JP2015534972A5 - - Google Patents
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- Publication number
- JP2015534972A5 JP2015534972A5 JP2015537289A JP2015537289A JP2015534972A5 JP 2015534972 A5 JP2015534972 A5 JP 2015534972A5 JP 2015537289 A JP2015537289 A JP 2015537289A JP 2015537289 A JP2015537289 A JP 2015537289A JP 2015534972 A5 JP2015534972 A5 JP 2015534972A5
- Authority
- JP
- Japan
- Prior art keywords
- lys
- arg
- phe
- gly
- trp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 claims 71
- 125000000539 amino acid group Chemical group 0.000 claims 33
- 108090000765 processed proteins & peptides Proteins 0.000 claims 29
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 26
- KZSNJWFQEVHDMF-SCSAIBSYSA-N D-valine Chemical compound CC(C)[C@@H](N)C(O)=O KZSNJWFQEVHDMF-SCSAIBSYSA-N 0.000 claims 25
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 21
- ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical compound OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 claims 18
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- -1 Ac-Lys-Gly- Lys Chemical compound 0.000 claims 9
- 101100512078 Caenorhabditis elegans lys-1 gene Proteins 0.000 claims 8
- 101100129088 Caenorhabditis elegans lys-2 gene Proteins 0.000 claims 7
- 210000000056 organ Anatomy 0.000 claims 7
- 150000005693 branched-chain amino acids Chemical class 0.000 claims 5
- 239000000523 sample Substances 0.000 claims 5
- KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 claims 4
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 4
- 238000001356 surgical procedure Methods 0.000 claims 4
- PQBHGSGQZSOLIR-RYUDHWBXSA-N Arg-Phe Chemical compound NC(N)=NCCC[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 PQBHGSGQZSOLIR-RYUDHWBXSA-N 0.000 claims 3
- GSUFZRURORXYTM-STQMWFEESA-N Arg-Phe-Gly Chemical compound NC(N)=NCCC[C@H](N)C(=O)N[C@H](C(=O)NCC(O)=O)CC1=CC=CC=C1 GSUFZRURORXYTM-STQMWFEESA-N 0.000 claims 3
- 101100455752 Caenorhabditis elegans lys-3 gene Proteins 0.000 claims 3
- YSPZCHGIWAQVKQ-AVGNSLFASA-N Lys-Pro-Val Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN YSPZCHGIWAQVKQ-AVGNSLFASA-N 0.000 claims 3
- 108010060534 MSH (11-13) Proteins 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 210000002216 heart Anatomy 0.000 claims 3
- 241000024188 Andala Species 0.000 claims 2
- 208000012659 Joint disease Diseases 0.000 claims 2
- 206010051379 Systemic Inflammatory Response Syndrome Diseases 0.000 claims 2
- 210000004204 blood vessel Anatomy 0.000 claims 2
- 230000004968 inflammatory condition Effects 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 230000000302 ischemic effect Effects 0.000 claims 2
- 210000003734 kidney Anatomy 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- 108010054155 lysyllysine Proteins 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 230000002980 postoperative effect Effects 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- XDEHMKQLKPZERH-BYPYZUCNSA-N (2s)-2-amino-3-methylbutanamide Chemical compound CC(C)[C@H](N)C(N)=O XDEHMKQLKPZERH-BYPYZUCNSA-N 0.000 claims 1
- RRBGTUQJDFBWNN-MUGJNUQGSA-N (2s)-6-amino-2-[[(2s)-6-amino-2-[[(2s)-6-amino-2-[[(2s)-2,6-diaminohexanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoic acid Chemical compound NCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O RRBGTUQJDFBWNN-MUGJNUQGSA-N 0.000 claims 1
