JP2015524798A5 - - Google Patents
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- Publication number
- JP2015524798A5 JP2015524798A5 JP2015521836A JP2015521836A JP2015524798A5 JP 2015524798 A5 JP2015524798 A5 JP 2015524798A5 JP 2015521836 A JP2015521836 A JP 2015521836A JP 2015521836 A JP2015521836 A JP 2015521836A JP 2015524798 A5 JP2015524798 A5 JP 2015524798A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- cyano
- imidazo
- chloro
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CN(**)c(nc1N*)n[n]2c1ncc2N Chemical compound CN(**)c(nc1N*)n[n]2c1ncc2N 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261671179P | 2012-07-13 | 2012-07-13 | |
| US61/671,179 | 2012-07-13 | ||
| US201361790511P | 2013-03-15 | 2013-03-15 | |
| US61/790,511 | 2013-03-15 | ||
| PCT/US2013/050247 WO2014011974A1 (en) | 2012-07-13 | 2013-07-12 | Imidazotriazinecarbonitriles useful as kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015524798A JP2015524798A (ja) | 2015-08-27 |
| JP2015524798A5 true JP2015524798A5 (enExample) | 2016-07-21 |
| JP6228199B2 JP6228199B2 (ja) | 2017-11-08 |
Family
ID=48833089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015521836A Expired - Fee Related JP6228199B2 (ja) | 2012-07-13 | 2013-07-12 | キナーゼ阻害剤として有用であるイミダゾトリアジンカルボニトリル |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US9273057B2 (enExample) |
| EP (1) | EP2872514B1 (enExample) |
| JP (1) | JP6228199B2 (enExample) |
| KR (1) | KR20150059647A (enExample) |
| CN (1) | CN104470925B (enExample) |
| AR (1) | AR092349A1 (enExample) |
| AU (1) | AU2013290054A1 (enExample) |
| BR (1) | BR112015000704A2 (enExample) |
| CA (1) | CA2878852A1 (enExample) |
| CL (1) | CL2015000094A1 (enExample) |
| CO (1) | CO7180199A2 (enExample) |
| EA (1) | EA201590224A1 (enExample) |
| HK (1) | HK1210775A1 (enExample) |
| IL (1) | IL236605A0 (enExample) |
| MX (1) | MX2015000310A (enExample) |
| PE (1) | PE20150332A1 (enExample) |
| PH (1) | PH12015500064A1 (enExample) |
| SG (1) | SG11201500158RA (enExample) |
| TN (1) | TN2015000002A1 (enExample) |
| TW (1) | TW201414737A (enExample) |
| WO (1) | WO2014011974A1 (enExample) |
| ZA (1) | ZA201501009B (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2680741A1 (en) | 2007-03-22 | 2009-01-15 | The Regents Of The University Of California | Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins |
| US9000131B2 (en) | 2008-07-31 | 2015-04-07 | The Regents Of The University Of California | Antibodies that neutralize botulinum neurotoxins |
| WO2012047427A2 (en) | 2010-08-31 | 2012-04-12 | The Regents Of The University Of California | Antibodies for botulinum neurotoxins |
| TWI572605B (zh) | 2012-04-26 | 2017-03-01 | 必治妥美雅史谷比公司 | 血小板聚集之抑制劑 |
| TWI568722B (zh) | 2012-06-15 | 2017-02-01 | 葛蘭馬克製藥公司 | 作爲ｍＰＧＥＳ－１抑制劑之三唑酮化合物 |
| TW201414737A (zh) | 2012-07-13 | 2014-04-16 | 必治妥美雅史谷比公司 | 作爲激酶抑制劑之咪唑并三□甲腈 |
