JP2015526514A - Dickkopf−1発現調整組成物及びその使用 - Google Patents
Dickkopf−1発現調整組成物及びその使用 Download PDFInfo
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- JP2015526514A JP2015526514A JP2015529770A JP2015529770A JP2015526514A JP 2015526514 A JP2015526514 A JP 2015526514A JP 2015529770 A JP2015529770 A JP 2015529770A JP 2015529770 A JP2015529770 A JP 2015529770A JP 2015526514 A JP2015526514 A JP 2015526514A
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Abstract
Description
タイプI(点数0−7)白色;非常に色白;そばかす;典型的白子皮膚。
常に日焼けする、着色しない
タイプII(点数8−16)白色;色白。
通常日焼けする、着色が困難
タイプIII(点数17−24)ベージュ;非常に一般的。
時々軽く日焼けする、明るい茶色まで徐々に着色
タイプIV(点数25−30)茶色がかったベージュ;典型的な地中海の白人。
まれに日焼けする、穏やかな茶色まで容易に着色
タイプV(点数30以上)濃い茶色。
ほとんど日焼けしない、非常に容易に着色
タイプVI:黒色。
日焼けしない、非常に容易に着色、深く色素沈着。
表皮は皮膚の層の最上部であり、防水性を与え、汚染物質及び他の外部物質に対する障壁として機能する。この層はほとんど角質細胞からなり、角質細胞は基底層(表皮の最深層)においてケラチン幹細胞の部分から発生する。角質細胞は表皮の層を通って押し上げられて段階的に分化する。これらの細胞が皮膚の表面に移動する間に、角質細胞は細胞核を摘出され、平坦にされて高度に角質化される。やがて角質細胞は死滅して上皮角質層(表皮の最外層)を形成し、外部の物体及び伝染性の薬剤の体への侵入の効果的な障壁として機能するとともに湿度の損失を最小限にする。通常の健全な皮膚においては、角質は連続的に30日ごとに剥離して再生する。ところが、老化した皮膚においては、上皮角質層はその湿度を保持する容量を失い、角質の再生が低減し、皮膚は水分を失う。
[真皮]
真皮は、皮膚の下部の層であり、表皮と皮下組織との間に位置している。真皮は皮膚層の中で最も厚く、線維細胞芽によって維持される皮膚の細胞外複合相を含有している。線維細胞芽は、細胞外複合相の前駆物質が継続的に分泌されることによって、接続組織の構造的に完全な状態を維持している。老化した皮膚においては、コラーゲンと弾性繊維の双方の合成と成熟の間の平衡、及びそれらの分解を確保している線維細胞芽は、この均衡をコラーゲンと弾性繊維の分解へと向ける。
皮膚及び毛の色素沈着は、表皮及び毛線維のそれぞれにおける、メラニン存在量によって決定される。例えば、3種の異なる型のメラニンが表皮に存在する:DHI−メラニン、DHICA−メラニン及びフェオメラニンである。メラニンの異なる型は、色または陰影を多様にする。DHI−メラニンは最も暗く、色的には黒い。DHICA−メラニンは色的には茶色がかっている。フェオメラニンは最も明るく、色的には赤みがかっている。
1つの実施形態においては、限定されるものではないが、天然植物材料として酵母/C−ボレアリス発酵抽出物が用いられ、これは線維細胞芽及び角質細胞の増殖を促し、コラーゲンの発現を増加させ、そしてコラゲナーゼの活性を阻害する。天然植物材料を有する組成物が、老化と環境ストレスに影響を受けた皮膚に局所的に塗られた時には、老化の皮膚病学的な徴候に作用して、皮膚の状態及び美的外観、すなわち、顔の線、しわ、及び皮膚のたるみが改善される。副次的に、皮膚の堅さ、皮膚の丸さ、皮膚の柔軟性、または皮膚の厚さのうち1または2以上の増加により証明される、老化した皮膚の美的外観の改善が見られる。一実施形態では、天然の植物材料は、これらに限定されないが、酵母/ C.