JP2015531346A5 - - Google Patents
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- JP2015531346A5 JP2015531346A5 JP2015531176A JP2015531176A JP2015531346A5 JP 2015531346 A5 JP2015531346 A5 JP 2015531346A5 JP 2015531176 A JP2015531176 A JP 2015531176A JP 2015531176 A JP2015531176 A JP 2015531176A JP 2015531346 A5 JP2015531346 A5 JP 2015531346A5
- Authority
- JP
- Japan
- Prior art keywords
- amount
- pharmaceutically acceptable
- acceptable salts
- solvates
- hydrochloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000003839 salts Chemical class 0.000 claims description 28
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 229960002462 glycopyrronium bromide Drugs 0.000 claims description 7
- HWMFFWCDLWDYGX-UHFFFAOYSA-N n-(4-aminophenyl)furan-2-carboxamide Chemical compound C1=CC(N)=CC=C1NC(=O)C1=CC=CO1 HWMFFWCDLWDYGX-UHFFFAOYSA-N 0.000 claims description 5
- 229960001187 propiverine hydrochloride Drugs 0.000 claims description 5
- ANGKOCUUWGHLCE-UHFFFAOYSA-N 2-cyclopentyl-2-hydroxy-2-phenylacetic acid (1,1-dimethyl-3-pyrrolidin-1-iumyl) ester Chemical compound C1[N+](C)(C)CCC1OC(=O)C(O)(C=1C=CC=CC=1)C1CCCC1 ANGKOCUUWGHLCE-UHFFFAOYSA-N 0.000 claims description 4
- QPCVHQBVMYCJOM-UHFFFAOYSA-N Propiverine Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(OCCC)C(=O)OC1CCN(C)CC1 QPCVHQBVMYCJOM-UHFFFAOYSA-N 0.000 claims description 4
- RVCSYOQWLPPAOA-CVPHZBIISA-M [(5s)-spiro[8-azoniabicyclo[3.2.1]octane-8,1'-azolidin-1-ium]-3-yl] 2-hydroxy-2,2-diphenylacetate;chloride Chemical compound [Cl-].[N+]12([C@H]3CCC2CC(C3)OC(=O)C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CCCC1 RVCSYOQWLPPAOA-CVPHZBIISA-M 0.000 claims description 4
- 229960003510 propiverine Drugs 0.000 claims description 4
- 229960001530 trospium chloride Drugs 0.000 claims description 4
- ANGKOCUUWGHLCE-HKUYNNGSSA-N [(3s)-1,1-dimethylpyrrolidin-1-ium-3-yl] (2r)-2-cyclopentyl-2-hydroxy-2-phenylacetate Chemical class C1[N+](C)(C)CC[C@@H]1OC(=O)[C@](O)(C=1C=CC=CC=1)C1CCCC1 ANGKOCUUWGHLCE-HKUYNNGSSA-N 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- 229960003688 tropisetron Drugs 0.000 claims description 3
- 229960001491 trospium Drugs 0.000 claims description 3
- OYYDSUSKLWTMMQ-JKHIJQBDSA-N trospium Chemical compound [N+]12([C@@H]3CC[C@H]2C[C@H](C3)OC(=O)C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CCCC1 OYYDSUSKLWTMMQ-JKHIJQBDSA-N 0.000 claims description 3
- 230000003474 anti-emetic effect Effects 0.000 claims description 2
- 239000002111 antiemetic agent Substances 0.000 claims description 2
- 239000012453 solvate Substances 0.000 claims 12
- GIYAQDDTCWHPPL-UHFFFAOYSA-N 4-amino-5-bromo-N-[2-(diethylamino)ethyl]-2-methoxybenzamide Chemical compound CCN(CC)CCNC(=O)C1=CC(Br)=C(N)C=C1OC GIYAQDDTCWHPPL-UHFFFAOYSA-N 0.000 claims 6
- 229960001253 domperidone Drugs 0.000 claims 6
- FGXWKSZFVQUSTL-UHFFFAOYSA-N domperidone Chemical compound C12=CC=CC=C2NC(=O)N1CCCN(CC1)CCC1N1C2=CC=C(Cl)C=C2NC1=O FGXWKSZFVQUSTL-UHFFFAOYSA-N 0.000 claims 6