| JP6437452B2 (ja) | 2013-01-14 | 2018-12-12 | インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ | Ｐｉｍキナーゼ阻害剤として有用な二環式芳香族カルボキサミド化合物 |
| LT2945939T (lt) | 2013-01-15 | 2020-07-27 | Incyte Holdings Corporation | Triazolkarboksamidai ir piridinkarboksamido junginiai, naudotini kaip pim kinazės inhibitoriai |
| US9227978B2 (en) | 2013-03-15 | 2016-01-05 | Araxes Pharma Llc | Covalent inhibitors of Kras G12C |
| EP3036238A1 (en) | 2013-08-23 | 2016-06-29 | Incyte Corporation | Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors |
| JO3805B1 (ar) | 2013-10-10 | 2021-01-31 | Araxes Pharma Llc | مثبطات كراس جي12سي |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| US9822124B2 (en) | 2014-07-14 | 2017-11-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors |
| DE102014111834A1 (de) * | 2014-08-19 | 2016-02-25 | Illinois Tool Works Inc. | Einfülleinrichtung für einen Betriebsstofftank |
| EA201792214A1 (ru) | 2015-04-10 | 2018-01-31 | Араксис Фарма Ллк | Соединения замещенного хиназолина |
| US9540347B2 (en) | 2015-05-29 | 2017-01-10 | Incyte Corporation | Pyridineamine compounds useful as Pim kinase inhibitors |
| AR105967A1 (es) | 2015-09-09 | 2017-11-29 | Incyte Corp | Sales de un inhibidor de pim quinasa |
| WO2017058915A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| US10858343B2 (en) | 2015-09-28 | 2020-12-08 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| US10875842B2 (en) | 2015-09-28 | 2020-12-29 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| WO2017058792A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| WO2017059251A1 (en) | 2015-10-02 | 2017-04-06 | Incyte Corporation | Heterocyclic compounds useful as pim kinase inhibitors |
| WO2017070137A1 (en) * | 2015-10-20 | 2017-04-27 | Bristol-Myers Squibb Company | Combination of ck2 inhibitors and immune checkpoint modulators for cancer treatment |
| WO2017070135A1 (en) * | 2015-10-20 | 2017-04-27 | Bristol-Myers Squibb Company | Prodrugs of 2-(4-(3-((4-amino-7-cyano-imidazo[2,1-f][1,2,4]triazin-2-yl)amino)phenyl)piperaz in-1-yl)propanamide derivatives as ck2 inhibitors for the treatment of cancer |
| TW201726656A (zh) | 2015-11-16 | 2017-08-01 | 亞瑞克西斯製藥公司 | 包含經取代雜環基團之２－經取代喹唑啉化合物及其使用方法 |
| EP3474855B1 (en) * | 2016-06-24 | 2022-01-26 | Polaris Pharmaceuticals, Inc. | Ck2 inhibitors, compositions and methods thereof |
| TW201803871A (zh) | 2016-06-24 | 2018-02-01 | 英塞特公司 | 作為ＰＩ３Ｋ-γ抑制劑之雜環化合物 |
| WO2018140514A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer |
| EP3573971A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer |
| WO2018140599A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | Benzothiophene and benzothiazole compounds and methods of use thereof |
| CN110382482A (zh) | 2017-01-26 | 2019-10-25 | 亚瑞克西斯制药公司 | 稠合的杂-杂二环化合物及其使用方法 |
| US11274093B2 (en) | 2017-01-26 | 2022-03-15 | Araxes Pharma Llc | Fused bicyclic benzoheteroaromatic compounds and methods of use thereof |