- TVEXGJYMHHTVKP-UHFFFAOYSA-N 6-oxabicyclo[3.2.1]oct-3-en-7-one Chemical compound C1C2C(=O)OC1C=CC2 TVEXGJYMHHTVKP-UHFFFAOYSA-N 0.000 claims 1
- 206010002329 Aneurysm Diseases 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 208000036487 Arthropathies Diseases 0.000 claims 1
- 201000000057 Coronary Stenosis Diseases 0.000 claims 1
- 208000017189 Gastrointestinal inflammatory disease Diseases 0.000 claims 1
- 201000005569 Gout Diseases 0.000 claims 1
- 208000010496 Heart Arrest Diseases 0.000 claims 1
- 208000001953 Hypotension Diseases 0.000 claims 1
- QOOWRKBDDXQRHC-BQBZGAKWSA-N L-lysyl-L-alanine Chemical compound OC(=O)[C@H](C)NC(=O)[C@@H](N)CCCCN QOOWRKBDDXQRHC-BQBZGAKWSA-N 0.000 claims 1
- OBSIQMZKFXFYLV-QMMMGPOBSA-N L-phenylalanine amide Chemical compound NC(=O)[C@@H](N)CC1=CC=CC=C1 OBSIQMZKFXFYLV-QMMMGPOBSA-N 0.000 claims 1
- WSXTWLJHTLRFLW-SRVKXCTJSA-N Lys-Ala-Lys Chemical compound NCCCC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(O)=O WSXTWLJHTLRFLW-SRVKXCTJSA-N 0.000 claims 1
- NPBGTPKLVJEOBE-IUCAKERBSA-N Lys-Arg Chemical compound NCCCC[C@H](N)C(=O)N[C@H](C(O)=O)CCCNC(N)=N NPBGTPKLVJEOBE-IUCAKERBSA-N 0.000 claims 1
- SJNZALDHDUYDBU-IHRRRGAJSA-N Lys-Arg-Lys Chemical compound NCCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(O)=O SJNZALDHDUYDBU-IHRRRGAJSA-N 0.000 claims 1
- HGNRJCINZYHNOU-LURJTMIESA-N Lys-Gly Chemical compound NCCCC[C@H](N)C(=O)NCC(O)=O HGNRJCINZYHNOU-LURJTMIESA-N 0.000 claims 1
- NKKFVJRLCCUJNA-QWRGUYRKSA-N Lys-Gly-Lys Chemical compound NCCCC[C@H](N)C(=O)NCC(=O)N[C@H](C(O)=O)CCCCN NKKFVJRLCCUJNA-QWRGUYRKSA-N 0.000 claims 1
- IGRMTQMIDNDFAA-UWVGGRQHSA-N Lys-His Chemical compound NCCCC[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CN=CN1 IGRMTQMIDNDFAA-UWVGGRQHSA-N 0.000 claims 1
- FGMHXLULNHTPID-KKUMJFAQSA-N Lys-His-Lys Chemical compound NCCCC[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(O)=O)CC1=CN=CN1 FGMHXLULNHTPID-KKUMJFAQSA-N 0.000 claims 1
- NVGBPTNZLWRQSY-UWVGGRQHSA-N Lys-Lys Chemical compound NCCCC[C@H](N)C(=O)N[C@H](C(O)=O)CCCCN NVGBPTNZLWRQSY-UWVGGRQHSA-N 0.000 claims 1
- XOQMURBBIXRRCR-SRVKXCTJSA-N Lys-Lys-Ala Chemical compound OC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN XOQMURBBIXRRCR-SRVKXCTJSA-N 0.000 claims 1
- ZJWIXBZTAAJERF-IHRRRGAJSA-N Lys-Lys-Arg Chemical compound NCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(O)=O)CCCN=C(N)N ZJWIXBZTAAJERF-IHRRRGAJSA-N 0.000 claims 1
- YUAXTFMFMOIMAM-QWRGUYRKSA-N Lys-Lys-Gly Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(O)=O YUAXTFMFMOIMAM-QWRGUYRKSA-N 0.000 claims 1
- WBSCNDJQPKSPII-KKUMJFAQSA-N Lys-Lys-Lys Chemical compound NCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O WBSCNDJQPKSPII-KKUMJFAQSA-N 0.000 claims 1
- LUTDBHBIHHREDC-IHRRRGAJSA-N Lys-Pro-Lys Chemical compound NCCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(O)=O LUTDBHBIHHREDC-IHRRRGAJSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000009525 Myocarditis Diseases 0.000 claims 1
- 206010028665 Myxoedema Diseases 0.000 claims 1
- 206010056675 Postoperative renal failure Diseases 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 206010040070 Septic Shock Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 206010047163 Vasospasm Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 238000012084 abdominal surgery Methods 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000002255 anal canal Anatomy 0.000 claims 1
