IN2015DN01706A - - Google Patents

Download PDF

Info

Publication number
IN2015DN01706A
IN2015DN01706A IN1706DEN2015A IN2015DN01706A IN 2015DN01706 A IN2015DN01706 A IN 2015DN01706A IN 1706DEN2015 A IN1706DEN2015 A IN 1706DEN2015A IN 2015DN01706 A IN2015DN01706 A IN 2015DN01706A
Authority
IN
India
Prior art keywords
achei
increasing
pharmaceutical composition
high dose
relates
Prior art date
Application number
Inventor
Smith Kathleen E Clarence
Thomas N Chase
Original Assignee
Chase Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chase Pharmaceuticals Corp filed Critical Chase Pharmaceuticals Corp
Publication of IN2015DN01706A publication Critical patent/IN2015DN01706A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2063—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to a pharmaceutical composition comprising propiverine trospium or glycopyrrolate; and a non anticholinergic antiemetic agent. It is also related to a pharmaceutical composition comprising a high dose of solifenacin or a pharmaceutically acceptable salts thereof; and a non anticholinergic antiemetic agent. Pharmaceutical compositions containing high dose of nsPAChA for use for increasing the AChEI blood concentrations and for combating neurodegeneration are also described. The invention also relates to a method for inducing neuroprotection and combating neurodegeneration in a patient suffering from Alzheimer type dementia as well as to a method for increasing the blood levels of an acetyl choline esterase inhibitor (AChEI) in a human subject treated with an AChEI dose.
IN1706DEN2015 2012-09-05 2013-09-05 IN2015DN01706A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261697039P 2012-09-05 2012-09-05
US201261697069P 2012-09-05 2012-09-05
US201261697021P 2012-09-05 2012-09-05
US201261696978P 2012-09-05 2012-09-05
PCT/US2013/058172 WO2014039627A1 (en) 2012-09-05 2013-09-05 Anticholinergic neuroprotective composition and methods

Publications (1)

Publication Number Publication Date
IN2015DN01706A true IN2015DN01706A (en) 2015-05-22

Family

ID=50237591

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1706DEN2015 IN2015DN01706A (en) 2012-09-05 2013-09-05

Country Status (14)

