JP2015532425A5 - - Google Patents
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- JP2015532425A5 JP2015532425A5 JP2015535153A JP2015535153A JP2015532425A5 JP 2015532425 A5 JP2015532425 A5 JP 2015532425A5 JP 2015535153 A JP2015535153 A JP 2015535153A JP 2015535153 A JP2015535153 A JP 2015535153A JP 2015532425 A5 JP2015532425 A5 JP 2015532425A5
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- JP
- Japan
- Prior art keywords
- subject
- marker
- mucosal healing
- markers
- score
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 27
- 239000003550 marker Substances 0.000 claims 21
- 230000035876 healing Effects 0.000 claims 19
- 238000012544 monitoring process Methods 0.000 claims 8
- 206010061218 Inflammation Diseases 0.000 claims 6
- 230000004054 inflammatory process Effects 0.000 claims 6
- 239000000090 biomarker Substances 0.000 claims 4
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 3
- 230000003698 anagen phase Effects 0.000 claims 3
- 230000035755 proliferation Effects 0.000 claims 3
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 2
- 102100021866 Hepatocyte growth factor Human genes 0.000 claims 2
- 101000746373 Homo sapiens Granulocyte-macrophage colony-stimulating factor Proteins 0.000 claims 2
- -1 IFNγ Proteins 0.000 claims 2
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- 241000208202 Linaceae Species 0.000 claims 2
- 235000004431 Linum usitatissimum Nutrition 0.000 claims 2
- 108700028353 OmpC Proteins 0.000 claims 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 2
- 230000000405 serological effect Effects 0.000 claims 2
- 102100038778 Amphiregulin Human genes 0.000 claims 1
- 101800001382 Betacellulin Proteins 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 102000009024 Epidermal Growth Factor Human genes 0.000 claims 1
- 108010008165 Etanercept Proteins 0.000 claims 1
- 102000003971 Fibroblast Growth Factor 1 Human genes 0.000 claims 1
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 claims 1
- 102100035290 Fibroblast growth factor 13 Human genes 0.000 claims 1
- 102100031734 Fibroblast growth factor 19 Human genes 0.000 claims 1
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 1
- 102100028072 Fibroblast growth factor 4 Human genes 0.000 claims 1
- 102100028071 Fibroblast growth factor 7 Human genes 0.000 claims 1
- 102100037665 Fibroblast growth factor 9 Human genes 0.000 claims 1
- 101800001649 Heparin-binding EGF-like growth factor Proteins 0.000 claims 1
- 101000809450 Homo sapiens Amphiregulin Proteins 0.000 claims 1
- 101000846394 Homo sapiens Fibroblast growth factor 19 Proteins 0.000 claims 1
- 101001060274 Homo sapiens Fibroblast growth factor 4 Proteins 0.000 claims 1
- 101001060261 Homo sapiens Fibroblast growth factor 7 Proteins 0.000 claims 1
- 101001027380 Homo sapiens Fibroblast growth factor 9 Proteins 0.000 claims 1
- 101000898034 Homo sapiens Hepatocyte growth factor Proteins 0.000 claims 1
- 101001076408 Homo sapiens Interleukin-6 Proteins 0.000 claims 1
- 101000611888 Homo sapiens Platelet-derived growth factor C Proteins 0.000 claims 1
- 101001056707 Homo sapiens Proepiregulin Proteins 0.000 claims 1
- 101000655540 Homo sapiens Protransforming growth factor alpha Proteins 0.000 claims 1
- 101000868152 Homo sapiens Son of sevenless homolog 1 Proteins 0.000 claims 1
- 101000635938 Homo sapiens Transforming growth factor beta-1 proprotein Proteins 0.000 claims 1
- 101000808011 Homo sapiens Vascular endothelial growth factor A Proteins 0.000 claims 1
