JP2015526088A5 - - Google Patents
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- JP2015526088A5 JP2015526088A5 JP2015527530A JP2015527530A JP2015526088A5 JP 2015526088 A5 JP2015526088 A5 JP 2015526088A5 JP 2015527530 A JP2015527530 A JP 2015527530A JP 2015527530 A JP2015527530 A JP 2015527530A JP 2015526088 A5 JP2015526088 A5 JP 2015526088A5
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- JP
- Japan
- Prior art keywords
- cells
- duration
- days
- progenitor
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims 23
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 18
- 210000000130 stem cell Anatomy 0.000 claims 13
- 238000000034 method Methods 0.000 claims 11
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 4
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 4
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 4
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 4
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 4
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 4
- 108090001005 Interleukin-6 Proteins 0.000 claims 4
- 108010002586 Interleukin-7 Proteins 0.000 claims 4
- 101710177504 Kit ligand Proteins 0.000 claims 4
- 230000003169 placental effect Effects 0.000 claims 4
- 102100020715 Fms-related tyrosine kinase 3 ligand protein Human genes 0.000 claims 3
- 101710162577 Fms-related tyrosine kinase 3 ligand protein Proteins 0.000 claims 3
- 102000003812 Interleukin-15 Human genes 0.000 claims 3
- 108090000172 Interleukin-15 Proteins 0.000 claims 3
- 102000004889 Interleukin-6 Human genes 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
- 102000013135 CD52 Antigen Human genes 0.000 claims 2
- 108010065524 CD52 Antigen Proteins 0.000 claims 2
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims 2
- 102000000704 Interleukin-7 Human genes 0.000 claims 2
- 102100020880 Kit ligand Human genes 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 210000004700 fetal blood Anatomy 0.000 claims 2
- 230000002489 hematologic effect Effects 0.000 claims 2
- 210000002826 placenta Anatomy 0.000 claims 2
- 210000003954 umbilical cord Anatomy 0.000 claims 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010052360 Colorectal adenocarcinoma Diseases 0.000 claims 1
- 208000006402 Ductal Carcinoma Diseases 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000009052 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 201000000582 Retinoblastoma Diseases 0.000 claims 1
- 208000029052 T-cell acute lymphoblastic leukemia Diseases 0.000 claims 1
- 102100027188 Thyroid peroxidase Human genes 0.000 claims 1
- 101710113649 Thyroid peroxidase Proteins 0.000 claims 1
- 201000011186 acute T cell leukemia Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 201000010897 colon adenocarcinoma Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 201000006845 reticulosarcoma Diseases 0.000 claims 1
