JP2015526468A5 - - Google Patents
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- Publication number
- JP2015526468A5 JP2015526468A5 JP2015528552A JP2015528552A JP2015526468A5 JP 2015526468 A5 JP2015526468 A5 JP 2015526468A5 JP 2015528552 A JP2015528552 A JP 2015528552A JP 2015528552 A JP2015528552 A JP 2015528552A JP 2015526468 A5 JP2015526468 A5 JP 2015526468A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- heteroaryl
- cycloheteroalkyl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 193
- 125000003118 aryl group Chemical group 0.000 claims 60
- 125000001072 heteroaryl group Chemical group 0.000 claims 55
- 150000001875 compounds Chemical class 0.000 claims 46
- 125000001424 substituent group Chemical group 0.000 claims 44
- 229910052736 halogen Inorganic materials 0.000 claims 37
- 150000002367 halogens Chemical class 0.000 claims 33
- 229910052739 hydrogen Inorganic materials 0.000 claims 31
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 27
- 239000001257 hydrogen Substances 0.000 claims 27
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 24
- 150000003839 salts Chemical class 0.000 claims 23
- 125000000304 alkynyl group Chemical group 0.000 claims 20
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 20
- 125000000753 cycloalkyl group Chemical group 0.000 claims 18
- 125000004093 cyano group Chemical group *C#N 0.000 claims 14
- 229910052757 nitrogen Inorganic materials 0.000 claims 11
- 125000003342 alkenyl group Chemical group 0.000 claims 10
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 125000005418 aryl aryl group Chemical group 0.000 claims 7
- -1 -C 3-7 cycloalkyl Chemical group 0.000 claims 5
- 150000001204 N-oxides Chemical class 0.000 claims 5
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 125000006717 (C3-C10) cycloalkenyl group Chemical group 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- 102000014156 AMP-Activated Protein Kinases Human genes 0.000 claims 2
- 108010011376 AMP-Activated Protein Kinases Proteins 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 125000005025 alkynylaryl group Chemical group 0.000 claims 2
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 229910052727 yttrium Inorganic materials 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- OLNTVTPDXPETLC-XPWALMASSA-N ezetimibe Chemical compound N1([C@@H]([C@H](C1=O)CC[C@H](O)C=1C=CC(F)=CC=1)C=1C=CC(O)=CC=1)C1=CC=C(F)C=C1 OLNTVTPDXPETLC-XPWALMASSA-N 0.000 claims 1
- 229960000815 ezetimibe Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 claims 1
- 229960002855 simvastatin Drugs 0.000 claims 1
- MFFMDFFZMYYVKS-SECBINFHSA-N sitagliptin Chemical compound C([C@H](CC(=O)N1CC=2N(C(=NN=2)C(F)(F)F)CC1)N)C1=CC(F)=C(F)C=C1F MFFMDFFZMYYVKS-SECBINFHSA-N 0.000 claims 1
- 229960004034 sitagliptin Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261692018P | 2012-08-22 | 2012-08-22 | |
| US61/692,018 | 2012-08-22 | ||
| PCT/US2013/055528 WO2014031515A1 (en) | 2012-08-22 | 2013-08-19 | Novel azabenzimidazole hexahydrofuro[3,2-b]furan derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015526468A JP2015526468A (ja) | 2015-09-10 |
| JP2015526468A5 true JP2015526468A5 (https=) | 2015-10-29 |
Family
ID=50150322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015528552A Pending JP2015526468A (ja) | 2012-08-22 | 2013-08-19 | 新規なアザベンズイミダゾールヘキサヒドロフロ［３，２−ｂ］フラン誘導体 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9290517B2 (https=) |
| EP (1) | EP2888005B1 (https=) |
| JP (1) | JP2015526468A (https=) |
| KR (1) | KR20150045436A (https=) |
| CN (1) | CN104718004A (https=) |
| AR (1) | AR092201A1 (https=) |
