JP2015534980A5 - - Google Patents
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- Publication number
- JP2015534980A5 JP2015534980A5 JP2015537793A JP2015537793A JP2015534980A5 JP 2015534980 A5 JP2015534980 A5 JP 2015534980A5 JP 2015537793 A JP2015537793 A JP 2015537793A JP 2015537793 A JP2015537793 A JP 2015537793A JP 2015534980 A5 JP2015534980 A5 JP 2015534980A5
- Authority
- JP
- Japan
- Prior art keywords
- halobetasol
- external
- lotion composition
- composition
- lotion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 35
- 239000006210 lotion Substances 0.000 claims 28
- BDSYKGHYMJNPAB-LICBFIPMSA-N ulobetasol propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H](C)[C@@](C(=O)CCl)(OC(=O)CC)[C@@]2(C)C[C@@H]1O BDSYKGHYMJNPAB-LICBFIPMSA-N 0.000 claims 19
- 229940115747 halobetasol Drugs 0.000 claims 17
- 229940100617 topical lotion Drugs 0.000 claims 16
- 150000002191 fatty alcohols Chemical class 0.000 claims 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 9
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims 8
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims 8
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 claims 7
- 229940031578 diisopropyl adipate Drugs 0.000 claims 7
- 238000003860 storage Methods 0.000 claims 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 6
- 239000002245 particle Substances 0.000 claims 6
- 230000015556 catabolic process Effects 0.000 claims 5
- 238000006731 degradation reaction Methods 0.000 claims 5
- 239000003906 humectant Substances 0.000 claims 5
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 claims 4
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 claims 4
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 claims 4
- 229960000541 cetyl alcohol Drugs 0.000 claims 4
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims 4
- 229920005862 polyol Polymers 0.000 claims 4
- 150000003077 polyols Chemical class 0.000 claims 4
- 239000003755 preservative agent Substances 0.000 claims 4
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical group CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims 4
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 claims 4
- 239000008346 aqueous phase Substances 0.000 claims 3
- 238000009826 distribution Methods 0.000 claims 3
- 239000000839 emulsion Substances 0.000 claims 3
- 235000011187 glycerol Nutrition 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000007764 o/w emulsion Substances 0.000 claims 3
- 239000003002 pH adjusting agent Substances 0.000 claims 3
- 230000002335 preservative effect Effects 0.000 claims 3
- 239000004094 surface-active agent Substances 0.000 claims 3
- 239000004034 viscosity adjusting agent Substances 0.000 claims 3
- FDCJDKXCCYFOCV-UHFFFAOYSA-N 1-hexadecoxyhexadecane Chemical compound CCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCC FDCJDKXCCYFOCV-UHFFFAOYSA-N 0.000 claims 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims 2
- 229940067596 butylparaben Drugs 0.000 claims 2
- 239000006071 cream Substances 0.000 claims 2
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims 2
- 229940043348 myristyl alcohol Drugs 0.000 claims 2
- 239000012071 phase Substances 0.000 claims 2
- 229940113116 polyethylene glycol 1000 Drugs 0.000 claims 2
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims 2
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims 2
- 229960003415 propylparaben Drugs 0.000 claims 2
- 208000017520 skin disease Diseases 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims 1
- 229940043375 1,5-pentanediol Drugs 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 229910000640 Fe alloy Inorganic materials 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 1
