JP2015533162A5 - - Google Patents
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- Publication number
- JP2015533162A5 JP2015533162A5 JP2015536852A JP2015536852A JP2015533162A5 JP 2015533162 A5 JP2015533162 A5 JP 2015533162A5 JP 2015536852 A JP2015536852 A JP 2015536852A JP 2015536852 A JP2015536852 A JP 2015536852A JP 2015533162 A5 JP2015533162 A5 JP 2015533162A5
- Authority
- JP
- Japan
- Prior art keywords
- particles
- water
- soluble
- core
- particle size
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002245 particle Substances 0.000 claims description 65
- 238000000034 method Methods 0.000 claims description 61
- 238000000576 coating method Methods 0.000 claims description 23
- 239000011248 coating agent Substances 0.000 claims description 22
- 239000000463 material Substances 0.000 claims description 21
- 239000008186 active pharmaceutical agent Substances 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 5
- 229920000642 polymer Polymers 0.000 claims description 4
- 239000007771 core particle Substances 0.000 claims 33
- 229920003176 water-insoluble polymer Polymers 0.000 claims 13
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 8
- 238000007922 dissolution test Methods 0.000 claims 7
- 230000002209 hydrophobic effect Effects 0.000 claims 4
- 239000000377 silicon dioxide Substances 0.000 claims 4
- 238000004090 dissolution Methods 0.000 claims 3
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 3
- 210000000214 mouth Anatomy 0.000 claims 3
- -1 polyethylene Polymers 0.000 claims 3
- 239000012528 membrane Substances 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 238000007873 sieving Methods 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- WCOXQTXVACYMLM-UHFFFAOYSA-N 2,3-bis(12-hydroxyoctadecanoyloxy)propyl 12-hydroxyoctadecanoate Chemical compound CCCCCCC(O)CCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCC(O)CCCCCC)COC(=O)CCCCCCCCCCC(O)CCCCCC WCOXQTXVACYMLM-UHFFFAOYSA-N 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 239000004952 Polyamide Substances 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 239000004743 Polypropylene Substances 0.000 claims 1
- 239000004203 carnauba wax Substances 0.000 claims 1
- 235000013869 carnauba wax Nutrition 0.000 claims 1
- 229920001477 hydrophilic polymer Polymers 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229920002647 polyamide Polymers 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 229920000193 polymethacrylate Polymers 0.000 claims 1
- 229920001155 polypropylene Polymers 0.000 claims 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims 1
- 239000004810 polytetrafluoroethylene Substances 0.000 claims 1
- 239000001993 wax Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 description 7
- 238000003801 milling Methods 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- HIGRAKVNKLCVCA-UHFFFAOYSA-N alumine Chemical compound C1=CC=[Al]C=C1 HIGRAKVNKLCVCA-UHFFFAOYSA-N 0.000 description 1
- 238000000498 ball milling Methods 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000007596 consolidation process Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000005243 fluidization Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/651,977 US9107851B2 (en) | 2012-10-15 | 2012-10-15 | Solventless mixing process for coating pharmaceutical ingredients |
| US13/651,977 | 2012-10-15 | ||
| PCT/US2013/064058 WO2014062444A1 (en) | 2012-10-15 | 2013-10-09 | Solventless mixing process for coating pharmaceutical ingredients |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015533162A JP2015533162A (ja) | 2015-11-19 |
| JP2015533162A5 true JP2015533162A5 (cg-RX-API-DMAC7.html) | 2016-11-17 |
| JP6159504B2 JP6159504B2 (ja) | 2017-07-05 |
Family
ID=49474713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015536852A Active JP6159504B2 (ja) | 2012-10-15 | 2013-10-09 | 医薬品成分を被覆するための無溶剤混合方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9107851B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2906205B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6159504B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN104853751B (cg-RX-API-DMAC7.html) |
| AR (1) | AR093013A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112015008285B1 (cg-RX-API-DMAC7.html) |
| CY (1) | CY1121241T1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK2906205T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2688889T3 (cg-RX-API-DMAC7.html) |
| HR (1) | HRP20181463T1 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE039772T2 (cg-RX-API-DMAC7.html) |
| PL (1) | PL2906205T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2906205T (cg-RX-API-DMAC7.html) |
| RS (1) | RS57918B1 (cg-RX-API-DMAC7.html) |
| SI (1) | SI2906205T1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014062444A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016011412A1 (en) | 2014-07-17 | 2016-01-21 | Ada Technologies, Inc. | Extreme long life, high energy density batteries and method of making and using the same |
| CN104587472B (zh) * | 2014-12-31 | 2017-12-15 | 广东国方医药科技有限公司 | 一种含纳米SiO2的包衣剂及其制备方法 |
| WO2016209460A2 (en) | 2015-05-21 | 2016-12-29 | Ada Technologies, Inc. | High energy density hybrid pseudocapacitors and method of making and using the same |