| AU (1) | AU2013306030A1 (https=) |
| BR (1) | BR112015003109A2 (https=) |
| CA (1) | CA2881836A1 (https=) |
| RU (1) | RU2015109706A (https=) |
| TW (1) | TW201412751A (https=) |
| WO (1) | WO2014031515A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014031441A1 (en) * | 2012-08-22 | 2014-02-27 | Merck Sharp & Dohme Corp. | Novel benzimidazole tetrahydrofuran derivatives |
| WO2014031465A1 (en) | 2012-08-22 | 2014-02-27 | Merck Sharp & Dohme Corp. | Novel azabenzimidazole tetrahydropyran derivatives |
| EP2888008B1 (en) | 2012-08-22 | 2018-12-26 | Merck Sharp & Dohme Corp. | Novel azabenzimidazole tetrahydrofuran derivatives |
| WO2014031445A1 (en) | 2012-08-22 | 2014-02-27 | Merck Sharp & Dohme Corp. | Novel benzimidazole tetrahydropyran derivatives |
| WO2014031468A1 (en) * | 2012-08-22 | 2014-02-27 | Merck Sharp & Dohme Corp. | Novel benzimidazole hexahydrofuro[3,2-b]furan derivatives |
| JP6278472B2 (ja) | 2013-02-27 | 2018-02-14 | 塩野義製薬株式会社 | Ａｍｐｋ活性化作用を有するインドールおよびアザインドール誘導体 |
| PL3022210T3 (pl) * | 2013-07-17 | 2018-08-31 | Boehringer Ingelheim International Gmbh | Nowy pochodne azabenzimidazolu |
| RU2017107543A (ru) | 2014-08-27 | 2018-10-02 | Шионоги Энд Ко., Лтд. | Производное азаиндола с аmpk-активирующим действием |
| CA2965781A1 (en) | 2014-10-28 | 2016-05-06 | Shionogi & Co., Ltd. | Heterocyclic derivative having ampk activating effect |
| WO2016113300A1 (en) * | 2015-01-16 | 2016-07-21 | Boehringer Ingelheim International Gmbh | New azabenzimidazole derivatives as agonists of the amp-activated protein kinase |
| KR20180026459A (ko) * | 2015-06-18 | 2018-03-12 | 세파론, 인코포레이티드 | 1,4-치환된 피페리딘 유도체 |
| WO2016205590A1 (en) | 2015-06-18 | 2016-12-22 | Cephalon, Inc. | Substituted 4-benzyl and 4-benzoyl piperidine derivatives |
| CN105503927B (zh) * | 2016-01-11 | 2017-04-26 | 沧州普瑞东方科技有限公司 | 一种合成3,6‑二氢‑2h‑吡(噻)喃‑4‑硼酸酯的方法 |
| WO2017146186A1 (ja) | 2016-02-26 | 2017-08-31 | 塩野義製薬株式会社 | Ａｍｐｋ活性化作用を有する５－フェニルアザインドール誘導体 |
| CN109476661A (zh) | 2016-05-20 | 2019-03-15 | 盐野义制药株式会社 | 具有ampk活化作用的5-取代苯并咪唑及5-取代氮杂苯并咪唑衍生物 |
| CN106478653B (zh) * | 2016-10-16 | 2018-10-12 | 云南民族大学 | 异山梨醇—单咪唑盐类化合物及其制备方法 |
| US11590161B2 (en) | 2018-08-13 | 2023-02-28 | Viscera Labs, Inc. | Therapeutic composition and methods |
| US11524029B2 (en) | 2018-08-13 | 2022-12-13 | Viscera Labs, Inc. | Therapeutic composition and methods |
| US12398139B2 (en) * | 2019-03-05 | 2025-08-26 | Centre For Addiction And Mental Health | Modulators of AMPA receptor signaling |
| CN111423435B (zh) * | 2020-03-30 | 2021-10-15 | 厦门大学 | (1H-咪唑并[4,5-b]吡啶-6-基)吡啶衍生物及其应用 |
| WO2021236617A1 (en) | 2020-05-19 | 2021-11-25 | Kallyope, Inc. | Ampk activators |
| CN116390925A (zh) * | 2020-06-26 | 2023-07-04 | 卡尔优普公司 | Ampk活化剂 |
| JP2024513566A (ja) * | 2021-04-09 | 2024-03-26 | ザ・ブロード・インスティテュート・インコーポレイテッド | 標的基質の選択的修飾のための二官能性分子 |
| CA3261365A1 (en) * | 2022-07-28 | 2024-02-01 | Ac Immune Sa | NEW COMPOUNDS |
| CN115944612A (zh) * | 2022-12-23 | 2023-04-11 | 敖虎山 | 胰高血糖素拮抗剂阿度格列凡的新用途 |
| KR102638391B1 (ko) * | 2023-05-30 | 2024-02-20 | 삼화페인트공업주식회사 | 다이알칸설포닐 아이소소바이드 화합물의 제조 방법, 리튬이차전지용 전해액 첨가제, 리튬이차전지용 전해액 및 리튬이차전지 |
| CN117838690B (zh) * | 2023-10-09 | 2024-09-13 | 中国药科大学 | 一种治疗以ampk激活为治疗靶点的疾病的复方药物及其应用 |
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| JPS58193541A (ja) | 1982-05-07 | 1983-11-11 | Konishiroku Photo Ind Co Ltd | 熱現像画像記録材料 |
| JPH0245181B2 (ja) | 1983-03-16 | 1990-10-08 | Fuji Photo Film Co Ltd | Netsugenzokaraakankozairyo |
| GB8313321D0 (en) | 1983-05-14 | 1983-06-22 | Ciba Geigy Ag | Preparation of mercaptan substituted carboxylic acids |