- 229910052782 aluminium Inorganic materials 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000004140 cleaning Methods 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims 1
- 229940113120 dipropylene glycol Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 238000007046 ethoxylation reaction Methods 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 229940051250 hexylene glycol Drugs 0.000 claims 1
- 230000036571 hydration Effects 0.000 claims 1
- 238000006703 hydration reaction Methods 0.000 claims 1
- 230000003020 moisturizing effect Effects 0.000 claims 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims 1
- 239000002304 perfume Substances 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 229920003023 plastic Polymers 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 239000011253 protective coating Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 229940012831 stearyl alcohol Drugs 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000036572 transepidermal water loss Effects 0.000 claims 1
- 229950008396 ulobetasol propionate Drugs 0.000 claims 1
- 229940020901 ultravate Drugs 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261715467P | 2012-10-18 | 2012-10-18 | |
| US61/715,467 | 2012-10-18 | ||
| US13/921,859 | 2013-06-19 | ||
| US13/921,833 US8962028B2 (en) | 2012-10-18 | 2013-06-19 | Topical steroid composition and method |
| US13/921,859 US20140112959A1 (en) | 2012-10-18 | 2013-06-19 | Topical steroid composition and method |
| US13/921,833 | 2013-06-19 | ||
| PCT/US2013/065266 WO2014062817A1 (en) | 2012-10-18 | 2013-10-16 | Topical steroid composition and method |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015534980A JP2015534980A (ja) | 2015-12-07 |
| JP2015534980A5 true JP2015534980A5 (cg-RX-API-DMAC7.html) | 2016-11-17 |
| JP6385938B2 JP6385938B2 (ja) | 2018-09-05 |
Family
ID=50485547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015537793A Expired - Fee Related JP6385938B2 (ja) | 2012-10-18 | 2013-10-16 | 外用ステロイド組成物および方法 |
Country Status (19)
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11957753B2 (en) | 2010-11-22 | 2024-04-16 | Bausch Health Ireland Limited | Pharmaceutical formulations containing corticosteroids for topical administration |
| US8809307B2 (en) | 2010-11-22 | 2014-08-19 | Dow Pharmaceutical Sciences, Inc. | Pharmaceutical formulations containing corticosteroids for topical administration |
| US10251895B2 (en) | 2015-06-18 | 2019-04-09 | Valeant Pharmaceuticals North America | Topical compositions and methods for treating psoriasis |
| US11311482B2 (en) | 2017-05-12 | 2022-04-26 | Bausch Health Us, Llc | Topical compositions and methods for treating skin diseases |
| US9895359B1 (en) | 2017-06-07 | 2018-02-20 | Arcutis, Inc. | Inhibition of crystal growth of roflumilast |
| US12042487B2 (en) | 2018-11-16 | 2024-07-23 | Arcutis Biotherapeutics, Inc. | Method for reducing side effects from administration of phosphodiesterase-4 inhibitors |
| US12011437B1 (en) | 2017-06-07 | 2024-06-18 | Arcutis Biotherapeutics, Inc. | Roflumilast formulations with an improved pharmacokinetic profile |
| US20200155524A1 (en) | 2018-11-16 | 2020-05-21 | Arcutis, Inc. | Method for reducing side effects from administration of phosphodiesterase-4 inhibitors |
| US20210161870A1 (en) | 2017-06-07 | 2021-06-03 | Arcutis Biotherapeutics, Inc. | Roflumilast formulations with an improved pharmacokinetic profile |
| US11129818B2 (en) | 2017-06-07 | 2021-09-28 | Arcutis Biotherapeutics, Inc. | Topical roflumilast formulation having improved delivery and plasma half life |
| US11534382B2 (en) | 2017-06-19 | 2022-12-27 | Novan, Inc. | Topical compositions and methods of using the same |
| CA3102689C (en) | 2018-06-04 | 2023-08-29 | Arcutis, Inc. | Method and formulation for improving roflumilast skin penetration lag time |
