JP2015526076A5 - - Google Patents
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- JP2015526076A5 JP2015526076A5 JP2015524746A JP2015524746A JP2015526076A5 JP 2015526076 A5 JP2015526076 A5 JP 2015526076A5 JP 2015524746 A JP2015524746 A JP 2015524746A JP 2015524746 A JP2015524746 A JP 2015524746A JP 2015526076 A5 JP2015526076 A5 JP 2015526076A5
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- Japan
- Prior art keywords
- rna
- group
- molecule
- binding molecule
- interest
- Prior art date
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- 229920002477 rna polymer Polymers 0.000 claims description 212
- 238000000034 method Methods 0.000 claims description 85
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- 108020004707 nucleic acids Proteins 0.000 claims description 54
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 43
- 239000003153 chemical reaction reagent Substances 0.000 claims description 37
- 238000007306 functionalization reaction Methods 0.000 claims description 37
- 238000002372 labelling Methods 0.000 claims description 32
- 238000006243 chemical reaction Methods 0.000 claims description 27
- 125000003729 nucleotide group Chemical group 0.000 claims description 26
- 239000002773 nucleotide Substances 0.000 claims description 25
- OINYTHCNBVUELD-UHFFFAOYSA-N 1h-pyrido[3,2-d][1,3]oxazine-2,4-dione Chemical compound C1=CN=C2C(=O)OC(=O)NC2=C1 OINYTHCNBVUELD-UHFFFAOYSA-N 0.000 claims description 19
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| FR3053968A1 (fr) * | 2016-07-13 | 2018-01-19 | Biomerieux | Reactifs pour la protection reversible de molecules biologiques |
| WO2019109046A1 (en) | 2017-11-30 | 2019-06-06 | Arrakis Therapeutics, Inc. | Nucleic acid-binding photoprobes and uses thereof |
| CN111913028A (zh) * | 2020-08-18 | 2020-11-10 | 宁波中车时代传感技术有限公司 | 基于芯片型线圈的磁通门电流传感器 |
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| CA1223831A (en) | 1982-06-23 | 1987-07-07 | Dean Engelhardt | Modified nucleotides, methods of preparing and utilizing and compositions containing the same |
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| FR2934595B1 (fr) | 2008-07-29 | 2013-04-05 | Biomerieux Sa | Reactifs de marquage ayant un noyau pyridine portant une fonction diazomethyle, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques |
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2012
- 2012-08-02 FR FR1257526A patent/FR2994184B1/fr not_active Expired - Fee Related
-
2013
- 2013-07-26 JP JP2015524746A patent/JP6407151B2/ja not_active Expired - Fee Related
- 2013-07-26 EP EP13744493.1A patent/EP2880016A1/fr not_active Withdrawn
- 2013-07-26 US US14/416,996 patent/US10174068B2/en not_active Expired - Fee Related
- 2013-07-26 WO PCT/EP2013/065854 patent/WO2014019966A1/fr not_active Ceased
-
2018
- 2018-12-12 US US16/217,483 patent/US20190112329A1/en not_active Abandoned
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