JP2015522632A5 - - Google Patents
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- JP2015522632A5 JP2015522632A5 JP2015523491A JP2015523491A JP2015522632A5 JP 2015522632 A5 JP2015522632 A5 JP 2015522632A5 JP 2015523491 A JP2015523491 A JP 2015523491A JP 2015523491 A JP2015523491 A JP 2015523491A JP 2015522632 A5 JP2015522632 A5 JP 2015522632A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- component
- weight
- hypochlorite
- aqueous component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical compound Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 claims 8
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 5
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 5
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 5
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 5
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 5
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 5
- 239000004472 Lysine Substances 0.000 claims 5
- 235000013922 glutamic acid Nutrition 0.000 claims 5
- 239000004220 glutamic acid Substances 0.000 claims 5
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical class ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 claims 5
- 235000005772 leucine Nutrition 0.000 claims 5
- 235000018977 lysine Nutrition 0.000 claims 5
- XTEGARKTQYYJKE-UHFFFAOYSA-M Chlorate Chemical compound [O-]Cl(=O)=O XTEGARKTQYYJKE-UHFFFAOYSA-M 0.000 claims 4
- 206010016717 Fistula Diseases 0.000 claims 4
- 208000005141 Otitis Diseases 0.000 claims 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
- 208000025865 Ulcer Diseases 0.000 claims 4
- 235000001014 amino acid Nutrition 0.000 claims 4
- 229940024606 amino acid Drugs 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 4
- 150000001805 chlorine compounds Chemical class 0.000 claims 4
- 208000019258 ear infection Diseases 0.000 claims 4
- 230000003628 erosive effect Effects 0.000 claims 4
- 230000003890 fistula Effects 0.000 claims 4
- 239000000463 material Substances 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- 230000001225 therapeutic effect Effects 0.000 claims 4
- 231100000397 ulcer Toxicity 0.000 claims 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 3
- 239000004475 Arginine Substances 0.000 claims 2
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 2
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 2
- 206010052428 Wound Diseases 0.000 claims 2
- 208000027418 Wounds and injury Diseases 0.000 claims 2
- 235000004279 alanine Nutrition 0.000 claims 2
- 230000000844 anti-bacterial effect Effects 0.000 claims 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
- 235000009697 arginine Nutrition 0.000 claims 2
- 235000009582 asparagine Nutrition 0.000 claims 2
- 229960001230 asparagine Drugs 0.000 claims 2
- 235000003704 aspartic acid Nutrition 0.000 claims 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 2
- 239000000460 chlorine Substances 0.000 claims 2
- 229910001919 chlorite Inorganic materials 0.000 claims 2
- 229910052619 chlorite group Inorganic materials 0.000 claims 2
- QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical compound OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 2
- 235000004554 glutamine Nutrition 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 229960000310 isoleucine Drugs 0.000 claims 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 2
- 235000014705 isoleucine Nutrition 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000017074 necrotic cell death Effects 0.000 claims 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 claims 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 239000004474 valine Substances 0.000 claims 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 239000005708 Sodium hypochlorite Substances 0.000 claims 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 150000002366 halogen compounds Chemical class 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1250891A SE536581C2 (sv) | 2012-07-24 | 2012-07-24 | Ett kit för behandling av sår eller liknande och ett preparat och metoder därav |