| GB8313320D0 (en) | 1983-05-14 | 1983-06-22 | Ciba Geigy Ag | Coating compositions |
| GB8313322D0 (en) | 1983-05-14 | 1983-06-22 | Ciba Geigy Ag | Heterocyclic-(cyclo)aliphatic carboxylic acids |
| PT100905A (pt) | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem |
| JPH06298731A (ja) | 1993-04-13 | 1994-10-25 | Fuji Photo Film Co Ltd | 複素環化合物の製造方法 |
| ES2132419T3 (es) * | 1993-07-23 | 1999-08-16 | Merrell Pharma Inc | Nuevos agentes de nucleosidos 9-n-biciclicos utiles como inhibidores selectivos de citocinas proinflamatorias. |
| WO1995029897A1 (en) | 1994-04-29 | 1995-11-09 | G.D. Searle & Co. | METHOD OF USING (H+/K+) ATPase INHIBITORS AS ANTIVIRAL AGENTS |
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| DE69819311T2 (de) | 1997-03-07 | 2004-07-29 | Metabasis Therapeutics Inc., San Diego | Neue benzimidazol inhibitoren der fructose-1,6-bisphosphatase |
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| US20030083315A1 (en) | 2000-01-17 | 2003-05-01 | Naoki Tsuchiya | Human chymase inhibitors |
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| FR2903695B1 (fr) | 2006-07-13 | 2008-10-24 | Merck Sante Soc Par Actions Si | Utilisation de derives d'imidazole activateurs de l'ampk, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US8394969B2 (en) * | 2008-09-26 | 2013-03-12 | Merck Sharp & Dohme Corp. | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| EP2348857B1 (en) | 2008-10-22 | 2016-02-24 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| EP2352374B1 (en) * | 2008-10-29 | 2014-09-24 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| US8329914B2 (en) * | 2008-10-31 | 2012-12-11 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| JP2013520502A (ja) * | 2010-02-25 | 2013-06-06 | メルク・シャープ・エンド・ドーム・コーポレイション | 有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体 |
| WO2012033149A1 (ja) * | 2010-09-10 | 2012-03-15 | 塩野義製薬株式会社 | Ａｍｐｋ活性化作用を有するヘテロ環縮合イミダゾール誘導体 |
| SG192941A1 (en) * | 2011-02-25 | 2013-09-30 | Merck Sharp & Dohme | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
| WO2014031445A1 (en) | 2012-08-22 | 2014-02-27 | Merck Sharp & Dohme Corp. | Novel benzimidazole tetrahydropyran derivatives |
| WO2014031465A1 (en) | 2012-08-22 | 2014-02-27 | Merck Sharp & Dohme Corp. | Novel azabenzimidazole tetrahydropyran derivatives |
| EP2888008B1 (en) | 2012-08-22 | 2018-12-26 | Merck Sharp & Dohme Corp. | Novel azabenzimidazole tetrahydrofuran derivatives |
| WO2014031441A1 (en) | 2012-08-22 | 2014-02-27 | Merck Sharp & Dohme Corp. | Novel benzimidazole tetrahydrofuran derivatives |
| WO2014031468A1 (en) | 2012-08-22 | 2014-02-27 | Merck Sharp & Dohme Corp. | Novel benzimidazole hexahydrofuro[3,2-b]furan derivatives |
-
2013
- 2013-08-19 EP EP13830277.3A patent/EP2888005B1/en active Active
- 2013-08-19 JP JP2015528552A patent/JP2015526468A/ja active Pending
- 2013-08-19 RU RU2015109706A patent/RU2015109706A/ru not_active Application Discontinuation
- 2013-08-19 AU AU2013306030A patent/AU2013306030A1/en not_active Abandoned
- 2013-08-19 US US14/419,774 patent/US9290517B2/en active Active
- 2013-08-19 BR BR112015003109A patent/BR112015003109A2/pt not_active Application Discontinuation
- 2013-08-19 WO PCT/US2013/055528 patent/WO2014031515A1/en not_active Ceased
- 2013-08-19 KR KR20157003910A patent/KR20150045436A/ko not_active Withdrawn
- 2013-08-19 CA CA2881836A patent/CA2881836A1/en not_active Abandoned
- 2013-08-19 CN CN201380055225.0A patent/CN104718004A/zh active Pending
- 2013-08-22 AR ARP130102977 patent/AR092201A1/es unknown
- 2013-08-22 TW TW102130132A patent/TW201412751A/zh unknown
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