| JP2020521740A (ja) | 2017-05-25 | 2020-07-27 | アラクセス ファーマ エルエルシー | 変異体ｋｒａｓ、ｈｒａｓまたはｎｒａｓの調節因子としてのキナゾリン誘導体 |
| TW201900633A (zh) | 2017-05-25 | 2019-01-01 | 美商亞瑞克西斯製藥公司 | Kras之共價抑制劑 |
| TWI851542B (zh) * | 2017-09-11 | 2024-08-11 | 美商克魯松藥物公司 | Ｓｈｐ２之八氫環戊烷并[c]吡咯別構抑制劑 |
| TW201924683A (zh) | 2017-12-08 | 2019-07-01 | 美商英塞特公司 | 用於治療骨髓增生性贅瘤的低劑量組合療法 |
| US12134620B2 (en) | 2018-08-01 | 2024-11-05 | Araxes Pharma Llc | Heterocyclic spiro compounds and methods of use thereof for the treatment of cancer |
| KR20210083286A (ko) * | 2018-10-24 | 2021-07-06 | 아락세스 파마 엘엘씨 | 종양 전이를 억제하기 위한 g12c 돌연변이 kras 단백질의 억제제로서 2-(2-아크릴로일-2,6-디아자스피로[3.4]옥탄-6-일)-6-(1h-인다졸-4-일)-벤조니트릴 유도체 및 관련 화합물 |
| CN113454086B (zh) * | 2019-02-07 | 2025-03-14 | 百济神州有限公司 | 作为tlr7激动剂的咪唑并[2,1-f][1,2,4]三嗪-4-胺衍生物 |
| AR119494A1 (es) * | 2019-07-29 | 2021-12-22 | Servier Lab | DERIVADOS DE 6,7-DIHIDRO-5H-PIRIDO[2,3-c]PIRIDAZIN-8-ILO, COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN Y SUS USOS COMO AGENTES PROAPOPTÓTICOS |
| BR112022006394A2 (pt) * | 2019-10-02 | 2022-07-26 | Tolremo Therapeutics Ag | Derivados heterocíclicos, composições farmacêuticas e seu uso no tratamento ou melhora do câncer |
| US12472179B2 (en) | 2020-06-25 | 2025-11-18 | Tolremo Therapeutics Ag | Combination of a CBP/p300 bromodomain inhibitor and a KRAS inhibitor for the treatment of cancer |
| KR20250133646A (ko) * | 2022-11-03 | 2025-09-08 | 바이오스플라이스 테라퓨틱스, 인크. | 4-아미노피롤로[2,1-f][1,2,4]트라이아진 및 이의 제조 및 용도 |
| WO2024220399A1 (en) * | 2023-04-17 | 2024-10-24 | Bristol-Myers Squibb Company | Pyrazolotriazinecarbonitriles useful as kinase inhibitors |
| WO2025074096A1 (en) * | 2023-10-02 | 2025-04-10 | Turbine Simulated Cell Technologies Ltd | P97 (vcp) atpase inhibitors |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4327027A1 (de) | 1993-02-15 | 1994-08-18 | Bayer Ag | Imidazoazine |
| TWI312347B (en) | 2001-02-08 | 2009-07-21 | Eisai R&D Man Co Ltd | Bicyclic nitrogen-containing condensed ring compounds |
| MY145634A (en) | 2003-12-29 | 2012-03-15 | Bristol Myers Squibb Co | Pyrrolotriazine compounds as kinase inhibitors |
| WO2006065755A2 (en) | 2004-12-13 | 2006-06-22 | Glaxo Group Limited | Quaternary ammonium salts of fused hetearomatic amines as novel muscarinic acetylcholine receptor antagonists |
| WO2006065788A2 (en) | 2004-12-13 | 2006-06-22 | Glaxo Group Limited | Novel muscarinic acetylcholine receptor antagonists |
| CN101312977B (zh) * | 2005-09-22 | 2012-06-13 | 布里斯托尔-迈尔斯.斯奎布公司 | 用作激酶调节剂的稠合杂环化合物 |
| US20070078136A1 (en) * | 2005-09-22 | 2007-04-05 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
| US7723336B2 (en) | 2005-09-22 | 2010-05-25 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
| WO2008057402A2 (en) | 2006-11-02 | 2008-05-15 | Cytovia, Inc. | N-aryl-isoxazolopyrimidin-4-amines and related compounds as activators of caspases and inducers of apoptosis and the use thereof |