- 101000742579 Homo sapiens Vascular endothelial growth factor B Proteins 0.000 claims 1
- 101000742596 Homo sapiens Vascular endothelial growth factor C Proteins 0.000 claims 1
- 101000742599 Homo sapiens Vascular endothelial growth factor D Proteins 0.000 claims 1
- 102000003814 Interleukin-10 Human genes 0.000 claims 1
- 108090000174 Interleukin-10 Proteins 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 108090001007 Interleukin-8 Proteins 0.000 claims 1
- 102100020880 Kit ligand Human genes 0.000 claims 1
- 101710177504 Kit ligand Proteins 0.000 claims 1
- 102100040681 Platelet-derived growth factor C Human genes 0.000 claims 1
- 102100037596 Platelet-derived growth factor subunit A Human genes 0.000 claims 1
- 102100040990 Platelet-derived growth factor subunit B Human genes 0.000 claims 1
- 101710098940 Pro-epidermal growth factor Proteins 0.000 claims 1
- 102100029837 Probetacellulin Human genes 0.000 claims 1
- 102100025498 Proepiregulin Human genes 0.000 claims 1
- 102100033762 Proheparin-binding EGF-like growth factor Human genes 0.000 claims 1
- 108010019674 Proto-Oncogene Proteins c-sis Proteins 0.000 claims 1
- 102100032350 Protransforming growth factor alpha Human genes 0.000 claims 1
- 102100030742 Transforming growth factor beta-1 proprotein Human genes 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 102100039037 Vascular endothelial growth factor A Human genes 0.000 claims 1
- 102100038217 Vascular endothelial growth factor B Human genes 0.000 claims 1
- 102100038232 Vascular endothelial growth factor C Human genes 0.000 claims 1
- 102100038234 Vascular endothelial growth factor D Human genes 0.000 claims 1
- 229960002964 adalimumab Drugs 0.000 claims 1
- 238000001574 biopsy Methods 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 229960003115 certolizumab pegol Drugs 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229960000403 etanercept Drugs 0.000 claims 1
- 229940048921 humira Drugs 0.000 claims 1
- 229960000598 infliximab Drugs 0.000 claims 1
- 108010017843 platelet-derived growth factor A Proteins 0.000 claims 1
- 230000002250 progressing effect Effects 0.000 claims 1
- 229940116176 remicade Drugs 0.000 claims 1
- 238000005070 sampling Methods 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 230000000391 smoking effect Effects 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
- 238000011269 treatment regimen Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261710491P | 2012-10-05 | 2012-10-05 | |
| US61/710,491 | 2012-10-05 | ||
| US201361824959P | 2013-05-17 | 2013-05-17 | |
| US61/824,959 | 2013-05-17 | ||
| PCT/IB2013/059077 WO2014054013A1 (en) | 2012-10-05 | 2013-10-02 | Methods for predicting and monitoring mucosal healing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015532425A JP2015532425A (ja) | 2015-11-09 |
| JP2015532425A5 true JP2015532425A5 (cg-RX-API-DMAC10.html) | 2016-11-24 |
Family
ID=49447587
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015535153A Pending JP2015532425A (ja) | 2012-10-05 | 2013-10-02 | 粘膜治癒を予測及びモニタリングするための方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20150355195A1 (cg-RX-API-DMAC10.html) |
| EP (3) | EP3640645A1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2015532425A (cg-RX-API-DMAC10.html) |
| CN (1) | CN104838270A (cg-RX-API-DMAC10.html) |
| AU (2) | AU2013326070A1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2887035A1 (cg-RX-API-DMAC10.html) |