- 208000029922 reticulum cell sarcoma Diseases 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 230000004565 tumor cell growth Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261682706P | 2012-08-13 | 2012-08-13 | |
| US61/682,706 | 2012-08-13 | ||
| US201361799211P | 2013-03-15 | 2013-03-15 | |
| US61/799,211 | 2013-03-15 | ||
| PCT/US2013/054677 WO2014028453A2 (en) | 2012-08-13 | 2013-08-13 | Natural killer cells and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018132290A Division JP2018183161A (ja) | 2012-08-13 | 2018-07-12 | ナチュラルキラー細胞及びその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015526088A JP2015526088A (ja) | 2015-09-10 |
| JP2015526088A5 true JP2015526088A5 (https=) | 2016-09-23 |
Family
ID=50101590
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015527530A Pending JP2015526088A (ja) | 2012-08-13 | 2013-08-13 | ナチュラルキラー細胞及びその使用 |
| JP2018132290A Pending JP2018183161A (ja) | 2012-08-13 | 2018-07-12 | ナチュラルキラー細胞及びその使用 |
| JP2020121929A Withdrawn JP2020188782A (ja) | 2012-08-13 | 2020-07-16 | ナチュラルキラー細胞及びその使用 |
| JP2022195426A Pending JP2023036639A (ja) | 2012-08-13 | 2022-12-07 | ナチュラルキラー細胞及びその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018132290A Pending JP2018183161A (ja) | 2012-08-13 | 2018-07-12 | ナチュラルキラー細胞及びその使用 |
| JP2020121929A Withdrawn JP2020188782A (ja) | 2012-08-13 | 2020-07-16 | ナチュラルキラー細胞及びその使用 |
| JP2022195426A Pending JP2023036639A (ja) | 2012-08-13 | 2022-12-07 | ナチュラルキラー細胞及びその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20150225697A1 (https=) |
| EP (2) | EP3722416A1 (https=) |
| JP (4) | JP2015526088A (https=) |
| KR (3) | KR20220166873A (https=) |
| CN (2) | CN114134113A (https=) |
| AU (3) | AU2013302853A1 (https=) |
| BR (1) | BR112015003149A2 (https=) |
| CA (1) | CA2881792C (https=) |
| HK (1) | HK1211620A1 (https=) |
| MX (1) | MX2015001871A (https=) |
| RU (2) | RU2019124982A (https=) |
| WO (1) | WO2014028453A2 (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013204922B2 (en) | 2012-12-20 | 2015-05-14 | Celgene Corporation | Chimeric antigen receptors |
| JP6493692B2 (ja) | 2013-03-15 | 2019-04-10 | セルジーン コーポレイション | 修飾されたｔリンパ球 |
| CN105916521A (zh) * | 2013-11-15 | 2016-08-31 | 人类起源公司 | 包含人胎盘灌注液细胞、其亚群的组合物及其用途 |
| BR112017014269A2 (pt) * | 2014-12-31 | 2018-03-27 | Anthrogenesis Corp | células exterminadoras naturais e usos das mesmas |
| JP6797803B2 (ja) * | 2014-12-31 | 2020-12-09 | セルジーン コーポレイション | ナチュラルキラー細胞を用いて血液障害、固形腫瘍、又は感染性疾患を治療する方法 |
| EP3280796B1 (en) * | 2015-04-09 | 2019-09-11 | Universita' degli Studi di Genova | Population of human lymphoid precursors, method for their identification and uses thereof |
| JP6073417B2 (ja) * | 2015-06-26 | 2017-02-01 | チャ バイオテック カンパニー リミテッド | 自然殺害細胞増殖方法、及び自然殺害細胞増殖用の組成物 |
| WO2017042393A1 (en) * | 2015-09-11 | 2017-03-16 | Emercell Sas | Pooled nk cells from umbilical cord blood associated with antibodies and their uses for the treatment of disease |
| EP3747472B1 (en) | 2015-09-15 | 2024-04-03 | Acerta Pharma B.V. | Therapeutic combinations of a cd19 inhibitor and a btk inhibitor |