| WO2008116064A2 (en) | 2007-03-21 | 2008-09-25 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful for the treatment of proliferative, allergic, autoimmune or inflammatory diseases |
| EP2323665B1 (en) | 2008-07-24 | 2013-06-19 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
| TWI491610B (zh) * | 2008-10-09 | 2015-07-11 | 必治妥美雅史谷比公司 | 作為激酶抑制劑之咪唑并嗒腈 |
| WO2010068810A2 (en) * | 2008-12-10 | 2010-06-17 | Cgi Pharmaceuticals, Inc. | Certain substituted amides, method of making, and method of use thereof |
| CN102625803A (zh) * | 2009-09-11 | 2012-08-01 | 赛林药物股份有限公司 | 药学上有用的杂环-取代的内酰胺 |
| JP5802676B2 (ja) * | 2009-12-04 | 2015-10-28 | センワ バイオサイエンシズ インコーポレイテッド | Ｃｋ２阻害剤としてのピラゾロピリミジンおよび関連複素環化合物 |
| EP2526102B1 (en) | 2010-01-22 | 2017-03-08 | Fundación Centro Nacional de Investigaciones Oncológicas Carlos III | Inhibitors of PI3 kinase |
| US20130131057A1 (en) | 2010-05-13 | 2013-05-23 | Centro Nacional De Investigaciones Oncologicas (Cnio | New bicyclic compounds as pi3-k and mtor inhibitors |
| TW201414737A (zh) | 2012-07-13 | 2014-04-16 | 必治妥美雅史谷比公司 | 作爲激酶抑制劑之咪唑并三□甲腈 |
-
2013
- 2013-07-11 TW TW102125007A patent/TW201414737A/zh unknown
- 2013-07-12 MX MX2015000310A patent/MX2015000310A/es unknown
- 2013-07-12 CA CA2878852A patent/CA2878852A1/en not_active Abandoned
- 2013-07-12 KR KR1020157003512A patent/KR20150059647A/ko not_active Withdrawn
- 2013-07-12 EA EA201590224A patent/EA201590224A1/ru unknown
- 2013-07-12 PE PE2015000038A patent/PE20150332A1/es not_active Application Discontinuation
- 2013-07-12 HK HK15111498.7A patent/HK1210775A1/xx unknown
- 2013-07-12 CN CN201380037444.6A patent/CN104470925B/zh not_active Expired - Fee Related
- 2013-07-12 US US14/414,152 patent/US9273057B2/en active Active
- 2013-07-12 AU AU2013290054A patent/AU2013290054A1/en not_active Abandoned
- 2013-07-12 JP JP2015521836A patent/JP6228199B2/ja not_active Expired - Fee Related
- 2013-07-12 EP EP13739922.6A patent/EP2872514B1/en not_active Not-in-force
- 2013-07-12 WO PCT/US2013/050247 patent/WO2014011974A1/en not_active Ceased
- 2013-07-12 AR ARP130102495A patent/AR092349A1/es unknown
- 2013-07-12 SG SG11201500158RA patent/SG11201500158RA/en unknown
- 2013-07-12 BR BR112015000704A patent/BR112015000704A2/pt not_active IP Right Cessation
- 2013-07-12 US US13/940,619 patent/US8940736B2/en active Active
-
2014
- 2014-11-04 US US14/532,218 patent/US9556178B2/en active Active
-
2015
- 2015-01-05 TN TNP2015000002A patent/TN2015000002A1/fr unknown
- 2015-01-06 IL IL236605A patent/IL236605A0/en unknown
- 2015-01-12 PH PH12015500064A patent/PH12015500064A1/en unknown
- 2015-01-13 CL CL2015000094A patent/CL2015000094A1/es unknown
- 2015-01-26 CO CO15014912A patent/CO7180199A2/es unknown
- 2015-02-12 ZA ZA2015/01009A patent/ZA201501009B/en unknown
- 2015-12-21 US US14/976,476 patent/US20160108050A1/en not_active Abandoned
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