は、それに由来する成分または抽出物を含む、発酵抽出物をボレアリス線維芽細胞およびケラチノサイトの増殖を刺激し、コラーゲンの発現を増加させ、コラゲナーゼ活性を阻害し、そのような天然植物材料を有する組成物が老化または環境ストレスの影響を受けた皮膚に局所的に投与されたとき、状態、老化の皮膚科学的徴候の影響を受けた皮膚の美的外観を向上すること、例えば、顔のしわの線、しわを軽減し、皮膚のたるみによって。付随的に、改善、皮膚の硬さ、皮膚のふくよかさ、皮膚の柔軟性、または皮膚の厚さの一つ以上の増加によって証明される老化皮膚の美的外観である。局所組成物は、毎日適用され、患部に残る。
1つの実施形態においては、本発明は皮膚の状態と外観を向上させる方法を包含し、この方法は、酵母/C−ボレアリス発酵抽出物を含む組成物を、影響を受けた皮膚の領域に、色素沈着を減少させ;皮膚を明色化し;色素過剰の皮膚を治療し;皮膚の厚さを増加させ;皮膚多毛症を低減し;及び/または皮膚形質を非手掌足底から手掌足底へ変化させるために、塗布することを含む。
本発明の組成物は、酵母/C−ボレアリス抽出物に加えて、1または2以上の活性皮膚処理剤を含む。
本発明に関して、酵母/C−ボレアリス抽出物を含む組成物は、抗酸化剤、耐燃焼剤、日焼け止め剤、化粧剤、老化防止製剤、例えば、細い線及び/または小じわ用のクリーム、外用剤、皮膚浸透促進剤、スプレー、及び類似物を含む化粧品、をさらに含むことができる。また、本発明に関し、このような組成物に含まれる植物成分及び追加要素成分は、多様な製品形状に形成できる。局所的投与のための1つの実施形態では、組成物は、例えばクリーム、ローション、ジェル、血清、経皮性絆創膏、及び類似物のような、目標を定めた供与形態により作製される。目標を定めた供与及び/または浸透促進は、イオン泳動によっても達成される。
特定の態様において、本明細書に記載の化粧品組成物は、皮膚又は毛髪を明るくするために、例えば、治療および/または皮膚の色素沈着及び/または毛髪を防止するために使用することができる。いくつかの実施形態では、酵母/Cの有効量を含む組成物は、発酵抽出物がハイパー色素沈着した皮膚または毛髪の領域に、例えば、皮膚または毛髪に局所的に適用されるボレアリス。ハイパー色素沈着は、個人が希望すると、そのメラノサイトによって引き起こされるよりも暗い個人の皮膚や髪のいずれかの着色が含まれる。このような不要な色素沈着も変色と呼ばれることがある。皮膚のハイパー色素沈着領域は、ディスクリートまたはまだらハイパー色素沈着の領域を含む。離散ハイパー色素沈着の領域は暗い色の明確な、均一な領域とすることができ、一般的に色素斑やシミと呼ばれるマークを含む皮膚に茶色の斑点やそばかす、として表示されることがある。皮膚の斑状色素沈着の領域は別個の色素沈着の面積よりも大きさや形状がより大きく、より不規則な暗い斑点とすることができる。ハイパー色素沈着の領域も日焼けした皮膚の領域、例えば、原因がUV曝露に日焼けした肌が含まれる。ハイパー色素沈着の髪は適切でない暗い髪のいずれかの影が含まれる。
皮膚の色素沈着にDICKKOPF−1発現の増強剤の効果に加えて、DICKKOPF−1発現促進剤はまた、非掌の皮膚に皮膚の厚さを増加させる。これは、インスタンスの皮膚移植、皮膚潰瘍、皮膚の擦り傷や裂離/(ボリューム欠陥を残すものなど)切除、反復的な衝撃や機械的なストレスによる傷害に傷害または素因、年齢、皮膚科様々な条件を治療するのに有用である原因ステロイド治療に関連の皮膚の変化(例えば、間伐やしわの皮膚)、または皮膚損傷。
[C−ボレアリス抽出物の作製]
クリントニア・ボレアリスが採取され、200mgの乾燥植物材料から1mLの抽出物が得られ、1:5の水溶液として水性注入液が作製された。注入液は有機溶剤を使わない水性調合物である。
[酵母/C−ボレアリス発酵抽出物の作製]
上記のクリントニア・ボレアリス抽出物は、通常のPichia pastoris 発酵媒体で72〜140時間の期間、植物組成物が少なくとも吸光度測定により評価される一部が代謝されるまで、発酵された。粗生成した酵母/C−ボレアリス発酵抽出物は、多糖類を含む細胞壁成要素に溶解し、精製された。不溶解物は、色彩と香りを向上させるために濾過により除去された。最終的に得られた液体発酵抽出製品が保存された。