- 229960005343 ondansetron Drugs 0.000 claims 6
- FELGMEQIXOGIFQ-CYBMUJFWSA-N (3r)-9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1h-carbazol-4-one Chemical compound CC1=NC=CN1C[C@@H]1C(=O)C(C=2C(=CC=CC=2)N2C)=C2CC1 FELGMEQIXOGIFQ-CYBMUJFWSA-N 0.000 claims 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 5
- 229960003727 granisetron Drugs 0.000 claims 5
- MFWNKCLOYSRHCJ-BTTYYORXSA-N granisetron Chemical compound C1=CC=C2C(C(=O)N[C@H]3C[C@H]4CCC[C@@H](C3)N4C)=NN(C)C2=C1 MFWNKCLOYSRHCJ-BTTYYORXSA-N 0.000 claims 5
- 229960004503 metoclopramide Drugs 0.000 claims 4
- TTWJBBZEZQICBI-UHFFFAOYSA-N metoclopramide Chemical compound CCN(CC)CCNC(=O)C1=CC(Cl)=C(N)C=C1OC TTWJBBZEZQICBI-UHFFFAOYSA-N 0.000 claims 4
- 229960003111 prochlorperazine Drugs 0.000 claims 4
- FEZBIKUBAYAZIU-UHFFFAOYSA-N trimethobenzamide Chemical compound COC1=C(OC)C(OC)=CC(C(=O)NCC=2C=CC(OCCN(C)C)=CC=2)=C1 FEZBIKUBAYAZIU-UHFFFAOYSA-N 0.000 claims 4
- 229960004161 trimethobenzamide Drugs 0.000 claims 4
- BGRJTUBHPOOWDU-NSHDSACASA-N (S)-(-)-sulpiride Chemical compound CCN1CCC[C@H]1CNC(=O)C1=CC(S(N)(=O)=O)=CC=C1OC BGRJTUBHPOOWDU-NSHDSACASA-N 0.000 claims 3
- KSEYRUGYKHXGFW-UHFFFAOYSA-N 6-methoxy-N-[(1-prop-2-enyl-2-pyrrolidinyl)methyl]-2H-benzotriazole-5-carboxamide Chemical compound COC1=CC2=NNN=C2C=C1C(=O)NCC1CCCN1CC=C KSEYRUGYKHXGFW-UHFFFAOYSA-N 0.000 claims 3
- OCJYIGYOJCODJL-UHFFFAOYSA-N Meclizine Chemical compound CC1=CC=CC(CN2CCN(CC2)C(C=2C=CC=CC=2)C=2C=CC(Cl)=CC=2)=C1 OCJYIGYOJCODJL-UHFFFAOYSA-N 0.000 claims 3
- UKTAZPQNNNJVKR-KJGYPYNMSA-N chembl2368925 Chemical compound C1=CC=C2C(C(O[C@@H]3C[C@@H]4C[C@H]5C[C@@H](N4CC5=O)C3)=O)=CNC2=C1 UKTAZPQNNNJVKR-KJGYPYNMSA-N 0.000 claims 3
- 229960003413 dolasetron Drugs 0.000 claims 3
- 229960004145 levosulpiride Drugs 0.000 claims 3
- 229960001474 meclozine Drugs 0.000 claims 3
- WIKYUJGCLQQFNW-UHFFFAOYSA-N prochlorperazine Chemical compound C1CN(C)CCN1CCCN1C2=CC(Cl)=CC=C2SC2=CC=CC=C21 WIKYUJGCLQQFNW-UHFFFAOYSA-N 0.000 claims 3
- PWWVAXIEGOYWEE-UHFFFAOYSA-N Isophenergan Chemical compound C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 PWWVAXIEGOYWEE-UHFFFAOYSA-N 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 229960001372 aprepitant Drugs 0.000 claims 2
- ATALOFNDEOCMKK-OITMNORJSA-N aprepitant Chemical compound O([C@@H]([C@@H]1C=2C=CC(F)=CC=2)O[C@H](C)C=2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)CCN1CC1=NNC(=O)N1 ATALOFNDEOCMKK-OITMNORJSA-N 0.000 claims 2
- 229960001076 chlorpromazine Drugs 0.000 claims 2
- ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 claims 2
- LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 claims 2
- 229960003910 promethazine Drugs 0.000 claims 2
- UIVFDCIXTSJXBB-ITGUQSILSA-N tropisetron Chemical compound C1=CC=C[C]2C(C(=O)O[C@H]3C[C@H]4CC[C@@H](C3)N4C)=CN=C21 UIVFDCIXTSJXBB-ITGUQSILSA-N 0.000 claims 2
