JP2015529826A5 - - Google Patents
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- JP2015529826A5 JP2015529826A5 JP2015529850A JP2015529850A JP2015529826A5 JP 2015529826 A5 JP2015529826 A5 JP 2015529826A5 JP 2015529850 A JP2015529850 A JP 2015529850A JP 2015529850 A JP2015529850 A JP 2015529850A JP 2015529826 A5 JP2015529826 A5 JP 2015529826A5
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- JP
- Japan
- Prior art keywords
- cell
- antibody
- target molecule
- expressing
- phenotype
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261695527P | 2012-08-31 | 2012-08-31 | |
| US61/695,527 | 2012-08-31 | ||
| US201361814646P | 2013-04-22 | 2013-04-22 | |
| US61/814,646 | 2013-04-22 | ||
| PCT/US2013/055362 WO2014035693A2 (en) | 2012-08-31 | 2013-08-16 | Methods and compositions related to modulators of eukaryotic cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015529826A JP2015529826A (ja) | 2015-10-08 |
| JP2015529826A5 true JP2015529826A5 (https=) | 2018-01-18 |
| JP6590694B2 JP6590694B2 (ja) | 2019-10-16 |
Family
ID=50184579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015529850A Active JP6590694B2 (ja) | 2012-08-31 | 2013-08-16 | 真核生物細胞の調節因子に関する方法及び組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9738719B2 (https=) |
| EP (2) | EP2890836B1 (https=) |
| JP (1) | JP6590694B2 (https=) |
| CN (1) | CN105452546B (https=) |
| AU (2) | AU2013309272B2 (https=) |
| CA (1) | CA2883454C (https=) |
| DK (1) | DK2890836T3 (https=) |
| IL (1) | IL237479B (https=) |
| PT (1) | PT2890836T (https=) |
| WO (1) | WO2014035693A2 (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2928921T3 (da) | 2012-12-05 | 2021-04-19 | Novartis Ag | Sammensætninger og fremgangsmåder til antistoffer målrettet epo |
| SG11201600853UA (en) | 2013-08-05 | 2016-03-30 | Twist Bioscience Corp | De novo synthesized gene libraries |
| WO2016089829A1 (en) * | 2014-12-01 | 2016-06-09 | The Scripps Research Institute | Methods and compositions related to functional polypeptides embedded in heterologous protein scaffolds |
| CA2975855C (en) | 2015-02-04 | 2025-09-23 | Twist Bioscience Corporation | SYNTHETIC GENE COMPOSITIONS AND ASSEMBLY METHODS |
| US10669304B2 (en) | 2015-02-04 | 2020-06-02 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
| US9981239B2 (en) | 2015-04-21 | 2018-05-29 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
| WO2016205784A1 (en) * | 2015-06-19 | 2016-12-22 | The Scripps Research Institute | Methods and compositions for producing activated natural killer cells and related uses |
| CN107922975B (zh) | 2015-08-12 | 2022-06-28 | 诺华股份有限公司 | 治疗眼科病症的方法 |
| EP3350314A4 (en) * | 2015-09-18 | 2019-02-06 | Twist Bioscience Corporation | OLIGONUCLEIC ACID VARIANT LIBRARIES VARIANT AND SYNTHESIS THEREOF |
| KR102794025B1 (ko) | 2015-09-22 | 2025-04-09 | 트위스트 바이오사이언스 코포레이션 | 핵산 합성을 위한 가요성 기판 |
| CN115920796A (zh) | 2015-12-01 | 2023-04-07 | 特韦斯特生物科学公司 | 功能化表面及其制备 |
| WO2017189588A1 (en) * | 2016-04-25 | 2017-11-02 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind stat3 |
| WO2017214828A1 (zh) * | 2016-06-14 | 2017-12-21 | 石庆学 | 特异促进 Prkcz 基因高表达的慢病毒表达载体及其应用 |
| WO2017214829A1 (zh) * | 2016-06-14 | 2017-12-21 | 石庆学 | 特异促进 pd-l1 基因高表达的慢病毒表达载体及其应用 |
| WO2017214832A1 (zh) * | 2016-06-14 | 2017-12-21 | 石庆学 | 特异促进 Foxp3 基因高表达的慢病毒载体及其应用 |
| WO2017214830A1 (zh) * | 2016-06-14 | 2017-12-21 | 石庆学 | 特异促进 pd-1 基因高表达的慢病毒载体及其应用 |
| WO2017214831A1 (zh) * | 2016-06-14 | 2017-12-21 | 石庆学 | 特异促进 nrg1 基因高表达的慢病毒载体及其应用 |
| WO2017214910A1 (zh) * | 2016-06-15 | 2017-12-21 | 石庆学 | 特异促进Tβ4基因高表达的慢病毒表达载体及其应用 |