[線維芽細胞の組織培養]
ヒト皮膚線維芽細胞、成人(22yrs;カスケード;♯5C0759)が、10%FBS、1%L−グルタミン、及び1%P/Sを含む線維芽細胞成長媒体中で育てられた。線維芽細胞を350,000細胞/ウェルの密度で6−ウェルプレートの上に播種して、一晩培養した。上澄みを、純水粗生物から除去した。溶媒または酵母/C−ボレアリス発酵抽出物のいずれかを含有する無血清培地(1%L−グルタミン、1%P/Sを含み、FBSを含まない)を、細胞に添加した。48時間後に、細胞溶解物を収集した。
[タンパク質濃度の測定]
タンパク質濃度は、クーマシータンパク質分析によって測定した。手短に言えば、標準物質を、ウシ血清アルブミン(BSA)を用いて作製した。1:100に希釈された細胞可溶化物を用意した。標準物質と可溶化物を、同量のクーマシー溶液(♯1856209;サーモ・サイエンティフィック)と混合した。0.2mLの混合物を96ウェルプレートに加えて、570nmの波長で読み取った。
[DICKKOPF−1の量の測定]
DICKKOPF−1の量は、R&Dシステム(DY1906E)のヒトDICKKOPF−1・エリサキット(ELISA(Enzyme-Linked Immuno sorbent Assay)Kit)を用いて測定した。製造業者の定めた実験手順は以下のようであった。手短に言えば、96ウェルプレートは4μg/mLの捕獲抗体で、100μL/ウェルで一晩覆われた。プレートは3回洗浄され、300μL/ウェルの試薬希釈剤(PBS中に1%のBSAを含む)で1時間ブロックされた。プレートは3回洗浄された。試験サンプルがクーマシータンパク質分析のデータを用いて準備された;このように全てのサンプルが等量のタンパク質を有する。DICKKOPF−1基準物質と試験サンプルが、100μL/ウェルにおいて2時間添加された。プレートは3回洗浄され、それから100μLの検出用抗体(10ng/mL)が添加され、2時間培養された。プレートは3回洗浄され、続いて100μL/ウェルのストレプトアビジン−HRPが20分間添加された。プレートは3回洗浄され、それから100μL/ウェルの基質溶液が20分間添加された。50μL/ウェルの停止溶液を添加し、続いてプレートを静かに軽くたたいた。プレートを波長450nmにおいて読み取った。
[生体外におけるC−ボレアリス/酵母発酵抽出物による処理後のDICKKOPF−1発現の増加]
表1に示されるように、酵母/C−ボレアリス発酵抽出物により処理された線維芽細胞は、タンパク質レベルでのDICKKOPF−1発現を誘発する。
[生体外における酵母/C−ボレアリス発酵抽出物による皮膚の明色化]
既知の皮膚明色化剤の存在下における、生体外での皮膚の明色化の有効性を実証するための酵母/C−ボレアリス抽出物の能力を評価する実験が企画された。2種類の成分混合物が準備された:混合物1はチオジプロピオン酸/エステル、アスコルビン酸テトラヘキシルデシル、ストレスのかかった酵母抽出物、例えば米国特許公報番号第2011/0052517号に記載されている酵母抽出物/アグーチペプチド、アスコルビングルコシドを含有し、混合物2は混合物1の成分+酵母/C−ボレアリス発酵抽出物を含有していた。メラミン合成の速度を制限する酵素であることから、チロシナーゼ発現が皮膚の明色化の有効性を測定するために用いられた。
[生体外における酵母/C−ボレアリス発酵抽出物を含む製剤による皮膚の明色化]
酵母/C−ボレアリス発酵抽出物を含むスキンケア製剤のメラニン合成を抑制する効力は、メラノダーム(商標)FTB(MEL-300-FTB;マテック、アッシュランド、MA)を用いて、通常のケラチン生成細胞、メラニン形成細胞(アフリカ系アメリカ人に由来する)、及び線維芽細胞を含有する、再構成された三次元のヒト皮膚等価組織モデルについて評価された。組織は、製造業者に推奨されるMEL−300−FT−NMM−113媒体中で、成長した。10マイクロLのエッセンス製剤(実施例13に類似したもの)が1日目、2日目、4日目、7日目、9日目及び11日目に、局所的に塗布された。それぞれの塗布の前に、組織(N=4または5)は300μLのリン酸緩衝食塩水で2回洗浄された。