JP2015524408A5 - - Google Patents
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- Publication number
- JP2015524408A5 JP2015524408A5 JP2015523158A JP2015523158A JP2015524408A5 JP 2015524408 A5 JP2015524408 A5 JP 2015524408A5 JP 2015523158 A JP2015523158 A JP 2015523158A JP 2015523158 A JP2015523158 A JP 2015523158A JP 2015524408 A5 JP2015524408 A5 JP 2015524408A5
- Authority
- JP
- Japan
- Prior art keywords
- drug
- mammal
- pharmaceutical preparation
- cells
- preparation according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000124008 Mammalia Species 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims 8
- 229940079593 drug Drugs 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 7
- 239000000825 pharmaceutical preparation Substances 0.000 claims 7
- 206010011878 Deafness Diseases 0.000 claims 4
- 208000016354 hearing loss disease Diseases 0.000 claims 4
- 231100000888 hearing loss Toxicity 0.000 claims 3
- 230000010370 hearing loss Effects 0.000 claims 3
- 230000003834 intracellular effect Effects 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 claims 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims 1
- 229930182566 Gentamicin Natural products 0.000 claims 1
- 208000027530 Meniere disease Diseases 0.000 claims 1
- JLEBZPBDRKPWTD-TURQNECASA-O N-ribosylnicotinamide Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)=C1 JLEBZPBDRKPWTD-TURQNECASA-O 0.000 claims 1
- 108091005770 SIRT3 Proteins 0.000 claims 1
- 102000000478 Sirtuin 3 Human genes 0.000 claims 1
- 206010070863 Toxicity to various agents Diseases 0.000 claims 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
- 229960004316 cisplatin Drugs 0.000 claims 1
- 231100000895 deafness Toxicity 0.000 claims 1
- 210000000959 ear middle Anatomy 0.000 claims 1
- 229960002518 gentamicin Drugs 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 210000000067 inner hair cell Anatomy 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 235000020956 nicotinamide riboside Nutrition 0.000 claims 1
- 239000011618 nicotinamide riboside Substances 0.000 claims 1
- 230000004792 oxidative damage Effects 0.000 claims 1
- 239000011814 protection agent Substances 0.000 claims 1
- 210000004116 schwann cell Anatomy 0.000 claims 1
- 210000001323 spiral ganglion Anatomy 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261672169P | 2012-07-16 | 2012-07-16 | |
| US61/672,169 | 2012-07-16 | ||
| PCT/US2013/050511 WO2014014828A1 (en) | 2012-07-16 | 2013-07-15 | Nicotinamide riboside to treat hearing loss |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015524408A JP2015524408A (ja) | 2015-08-24 |
| JP2015524408A5 true JP2015524408A5 (https=) | 2016-09-08 |
| JP6289460B2 JP6289460B2 (ja) | 2018-03-07 |
Family
ID=49949192
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015523158A Expired - Fee Related JP6289460B2 (ja) | 2012-07-16 | 2013-07-15 | 難聴を治療するためのニコチンアミドリボシド |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9861651B2 (https=) |
| EP (1) | EP2872128B1 (https=) |
| JP (1) | JP6289460B2 (https=) |
| ES (1) | ES2785303T3 (https=) |
| WO (1) | WO2014014828A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3369738B1 (en) | 2005-11-18 | 2020-05-20 | Cornell Research Foundation, Inc. | Method for making nicotinoyl ribosides and nicotinamide beta-riboside |
| AU2015270090A1 (en) | 2014-06-06 | 2016-12-22 | Glaxosmithkline Intellectual Property (No.2) Limited | Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof |
| US10323058B2 (en) | 2014-07-24 | 2019-06-18 | W. R. Grace & Co.-Conn. | Crystalline form of nicotinamide riboside |
| EP3268379B1 (en) | 2015-03-09 | 2023-11-01 | W.R. Grace & CO. - CONN. | Crystalline form of nicotinamide riboside |
| ES2882602T3 (es) | 2015-05-18 | 2021-12-02 | Sensorion | Azasetrón para usar en el tratamiento de la pérdida auditiva |
| WO2017011788A1 (en) | 2015-07-15 | 2017-01-19 | Cornell University | Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives |
| US9855289B2 (en) | 2015-08-05 | 2018-01-02 | Metro International Biotech, Llc | Nicotinamide mononucleotide derivatives and their uses |
| GB2542881B (en) | 2015-10-02 | 2020-01-01 | Carr Andrew | Crystal forms of ß-nicotinamide mononucleotide |
| RS65379B1 (sr) | 2016-04-14 | 2024-04-30 | Sensorion | (+)-azasetron za upotrebu u lečenju poremećaja uha |
| CN110248650A (zh) * | 2016-10-31 | 2019-09-17 | 霍夫耳科研究所 | 用于增强突触发生和神经突发生的方法 |
| EP3538099B1 (en) | 2016-11-11 | 2026-04-22 | The Queen's University of Belfast | Efficient and scalable syntheses of nicotinoyl ribosides and reduced nicotinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof |
| JP7136795B2 (ja) | 2016-11-29 | 2022-09-13 | ユニバーシティー オブ アイオワ リサーチ ファウンデーション | 母体の健康および／または子の健康を向上させるためのｎａｄ前駆体の使用 |
| US11071747B2 (en) | 2016-11-29 | 2021-07-27 | University Of Iowa Research Foundation | Use of NAD precursors for breast enhancement |
| US10961268B2 (en) | 2017-04-05 | 2021-03-30 | Cornell University | β-nicotinate ester nucleotides and process for preparing same |
| CN112020363A (zh) | 2017-12-22 | 2020-12-01 | 益力舒健康公司 | 烟酰胺核苷氯化物的结晶形式 |
| AU2019214858B2 (en) | 2018-01-30 | 2023-02-02 | Metro International Biotech, Llc | Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof |
| US10618927B1 (en) | 2019-03-22 | 2020-04-14 | Metro International Biotech, Llc | Compositions and methods for modulation of nicotinamide adenine dinucleotide |
| US11939348B2 (en) | 2019-03-22 | 2024-03-26 | Metro International Biotech, Llc | Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide |
| BR112022000963A2 (pt) | 2019-07-19 | 2022-04-05 | Biosynth Ag | Método de fabricação de sais de nicotinamida ribofuranosídeo, sais de nicotinamida ribofuranosídeo como tal e usos dos mesmos |
| AU2022281388A1 (en) | 2021-05-27 | 2023-12-07 | Metro International Biotech, Llc | Crystalline solids of nicotinic acid mononucleotide and esters thereof and methods of making and use |
| CN121793959A (zh) | 2023-06-14 | 2026-04-03 | 可劳迈戴斯有限公司 | 静脉内配制品中的烟酰胺核苷及其衍生物与使用方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH695593A5 (de) | 2002-12-17 | 2006-06-30 | Granite Trading Ltd | Vorsatzlinse. |
| US20060063802A1 (en) * | 2004-03-29 | 2006-03-23 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| WO2007008548A2 (en) | 2005-07-07 | 2007-01-18 | Sirtris Pharmaceuticals, Inc. | Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders |
| US20070149466A1 (en) * | 2005-07-07 | 2007-06-28 | Michael Milburn | Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders |
| KR20130097813A (ko) * | 2008-04-21 | 2013-09-03 | 오토노미, 인코포레이티드 | 귀 질환 및 병태를 치료하기 위한 귀 조제물 |
-
2013
- 2013-07-15 EP EP13820653.7A patent/EP2872128B1/en active Active
- 2013-07-15 ES ES13820653T patent/ES2785303T3/es active Active
- 2013-07-15 US US14/414,924 patent/US9861651B2/en active Active
- 2013-07-15 JP JP2015523158A patent/JP6289460B2/ja not_active Expired - Fee Related
- 2013-07-15 WO PCT/US2013/050511 patent/WO2014014828A1/en not_active Ceased
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