| SE1250891-7 | 2012-07-24 | ||
| PCT/EP2013/064919 WO2014016157A1 (en) | 2012-07-24 | 2013-07-15 | Preparation for treatment of wounds and sores comprising hypochlorite and amino acids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015522632A JP2015522632A (ja) | 2015-08-06 |
| JP2015522632A5 true JP2015522632A5 (https=) | 2016-06-02 |
| JP6169693B2 JP6169693B2 (ja) | 2017-07-26 |
Family
ID=48783266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015523491A Expired - Fee Related JP6169693B2 (ja) | 2012-07-24 | 2013-07-15 | 次亜塩素酸およびアミノ酸を含む創傷およびびらんを治療するための製剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9999605B2 (https=) |
| EP (2) | EP3299022A1 (https=) |
| JP (1) | JP6169693B2 (https=) |
| CN (1) | CN104619330B (https=) |
| CA (1) | CA2879362C (https=) |
| ES (1) | ES2657598T3 (https=) |
| MX (1) | MX360207B (https=) |
| SE (1) | SE536581C2 (https=) |
| WO (1) | WO2014016157A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE536581C2 (sv) | 2012-07-24 | 2014-03-11 | Rls Global Ab | Ett kit för behandling av sår eller liknande och ett preparat och metoder därav |
| WO2015063468A1 (en) | 2013-10-29 | 2015-05-07 | Hypo-Stream Limited | Anti-inflammatory solution comprising sodium hypochlorite |
| GB2519774A (en) * | 2013-10-29 | 2015-05-06 | Hypo Stream Ltd | Anti-inflammatory solution |
| CA3081332A1 (en) * | 2017-10-31 | 2019-05-09 | Otomagnetics, Inc. | Magnetically-assisted delivery into and through the skin |
| RU2684415C1 (ru) * | 2018-04-18 | 2019-04-09 | Федеральное государственное бюджетное образовательное учреждение высшего образования Кубанский государственный медицинский университет Министерства здравоохранения Российской Федерации, ФГБОУ ВО КубГМУ МЗ РФ | Способ лечения гнойных ран |
| CN114555073A (zh) * | 2019-09-19 | 2022-05-27 | Rls全球公司 | 用于去除和/或预防与表皮葡萄球菌相关的感染的制剂 |
| RU2741954C1 (ru) * | 2020-07-20 | 2021-02-01 | Государственное бюджетное учреждение здравоохранения "Научно-исследовательский институт - краевая клиническая больница N 1 имени профессора С.В. Очаповского" Министерства здравоохранения Краснодарского края (ГБУЗ "НИИ-ККБ N 1 им. проф. Очаповского" Минздрава Краснодарского края) | Способ лечения локальных ран головы с остеонекрозом костей свода черепа |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1418193A (en) | 1973-03-14 | 1975-12-17 | Wilkinson Sword Ltd | Dispenser for hypochlorite gels |
| US3950536A (en) | 1974-02-01 | 1976-04-13 | Sol Joseph Barer | N,N-Dichloro substituted aminocarboxylic acids as bactericides and fungicides |
| JPH0233013B2 (ja) | 1980-03-21 | 1990-07-25 | Masatoshi Fumiiri | Sokonchiryozai |
| GB8324487D0 (en) | 1983-09-13 | 1983-10-12 | Geistlich Soehne Ag | Topically administrable pharmaceutical compositions |
| SE507437C2 (sv) | 1996-11-14 | 1998-06-08 | Medi Team Dentalutveckling I G | Preparat för användning vid kemisk-mekanisk behandling av kariesangrepp och förfarande för framställning av preparatet |
| JPH10175857A (ja) | 1996-12-19 | 1998-06-30 | Sekisui Chem Co Ltd | 創傷治療剤 |
| IL137869A0 (en) | 1998-02-27 | 2001-10-31 | Biora Bioex Ab | Matrix protein compositions for wound healing |
| US6350438B1 (en) | 1998-02-27 | 2002-02-26 | The Procter & Gamble Company | Oral care compositions comprising chlorite and methods |
| US6846478B1 (en) | 1998-02-27 | 2005-01-25 | The Procter & Gamble Company | Promoting whole body health |
| FR2819723B1 (fr) | 2001-01-23 | 2006-11-17 | Arnaud Mainnemare | Composition halogene, son procede de preparation et ses utilisations |
| US20030194445A1 (en) * | 2001-11-12 | 2003-10-16 | Kuhner Carla H. | Compositions and methods of use of peptides in combination with biocides and/or germicides |