14日目に、組織内のメラニン含有量が測定された。端的に言えば、組織は、0.4mLの1%SDS、50mMのEDTA、及び10mMのTris中で、pH6.8において細胞破砕された。それぞれの細胞破砕液に対して、20μLのタンパク質分解酵素・プロテナーゼK(5mg/mL)を加えて、45℃で一晩培養した。20μLの追加のプロテナーゼKを添加して、45℃で4時間培養した。それから、0.5Mの炭酸ナトリウム50μLと、30%のH2O210μLを加えて、80℃で30分間培養した。組織を冷却して、混合物を100μLのクロロホルム/メタノール(2:1)で抽出した。10,000gで10分間の遠心分離の後、上部相の吸光度を405nmで測定した。組織の画像をメラニン分離の前に撮影した。
[消費者パネル試験]
本発明の組成物は多様な対象(パネリスト)によって、すなわち、商業的に利用可能な局所塗布用組成物として有用かがテストされ比較された。開業医にとって高く評価されるように、制御組成物及びプロトタイプ組成物を、パネリストの皮膚に、時間単位、日単位、または月単位で塗布することをパネリストに依頼することができ、パネリストは質問票に基づいて製剤を評価した。例えば、パネリストはプロトタイプ組成物が色素沈着を低減したか;皮膚を明色化したか;色素過剰を治療したか;皮膚の厚さを増加させたか;皮膚の多毛性を改善したか;及び/または皮膚形質を非手掌足底から手掌足底形質へ変化させたか、についての質問を受けた。回答結果は、皮膚の明色化の向上;色素過剰皮膚の治療;色素沈着の低減;皮膚の厚さの増加;皮膚の多毛性の改善;及び/または皮膚形質の非手掌足底から手掌足底形質への変化を証明するものと思われる。
[生体内における酵母/C−ボレアリス発酵抽出物を含む製剤の局所的な塗布による皮膚への有益な効果の評価]
臨床的な有効性の研究が、光損傷を受けた顔の皮膚に関連する特質に影響を及ぼすために、他の選択された皮膚明色化成分に加えて、酵母/C−ボレアリス発酵抽出物を含む局所的なスキンケア基礎製剤を評価するために行われた。無作為のブラインド試験が、25〜40歳の年齢範囲の34人の女性について、実質的に実施例13で述べられた製剤を1日2回、12週間にわたって顔に塗布することにより実施された。基準時、2週間後、4週間後、8週間後及び12週間後に写真が撮影された。写真は、委員会認定の皮膚科専門医によって、以下の0〜9の等級で評価された。9等級が最も厳しい条件に相当する;分離した色素沈着、斑の色素沈着、目じりの小じわの細い線としわ、目じりの小じわの粗い線としわ、むらがない肌の色、透明性、病的に黄ばんだ肌の色、という皮膚の特質について評価された。これらのパラメータのそれぞれについて、t−検定を用いて、個々の時点における基準状態からの平均パーセント変化が基準値と比較された。0.05以下の有意確率(P値)が有意と思われた。基準値からの改善を示したもののパーセンテージも算出された。
[生体内での皮膚の厚さ増加]
本発明の抽出物により促進されたDICKKOPF−1により皮膚の厚さを増加させる効果は、メラノダーム(商標)FTB(MEL-300-FTB;マテック、アッシュランド、MA)の皮膚等価3D組織を用いて評価された。C−ボレアリスの酵母抽出物を含む組成物は、組織に局所的にまたは基底側の媒体中に数日間塗布された。処理の終了時に、組織部分は4%のパラホルムアルデヒドで固定され、そして Fontana-Masson 染色が実施された。皮膚等価物の厚さは、顕微鏡を用いて測定された。
[皮膚の明色化及び/または老化防止エッセンス製剤]
典型的な、酵母/C−ボレアリス発酵抽出物を含む変性された酵母ペプチド片を含有する、皮膚に局所的に塗布するための化粧品組成物は、以下の配合で得られる。この組成物は、老化防止及び/または皮膚の明色化の応用を有するエッセンスの形で供給される。
[皮膚を明るくする及び/または老化防止エッセンス製剤]
さらに典型的な、酵母/C−ボレアリス発酵抽出物を含有する、皮膚に局所的に塗布するための化粧品組成物は、以下の配合で得られる。再度、組成物は、老化防止及び/または皮膚の明色化の応用を有するエッセンスの形で供給され、典型的な化粧品組成物の全体がw/wパーセンテージとして明確に示される。
[制汗剤/または防臭剤]