| WO2017214945A1 (zh) * | 2016-06-16 | 2017-12-21 | 毛侃琅 | 提升Hepcidin基因表达水平的慢病毒表达载体及其应用 |
| EP3500672A4 (en) | 2016-08-22 | 2020-05-20 | Twist Bioscience Corporation | DE NOVO SYNTHETIZED NUCLEIC ACID LIBRARIES |
| US10417457B2 (en) | 2016-09-21 | 2019-09-17 | Twist Bioscience Corporation | Nucleic acid based data storage |
| GB2573069A (en) | 2016-12-16 | 2019-10-23 | Twist Bioscience Corp | Variant libraries of the immunological synapse and synthesis thereof |
| CA3051714A1 (en) * | 2017-01-31 | 2018-08-09 | The Governors Of The University Of Alberta | Display of molecules on silently genetically encoded nanoscale carriers for determining synergistic molecular interactions |
| EP4556433A3 (en) | 2017-02-22 | 2025-08-06 | Twist Bioscience Corporation | Nucleic acid based data storage |
| AU2018234624B2 (en) * | 2017-03-15 | 2023-11-16 | Twist Bioscience Corporation | De novo synthesized combinatorial nucleic acid libraries |
| WO2018170169A1 (en) | 2017-03-15 | 2018-09-20 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
| WO2018231872A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| US11407837B2 (en) | 2017-09-11 | 2022-08-09 | Twist Bioscience Corporation | GPCR binding proteins and synthesis thereof |
| EP3692370A2 (en) | 2017-10-04 | 2020-08-12 | OPKO Pharmaceuticals, LLC | Articles and methods directed to personalized therapy of cancer |
| CN111565834B (zh) | 2017-10-20 | 2022-08-26 | 特韦斯特生物科学公司 | 用于多核苷酸合成的加热的纳米孔 |
| IL275239B2 (en) * | 2017-12-11 | 2026-03-01 | Abalone Bio Inc | Yeast presentation of proteins in the subplasmic space |
| KR102804057B1 (ko) | 2018-01-04 | 2025-05-07 | 트위스트 바이오사이언스 코포레이션 | Dna 기반 디지털 정보 저장 |
| CA3100739A1 (en) | 2018-05-18 | 2019-11-21 | Twist Bioscience Corporation | Polynucleotides, reagents, and methods for nucleic acid hybridization |
| SG11202100721SA (en) | 2018-07-23 | 2021-02-25 | Univ Alberta | Genetically-encoded bicyclic peptide libraries |
| EP3864199A4 (en) | 2018-10-08 | 2023-05-03 | Amberstone Biosciences, Inc. | COMPARTMENTAL TESTING FOR BISPECIFIC AND MULTISPECIFIC BIOLOGICALS |
| WO2020139871A1 (en) | 2018-12-26 | 2020-07-02 | Twist Bioscience Corporation | Highly accurate de novo polynucleotide synthesis |
| CN113766930B (zh) | 2019-02-26 | 2025-07-22 | 特韦斯特生物科学公司 | Glp1受体的变异核酸文库 |
| JP2022522668A (ja) | 2019-02-26 | 2022-04-20 | ツイスト バイオサイエンス コーポレーション | 抗体を最適化するための変異体核酸ライブラリ |
| CN113544509A (zh) * | 2019-03-08 | 2021-10-22 | 牛津遗传学有限公司 | 选择抗体的方法 |
| US11332738B2 (en) | 2019-06-21 | 2022-05-17 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
| JP2022548783A (ja) | 2019-09-23 | 2022-11-21 | ツイスト バイオサイエンス コーポレーション | 単一ドメイン抗体のバリアント核酸ライブラリー |
| EP4034566A4 (en) | 2019-09-23 | 2024-01-24 | Twist Bioscience Corporation | VARIANT NUCLEIC ACID BANKS FOR CRTH2 |
| BR112022011235A2 (pt) | 2019-12-09 | 2022-12-13 | Twist Bioscience Corp | Bibliotecas de variantes de ácido nucleico para receptores de adenosina |
| CN116102644B (zh) * | 2020-05-19 | 2025-06-03 | 益科思特(北京)医药科技发展有限公司 | 抗新型冠状病毒Spike蛋白抗体及其应用 |
| US20230348891A1 (en) * | 2020-08-21 | 2023-11-02 | Hifibio (Shanghai) Limited | Functional screening using droplet-based microfluidics |
| KR102579393B1 (ko) * | 2020-11-24 | 2023-09-18 | 재단법인대구경북과학기술원 | 신규한 항-c-mpl 항체 및 이의 용도 |
| EP4253417A4 (en) | 2020-11-24 | 2024-10-23 | Daegu Gyeongbuk Institute Of Science and Technology | NEW ANTI-C-MPL ANTIBODY AND ITS USE |