Country Link
US (4) US9561218B2 (en)
EP (2) EP2892514A4 (en)
JP (4) JP2015531346A (en)
KR (2) KR20200065113A (en)
CN (1) CN104768540A (en)
AU (1) AU2013312749B2 (en)
BR (3) BR112015004902A2 (en)
CA (1) CA2882407C (en)
EA (1) EA038489B1 (en)
HK (1) HK1210947A1 (en)
IL (3) IL237176B (en)
IN (1) IN2015DN01706A (en)
MX (2) MX385976B (en)
WO (1) WO2014039627A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8969402B2 (en) * 2006-11-15 2015-03-03 Steven A. Rich Combined acetylcholinesterase inhibitor and quaternary ammonium antimuscarinic therapy to alter progression of cognitive diseases
CA2804215C (en) 2009-07-22 2019-10-01 Eric Elenko Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation
MX356386B (en) * 2012-08-09 2018-05-28 Chase Pharmaceuticals Corp Piperidinium quaternary salts.
BR112015004902A2 (en) * 2012-09-05 2017-07-04 Chase Pharmaceuticals Corp anticholinergic neutroprotective methods and composition
US10149828B2 (en) * 2015-01-09 2018-12-11 Chase Pharmaceuticals Corporation Oxybutynin transdermal therapeutic system combination
US10307409B2 (en) 2015-03-06 2019-06-04 Chase Pharmaceuticals Corporation Muscarinic combinations and their use for combating hypocholinergic disorders of the central nervous system
CA2978201A1 (en) 2015-03-06 2016-09-15 Chase Pharmaceuticals Corporation Use of oxybutynin transdermal formulations to reduce side effects associated with muscarinic agonists
US20180360845A1 (en) * 2015-07-20 2018-12-20 Chase Pharmaceuticals Corporation Muscarinic combination of a selective m2-antagonist and a peripheral non-selective antagonist for treating hypocholinergic disorders
CA2996717A1 (en) * 2015-09-11 2017-03-16 Chase Pharmaceuticals Corporation Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system
CA2996719A1 (en) * 2015-09-11 2017-03-16 Chase Pharmaceuticals Corporation Muscarinic combinations and their use for combating hypocholinergic disorders of the central nervous system
US10357487B2 (en) * 2015-12-03 2019-07-23 Sidney J. Goldfarb Combinations of acetylcholinesterase inhibitors and muscarinic agonists and methods of use thereof
WO2017147104A1 (en) * 2016-02-24 2017-08-31 Chase Pharmaceuticals Corporation Muscarinic m2-antagonist combinations
US10548855B2 (en) * 2016-10-28 2020-02-04 Chase Pharmaceuticals Corporation Memantine combinations and use
EP3589369A4 (en) 2017-01-09 2020-03-18 DAS-MG, Inc. USE AND COMPOSITION FOR TREATING MYASTHENIA GRAVIS AND OTHER MYASTHENIC SYNDROME
WO2018140412A1 (en) * 2017-01-24 2018-08-02 Gt Biopharma, Inc. Neostigmine combination and compositions
AU2018243718A1 (en) * 2017-03-27 2019-11-07 Chase Therapeutics Corporation Compositions and methods for treating synucleinopathies
NZ773719A (en) 2018-09-28 2022-07-29 Karuna Therapeutics Inc Compositions and methods for treating disorders ameliorated by muscarinic receptor activation
US12112463B2 (en) 2020-09-14 2024-10-08 City University Of Hong Kong Method, device and computer readable medium for intrinsic popularity evaluation and content compression based thereon
US11759451B2 (en) 2020-09-15 2023-09-19 City University Of Hong Kong Therapeutic potential of glycopyrrolate and mexiletine for nervous system injury
US12109202B2 (en) * 2021-01-29 2024-10-08 Qaam Pharmaceuticals, Llc Fixed dose combination of cholinesterase inhibitor and a quaternary ammonium antimuscarinic agent to treat neurodegenerative cognitive disorders
US20220304946A1 (en) * 2021-03-28 2022-09-29 Muhammad Imran Khan Trans-anethole ((e)-1-methoxy-4- (1-propenyl) benzene), a new and potent inhibitor of prolyl endopeptidase