| ES (2) | ES2638971T3 (cg-RX-API-DMAC10.html) |
| HK (1) | HK1213051A1 (cg-RX-API-DMAC10.html) |
| MX (1) | MX358730B (cg-RX-API-DMAC10.html) |
| SG (1) | SG11201502646RA (cg-RX-API-DMAC10.html) |
| WO (1) | WO2014054013A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3295783A1 (en) | 2011-05-10 | 2026-03-02 | Prometheus Laboratories, Inc. | Methods of disease activity profiling for personalized therapy management |
| WO2016063223A1 (en) * | 2014-10-20 | 2016-04-28 | Nestec S.A. | Methods for predicting clinical outcomes in subjects afflicted with ulcerative colitis |
| US20170258820A1 (en) | 2014-10-29 | 2017-09-14 | Glycom A/S | Synthetic composition and method for promoting mucosal healing |
| GB201501612D0 (en) * | 2015-01-30 | 2015-03-18 | Univ Birmingham | Assay |
| CN109462996A (zh) | 2016-03-17 | 2019-03-12 | 西达-赛奈医疗中心 | 通过rnaset2诊断炎性肠病的方法 |
| GB201611738D0 (en) * | 2016-07-05 | 2016-08-17 | Cambridge Entpr Ltd | Biomarkers for inflammatory bowel disease |
| KR20200009095A (ko) * | 2017-05-31 | 2020-01-29 | 프로메테우스 바이오사이언시즈, 인크. | 크론병 환자에서 점막 치유를 평가하는 방법 |
| WO2020112890A1 (en) | 2018-11-29 | 2020-06-04 | Cedars-Sinai Medical Center | Rnaset2 compositions and methods of treatment therewith |
| CN110646620A (zh) * | 2019-09-29 | 2020-01-03 | 湖北新纵科病毒疾病工程技术有限公司 | 一种同时检测四项炎症标志物的方法及其试剂盒 |
| CN111477325A (zh) * | 2020-04-09 | 2020-07-31 | 赣南师范大学 | 基于粒子群优化算法对引发肠道溃疡疾病进行鉴别的方法 |
| CN120600283B (zh) * | 2025-05-29 | 2026-02-17 | 北京大学第三医院（北京大学第三临床医学院） | 一种基于临床知识图谱的中医生殖内分泌疾病诊断辅助系统 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5830675A (en) | 1993-03-10 | 1998-11-03 | Cedars-Sinai Medical Center | Methods for selectively detecting perinuclear anti-neutrophil cytoplasmic antibody of ulcerative colitis, primary sclerosing cholangitis, or type 1 autoimmune hepatitis |
| EP0615129B1 (en) | 1993-03-10 | 2000-05-31 | Cedars-Sinai Medical Center | Methods for selectively detecting perinuclear anti-neutrophil cytoplasmic antibody of ulcerative colitis or primary sclerosing cholangitis |
| US6218129B1 (en) | 1998-05-15 | 2001-04-17 | Prometheus Laboratories, Inc. | Inflammatory bowel disease first step assay system |
| US6406862B1 (en) | 1998-10-06 | 2002-06-18 | The United States Of America As Represented By The Secretary Of The Army | Dip-stick assay for C-reactive protein |
| FR2802536B1 (fr) | 1999-11-23 | 2003-06-13 | Chru Lille | Oligomannosides de synthese, leur preparation et leur utilisation a la detection d'anticorps et a la prevention d'infections |
| US6838250B2 (en) | 2000-03-31 | 2005-01-04 | Ortho-Clinical Diagnostics, Inc. | Immunoassay for C-reactive protein |
| AU2001253746A1 (en) * | 2000-04-20 | 2001-11-07 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Inducible plasmid vector encoding tgf-beta and uses thereof |
| US7138237B1 (en) | 2000-05-19 | 2006-11-21 | Cedars-Sinai Medical Center | Diagnosis, prevention and treatment of Crohn's disease using the OmpC antigen |
| EP1581119B1 (en) | 2001-12-17 | 2013-01-30 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of inflammatory bowel disease |
| US20040197304A1 (en) * | 2003-04-01 | 2004-10-07 | The Procter & Gamble Company And Alimentary Health, Ltd. | Methods of determining efficacy of treatments of inflammatory diseases of the bowel |
| CA2549971A1 (en) | 2003-11-03 | 2005-05-12 | Duke University | Methods of identifying individuals at risk of perioperative bleeding, renal dysfunction or stroke |