| US12027661B2 (en) | 2015-06-01 | 2024-07-02 | Forge Nano Inc. | Nano-engineered coatings for anode active materials, cathode active materials, and solid-state electrolytes and methods of making batteries containing nano-engineered coatings |
| US11996564B2 (en) | 2015-06-01 | 2024-05-28 | Forge Nano Inc. | Nano-engineered coatings for anode active materials, cathode active materials, and solid-state electrolytes and methods of making batteries containing nano-engineered coatings |
| US12401042B2 (en) | 2015-06-01 | 2025-08-26 | Forge Nano Inc. | Nano-engineered coatings for anode active materials, cathode active materials, and solid-state electrolytes and methods of making batteries containing nano-engineered coatings |
| WO2017023797A1 (en) | 2015-07-31 | 2017-02-09 | Ada Technologies, Inc. | High energy and power electrochemical device and method of making and using same |
| JP7069538B2 (ja) * | 2016-12-05 | 2022-05-18 | マルボシ酢株式会社 | 食酢含有飲料組成物 |
| US11024846B2 (en) | 2017-03-23 | 2021-06-01 | Ada Technologies, Inc. | High energy/power density, long cycle life, safe lithium-ion battery capable of long-term deep discharge/storage near zero volt and method of making and using the same |
| WO2019009335A1 (ja) * | 2017-07-04 | 2019-01-10 | 村上 正裕 | 微粒子の製造方法及び微粒子 |
| SG11202108659XA (en) | 2019-02-22 | 2021-09-29 | Catalent Uk Swindon Zydis Ltd | Minimizing aeration of suspensions during in-line mixing |
| KR20210130720A (ko) * | 2019-02-22 | 2021-11-01 | 카탈렌트 유.케이. 스윈던 지디스 리미티드 | 수성 현탁액에서 무용매 혼합 공정에 의해 생성된 기능적으로-코팅된 api 입자 보존 |
| WO2020169989A1 (en) * | 2019-02-22 | 2020-08-27 | Catalent U.K. Swindon Zydis Limited | Minimizing agglomeration, aeration, and preserving the coating of pharmaceutical compositions comprising ibuprofen |
| WO2020169992A1 (en) | 2019-02-22 | 2020-08-27 | Catalent U.K. Swindon Zydis Limited | Minimizing agglomeration of drug particle coating material during storage to stabilize disintegration times of pharmaceutical products |
| US20210009767A1 (en) * | 2019-07-11 | 2021-01-14 | International Flavors & Fragrances Inc. | Solventless particle coating via acoustic mixing |
| US12285731B2 (en) | 2019-09-12 | 2025-04-29 | United States Of America, As Represented By The Secretary Of The Army | Acoustic mixing system for creating propellant mixture |
| CA3189404A1 (en) | 2020-07-31 | 2022-02-03 | Catalent U.K. Swindon Zydis Limited | Pharmaceutical compositions comprising coated api |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5628945A (en) | 1992-08-03 | 1997-05-13 | Riman; Richard E. | Multicomponent powder mixing process and compositions produced thereby |
| WO1994015374A1 (fr) * | 1992-12-25 | 1994-07-07 | Tdk Corporation | Element secondaire au lithium |
| US5769917A (en) * | 1996-12-09 | 1998-06-23 | Belko; William C. | Process for producing low shrink ceramic bodies |
| US6740341B1 (en) | 1998-11-25 | 2004-05-25 | Cima Labs Inc. | Taste masking rapid release coating system |
| DE10062176A1 (de) * | 2000-12-14 | 2002-07-04 | Wacker Polymer Systems Gmbh | Polyvinylacetal-gepfropfte Polymerisate |
| US8163114B2 (en) | 2004-04-07 | 2012-04-24 | New Jersey Institute Of Technology | Netshape manufacturing processes and compositions |
| DE102004059792A1 (de) * | 2004-12-10 | 2006-06-14 | Röhm GmbH & Co. KG | Multipartikuläre Arzneiform, enthaltend mucoadhaesiv formulierte Nukleinsäure-Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform |
| US20060210694A1 (en) * | 2005-03-18 | 2006-09-21 | Chappell Rulon A | Anti-caking agents and methods |
| CA2617190C (en) | 2005-08-03 | 2017-07-18 | The University Of Western Ontario | Direct coating solid dosage forms using powdered materials |
| HRP20180026T1 (hr) * | 2010-06-08 | 2018-02-23 | Kobe Gakuin Educational Foundation | Obložena čestica i postupak proizvodnje obložene čestice |
| GB201205632D0 (en) | 2012-03-30 | 2012-05-16 | Vectura Ltd | Method and apparatus |
| US8993041B2 (en) * | 2012-10-15 | 2015-03-31 | New Jersey Institute Of Technology | Taste masked active pharmaceutical powder compositions and processes for making them |
-
2012
- 2012-10-15 US US13/651,977 patent/US9107851B2/en active Active
-
2013
- 2013-10-09 SI SI201331167T patent/SI2906205T1/sl unknown
- 2013-10-09 RS RS20181079A patent/RS57918B1/sr unknown
- 2013-10-09 ES ES13780276.5T patent/ES2688889T3/es active Active
- 2013-10-09 PT PT13780276T patent/PT2906205T/pt unknown
- 2013-10-09 JP JP2015536852A patent/JP6159504B2/ja active Active
- 2013-10-09 EP EP13780276.5A patent/EP2906205B1/en active Active
- 2013-10-09 PL PL13780276T patent/PL2906205T3/pl unknown
- 2013-10-09 HU HUE13780276A patent/HUE039772T2/hu unknown
- 2013-10-09 BR BR112015008285-8A patent/BR112015008285B1/pt active IP Right Grant
- 2013-10-09 WO PCT/US2013/064058 patent/WO2014062444A1/en not_active Ceased
- 2013-10-09 DK DK13780276.5T patent/DK2906205T3/en active
- 2013-10-09 HR HRP20181463TT patent/HRP20181463T1/hr unknown
- 2013-10-09 CN CN201380053927.5A patent/CN104853751B/zh active Active
- 2013-10-15 AR ARP130103731A patent/AR093013A1/es not_active Application Discontinuation
-
2018
- 2018-09-13 CY CY20181100951T patent/CY1121241T1/el unknown
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