- AKUVRZKNLXYTJX-UHFFFAOYSA-N 3-benzylazetidine Chemical compound C=1C=CC=CC=1CC1CNC1 AKUVRZKNLXYTJX-UHFFFAOYSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- CYQFCXCEBYINGO-DLBZAZTESA-N Dronabinol Natural products C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@H]21 CYQFCXCEBYINGO-DLBZAZTESA-N 0.000 claims 1
- FELGMEQIXOGIFQ-UHFFFAOYSA-N Ondansetron Chemical compound CC1=NC=CN1CC1C(=O)C(C=2C(=CC=CC=2)N2C)=C2CC1 FELGMEQIXOGIFQ-UHFFFAOYSA-N 0.000 claims 1
- ZGUGWUXLJSTTMA-UHFFFAOYSA-N Promazinum Chemical compound C1=CC=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZGUGWUXLJSTTMA-UHFFFAOYSA-N 0.000 claims 1
- CYQFCXCEBYINGO-UHFFFAOYSA-N THC Natural products C1=C(C)CCC2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3C21 CYQFCXCEBYINGO-UHFFFAOYSA-N 0.000 claims 1
- 229960003687 alizapride Drugs 0.000 claims 1
- FLZQKRKHLSUHOR-UHFFFAOYSA-N alosetron Chemical compound CC1=NC=N[C]1CN1C(=O)C(C=2C(=CC=CC=2)N2C)=C2CC1 FLZQKRKHLSUHOR-UHFFFAOYSA-N 0.000 claims 1
- 229960003550 alosetron Drugs 0.000 claims 1
- 229960001034 bromopride Drugs 0.000 claims 1
- 229930003827 cannabinoid Natural products 0.000 claims 1
- 239000003557 cannabinoid Substances 0.000 claims 1
- 229940065144 cannabinoids Drugs 0.000 claims 1
- 229960001657 chlorpromazine hydrochloride Drugs 0.000 claims 1
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims 1
- 229960003218 dolasetron mesylate Drugs 0.000 claims 1
- 229960004242 dronabinol Drugs 0.000 claims 1
- 229960003607 granisetron hydrochloride Drugs 0.000 claims 1
- 229960003878 haloperidol Drugs 0.000 claims 1
- QMEZUZOCLYUADC-UHFFFAOYSA-N hydrate;dihydrochloride Chemical compound O.Cl.Cl QMEZUZOCLYUADC-UHFFFAOYSA-N 0.000 claims 1
- DKAGJZJALZXOOV-UHFFFAOYSA-N hydrate;hydrochloride Chemical compound O.Cl DKAGJZJALZXOOV-UHFFFAOYSA-N 0.000 claims 1
- QYZRTBKYBJRGJB-UHFFFAOYSA-N hydron;1-methyl-n-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)indazole-3-carboxamide;chloride Chemical compound Cl.C1=CC=C2C(C(=O)NC3CC4CCCC(C3)N4C)=NN(C)C2=C1 QYZRTBKYBJRGJB-UHFFFAOYSA-N 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 229940049920 malate Drugs 0.000 claims 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
- KJBLQGHJOCAOJP-UHFFFAOYSA-N metoclopramide hydrochloride Chemical compound O.Cl.CCN(CC)CCNC(=O)C1=CC(Cl)=C(N)C=C1OC KJBLQGHJOCAOJP-UHFFFAOYSA-N 0.000 claims 1
- GECBBEABIDMGGL-RTBURBONSA-N nabilone Chemical compound C1C(=O)CC[C@H]2C(C)(C)OC3=CC(C(C)(C)CCCCCC)=CC(O)=C3[C@@H]21 GECBBEABIDMGGL-RTBURBONSA-N 0.000 claims 1
- 229960002967 nabilone Drugs 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 230000004112 neuroprotection Effects 0.000 claims 1
- DSKIOWHQLUWFLG-SPIKMXEPSA-N prochlorperazine maleate Chemical compound [H+].[H+].[H+].[H+].[O-]C(=O)\C=C/C([O-])=O.[O-]C(=O)\C=C/C([O-])=O.C1CN(C)CCN1CCCN1C2=CC(Cl)=CC=C2SC2=CC=CC=C21 DSKIOWHQLUWFLG-SPIKMXEPSA-N 0.000 claims 1