典型的な、酵母/C−ボレアリス発酵抽出物を含む変性された酵母ペプチド片を含有する、皮膚に局所的に塗布するための化粧品組成物は、以下の配合で得られる。この組成物は、老化防止及び/または皮膚の明色化の応用を有する芳香剤の形で提供される。
水 qs
POP(15M)ステアリルエーテル 1−3%
パルミチン酸イソプロピル 1−3%
ステアレス−2 1−4%
アルミニウムクロロハイドレート 25%まで (またはアルミニウムジルコニウムトリクロロハイドレート20%まで)
酵母/C−ボレアリス発酵抽出物 0.001−3%
[調色液(トナー)]
典型的な、酵母/C−ボレアリス発酵抽出物を含む変性された酵母ペプチド片を含有する、皮膚に局所的に塗布するための化粧品組成物は、以下の配合で得られる。この組成物は、老化防止及び/または皮膚の明色化の応用を有するトナーの形で提供される。
[昼用クリーム]
典型的な、酵母/C−ボレアリス発酵抽出物を含む変性された酵母ペプチド片を含有する、皮膚に局所的に塗布するための化粧品組成物は、以下の配合で得られる。この組成物は、老化防止及び/または皮膚の明色化の応用を有する昼用クリームの形で提供される。
[乳液状ローション]
典型的な、酵母/C−ボレアリス発酵抽出物を含む変性された酵母ペプチド片を含有する、皮膚に局所的に塗布するための化粧品組成物は、以下の配合で得られる。この組成物は、老化防止及び/または皮膚の明色化の応用を有する乳液状ローションの形で提供される。
[夜用クリーム]
典型的な、酵母/C−ボレアリス発酵抽出物を含む変性された酵母ペプチド片を含有する、皮膚に局所的に塗布するための化粧品組成物は、以下の配合で得られる。この組成物は、老化防止及び/または皮膚の明色化の応用を有する夜用クリームの形で提供される。
[ブロックSPF50]
典型的な、酵母/C−ボレアリス発酵抽出物を含む変性された酵母ペプチド片を含有する、皮膚に局所的に塗布するための化粧品組成物は、以下の配合で得られる。この組成物は、老化防止及び/または皮膚の明色化の応用を有するブロックSPF50の形で提供される。
[洗顔料]
典型的な、酵母/C−ボレアリス発酵抽出物を含む変性された酵母ペプチド片を含有する、皮膚に局所的に塗布するための化粧品組成物は、以下の配合で得られる。この組成物は、洗顔料としての応用を有する芳香剤の形で提供される。
[21マスク]
典型的な、酵母/C−ボレアリス発酵抽出物を含む変性された酵母ペプチド片を含有する、皮膚に局所的に塗布するための化粧品組成物は、以下の配合で得られる。この組成物は、マスクとしての応用を有する芳香剤の形で提供される。
Claims (19)
- ヒトの皮膚の美的外観を改善するための方法であって、
色素過剰の皮膚の領域に、美容上許容可能な媒体中に有効な量のDICKKOPF−1発現増加剤を含有する組成物を局所的に塗布することを含み、
前記DICKKOPF−1発現増加剤は前記色素過剰の皮膚の領域において十分な色素沈着を減少させるのに十分な量で存在する、
ヒトの皮膚の美的外観を改善するための方法。 - 前記DICKKOPF−1発現増加剤が酵母/クリントニア・ボレアリス発酵抽出物である、
請求項1に記載の方法。 - 前記DICKKOPF−1発現増加剤が未代謝のクリントニア・ボレアリス抽出物を除くことを条件とする、
請求項1に記載の方法。 - 前記DICKKOPF−1発現増加剤が前記組成物中に約0.0001%から約10%の範囲で存在する、
請求項1に記載の方法。 - 前記DICKKOPF−1発現増加剤が、前記組成物に添加した時に約5.0から約7.0の範囲のpHを呈する酵母/クリントニア・ボレアリス発酵抽出物を含む、
請求項1に記載の方法。 - 前記DICKKOPF−1発現増加剤が水性のクリントニア・ボレアリス抽出物に由来する、
請求項2に記載の方法。 - 前記酵母がPichia pastorisである、
請求項1に記載の方法。 - 前記DICKKOPF−1発現増加剤が、チオジプロピオン酸(TDPA)またはそのエステル誘導体から選ばれる少なくとも1つの他の皮膚明色化剤と組み合わされている、
請求項1に記載の方法。 - ヒトの皮膚の美的外観を改善するための方法であって、