| EA201890960A1 (ru) * | 2015-10-15 | 2018-10-31 | Селулэрити, Инк. | Натуральные киллеры и клетки ilc3 и их применение |
| CA3003923A1 (en) * | 2015-11-05 | 2017-05-11 | Glycostem Therapeutics B.V. | Composition for use in immunotherapy |
| CN106701677A (zh) * | 2015-11-18 | 2017-05-24 | 深圳爱生再生医学科技有限公司 | Nk细胞的体外扩增培养方法 |
| US20190037831A1 (en) * | 2016-02-01 | 2019-02-07 | Green Cross Lab Cell Corporation | Medium composition for cryopreservation of cell and use thereof |
| BR112018072701A2 (pt) * | 2016-05-07 | 2019-02-19 | Celularity, Inc. | métodos de tratamento de leucemia mieloide aguda e mieloma múltiplo usando células exterminadoras naturais |
| KR101926166B1 (ko) * | 2016-05-24 | 2018-12-06 | 재단법인 아산사회복지재단 | 수용체 시너지 활성을 이용한 nk 세포의 활성도 검사 방법 및 이를 이용한 nk 세포의 활성도가 관련된 질환의 진단 방법 |
| KR101866827B1 (ko) * | 2016-09-28 | 2018-07-19 | 한국원자력의학원 | 방사선 조사된 말초혈액단핵구를 이용한 고효율 자연살상세포의 제조방법 및 이를 이용한 항암 면역 세포치료제 조성물 |
| KR101846464B1 (ko) | 2016-11-14 | 2018-04-09 | 주식회사 파이안바이오테크놀로지 | 외래 미토콘드리아를 포함하는 자연살해세포 및 이를 포함하는 약학적 조성물 |
| EP3556849A4 (en) * | 2016-12-14 | 2020-08-19 | Otsuka Pharmaceutical Factory, Inc. | MAMMAL CELL CRYOPRESERVATION LIQUID |
| JP2020503043A (ja) * | 2016-12-30 | 2020-01-30 | セルラリティ インコーポレイテッド | 遺伝子改変されたナチュラルキラー細胞 |
| IL309689B1 (en) * | 2017-02-28 | 2026-02-01 | Univ Central Florida Res Found Inc | PM21 particles to enhance NK cell migration to the bone marrow |
| US12129487B2 (en) * | 2017-03-27 | 2024-10-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method to obtain lymphoid progenitors |
| CN107384859A (zh) * | 2017-09-05 | 2017-11-24 | 四川新生命干细胞科技股份有限公司 | 一种高纯度nk细胞的分离培养方法 |
| WO2019067792A1 (en) * | 2017-09-28 | 2019-04-04 | Celularity, Inc. | TUMOR CONTROL WITH INTERMEDIATE NATURAL KILLER CELLS DERIVED FROM HUMAN PLACENTA (PINK) IN COMBINATION WITH ANTIBODY |
| US11834677B2 (en) | 2017-10-02 | 2023-12-05 | Gamida Cell Ltd. | Expansion and use of expanded NK cell fractions |
| CN107904175B (zh) * | 2017-12-29 | 2018-09-25 | 广州沙艾生物科技有限公司 | 用于免疫细胞的诱导扩增的培养箱 |
| KR20210016567A (ko) * | 2018-05-30 | 2021-02-16 | 글리코스템 떼라퓨틱스 비.브이. | Car nk 세포 |
| EP3820994A1 (en) | 2018-07-10 | 2021-05-19 | Nantkwest, Inc. | Generating cik nkt cells from cord blood |
| CN109337870B (zh) * | 2018-12-24 | 2020-07-03 | 广东暨德康民生物科技有限责任公司 | 人Vγ9Vδ2T细胞扩增方法与培养基 |
| KR102032384B1 (ko) * | 2019-03-05 | 2019-11-08 | 주식회사 온코인사이트 | 제대혈 단핵세포에서의 자연살해세포의 제조 방법 |
| KR102216710B1 (ko) * | 2019-03-27 | 2021-02-17 | 신지섭 | Nk세포배양배지용 첨가조성물, 상기 첨가조성물을 이용한 nk세포배양방법 및 상기 배양방법으로 얻어진 피부트러블개선용 화장료조성물 |
| EP3922715A4 (en) | 2019-04-17 | 2022-03-30 | CHA Biotech Co., Ltd. | NATURAL KILLER CELLS WITH INCREASED ANTI-CANCER EFFECTS AND IMMUNOTHERAPEUTIC USE THEREOF |
| KR102233660B1 (ko) * | 2019-05-15 | 2021-03-30 | (주)포에버엔케이 | 효율적 자연살해세포 배양방법 및 이의 배지첨가 키트 |
| IT201900023922A1 (it) * | 2019-12-13 | 2021-06-13 | Univ Degli Studi Genova | Popolazione cellulare progenitrice CD56-CD16+PerfnegCD7- e progenie cellulare NK CD94/NKG2C+KIR+CD57+ originata da detta popolazione cellulare CD56-CD16+PerfnegCD7-, loro ottenimento e loro usi |