- 229960003598 promazine Drugs 0.000 claims 1
- 229960002244 promethazine hydrochloride Drugs 0.000 claims 1
- XXPDBLUZJRXNNZ-UHFFFAOYSA-N promethazine hydrochloride Chemical compound Cl.C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 XXPDBLUZJRXNNZ-UHFFFAOYSA-N 0.000 claims 1
- 239000003369 serotonin 5-HT3 receptor antagonist Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- QTFFGPOXNNGTGZ-RCSCTSIBSA-N u3c8e5bwkr Chemical compound O.CS(O)(=O)=O.C1=CC=C2C(C(OC3C[C@@H]4CC5C[C@@H](N4CC5=O)C3)=O)=CNC2=C1 QTFFGPOXNNGTGZ-RCSCTSIBSA-N 0.000 claims 1
- 0 CC1CC(C(C2)I)[N+](*)(*)C2C1 Chemical compound CC1CC(C(C2)I)[N+](*)(*)C2C1 0.000 description 4
- 239000000203 mixture Substances 0.000 description 2
- ZNRGQMMCGHDTEI-ITGUQSILSA-N tropisetron Chemical compound C1=CC=C2C(C(=O)O[C@H]3C[C@H]4CC[C@@H](C3)N4C)=CNC2=C1 ZNRGQMMCGHDTEI-ITGUQSILSA-N 0.000 description 2
- 230000001078 anti-cholinergic effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261697039P | 2012-09-05 | 2012-09-05 | |
| US201261697021P | 2012-09-05 | 2012-09-05 | |
| US201261696978P | 2012-09-05 | 2012-09-05 | |
| US201261697069P | 2012-09-05 | 2012-09-05 | |
| US61/696,978 | 2012-09-05 | ||
| US61/697,039 | 2012-09-05 | ||
| US61/697,069 | 2012-09-05 | ||
| US61/697,021 | 2012-09-05 | ||
| PCT/US2013/058172 WO2014039627A1 (en) | 2012-09-05 | 2013-09-05 | Anticholinergic neuroprotective composition and methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018082454A Division JP2018150314A (ja) | 2012-09-05 | 2018-04-23 | 抗コリン作用性神経保護組成物及び方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015531346A JP2015531346A (ja) | 2015-11-02 |
| JP2015531346A5 true JP2015531346A5 (https=) | 2017-02-02 |
Family
ID=50237591
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015531176A Pending JP2015531346A (ja) | 2012-09-05 | 2013-09-05 | 抗コリン作用性神経保護組成物及び方法 |
| JP2018082454A Pending JP2018150314A (ja) | 2012-09-05 | 2018-04-23 | 抗コリン作用性神経保護組成物及び方法 |
| JP2020038441A Pending JP2020105212A (ja) | 2012-09-05 | 2020-03-06 | 抗コリン作用性神経保護組成物及び方法 |
| JP2021132146A Pending JP2021191759A (ja) | 2012-09-05 | 2021-08-16 | 抗コリン作用性神経保護組成物及び方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018082454A Pending JP2018150314A (ja) | 2012-09-05 | 2018-04-23 | 抗コリン作用性神経保護組成物及び方法 |
| JP2020038441A Pending JP2020105212A (ja) | 2012-09-05 | 2020-03-06 | 抗コリン作用性神経保護組成物及び方法 |
| JP2021132146A Pending JP2021191759A (ja) | 2012-09-05 | 2021-08-16 | 抗コリン作用性神経保護組成物及び方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US9561218B2 (https=) |
| EP (2) | EP2892514A4 (https=) |
| JP (4) | JP2015531346A (https=) |
| KR (2) | KR20150048888A (https=) |
| CN (1) | CN104768540A (https=) |
| AU (1) | AU2013312749B2 (https=) |
| BR (3) | BR112015004902A2 (https=) |
| CA (1) | CA2882407C (https=) |
| EA (1) | EA038489B1 (https=) |
| HK (1) | HK1210947A1 (https=) |
| IL (3) | IL237176B (https=) |
| IN (1) | IN2015DN01706A (https=) |