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2956062A (en) 1959-02-26 1960-10-11 Robins Co Inc A H Esters of amino alcohols
US3480626A (en) 1967-05-18 1969-11-25 Chem Fab Dr R Pfleger Certain azoniaspironortropine derivatives
GB1204580A (en) 1968-10-05 1970-09-09 Aspro Nicholas Ltd Pharmaceutical dosage forms
US3576388A (en) 1968-12-05 1971-04-27 Stauffer Wacker Silicone Corp Electrical cable
DD106643A1 (en) 1973-07-12 1974-06-20
US4663318A (en) 1986-01-15 1987-05-05 Bonnie Davis Method of treating Alzheimer's disease
GB9423588D0 (en) 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
NO2005012I1 (en) 1994-12-28 2005-06-06 Debio Rech Pharma Sa Triptorelin and pharmaceutically acceptable salts thereof
IL128877A0 (en) 1997-07-09 2000-01-31 Axonyx And Nat Inst Of Health Highly selective butyrylcholinesterase inhibitors for the treatment and diagnosis of alzheimer's disease and dementias
GB9721139D0 (en) * 1997-10-07 1997-12-03 Glaxo Group Ltd Medicaments
EP0976404A3 (en) 1998-07-30 2001-06-27 Pfizer Products Inc. A pharmaceutical composition for the prevention and treatment of diseases of cognitive dysfunction in a mammal
WO2000019985A2 (en) 1998-10-01 2000-04-13 Novartis Ag New sustained release oral formulations
CN1285348A (en) 1999-08-20 2001-02-28 广东康美药业股份有限公司 Process for synthesizing propiverine hydrochloride
IL141235A (en) * 2000-02-09 2012-04-30 Novartis Int Pharm Ltd Combined use of an alpha-adrenoceptor antagonist and a muscarinic antagonist in the manufacture of a medicament for the treatment of benign prostatic hyperplasia
WO2002072093A2 (en) 2001-02-08 2002-09-19 Schering Corporation Use of dual h3/m2 antagonists with a bipiperidinic structure in the treatment of cognition deficit disorders
US7427280B2 (en) 2002-09-06 2008-09-23 Medtronic, Inc. Method, system and device for treating disorders of the pelvic floor by delivering drugs to various nerves or tissues
CN1520818A (en) 2003-02-09 2004-08-18 山东绿叶天然药物研究开发有限公司 Cholinesterase inhibitor pharmaceutical composition for senile dementia
KR100510788B1 (en) 2003-07-22 2005-08-26 동방에프티엘 주식회사 Process for preparation of the propiverine hydrochloride from O-n-propylbenzylic acid
KR100500760B1 (en) 2003-07-22 2005-07-14 동방에프티엘 주식회사 Process for preparation of the propiverine hydrochloride
GB0322140D0 (en) 2003-09-22 2003-10-22 Pfizer Ltd Combinations
AU2005207835A1 (en) 2004-01-16 2005-08-11 Wyeth Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole
AR051950A1 (en) 2004-11-10 2007-02-21 Osmotica Pharmaceutical Argent MULTI-PAD COMPRESSED WITH SEPARATING LAYERS
WO2006100453A1 (en) * 2005-03-24 2006-09-28 Sosei R & D Ltd. Glycopyrronium salts and their therapeutic use
US7390816B2 (en) 2005-06-21 2008-06-24 Bridge Pharma, Inc. Methods for treating urinary incontinence in patients suffering from memory disorders
US20070224259A1 (en) 2005-09-21 2007-09-27 Gupta Anil K Anti-inflammatory pharmaceutical composition
US20070093519A1 (en) * 2005-10-20 2007-04-26 Indevus Pharmaceuticals, Inc. Anti-emetic uses of cannabinoid analogs
WO2007055806A1 (en) * 2005-10-31 2007-05-18 Indevus Pharmaceuticals, Inc. Anti-emetic uses of (3r,4r)-δ8-tetrahydrocannabinol-11-oic acids
US20070173528A1 (en) 2005-12-21 2007-07-26 Nurit Perlman Process for preparing solifenacin
MX2008013539A (en) 2006-04-21 2008-10-29 Wyeth Corp Production of chirally pure amino alcohol intermediates, derivatives thereof, and uses thereof.
DE602007013559D1 (en) 2006-07-07 2011-05-12 Univ Aarhus NANOTEILES FOR THE DISTRIBUTION OF NUCLEIC ACID
US8097633B2 (en) 2006-11-15 2012-01-17 Rich Steven A Uses for quaternary ammonium anticholinergic muscarinic receptor antagonists in patients being treated for cognitive impairment or acute delirium
US8877768B2 (en) * 2009-09-18 2014-11-04 Chase Pharmaceuticals Corporation Method and composition for treating alzheimer-type dementia
US8404701B2 (en) 2008-03-27 2013-03-26 Chase Pharmaceuticals Corporation Use and composition for treating dementia
US20110201597A1 (en) 2008-03-27 2011-08-18 Chase Thomas N Method and composition for treating alzheimer-type dementia
WO2009139002A2 (en) 2008-05-12 2009-11-19 Msn Laboratories Limited An improved process for the preparation of solifenacin and its pharmaceutically acceptable salts thereof
SI2451809T1 (en) 2009-07-09 2017-01-31 KRKA, tovarna zdravil, d.d.,Novo mesto A process for the preparation and purification of solifenacin salts
KR20120023059A (en) 2010-03-15 2012-03-12 라마크리시나 라메샤 안다가 Synthesis of propiverine hydrochloride
WO2011125763A1 (en) * 2010-03-31 2011-10-13 小野薬品工業株式会社 Preventive and/or remedy for hand and foot syndrome
KR101149821B1 (en) 2010-04-05 2012-05-24 하나제약 주식회사 Novel synthetic method of diphenylacetate derivatives
US8772491B2 (en) 2010-06-28 2014-07-08 Aurobindo Pharma Ltd Process for the preparation of solifenacin succinate
CN102218063B (en) 2011-04-12 2013-03-13 贵州神奇制药有限公司 Method for preparing propiverine hydrochloride medicaments, and product and detection method thereof
BR112015004902A2 (en) * 2012-09-05 2017-07-04 Chase Pharmaceuticals Corp anticholinergic neutroprotective methods and composition

