JP2015529490A - 棚保存時における先端の無菌状態を維持するための、コンテナ閉鎖のための二重キャップシステム - Google Patents
棚保存時における先端の無菌状態を維持するための、コンテナ閉鎖のための二重キャップシステム Download PDFInfo
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Abstract
Description
本出願は、米国仮出願シリアル番号第61/675,909号(出願日:2012年7月26日)の恩恵を主張する。同文献の開示内容全体を出典を明示することにより本明細書の開示の一部とする。
本開示の実施形態は、コンテナ閉鎖および薬物送達システムに主に関する。いくつかの実施形態によれば、コンテナ閉鎖または薬物送達システムは、複数の単回投与分の治療用薬剤を溶液、エマルションまたは懸濁液の形態で分配用先端を通じて分配するように、構成される。単回投与分の治療用薬剤の投与後、残留量の薬剤および/または他の汚染物質(例えば、体液)が分配用先端の外面上に残留し得る。分配用先端上に残留している残留材料により、微生物増殖が促進される可能性がある。通気孔をコンテナのキャップへ付加することにより、残留薬剤の乾燥時間が短縮され、その結果、微生物増殖の可能性が低下する。コンテナの保存時において、キャップ中の通気孔により、外気が分配用先端と接触するため、コンテナの無菌状態が低下し得る。オーバーキャップを少なくとも通気型キャップの一部上に配置して、通気型キャップの一部上に通気孔を被覆し、分配用先端の無菌状態のための可能性が妥協されるのを低減する。
Claims (20)
- 治療用液体の分配のための装置であって、
前記治療用液体を保持するように構成されたコンテナであって、単回投与分の前記治療用液体を分配するように構成された分配用先端を有する、コンテナと、
前記分配用先端を含む前記コンテナの少なくとも一部上に適合するように構成された通気型キャップであって、前記通気型キャップは、前記通気型キャップと前記分配用先端との間に規定された空洞を通じた空気の進入および退出を可能にする1つ以上の通気孔を有する、通気型キャップと、
前記通気型キャップの少なくとも一部上に適合するように構成された第2のキャップと、
前記第2のキャップならびに前記コンテナおよび前記通気型キャップのうち一方または双方に連結された開封明示シールと、
を含む、装置。 - 前記コンテナは、複数の単回投与分の前記治療用液体を眼科用溶液、エマルションまたは懸濁液の形態で分配するように構成される、請求項1に記載の装置。
- 前記通気型キャップ中の1つ以上の通気孔は、前記治療用液体用量の分配後における前記コンテナの前記分配用先端における残留治療用液体の乾燥を加速させるために十分な前記空洞を通じた空気の進入および退出を可能にするように構成される、請求項1に記載の装置。
- 前記第2のキャップは、ねじられて前記装置から取り外されるように構成され、前記開封明示シールは、前記第2のキャップのねじれに応答して壊れるように構成される、請求項1に記載の装置。
- 前記通気型キャップおよび前記第2のキャップにより一体型構造が規定され、前記開封明示シールは、前記第2のキャップから剥離するように構成される、請求項1に記載の装置。
- 前記通気型キャップ、前記第2のキャップおよび前記開封明示シールにより一体型構造が規定され、前記開封明示シールは、前記通気型キャップおよび前記第2のキャップから剥離するように構成される請求項1に記載の装置。
- 前記第2のキャップにより第2の通気型キャップが規定され、前記第2の通気型キャップが前記コンテナに対してねじれると、前記通気型キャップおよび前記第2の通気型キャップの通気孔が重複する、請求項6に記載の装置。
- 前記コンテナは、1回分の用量よりも多くの前記治療用液体を含む、請求項7に記載の装置。
- 前記通気型キャップは、前記通気型キャップが前記コンテナ上に適合したときに、前記コンテナの前記分配用先端との接触を確立するように前記通気型キャップ上に配置された突起を含む、請求項1に記載の装置。
- 前記突起は、前記通気型キャップが前記コンテナ上に適合したときに、前記コンテナの前記分配用先端を密封するように構成される、請求項9に記載の装置。
- 前記第2のキャップは乾燥剤システムを含む、請求項1に記載の装置。
- 前記コンテナの前記分配用先端および前記通気型キャップの一方または双方は、抗菌剤を含む、請求項1に記載の装置。
- 前記治療用液体は、防腐剤の入っていない治療用液体である、請求項1に記載の装置。
- 前記治療用薬剤は、溶液、エマルションまたは懸濁液の形態であり、前記治療用薬剤は、ビマトプロスト、ブリモニジン、チモロール、シクロスポリン、ガチフロキサシン、オクロキサシン、プレドニゾロン、カルニチンおよびケトロラクからなる群から選択される、請求項1に記載の装置。
- 前記コンテナは一方弁を含み、前記一方弁は、前記分配用先端に配置され、流体が前記コンテナ中へ戻るのを回避するように構成される、請求項1に記載の装置。