| WO2026006919A1 (en) * | 2024-07-05 | 2026-01-08 | Evolved Therapeutics Inc. | Method for the generation of large, multispecific antibody libraries and applications for ultra-high-throughput functional screening |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| ATE114723T1 (de) | 1987-03-02 | 1994-12-15 | Enzon Lab Inc | Organismus als träger für ''single chain antibody domain (scad)''. |
| US6969586B1 (en) * | 1989-05-16 | 2005-11-29 | Scripps Research Institute | Method for tapping the immunological repertoire |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5401629A (en) | 1990-08-07 | 1995-03-28 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Assay methods and compositions useful for measuring the transduction of an intracellular signal |
| US6300065B1 (en) * | 1996-05-31 | 2001-10-09 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
| US6103879A (en) * | 1996-06-21 | 2000-08-15 | Axys Pharmaceuticals, Inc. | Bivalent molecules that form an activating complex with an erythropoietin receptor |
| US5980893A (en) * | 1997-07-17 | 1999-11-09 | Beth Israel Deaconess Medical Center, Inc. | Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis |
| US6342220B1 (en) * | 1997-08-25 | 2002-01-29 | Genentech, Inc. | Agonist antibodies |
| WO2000055378A1 (en) | 1999-03-16 | 2000-09-21 | Dana-Farber Cancer Institute, Inc. | Lentiviral vector system for high quantity screening |
| EP1169352A4 (en) * | 1999-04-14 | 2005-05-04 | Smithkline Beecham Corp | ANTIBODY AGAINST THE ERYTHROPOIETIN RECEPTOR |
| WO2002033072A1 (fr) * | 2000-10-20 | 2002-04-25 | Chugai Seiyaku Kabushiki Kaisha | Anticorps degrade, agoniste de tpo |
| US20030104402A1 (en) | 2001-01-23 | 2003-06-05 | University Of Rochester | Methods of producing or identifying intrabodies in eukaryotic cells |
| AU2004309373A1 (en) * | 2003-12-22 | 2005-07-14 | Amgen Inc. | Methods for identifying functional antibodies |
| US20080038265A1 (en) * | 2004-04-09 | 2008-02-14 | Reilly Edward B | Antibodies to Erythropoietin Receptor and Uses Thereof |
| ZA200705695B (en) * | 2004-12-21 | 2009-02-25 | Astrazeneca Ab | Antibodies directed to angiopoietin-2 and uses thereof |
| KR20080073293A (ko) * | 2005-10-14 | 2008-08-08 | 메디뮨 엘엘씨 | 항체 라이브러리의 세포 디스플레이 |
| JP4294082B2 (ja) * | 2006-03-23 | 2009-07-08 | 協和発酵キリン株式会社 | ヒトトロンボポエチン受容体に対するアゴニスト抗体 |
| TW200808822A (en) * | 2006-04-14 | 2008-02-16 | Amgen Inc | Erythropoietin receptor agonists |
| JP5105468B2 (ja) * | 2006-12-05 | 2012-12-26 | 独立行政法人産業技術総合研究所 | 細胞内で機能する抗体の創製および細胞表現型を制御するタンパク質の同定 |
| JP2010517577A (ja) * | 2007-02-09 | 2010-05-27 | メディミューン，エルエルシー | 酵母細胞原形質膜による抗体ライブラリー提示 |
| EP2604279A1 (en) * | 2008-03-27 | 2013-06-19 | ZymoGenetics, Inc. | Compositions and methods for inhibiting PDGFRBETA and VEGF-A |
-
2013
- 2013-08-16 PT PT13833286T patent/PT2890836T/pt unknown
- 2013-08-16 JP JP2015529850A patent/JP6590694B2/ja active Active
- 2013-08-16 US US14/424,663 patent/US9738719B2/en active Active
- 2013-08-16 WO PCT/US2013/055362 patent/WO2014035693A2/en not_active Ceased
- 2013-08-16 CA CA2883454A patent/CA2883454C/en active Active
- 2013-08-16 CN CN201380057193.8A patent/CN105452546B/zh active Active
- 2013-08-16 AU AU2013309272A patent/AU2013309272B2/en active Active
- 2013-08-16 EP EP13833286.1A patent/EP2890836B1/en active Active
- 2013-08-16 EP EP15161819.6A patent/EP2966088B1/en active Active
- 2013-08-16 DK DK13833286.1T patent/DK2890836T3/da active
-
2015
- 2015-03-01 IL IL237479A patent/IL237479B/en active IP Right Grant
-
2017
- 2017-04-20 AU AU2017202636A patent/AU2017202636B2/en active Active
- 2017-08-08 US US15/671,814 patent/US10494438B2/en active Active
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