09-03 | 2010-03-11 | Nanyang Technological University | Peptide nucleic acid monomers and oligomers |
| EP2393472B1 (en) * | 2008-12-05 | 2019-06-05 | NanoMed Holdings Pty Ltd | Amphiphile prodrugs |
| CN101525361B (zh) * | 2009-04-21 | 2010-11-17 | 济南圣鲁金药物技术开发有限公司 | 基于吉西他滨结构的前药及其合成方法及应用 |
| CN101921303A (zh) * | 2009-06-09 | 2010-12-22 | 曾慧慧 | 苯并异硒唑酮二氟胞苷类化合物及其制备方法和其用途 |
| US20120070411A1 (en) * | 2010-09-22 | 2012-03-22 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
| SI2827875T1 (sl) | 2012-03-21 | 2019-04-30 | Alios Biopharma, Inc. | Substituirani nukleozidi, nukleotidi in njihovi analogi |
| US9872919B2 (en) * | 2012-09-19 | 2018-01-23 | The Research Foundation For The State University Of New York | Prodrugs for selective anticancer therapy |
| US9447137B2 (en) * | 2012-11-07 | 2016-09-20 | Nucorion Pharmaceuticals, Inc. | Substituted gemcitabine aryl amide analogs |
| WO2014145207A1 (en) | 2013-03-15 | 2014-09-18 | Ohio State Innovation Foundation | Substituted gemcitabine bicyclic amide analogs and treatment methods using same |
| WO2015134334A1 (en) | 2014-03-03 | 2015-09-11 | Suo Zucai | Gemcitabine analogs |
-
2013
- 2013-11-07 US US14/440,811 patent/US9447137B2/en not_active Expired - Fee Related
- 2013-11-07 JP JP2015540915A patent/JP2015536954A/ja active Pending
- 2013-11-07 CA CA2890359A patent/CA2890359A1/en not_active Abandoned
- 2013-11-07 WO PCT/US2013/068965 patent/WO2014074725A1/en not_active Ceased
- 2013-11-07 EP EP13853078.7A patent/EP2916840B1/en not_active Not-in-force
- 2013-11-07 CN CN201380069308.5A patent/CN104955458A/zh active Pending
-
2016
- 2016-08-08 US US15/231,310 patent/US9744186B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2019231725B2 (en) | 4'-halogen containing nucleotide and nucleoside therapeutic compositions and uses related thereto | |
| RU2015126795A (ru) | Минующие нуклеозид киназу композиции и способы их получения и применения | |
| JP2016529324A5 (enExample) | ||
| JP2017536344A5 (enExample) | ||
| JP2020532532A5 (enExample) | ||
| RU2015126856A (ru) | Дисульфидные маскированные пролекарственные композиции и способы | |
| JP2016506916A5 (enExample) | ||
| JP2009524696A5 (enExample) | ||
| JP2015520143A5 (enExample) | ||
| JP2018504379A5 (enExample) | ||
| JP2018518201A5 (enExample) | ||
| JP2011500713A5 (enExample) | ||
| JP2018517686A5 (enExample) | ||
| JP2019537599A5 (enExample) | ||
| JP2016040288A5 (enExample) | ||
| JP2019511483A5 (enExample) | ||
| JP2008510770A5 (enExample) | ||
| JP2016519062A5 (enExample) | ||
| JP2011529918A5 (enExample) | ||
| JP2010513523A5 (enExample) | ||
| JP2016515561A5 (enExample) | ||
| JP2017526677A5 (enExample) | ||
| JP2008200039A5 (enExample) | ||
| JP2011501962A5 (enExample) | ||
| JP2015531760A5 (enExample) |