| JP2022525221A (ja) | 2019-03-14 | 2022-05-11 | クレシタ セラピューティクス インコーポレイテッド | 洗い流し組成物および活性剤を送達するためのそれらの使用 |
| CN109833291B (zh) * | 2019-04-03 | 2022-08-26 | 普霖贝利生物医药研发(上海)有限公司 | 一种稳定的丙酸氯倍他索软膏及其制备方法 |
| KR20230146513A (ko) | 2020-12-04 | 2023-10-19 | 아큐티스 바이오테라퓨틱스, 인크. | 항진균 특성을 갖는 국소 로플루밀라스트 제형 |
| IL313866A (en) | 2021-12-28 | 2024-08-01 | Arcutis Biotherapeutics Inc | Topical roflomilest spray foams |
| WO2024058848A1 (en) | 2022-09-15 | 2024-03-21 | Arcutis Biotherapeutics, Inc. | Pharmaceutical compositions of roflumilast and solvents capable of dissolving high amounts of the drug |
| US12059430B2 (en) | 2022-09-29 | 2024-08-13 | Adora Animal Health Corporation | Storage stable formulations of sulfated glycosaminoglycans and fragments derived therefrom for the treatment of pain and other medical conditions |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2655570A1 (de) | 1975-12-12 | 1977-06-16 | Ciba Geigy Ag | Neue polyhalogensteroide und verfahren zu ihrer herstellung |
| DE3225848A1 (de) * | 1982-07-07 | 1984-01-19 | Schering AG, 1000 Berlin und 4709 Bergkamen | Kortikoidhaltige zubereitung zur topischen applikation |
| US5064655A (en) | 1989-02-24 | 1991-11-12 | Liposome Technology, Inc. | Liposome gel composition and method |
| US5219877A (en) | 1989-09-25 | 1993-06-15 | Bristol-Myers Squibb Company | Lauryl alcohol as skin penetration enhancer for topical imidazole agents |
| TW218849B (cg-RX-API-DMAC7.html) * | 1991-05-17 | 1994-01-11 | Bristol Myers Squibb Co | |
| US5326566A (en) | 1991-05-17 | 1994-07-05 | Bristol-Myers Squibb Company | Use of dibutyl adipate and isopropyl myristate in topical and transdermal products |
| CA2143515A1 (en) | 1994-03-22 | 1995-09-23 | Prakash Parab | Method for enhancing the rate of skin permeation of lactic acid through use of the l-enantiomer |
| US6647058B1 (en) | 1997-06-23 | 2003-11-11 | Paradyne Corporation | Performance customization system and process for optimizing XDSL performance |
| US6171985B1 (en) | 1997-12-01 | 2001-01-09 | 3M Innovative Properties Company | Low trauma adhesive article |
| US6673374B2 (en) | 1998-07-31 | 2004-01-06 | Howard Murad | Pharmaceutical compositions and methods for managing skin conditions |
| US6315980B1 (en) | 1998-09-25 | 2001-11-13 | Shiseido Company, Ltd. | Skin barrier function recovery and promotion composition and evaluation method thereof |
| WO2000040250A1 (fr) * | 1999-01-06 | 2000-07-13 | Taisho Pharmaceutical Co.,Ltd. | Lotion a base d'amelometasone |
| US6495126B1 (en) | 1999-07-20 | 2002-12-17 | Mary Kay Inc. | Treatment and composition for achieving skin anti-aging benefits by corneum protease activation |
| US6656928B1 (en) | 1999-09-02 | 2003-12-02 | Mccadden Michael E. | Composition for the topical treatment of rashes, dermatoses and lesions |
| US6479058B1 (en) * | 1999-09-02 | 2002-11-12 | Mccadden Michael E. | Composition for the topical treatment of poison ivy and other forms of contact dermatitis |
| US6967023B1 (en) | 2000-01-10 | 2005-11-22 | Foamix, Ltd. | Pharmaceutical and cosmetic carrier or composition for topical application |
| US6756032B1 (en) | 2000-07-12 | 2004-06-29 | The Procter & Gamble Company | Method to enhance and/or prolong the effects of a primary challenge to a responsive system with a secondary challenge |
| US6387383B1 (en) | 2000-08-03 | 2002-05-14 | Dow Pharmaceutical Sciences | Topical low-viscosity gel composition |
| US6790203B2 (en) | 2000-12-20 | 2004-09-14 | Sca Hygiene Products Ab | Absorbent product comprising leakage barriers |
| US6830758B2 (en) | 2001-04-02 | 2004-12-14 | Lectec Corporation | Psoriasis patch |
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| US6765001B2 (en) * | 2001-12-21 | 2004-07-20 | Medicis Pharmaceutical Corporation | Compositions and methods for enhancing corticosteroid delivery |