| EP1558078B1 (en) | 2002-10-07 | 2012-05-30 | Alcide Corporation | Acidified chlorite compositions containing nitrogenous stabilizers and systems and methods related thereto |
| EP2725008A1 (en) | 2003-08-18 | 2014-04-30 | NovaBay Pharmaceuticals, Inc. | N,N-dihalogenated amino acids and derivatives |
| US7423064B2 (en) * | 2004-09-24 | 2008-09-09 | Olatec Industries, Llc | Composition for treating bacterial, viral, fungal diseases, inflammation and pain |
| TWI386201B (zh) | 2005-01-25 | 2013-02-21 | Novabay Pharmaceuticals Inc | Ｎ-鹵化胺基酸、ｎ，ｎ-二鹵化胺基酸與其衍生物；以及使用其之組合物與方法 |
| US20070032754A1 (en) * | 2005-08-02 | 2007-02-08 | Walsh Richard F | Method and apparatus for treating a wound |
| TW200843787A (en) | 2006-12-29 | 2008-11-16 | Novabay Pharmaceuticals Inc | N-halogenated amino compounds and derivatives; compositions and methods of using them |
| KR20080082742A (ko) | 2007-03-09 | 2008-09-12 | 이향락 | 충치 제거제 |
| UY31058A1 (es) | 2007-05-01 | 2008-10-31 | Alcon Res Ltd | Formulaciones de aminoacido n-halogenado con compuestos antiinflamatorios |
| US7879798B1 (en) | 2007-08-24 | 2011-02-01 | Regenicel, Inc. | Composition for indolent wound healing and methods of use therefor |
| UY31055A1 (es) | 2008-02-01 | 2008-10-31 | Alcon Res Ltd | Sales antimicrobianas de aminoacido n-halogenado |
| WO2010017405A1 (en) | 2008-08-06 | 2010-02-11 | Adam Heller | Methods and compositions for the treatment of pain |
| WO2010091280A1 (en) | 2009-02-06 | 2010-08-12 | Alcon Research, Ltd. | N-halogenated amino acid formulations comprising phosphine or amine oxides |
| AU2010226794A1 (en) | 2009-03-18 | 2011-10-27 | Olatec Industries Llc | Compounds for treating inflammation and pain |
| WO2011014460A1 (en) | 2009-07-27 | 2011-02-03 | Novabay Pharmaceuticals, Inc. | Methods of treating infections of the nail or skin using hypohalite |
| BR112012002333A2 (pt) | 2009-08-06 | 2017-07-18 | Neuraltus Pharmaceuticals Inc | método de reduzir os efeitos colaterais e método de potencializar o efeito de um imunomodulador administrado a um sujeito que dele necessita; métodos para tratar doença associada com excesso de ativação de monócitos para macrófagos ativados, diabetes tipo ii ou complicações relacionadas, doença associada com a migração de monócitos ou macrófagos ativados, doença associada a excesso de produção de scd14 e/ou scd163 por macrófagos ativados; composto de cloreto de sódio; composição farmacêutica; método para diagnosticar uma doença relacionada com macrófagos em um sujeito; e método para determinar a eficácia do tratamento com um agente oxidante para uma doença relacionada a macrófagos em um sujeito. |
| US8486155B2 (en) * | 2010-05-13 | 2013-07-16 | Ethicon Endo-Surgery, Inc. | Fistula repair plug having multiple layers |
| EP2510944A1 (en) | 2011-04-15 | 2012-10-17 | National University of Ireland, Galway | Treatment of bacterial infections |
| HUE047099T2 (hu) * | 2011-10-08 | 2020-04-28 | Next Science IP Holdings Pty Ltd | Antimikrobiális kompozíciók és eljárások alkalmazásukra |
| SE536581C2 (sv) | 2012-07-24 | 2014-03-11 | Rls Global Ab | Ett kit för behandling av sår eller liknande och ett preparat och metoder därav |
-
2012
- 2012-07-24 SE SE1250891A patent/SE536581C2/sv unknown
-
2013
- 2013-07-15 WO PCT/EP2013/064919 patent/WO2014016157A1/en not_active Ceased
- 2013-07-15 EP EP17196425.7A patent/EP3299022A1/en not_active Withdrawn
- 2013-07-15 ES ES13736590.4T patent/ES2657598T3/es active Active
- 2013-07-15 CN CN201380039773.4A patent/CN104619330B/zh not_active Expired - Fee Related
- 2013-07-15 JP JP2015523491A patent/JP6169693B2/ja not_active Expired - Fee Related
- 2013-07-15 MX MX2015001019A patent/MX360207B/es active IP Right Grant
- 2013-07-15 EP EP13736590.4A patent/EP2877188B1/en active Active
- 2013-07-15 US US14/416,718 patent/US9999605B2/en active Active
- 2013-07-15 CA CA2879362A patent/CA2879362C/en active Active
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