| MX (2) | MX385976B (https=) |
| WO (1) | WO2014039627A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8969402B2 (en) * | 2006-11-15 | 2015-03-03 | Steven A. Rich | Combined acetylcholinesterase inhibitor and quaternary ammonium antimuscarinic therapy to alter progression of cognitive diseases |
| PT3061821T (pt) | 2009-07-22 | 2019-09-05 | PureTech Health LLC | Composições para tratamento de distúrbios melhorados por ativação de recetores muscarínicos |
| AU2013300009B2 (en) * | 2012-08-09 | 2017-06-15 | Chase Pharmaceuticals Corporation | Piperidinium quaternary salts |
| BR112015004902A2 (pt) * | 2012-09-05 | 2017-07-04 | Chase Pharmaceuticals Corp | métodos e composição neutroprotetores anticolinérgicos |
| EP3242659A4 (en) * | 2015-01-09 | 2018-09-12 | Chase Pharmaceuticals Corporation | Oxybutynin transdermal therapeutic system combination |
| US10596139B2 (en) | 2015-03-06 | 2020-03-24 | Chase Pharmaceuticals Corporation | Oxybutynin transdermal therapeutic system muscarinic agonist combination |
| US10307409B2 (en) | 2015-03-06 | 2019-06-04 | Chase Pharmaceuticals Corporation | Muscarinic combinations and their use for combating hypocholinergic disorders of the central nervous system |
| US20180360845A1 (en) * | 2015-07-20 | 2018-12-20 | Chase Pharmaceuticals Corporation | Muscarinic combination of a selective m2-antagonist and a peripheral non-selective antagonist for treating hypocholinergic disorders |
| EP3347012A4 (en) * | 2015-09-11 | 2019-04-17 | Chase Pharmaceuticals Corporation | MUSCARIN COMBINATIONS AND THEIR USE FOR COMBATING HYPOCHOLINERGIC DISORDER OF THE CENTRAL NERVOUS SYSTEM |
| CA2996717A1 (en) * | 2015-09-11 | 2017-03-16 | Chase Pharmaceuticals Corporation | Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system |
| US10357487B2 (en) * | 2015-12-03 | 2019-07-23 | Sidney J. Goldfarb | Combinations of acetylcholinesterase inhibitors and muscarinic agonists and methods of use thereof |
| WO2017147104A1 (en) * | 2016-02-24 | 2017-08-31 | Chase Pharmaceuticals Corporation | Muscarinic m2-antagonist combinations |
| WO2018081508A1 (en) * | 2016-10-28 | 2018-05-03 | Chase Pharmaceutical Corporation | Memantine combinations and use |
| CA3071377C (en) | 2017-01-09 | 2021-11-30 | Kathleen E. Clarence-Smith | Compositions and methods for improving muscle weakness in patients suffering from myasthenia gravis and other myasthenic syndromes |
| US20200000756A1 (en) * | 2017-01-24 | 2020-01-02 | Gt Biopharma, Inc. | Neostigmine combination and compositions |
| IL269550B2 (en) | 2017-03-27 | 2025-01-01 | Chase Therapeutics Corp | Combining a 5HT3 antagonist and pramipexole for the treatment of synucleinopathies |
| KR102408292B1 (ko) | 2018-09-28 | 2022-06-10 | 카루나 세러퓨틱스 인코포레이티드 | 무스카린성 수용체 활성화에 의해 개선된 장애의 치료를 위한 조성물 및 방법 |