皮膚または毛を明るくするのに美容上許容可能な媒体中に有効な量のDICKKOPF−1発現増加剤を含有する組成物を、皮膚または毛に局所的に塗布することを含む、
ヒトの皮膚の美的外観を改善するための方法。 - ヒトの皮膚に有益な効果を提供するための方法であって、
美容上許容可能な媒体中に有効な量のDICKKOPF−1発現増加剤を含有する組成物を、それを必要とする皮膚の領域に、局所的に塗布することを含む、
ヒトの皮膚に有益な効果を提供するための方法。 - 前記DICKKOPF−1発現増加剤が非手掌足底(掌蹠)表現型を示す皮膚に塗布される、
請求項10に記載の方法。 - 前記有益な効果が皮膚の厚さの増加である、
請求項10に記載の方法。 - 前記有益な効果が女性多毛症の低減である、
請求項10に記載の方法。 - 前記有効な量のDICKKOPF−1発現増加剤が、
皮膚移植、皮膚潰瘍、皮膚の摩擦または剥離/切除(体積欠陥を残すようなもの)、傷害または反復的な衝撃または機械的な圧力に起因する傷つきやすくなっている皮膚質、年齢による皮膚の変化(例えば、皮膚の光老化または皮膚の薄化)、ステロイド治療による皮膚損傷、不均一な皮膚の色素沈着、色素過剰、炎症後の色素沈着、そばかす、芳香皮膚炎、白斑(例えば、広範囲に白斑を有する対象において色素消失がどこで要求されるか)、色素性母斑(例えばカフェオレ様スポット)、ほくろ、または慢性単純性苔癬による皮膚変化、肝斑、晩発性皮膚ポルフィリン症、アジソン病、ポイツ−ジェガーズ症候群、表皮肥厚症、多毛症、先天性副腎皮質過形成症、多嚢胞性卵巣症候群、異常多量毛髪成長、及び神経性無食欲症からなる群から選択される、少なくとも1つの皮膚の病状を治療するのに十分な量で存在する、
請求項10に記載の方法。 - 前記皮膚の有益な効果が、
(a)皮膚老化の徴候の治療または防止、(b)細い線または小じわの治療及び/または防止、(c)毛穴の大きさの低減、(d)皮膚の厚さ、ハリ、及び/または張りの改善、(e)皮膚のしなやかさ及び/または柔らかさの改善、(f)皮膚の色合い、輝き、及び/または透明感の改善、(g)皮膚のキメの改善及び/またはキメの再生の促進、(h)皮膚の障壁の回復及び/または機能の改善、(i)皮膚の輪郭の外観の改善、(j)皮膚のつや及び/または明るさの回復、(k)皮膚の必須栄養素及び/または成分の補充、(l)閉経により低下した皮膚の外観の改善、(m)皮膚のうるおいの改善及び/または水分補給、(n)皮膚の弾性及び/または弾力性の増加及び/または損失の防止、(o)コラーゲン前駆体及び/またはコラーゲンの合成の改善、(p)皮膚のたるみまたは萎縮の治療及び/または防止、(q)剥離の増強及び/または乾燥の減少、(r)皮膚の色素過剰の治療及び/または防止、(s)皮膚の明色化の改善、(t)過剰な皮脂生成の治療及び/または防止、及び(u)セルライトの治療及び/または防止、
からなる群から選択される、
請求項10に記載の方法。 - 前記皮膚の色素過剰が、老化班、斑の領域、分離した色素過剰領域、日焼け領域、脇の下の領域、または黒皮症の斑点を含む、
請求項10に記載の方法。 - 前記有益な効果が、アクネ病変、吹き出物、またはひりひりする領域の炎症の低減を含む、
請求項10に記載の方法。 - 0.001質量%から5質量%までの美容上許容可能な媒体中のDICKKOPF−1発現増加剤を含む局所外用組成物であって、
ローション、クリーム、美容軟膏、ジェル、またはスティックの形態である、
局所外用組成物。 - DICKKOPF−1発現を調整する有効な量の酵母発酵製品を、それを必要とする皮膚の領域に局所的に塗布することを含む皮膚の治療方法であって、
前記酵母発酵製品のDICKKOPF−1発現を調整する能力は、前記酵母発酵製品と接触した細胞内にDICKKOPF−1をコードするmRNAの濃度を測定する評価分析によって決定される、
皮膚の治療方法。
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PCT/US2012/053116 WO2014035401A1 (en) | 2012-08-30 | 2012-08-30 | Dickkopf-1 expression modulating compositions and uses thereof |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003212714A (ja) * | 2001-12-28 | 2003-07-30 | Avon Products Inc | 局所性ライトニング組成物およびその使用方法 |