| EP4114415A1 (en) | 2020-03-06 | 2023-01-11 | Sorrento Therapeutics, Inc. | Innate immunity killer cells targeting psma positive tumor cells |
| CN112029722A (zh) * | 2020-09-09 | 2020-12-04 | 广东昭泰体内生物医药科技有限公司 | 一种nk细胞培养基及其应用 |
| CN112029721A (zh) * | 2020-09-09 | 2020-12-04 | 广东昭泰体内生物医药科技有限公司 | 一种活性增强型nk细胞的制备方法 |
| CN112266900A (zh) * | 2020-10-30 | 2021-01-26 | 广东康盾生物工程技术有限公司 | 一种car-nk细胞的培养方法 |
| CN112708675A (zh) * | 2020-12-25 | 2021-04-27 | 中山大学肿瘤防治中心 | 骨髓nk细胞联合mcl1抑制剂在抗白血病中的应用 |
| CN113416701B (zh) * | 2021-07-28 | 2023-05-09 | 新疆西部赛澳生物科技有限责任公司 | 一种nk细胞培养基及培养方法 |
| WO2023011114A1 (zh) * | 2021-08-06 | 2023-02-09 | 中国科学院动物研究所 | 一种ric细胞及其制备方法和应用 |
| JPWO2023038037A1 (https=) * | 2021-09-08 | 2023-03-16 | ||
| CN113801846B (zh) * | 2021-09-22 | 2024-06-04 | 南京艾尔普再生医学科技有限公司 | 一种从人诱导多能干细胞分化为自然杀伤细胞的方法 |
| CN114891856B (zh) * | 2022-05-16 | 2025-08-15 | 武汉科技大学 | 大队列样本单细胞富集和混样建库测序方法 |
| CN114736859B (zh) * | 2022-06-13 | 2022-08-19 | 广东先康达生物科技有限公司 | 一种脐带血nk细胞的培养液及培养方法 |
| WO2024101863A1 (ko) * | 2022-11-07 | 2024-05-16 | 마루테라퓨틱스 주식회사 | 줄기세포 기원 및 발현 마커에 따른 nk 세포 분화 효율 증진 방법 |
| US20240279607A1 (en) * | 2023-02-17 | 2024-08-22 | FullHope Biomedical Co., Ltd. | Pharmaceutical composition comprising modified natural killer cells and antigen-specific t cells, manufacturing method thereof, and method of using the same |
| CN117603809A (zh) * | 2023-12-06 | 2024-02-27 | 威海紫光科技园有限公司 | 一种应用于nk细胞制备过程中复苏的温度控制方法及系统 |
| CN117946971B (zh) * | 2023-12-14 | 2025-07-15 | 深圳泽医细胞治疗集团有限公司 | 一种用于诱导C1型iNKT细胞的培养基、培养方法及其应用 |
| WO2025160465A1 (en) | 2024-01-26 | 2025-07-31 | Celularity Inc. | A method of treating signs or symptoms of the aging process |
| CN118370308B (zh) * | 2024-04-18 | 2025-11-11 | 维赛(佛山)生物科技有限公司 | 一种临床用犬自然杀伤细胞冷藏保存液及其制备方法和应用 |
| WO2025225667A1 (ja) * | 2024-04-26 | 2025-10-30 | 日機装株式会社 | 凍結された腎細胞凝集体を含むプレート、それを用いた薬物動態検査用キット、毒性検査用キット及び創薬開発用キット |
| CN120005821B (zh) * | 2025-04-21 | 2025-07-25 | 上海华颜医药科技有限公司 | 一种免疫细胞的培养方法 |
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| US4798824A (en) | 1985-10-03 | 1989-01-17 | Wisconsin Alumni Research Foundation | Perfusate for the preservation of organs |
| US5190556A (en) | 1991-03-19 | 1993-03-02 | O.B. Tech, Inc. | Cord cutter sampler |
| US5552267A (en) | 1992-04-03 | 1996-09-03 | The Trustees Of Columbia University In The City Of New York | Solution for prolonged organ preservation |
| US5372581A (en) | 1993-07-21 | 1994-12-13 | Minneapolis Children's Services Corporation | Method and apparatus for placental blood collection |
| DK1349918T3 (da) | 2000-12-06 | 2014-11-10 | Anthrogenesis Corp | Fremgangsmåde til indsamling af stamceller fra moderkagen |
| EP2316919B1 (en) | 2001-02-14 | 2015-10-07 | Anthrogenesis Corporation | Post-partum mammalian placenta, its use and placental stem cells therefrom |
| AU2002363322A1 (en) * | 2001-10-26 | 2003-05-19 | Large Scale Biology Corporation | Endothelial cell derived hemotopoietic growth factor |