Also Published As

Publication number Publication date
AU2013312749B2 (en) 2018-01-18
HK1210947A1 (en) 2016-05-13
MX2015002864A (en) 2015-07-14
US20190000826A1 (en) 2019-01-03
US20190365736A1 (en) 2019-12-05
AU2013312749A1 (en) 2015-04-02
AU2013312749A2 (en) 2015-04-16
BR122016020434A2 (en) 2019-08-27
EP2892514A4 (en) 2016-04-13
MX2020002113A (en) 2021-09-08
MX385976B (en) 2025-03-18
CA2882407A1 (en) 2014-03-13
BR122016020433A2 (en) 2019-08-27
IL237176B (en) 2018-02-28
IL268603B (en) 2021-03-25
KR20200065113A (en) 2020-06-08
US9561218B2 (en) 2017-02-07
IL237176A0 (en) 2015-04-30
JP2018150314A (en) 2018-09-27
IL268603A (en) 2019-10-31
CA2882407C (en) 2022-11-15
EA201500293A1 (en) 2015-07-30
CN104768540A (en) 2015-07-08
JP2021191759A (en) 2021-12-16
EP2892514A1 (en) 2015-07-15
KR20150048888A (en) 2015-05-07
WO2014039627A1 (en) 2014-03-13
US20170087142A1 (en) 2017-03-30
US20150231122A1 (en) 2015-08-20
JP2020105212A (en) 2020-07-09
EP4035668A1 (en) 2022-08-03
US9913836B2 (en) 2018-03-13
JP2015531346A (en) 2015-11-02
EA038489B1 (en) 2021-09-06
BR112015004902A2 (en) 2017-07-04
IL257150A (en) 2018-03-29
MX378091B (en) 2025-03-10

Similar Documents

Publication Publication Date Title
IN2015DN01706A (en)
EA201590450A1 (en) SULFAMOIL-Arylamides and Their Use as Medicinal Products for the Treatment of Hepatitis B
WO2014028600A3 (en) 3-AMINOCYCLOALKYL COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF
WO2014028597A3 (en) 3-CYCLOHEXENYL AND CYCLOHEXYL SUBSTITUTED INDOLE AND INDAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF
NZ708593A (en) Novel pyrazole derivative
IN2014MN01755A (en)
NZ703064A (en) Inhibitors of hepatitis c virus
EA201590371A1 (en) 1,4-DESIGNED PYRIDAZIN ANALOGUES AND METHODS OF TREATMENT RELATED TO SMN DEFICIENCY CONDITIONS
EA201590453A1 (en) CONDENSED BICYCLIC DERIVATIVES OF SULFAMOIL AND THEIR APPLICATION AS A MEDICINE PREPARATION FOR THE TREATMENT OF HEPATITIS B
MX344177B (en) Use and composition for treating dementia.
PH12013502677A1 (en) Benzylamine derivatives as inhibitors of plasma kallikrein
IN2015DN01156A (en)
WO2014028591A3 (en) N-ALKYLATED INDOLE AND INDAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF
TN2012000465A1 (en) Derivatives of 1-amino-2-cyclopropylethylboronic acid
MX2014003080A (en) Substituted n- [1-cyano-2- (phenyl) ethyl] -2-azabicyclo [2.2.1] heptane-3-carboxamide inhibitors of cathepsin c.
NZ706739A (en) Substituted benzene compounds
IN2014MN02658A (en)
IN2014DN10386A (en)
PH12014502757A1 (en) Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
IN2014MN02652A (en)
IN2014KN01075A (en)
IN2014MN01962A (en)
PH12013501393A1 (en) Heterocyclic compounds suitable for the treatment of dyslipidemia
NZ603625A (en) A crystalline form of (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate
IN2013DN02555A (en)