| US12112463B2 (en) | 2020-09-14 | 2024-10-08 | City University Of Hong Kong | Method, device and computer readable medium for intrinsic popularity evaluation and content compression based thereon |
| US11759451B2 (en) | 2020-09-15 | 2023-09-19 | City University Of Hong Kong | Therapeutic potential of glycopyrrolate and mexiletine for nervous system injury |
| US12109202B2 (en) * | 2021-01-29 | 2024-10-08 | Qaam Pharmaceuticals, Llc | Fixed dose combination of cholinesterase inhibitor and a quaternary ammonium antimuscarinic agent to treat neurodegenerative cognitive disorders |
| US20220304946A1 (en) * | 2021-03-28 | 2022-09-29 | Muhammad Imran Khan | Trans-anethole ((e)-1-methoxy-4- (1-propenyl) benzene), a new and potent inhibitor of prolyl endopeptidase |
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-
2013
- 2013-09-05 BR BR112015004902A patent/BR112015004902A2/pt not_active Application Discontinuation
- 2013-09-05 WO PCT/US2013/058172 patent/WO2014039627A1/en not_active Ceased
- 2013-09-05 KR KR1020157008875A patent/KR20150048888A/ko not_active Ceased
- 2013-09-05 MX MX2020002113A patent/MX385976B/es unknown
- 2013-09-05 AU AU2013312749A patent/AU2013312749B2/en not_active Ceased
- 2013-09-05 KR KR1020207015718A patent/KR20200065113A/ko not_active Ceased
- 2013-09-05 CN CN201380057910.7A patent/CN104768540A/zh active Pending
- 2013-09-05 HK HK15111735.0A patent/HK1210947A1/xx unknown
- 2013-09-05 JP JP2015531176A patent/JP2015531346A/ja active Pending
- 2013-09-05 EP EP13836121.7A patent/EP2892514A4/en not_active Withdrawn
- 2013-09-05 BR BR122016020433A patent/BR122016020433A2/pt not_active Application Discontinuation
- 2013-09-05 BR BR122016020434A patent/BR122016020434A2/pt not_active Application Discontinuation
- 2013-09-05 EP EP22162245.9A patent/EP4035668A1/en not_active Withdrawn
- 2013-09-05 EA EA201500293A patent/EA038489B1/ru unknown
- 2013-09-05 US US14/426,022 patent/US9561218B2/en not_active Expired - Fee Related
- 2013-09-05 CA CA2882407A patent/CA2882407C/en active Active
- 2013-09-05 IN IN1706DEN2015 patent/IN2015DN01706A/en unknown
- 2013-09-05 MX MX2015002864A patent/MX378091B/es unknown
-
2015
- 2015-02-10 IL IL237176A patent/IL237176B/en active IP Right Grant
-
2016
- 2016-12-13 US US15/377,344 patent/US9913836B2/en not_active Expired - Fee Related
-
2018
- 2018-01-25 IL IL257150A patent/IL257150A/en unknown
- 2018-01-25 US US15/879,803 patent/US20190000826A1/en not_active Abandoned
- 2018-04-23 JP JP2018082454A patent/JP2018150314A/ja active Pending
-
2019
- 2019-06-20 US US16/446,706 patent/US20190365736A1/en not_active Abandoned
- 2019-08-08 IL IL268603A patent/IL268603B/en active IP Right Grant
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2020
- 2020-03-06 JP JP2020038441A patent/JP2020105212A/ja active Pending
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2021
- 2021-08-16 JP JP2021132146A patent/JP2021191759A/ja active Pending
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