- 前記一方弁は、前記コンテナの外部の供給源からの前記治療用液体の汚染を回避するように構成される、請求項15に記載の装置。
- 前記コンテナおよび前記分配用先端は、低密度ポリエチレン、高密度ポリエチレンおよび耐衝撃性ポリスチレンからなる群から選択される1つ以上のポリマーによって形成される、請求項1に記載の装置。
- 治療用液体を保持するように構成されたコンテナのリザーバ中に前記治療用液体を保存することを含む方法であって、前記コンテナは、
単回投与分の前記治療用液体を分配するように構成された分配用先端と、
前記分配用先端を含む前記コンテナの少なくとも一部上に適合するように構成されかつ1つ以上の通気孔を有する通気型キャップであって、前記1つ以上の通気孔により、前記通気型キャップと前記分配用先端との間に規定された空洞を通じた空気の進入および退出が可能になる、通気型キャップと、
前記通気型キャップの少なくとも一部上に適合するように構成された第2のキャップと、
前記第2のキャップならびに前記コンテナおよび前記通気型キャップのうち一方または双方に連結された開封明示シールと、
を含む、方法。 - 前記コンテナは、複数の単回投与分の前記治療用液体を眼科用溶液、エマルションまたは懸濁液の形態で分配するように構成される、請求項18に記載の装置。
- 前記治療用液体を保持するように構成されたコンテナからキャップを取り外すことであって、前記コンテナは、単回投与分の前記治療用液体を分配するように構成された分配用先端を含み、前記キャップは、
前記分配用先端を含む前記コンテナの少なくとも一部上に適合されるように構成されかつ1つ以上の通気孔を有する通気型キャップであって、前記1つ以上の通気孔により、前記通気型キャップと前記分配用先端との間に規定された空洞を通じた空気の進入および退出が可能になる、通気型キャップと、
前記通気型キャップの少なくとも一部上に適合するように構成された第2のキャップと、
を含むことと、
前記コンテナから前記治療用液体を分配することと、
を含む、方法。
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PCT/US2013/052237 WO2014018847A1 (en) | 2012-07-26 | 2013-07-26 | Dual cap system for container-closures to maintain tip sterility during shelf storage |
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AU2013295636B2 (en) | 2017-12-14 |
US20240074894A1 (en) | 2024-03-07 |
US10806628B2 (en) | 2020-10-20 |
CN104507440A (zh) | 2015-04-08 |
CA2879703C (en) | 2021-11-16 |
US20140031767A1 (en) | 2014-01-30 |
CA2879703A1 (en) | 2014-01-30 |
BR112015001755B1 (pt) | 2021-08-24 |
WO2014018847A1 (en) | 2014-01-30 |
CO7180200A2 (es) | 2015-02-09 |
EP2877138A1 (en) | 2015-06-03 |
EP4265236A2 (en) | 2023-10-25 |
CN114099332A (zh) | 2022-03-01 |
BR112015001755A2 (pt) | 2017-07-04 |
RU2644257C2 (ru) | 2018-02-08 |
MY175070A (en) | 2020-06-04 |
ES2952616T3 (es) | 2023-11-02 |
RU2015105803A (ru) | 2016-09-20 |
KR102124667B1 (ko) | 2020-06-18 |
US20210015661A1 (en) | 2021-01-21 |
AU2013295636A1 (en) | 2015-02-05 |
SG10201801222YA (en) | 2018-04-27 |
ZA201500355B (en) | 2015-12-23 |
MX2015001220A (es) | 2015-04-14 |
JP6409192B2 (ja) | 2018-10-24 |
KR20150034774A (ko) | 2015-04-03 |
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NZ703922A (en) | 2017-04-28 |
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