WO2008070859A2 (en) * | 2006-12-07 | 2008-06-12 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Treatment of skin conditions by dickkopf1 (dkk1) |
JP2011528909A (ja) * | 2008-07-24 | 2011-12-01 | アーチ パーソナル ケア プロダクツ、エル.ピー. | 「酵母/レスベラトロール発酵」エキスを含有するパーソナルケア組成物 |
US20120165270A1 (en) * | 2009-04-27 | 2012-06-28 | Yeon Sook Choi | Inhibition of hair follicle growth by the wnt inhibitor dkk1 |
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US20040067245A1 (en) * | 2000-12-20 | 2004-04-08 | Harish Mahalingam | Cosmetic compositions and methods for using same to improve the aesthetic appearance of skin |
JP2003292417A (ja) * | 2002-04-01 | 2003-10-15 | Noevir Co Ltd | 表皮細胞賦活用組成物,真皮線維芽細胞賦活用組成物,コラーゲン産生促進用組成物、並びに皮膚外用剤 |
JP3611553B2 (ja) * | 2002-04-01 | 2005-01-19 | 株式会社ノエビア | 皮膚外用剤 |
JP2003306423A (ja) * | 2002-04-17 | 2003-10-28 | Noevir Co Ltd | 皮膚外用剤 |
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JP2003212714A (ja) * | 2001-12-28 | 2003-07-30 | Avon Products Inc | 局所性ライトニング組成物およびその使用方法 |
WO2008070859A2 (en) * | 2006-12-07 | 2008-06-12 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Treatment of skin conditions by dickkopf1 (dkk1) |
JP2011528909A (ja) * | 2008-07-24 | 2011-12-01 | アーチ パーソナル ケア プロダクツ、エル.ピー. | 「酵母/レスベラトロール発酵」エキスを含有するパーソナルケア組成物 |
US20120165270A1 (en) * | 2009-04-27 | 2012-06-28 | Yeon Sook Choi | Inhibition of hair follicle growth by the wnt inhibitor dkk1 |
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EP2890359B1 (en) | 2016-10-05 |
CA2877084A1 (en) | 2014-03-06 |
BR112015000339B1 (pt) | 2019-12-03 |
CN104470488B (zh) | 2018-03-27 |
HK1204558A1 (en) | 2015-11-27 |
EP2890359A1 (en) | 2015-07-08 |
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