- 210000000709 aorta Anatomy 0.000 claims 1
- 208000007474 aortic aneurysm Diseases 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 210000001367 artery Anatomy 0.000 claims 1
- 230000003143 atherosclerotic effect Effects 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 238000007675 cardiac surgery Methods 0.000 claims 1
- 230000002612 cardiopulmonary effect Effects 0.000 claims 1
- 238000013132 cardiothoracic surgery Methods 0.000 claims 1
- 210000001168 carotid artery common Anatomy 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000010102 embolization Effects 0.000 claims 1
- 206010014665 endocarditis Diseases 0.000 claims 1
- 210000003372 endocrine gland Anatomy 0.000 claims 1
- 210000003499 exocrine gland Anatomy 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- BEBCJVAWIBVWNZ-UHFFFAOYSA-N glycinamide Chemical group NCC(N)=O BEBCJVAWIBVWNZ-UHFFFAOYSA-N 0.000 claims 1
- 210000003709 heart valve Anatomy 0.000 claims 1
- 230000036543 hypotension Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 108010064235 lysylglycine Proteins 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 208000003786 myxedema Diseases 0.000 claims 1
- 230000004768 organ dysfunction Effects 0.000 claims 1
- 210000003101 oviduct Anatomy 0.000 claims 1
- 208000008494 pericarditis Diseases 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 210000000664 rectum Anatomy 0.000 claims 1
- 230000001850 reproductive effect Effects 0.000 claims 1
- 230000036303 septic shock Effects 0.000 claims 1
- 210000002356 skeleton Anatomy 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
- 210000000952 spleen Anatomy 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261716032P | 2012-10-19 | 2012-10-19 | |
| US61/716,032 | 2012-10-19 | ||
| PCT/EP2013/071935 WO2014060606A1 (en) | 2012-10-19 | 2013-10-21 | Alpha- and gamma-msh analogues |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015534972A JP2015534972A (ja) | 2015-12-07 |
| JP2015534972A5 true JP2015534972A5 (https=) | 2016-12-08 |
| JP6429782B2 JP6429782B2 (ja) | 2018-11-28 |
Family
ID=49448156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015537289A Active JP6429782B2 (ja) | 2012-10-19 | 2013-10-21 | アルファ−およびガンマ−ｍｓｈアナログ |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US9217023B2 (https=) |
| EP (2) | EP2944650A1 (https=) |
| JP (1) | JP6429782B2 (https=) |
| CN (1) | CN104822702B (https=) |
| AU (1) | AU2013333765B2 (https=) |
| CA (1) | CA2888277C (https=) |
| DK (1) | DK2722340T3 (https=) |
| ES (1) | ES2538702T3 (https=) |
| HU (1) | HUE025870T2 (https=) |
| PL (1) | PL2722340T3 (https=) |
| RU (1) | RU2668791C2 (https=) |
| WO (1) | WO2014060606A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2668791C2 (ru) | 2012-10-19 | 2018-10-02 | ТиЭксПи ФАРМА ГМБХ | АНАЛОГИ АЛЬФА- и ГАММА-MSH |
| WO2015162483A1 (en) * | 2014-04-22 | 2015-10-29 | Txp Pharma Gmbh | Alpha- and gamma-msh analogues |
| JP2017513875A (ja) * | 2014-04-22 | 2017-06-01 | ティーエックスピー ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 分枝状アミノ酸プローブを有するペプチド類似体 |
| US20170360896A1 (en) * | 2014-10-28 | 2017-12-21 | Clinuvel Ag | Inflammatory disease |
| WO2016066700A1 (en) * | 2014-10-28 | 2016-05-06 | Clinuvel Ag | New indication for alpha-msh analogues |
| WO2017068020A1 (en) | 2015-10-20 | 2017-04-27 | Txp Pharma Gmbh | W-peptide analog |
