JP2015526499A - 光力学療法における使用のためのピリジノン化合物 - Google Patents

光力学療法における使用のためのピリジノン化合物 Download PDF

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Publication number
JP2015526499A
JP2015526499A JP2015529127A JP2015529127A JP2015526499A JP 2015526499 A JP2015526499 A JP 2015526499A JP 2015529127 A JP2015529127 A JP 2015529127A JP 2015529127 A JP2015529127 A JP 2015529127A JP 2015526499 A JP2015526499 A JP 2015526499A
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Prior art keywords
compound
formula
ala
photodynamic therapy
mal
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JP2015529127A
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Japanese (ja)
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JP2015526499A5 (OSRAM
Inventor
クルナウ アリソン
クルナウ アリソン
ウッド マーク
ウッド マーク
ペリー アレクシス
ペリー アレクシス
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ユニバーシティ オブ エクセター
ユニバーシティ オブ エクセター
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Publication of JP2015526499A publication Critical patent/JP2015526499A/ja
Publication of JP2015526499A5 publication Critical patent/JP2015526499A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/81—Preparation or application process involves irradiation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Birds (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2015529127A 2012-09-03 2013-09-02 光力学療法における使用のためのピリジノン化合物 Pending JP2015526499A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1215675.8A GB201215675D0 (en) 2012-09-03 2012-09-03 Compound
GB1215675.8 2012-09-03
PCT/GB2013/052297 WO2014033477A1 (en) 2012-09-03 2013-09-02 Pyridinone compounds for use in photodynamic therapy

Publications (2)

Publication Number Publication Date
JP2015526499A true JP2015526499A (ja) 2015-09-10
JP2015526499A5 JP2015526499A5 (OSRAM) 2018-02-08

Family

ID=47075165

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015529127A Pending JP2015526499A (ja) 2012-09-03 2013-09-02 光力学療法における使用のためのピリジノン化合物

Country Status (15)

Country Link
US (1) US9346758B2 (OSRAM)
EP (1) EP2892881B1 (OSRAM)
JP (1) JP2015526499A (OSRAM)
KR (1) KR20150068374A (OSRAM)
CN (1) CN104718190B (OSRAM)
AU (1) AU2013308197B2 (OSRAM)
BR (1) BR112015004732A2 (OSRAM)
CA (1) CA2883754A1 (OSRAM)
GB (1) GB201215675D0 (OSRAM)
IN (1) IN2015DN02514A (OSRAM)
MX (1) MX2015002705A (OSRAM)
RU (1) RU2015111137A (OSRAM)
SG (1) SG11201501604TA (OSRAM)
WO (1) WO2014033477A1 (OSRAM)
ZA (1) ZA201502153B (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023549130A (ja) * 2020-10-29 2023-11-22 ワン キム，ジン ５‐アミノレブリン酸塩酸塩を含む組成物

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201215675D0 (en) 2012-09-03 2012-10-17 Univ Exeter Compound
EP3148528A1 (en) 2014-06-02 2017-04-05 University of Exeter Combinations of a photosensitizer with a hydrogen sulfide donor, thioredoxin inhibitor or nitroxide for use in photodynamic therapy
CN112062713B (zh) * 2020-08-04 2023-03-31 浙江工业大学 具铁螯合性和pdt活性的ala-hpo杂合衍生物及其制备方法与应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07500120A (ja) * 1992-08-12 1995-01-05 ビーティージー・インターナショナル・リミテッド 薬剤組成物
JP2000510123A (ja) * 1996-05-08 2000-08-08 ニューヨーク・ブラッド・センター・インコーポレイテッド ウイルス感染の治療方法
JP2004505105A (ja) * 2000-07-27 2004-02-19 フォトキュア　エイエスエイ 光化学治療における光増感剤としての５−アミノレブリン酸のエステル

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201215675D0 (en) 2012-09-03 2012-10-17 Univ Exeter Compound

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07500120A (ja) * 1992-08-12 1995-01-05 ビーティージー・インターナショナル・リミテッド 薬剤組成物
JP2000510123A (ja) * 1996-05-08 2000-08-08 ニューヨーク・ブラッド・センター・インコーポレイテッド ウイルス感染の治療方法
JP2004505105A (ja) * 2000-07-27 2004-02-19 フォトキュア　エイエスエイ 光化学治療における光増感剤としての５−アミノレブリン酸のエステル

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 34, no. 6, JPN6017023385, 1999, pages 475 - 485, ISSN: 0003585909 *
PHOTOCHEMISTRY AND PHOTOBIOLOGY, vol. Vol.86(5), JPN6017023387, 2010, pages 1154 - 1160, ISSN: 0003585910 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023549130A (ja) * 2020-10-29 2023-11-22 ワン キム，ジン ５‐アミノレブリン酸塩酸塩を含む組成物
JP7629525B2 (ja) 2020-10-29 2025-02-13 ワン キム，ジン ５‐アミノレブリン酸塩酸塩を含む組成物

Also Published As

Publication number Publication date
MX2015002705A (es) 2015-12-01
SG11201501604TA (en) 2015-05-28
AU2013308197B2 (en) 2018-02-01
BR112015004732A2 (pt) 2018-04-17
EP2892881A1 (en) 2015-07-15
IN2015DN02514A (OSRAM) 2015-09-11
CN104718190A (zh) 2015-06-17
RU2015111137A (ru) 2016-10-20
EP2892881B1 (en) 2017-07-19
WO2014033477A1 (en) 2014-03-06
CN104718190B (zh) 2017-03-08
GB201215675D0 (en) 2012-10-17
AU2013308197A1 (en) 2015-04-09
ZA201502153B (en) 2017-07-26
CA2883754A1 (en) 2014-03-06
US20150210642A1 (en) 2015-07-30
US9346758B2 (en) 2016-05-24
KR20150068374A (ko) 2015-06-19

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