| WO2006012472A1 (en) | 2004-07-21 | 2006-02-02 | Qualyst, Inc. | Apparatus, kits and methods for evaluating binding interactions, for detecting and quantifying binding molecules, and for sample preparation |
| WO2007087576A2 (en) | 2006-01-24 | 2007-08-02 | The Uab Research Foundation | Compositions and methods for the identification and treatment of immune-mediated inflammatory diseases |
| CN104198705B (zh) | 2006-09-21 | 2017-06-09 | 雀巢产品技术援助有限公司 | 检测稀有循环细胞内多种信号转导分子的基于抗体的阵列 |
| NZ582618A (en) | 2007-07-13 | 2012-07-27 | Prometheus Lab Inc | Drug selection for lung cancer therapy using antibody-based arrays |
| ES2553390T3 (es) | 2008-02-25 | 2015-12-09 | Nestec S.A. | Método para la detección de receptores truncados intracelulares |
| CN101780269A (zh) * | 2009-01-21 | 2010-07-21 | 北京三有利科技发展有限公司 | 细胞生长因子治疗溃疡性疾病和肺纤维化疾病的应用 |
| NZ596468A (en) | 2009-05-14 | 2013-11-29 | Nestec Sa | Biomarkers for determining sensitivity of breast cancer cells to her2-targeted therapy |
| JP5795311B2 (ja) | 2009-07-15 | 2015-10-14 | ネステク ソシエテ アノニム | 抗体ベースのアレイを使用する胃癌療法のための薬物選択 |
| DK2491385T3 (en) | 2009-10-20 | 2017-08-28 | Diatech Holdings Inc | PROXIMITY-MEDIED ASSAYS FOR DETECTING ONCOGEN FUSION PROTEINS |
| CN104634955B (zh) | 2009-10-26 | 2016-09-14 | 雀巢产品技术援助有限公司 | 检测抗-tnf药物和自身抗体的试验 |
| CA2781654A1 (en) * | 2009-11-25 | 2011-06-03 | Hua Gong | Novel genomic biomarkers for irritable bowel syndrome diagnosis |
| EP2576838A4 (en) * | 2010-06-04 | 2019-05-15 | Nestec S.A. | METHOD FOR IMPROVING DIAGNOSIS OF INFLAMMATORY ENDURANCE |
| WO2012054532A1 (en) | 2010-10-18 | 2012-04-26 | Prometheus Laboratories Inc. | Methods for determining anti-drug antibody isotypes |
| SG191230A1 (en) | 2010-12-23 | 2013-07-31 | Nestec Sa | Drug selection for malignant cancer therapy using antibody-based arrays |
| MX343327B (es) | 2011-02-17 | 2016-11-01 | Nestec Sa | Ensayos para detectar autoanticuerpos contra farmacos anti-tnfa. |
| EP2681552A2 (en) | 2011-03-02 | 2014-01-08 | Nestec S.A. | Prediction of drug sensitivity of lung tumors based on molecular and genetic signatures |
| WO2013006810A1 (en) | 2011-07-06 | 2013-01-10 | Nestec Sa | Assays for detecting neutralizing autoantibodies to biologic therapy with tnf alpha |
| KR101851425B1 (ko) | 2011-09-02 | 2018-04-23 | 네스텍 소시에테아노님 | 치료 효능 결정을 위한 신호 경로 단백질의 프로파일링 |
-
2013
- 2013-10-02 ES ES13779638.9T patent/ES2638971T3/es active Active
- 2013-10-02 CA CA2887035A patent/CA2887035A1/en not_active Abandoned
- 2013-10-02 EP EP19212960.9A patent/EP3640645A1/en not_active Withdrawn
- 2013-10-02 JP JP2015535153A patent/JP2015532425A/ja active Pending
- 2013-10-02 SG SG11201502646RA patent/SG11201502646RA/en unknown
- 2013-10-02 EP EP17167637.2A patent/EP3217179B9/en active Active
- 2013-10-02 HK HK16100852.9A patent/HK1213051A1/zh unknown
- 2013-10-02 AU AU2013326070A patent/AU2013326070A1/en not_active Abandoned
- 2013-10-02 MX MX2015004272A patent/MX358730B/es active IP Right Grant
- 2013-10-02 EP EP13779638.9A patent/EP2904405B1/en not_active Not-in-force
- 2013-10-02 ES ES17167637T patent/ES2771127T3/es active Active
- 2013-10-02 WO PCT/IB2013/059077 patent/WO2014054013A1/en not_active Ceased
- 2013-10-02 CN CN201380063566.2A patent/CN104838270A/zh active Pending
-
2015
- 2015-04-03 US US14/678,455 patent/US20150355195A1/en not_active Abandoned
-
2019
- 2019-06-19 AU AU2019204276A patent/AU2019204276A1/en not_active Abandoned
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