| LT3773558T (lt) | 2019-05-10 | 2022-09-12 | Synact Pharma Aps | Kompleksinis artrito gydymas |
| WO2022034062A1 (en) | 2020-08-12 | 2022-02-17 | Txp Pharma Ag | Exendin-4 peptide analogues |
| EP4347019A4 (en) * | 2021-05-27 | 2025-06-18 | The Regents Of The University Of Michigan | MC3R agonist peptides |
| EP4359076B1 (en) | 2021-06-21 | 2025-08-06 | SynAct Pharma ApS | Phenyl pyrrole aminoguanidine salts and formulations |
| EP4565259A2 (en) * | 2022-08-03 | 2025-06-11 | Sightstream Biotherapeutics, Inc. | Novel melanocortin analogs |
| CN117106057B (zh) * | 2022-08-19 | 2024-11-01 | 南京汉欣医药科技有限公司 | 一种高纯的人促肾上腺皮质激素或其类似物及其规模化制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| US4356108A (en) | 1979-12-20 | 1982-10-26 | The Mead Corporation | Encapsulation process |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| US5597894A (en) | 1995-06-05 | 1997-01-28 | The Louisiana State University Medical Center Foundation | Multi-tyrosinated somatostatin analogs |
| JP2001506996A (ja) | 1996-12-17 | 2001-05-29 | クアドラント ホールディングス ケンブリッジ リミテッド | メラノコルチン受容体３、４又は５の特異結合のためのメラノコルチン誘導体 |
| NZ506839A (en) * | 1998-03-09 | 2003-05-30 | Zealand Pharma As | Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis |
| SE9801571D0 (sv) | 1998-05-05 | 1998-05-05 | Wapharm Ab | Melanokortin-1-receptorselektiva föreningar |
| AU7593001A (en) | 2000-07-14 | 2002-01-30 | Zycos Inc | Alpha-msh related compounds and methods of use |
| US8912144B2 (en) | 2003-12-16 | 2014-12-16 | Children's Medical Center Corporation | Method for treating stroke via administration of NEP1-40 and inosine |
| NZ565217A (en) * | 2005-07-08 | 2010-03-26 | Ipsen Pharma Sas | Melanocortin receptor ligands |
| CN101273059B (zh) * | 2005-08-26 | 2014-02-19 | 艾伯维有限公司 | 治疗活性的α-MSH类似物 |
| RU2668791C2 (ru) | 2012-10-19 | 2018-10-02 | ТиЭксПи ФАРМА ГМБХ | АНАЛОГИ АЛЬФА- и ГАММА-MSH |
| WO2015162486A1 (en) | 2014-04-22 | 2015-10-29 | Txp Pharma Gmbh | Linear gamma msh with c- and / or n-terminal extensions of lysine and / or glutamic acid residues |
| JP2017513875A (ja) | 2014-04-22 | 2017-06-01 | ティーエックスピー ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 分枝状アミノ酸プローブを有するペプチド類似体 |
| WO2015162483A1 (en) | 2014-04-22 | 2015-10-29 | Txp Pharma Gmbh | Alpha- and gamma-msh analogues |
-
2013
- 2013-10-21 RU RU2015118576A patent/RU2668791C2/ru active
- 2013-10-21 EP EP15157262.5A patent/EP2944650A1/en not_active Withdrawn
- 2013-10-21 CN CN201380062117.6A patent/CN104822702B/zh active Active
- 2013-10-21 PL PL13189492T patent/PL2722340T3/pl unknown
- 2013-10-21 US US14/058,790 patent/US9217023B2/en active Active
- 2013-10-21 JP JP2015537289A patent/JP6429782B2/ja active Active
- 2013-10-21 DK DK13189492.5T patent/DK2722340T3/en active
- 2013-10-21 CA CA2888277A patent/CA2888277C/en active Active
- 2013-10-21 ES ES13189492.5T patent/ES2538702T3/es active Active
- 2013-10-21 AU AU2013333765A patent/AU2013333765B2/en active Active
- 2013-10-21 HU HUE13189492A patent/HUE025870T2/en unknown
- 2013-10-21 EP EP13189492.5A patent/EP2722340B1/en active Active
- 2013-10-21 WO PCT/EP2013/071935 patent/WO2014060606A1/en not_active Ceased
-
2015
- 2015-11-24 US US14/951,305 patent/US9486495B2/en active Active
-
2016
- 2016-10-10 US US15/289,562 patent/US9951116B2/en active Active
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