JP2015524821A - システイン変異及びμ尾部を介して多量体化した抗体又は融合タンパク質 - Google Patents

システイン変異及びμ尾部を介して多量体化した抗体又は融合タンパク質 Download PDF

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JP2015524821A
JP2015524821A JP2015525568A JP2015525568A JP2015524821A JP 2015524821 A JP2015524821 A JP 2015524821A JP 2015525568 A JP2015525568 A JP 2015525568A JP 2015525568 A JP2015525568 A JP 2015525568A JP 2015524821 A JP2015524821 A JP 2015524821A
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antibody
fusion protein
region
μtp
antibodies
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JP2015524821A5 (cg-RX-API-DMAC7.html
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ナオヤ ツルシタ,
ナオヤ ツルシタ,
ジェイ. ユン ツォ,
ジェイ. ユン ツォ,
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ジェイエヌ バイオサイエンシーズ エルエルシー
ジェイエヌ バイオサイエンシーズ エルエルシー
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Publication of JP2015524821A publication Critical patent/JP2015524821A/ja
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35Valency
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/524CH2 domain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/526CH3 domain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75Agonist effect on antigen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2015525568A 2012-08-02 2013-07-31 システイン変異及びμ尾部を介して多量体化した抗体又は融合タンパク質 Withdrawn JP2015524821A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261679045P 2012-08-02 2012-08-02
US61/679,045 2012-08-02
US201361767724P 2013-02-21 2013-02-21
US61/767,724 2013-02-21
PCT/US2013/053086 WO2014022592A1 (en) 2012-08-02 2013-07-31 Antibodies or fusion proteins multimerized via cysteine mutation and a mu tailpiece

Publications (2)

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JP2015524821A true JP2015524821A (ja) 2015-08-27
JP2015524821A5 JP2015524821A5 (cg-RX-API-DMAC7.html) 2016-08-25

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JP2015525568A Withdrawn JP2015524821A (ja) 2012-08-02 2013-07-31 システイン変異及びμ尾部を介して多量体化した抗体又は融合タンパク質

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US (1) US9540442B2 (cg-RX-API-DMAC7.html)
EP (1) EP2880057A4 (cg-RX-API-DMAC7.html)
JP (1) JP2015524821A (cg-RX-API-DMAC7.html)
CN (1) CN104684928A (cg-RX-API-DMAC7.html)
CA (1) CA2879814A1 (cg-RX-API-DMAC7.html)
IN (1) IN2015DN01361A (cg-RX-API-DMAC7.html)
WO (1) WO2014022592A1 (cg-RX-API-DMAC7.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018538283A (ja) * 2015-11-30 2018-12-27 ファイザー・インク 部位特異的コンジュゲーションのための抗体および抗体断片
JP2024535710A (ja) * 2021-08-27 2024-10-02 サンシャイン・グオジアン・ファーマシューティカル(シャンハイ)カンパニー・リミテッド Cdcプラットホーム抗体

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JP2018538283A (ja) * 2015-11-30 2018-12-27 ファイザー・インク 部位特異的コンジュゲーションのための抗体および抗体断片
JP2024535710A (ja) * 2021-08-27 2024-10-02 サンシャイン・グオジアン・ファーマシューティカル(シャンハイ)カンパニー・リミテッド Cdcプラットホーム抗体
JP7735545B2 (ja) 2021-08-27 2025-09-08 サンシャイン・グオジアン・ファーマシューティカル(シャンハイ)カンパニー・リミテッド Cdcプラットホーム抗体

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EP2880057A1 (en) 2015-06-10
WO2014022592A1 (en) 2014-02-06
US20140037621A1 (en) 2014-02-06
US9540442B2 (en) 2017-01-10
CN104684928A (zh) 2015-06-03
EP2880057A4 (en) 2016-03-23
IN2015DN01361A (cg-RX-API-DMAC7.html) 2015-07-03
CA2879814A1 (en) 2014-02-06

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