| US7704518B2 (en) | 2003-08-04 | 2010-04-27 | Foamix, Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
| US7208485B2 (en) | 2003-01-13 | 2007-04-24 | Chemagis Ltd. | Crystalline forms of halobetasol propionate |
| US7186416B2 (en) | 2003-05-28 | 2007-03-06 | Stiefel Laboratories, Inc. | Foamable pharmaceutical compositions and methods for treating a disorder |
| US8016811B2 (en) | 2003-10-24 | 2011-09-13 | Altea Therapeutics Corporation | Method for transdermal delivery of permeant substances |
| US20050153946A1 (en) * | 2003-12-24 | 2005-07-14 | Collegium Pharmaceuticals, Inc. | Temperature-stable formulations, and methods of development thereof |
| EP1727530A4 (en) | 2004-02-19 | 2009-10-21 | Chemaphor Inc | TOPICAL FORMULATIONS FOR THE TREATMENT OF DERMATOLOGICAL CONDITIONS |
| US8741333B2 (en) | 2004-06-07 | 2014-06-03 | Nuvo Research Inc. | Compositions and methods for treating dermatitis or psoriasis |
| US20070196457A1 (en) | 2004-06-07 | 2007-08-23 | Jie Zhang | Two or more volatile solvent-containing compositions and methods for dermal delivery of drugs |
| US20070189980A1 (en) | 2004-06-07 | 2007-08-16 | Jie Zhang | Compositions and methods for treating alopecia |
| ES2620363T3 (es) | 2004-12-21 | 2017-06-28 | Musc Foundation For Research Development | Composiciones y métodos para promover la cicatrización de heridas y la regeneración tisular |
| US20070167420A1 (en) * | 2005-04-07 | 2007-07-19 | Daniella Gutman | Process for preparing a crystalline form of halobetasol propionate |
| EP1985287A3 (en) | 2007-04-25 | 2009-04-29 | Teva Pharmaceutical Industries Ltd. | Pharmaceutical Excipient Complex |
| WO2009063493A2 (en) * | 2007-09-10 | 2009-05-22 | Glenmark Pharmaceuticals Limited | Topical pharmaceutical composition for the combination of fusidic acid and a corticosteroid |
| CH701253A1 (de) | 2009-06-12 | 2010-12-15 | Mibelle Ag | Verwendung eines Extraktes aus Schneealgen in kosmetischen oder dermatologischen Formulierungen. |
| US8809307B2 (en) * | 2010-11-22 | 2014-08-19 | Dow Pharmaceutical Sciences, Inc. | Pharmaceutical formulations containing corticosteroids for topical administration |
-
2013
- 2013-06-19 US US13/921,833 patent/US8962028B2/en active Active
- 2013-06-19 US US13/921,859 patent/US20140112959A1/en not_active Abandoned
- 2013-10-16 AU AU2013331271A patent/AU2013331271B2/en not_active Ceased
- 2013-10-16 EP EP13795611.6A patent/EP2919753A1/en not_active Withdrawn
- 2013-10-16 AP AP2015008420A patent/AP2015008420A0/xx unknown
- 2013-10-16 EA EA201590730A patent/EA029494B1/ru unknown
- 2013-10-16 UA UAA201504666A patent/UA115073C2/uk unknown
- 2013-10-16 BR BR112015008951A patent/BR112015008951A2/pt not_active Application Discontinuation
- 2013-10-16 MX MX2015004863A patent/MX371362B/es active IP Right Grant
- 2013-10-16 NZ NZ706918A patent/NZ706918A/en not_active IP Right Cessation
- 2013-10-16 IN IN4160DEN2015 patent/IN2015DN04160A/en unknown
- 2013-10-16 CN CN201380066518.9A patent/CN104884043B/zh not_active Expired - Fee Related
- 2013-10-16 CA CA2888853A patent/CA2888853C/en active Active
- 2013-10-16 SG SG11201502931YA patent/SG11201502931YA/en unknown
- 2013-10-16 MY MYPI2015701229A patent/MY179354A/en unknown
- 2013-10-16 WO PCT/US2013/065266 patent/WO2014062817A1/en not_active Ceased
- 2013-10-16 JP JP2015537793A patent/JP6385938B2/ja not_active Expired - Fee Related
- 2013-10-16 KR KR1020157012541A patent/KR101832041B1/ko not_active Expired - Fee Related
-
2015
- 2015-01-09 US US14/593,272 patent/US20150119827A1/en not_active Abandoned
- 2015-04-17 PH PH12015500859A patent/PH12015500859B1/en unknown
- 2015-04-21 ZA ZA2015/02692A patent/ZA201502692B/en unknown
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