| US20030187515A1 (en) | 2002-03-26 | 2003-10-02 | Hariri Robert J. | Collagen biofabric and methods of preparing and using the collagen biofabric |
| US7498171B2 (en) | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| US7147626B2 (en) | 2004-09-23 | 2006-12-12 | Celgene Corporation | Cord blood and placenta collection kit |
| PT2471904T (pt) | 2005-12-29 | 2019-02-25 | Celularity Inc | População de células estaminais placentárias |
| CA2633980A1 (en) | 2005-12-29 | 2007-07-12 | Anthrogenesis Corporation | Improved composition for collecting and preserving placental stem cells and methods of using the composition |
| US9193953B2 (en) * | 2007-03-27 | 2015-11-24 | Ipd-Therapeutics B.V. | Methods and means for stem cell proliferation and subsequent generation and expansion of progenitor cells |
| ES2666746T3 (es) * | 2010-07-13 | 2018-05-07 | Anthrogenesis Corporation | Métodos para generar linfocitos citolíticos naturales |
| US9476029B2 (en) * | 2010-11-13 | 2016-10-25 | Lung-Ji Chang | Ex vivo development, expansion and in vivo analysis of a novel lineage of dendritic cells |
| WO2012128622A1 (en) * | 2011-03-18 | 2012-09-27 | Ipd-Therapeutics B.V. | Generation of nk cells and nk-cell progenitors |
-
2013
- 2013-08-13 JP JP2015527530A patent/JP2015526088A/ja active Pending
- 2013-08-13 MX MX2015001871A patent/MX2015001871A/es unknown
- 2013-08-13 KR KR1020227042037A patent/KR20220166873A/ko not_active Ceased
- 2013-08-13 HK HK15112433.3A patent/HK1211620A1/xx unknown
- 2013-08-13 CN CN202111362929.5A patent/CN114134113A/zh active Pending
- 2013-08-13 RU RU2019124982A patent/RU2019124982A/ru unknown
- 2013-08-13 AU AU2013302853A patent/AU2013302853A1/en not_active Abandoned
- 2013-08-13 CA CA2881792A patent/CA2881792C/en active Active
- 2013-08-13 KR KR1020217017107A patent/KR20210076150A/ko not_active Ceased
- 2013-08-13 US US14/421,059 patent/US20150225697A1/en not_active Abandoned
- 2013-08-13 EP EP20162827.8A patent/EP3722416A1/en not_active Withdrawn
- 2013-08-13 BR BR112015003149A patent/BR112015003149A2/pt not_active Application Discontinuation
- 2013-08-13 RU RU2015108761A patent/RU2015108761A/ru not_active Application Discontinuation
- 2013-08-13 CN CN201380053349.5A patent/CN105008516A/zh active Pending
- 2013-08-13 KR KR1020157006395A patent/KR20150063374A/ko not_active Ceased
- 2013-08-13 EP EP13829894.8A patent/EP2882847A4/en not_active Withdrawn
- 2013-08-13 WO PCT/US2013/054677 patent/WO2014028453A2/en not_active Ceased
-
2018
- 2018-07-12 JP JP2018132290A patent/JP2018183161A/ja active Pending
-
2019
- 2019-06-07 AU AU2019204020A patent/AU2019204020A1/en not_active Abandoned
-
2020
- 2020-07-16 JP JP2020121929A patent/JP2020188782A/ja not_active Withdrawn
-
2022
- 2022-02-14 AU AU2022200976A patent/AU2022200976A1/en not_active Abandoned
- 2022-12-07 JP JP2022195426A patent/JP2023036639A/ja active Pending
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