JP2015522556A5 - - Google Patents
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- Publication number
- JP2015522556A5 JP2015522556A5 JP2015515410A JP2015515410A JP2015522556A5 JP 2015522556 A5 JP2015522556 A5 JP 2015522556A5 JP 2015515410 A JP2015515410 A JP 2015515410A JP 2015515410 A JP2015515410 A JP 2015515410A JP 2015522556 A5 JP2015522556 A5 JP 2015522556A5
- Authority
- JP
- Japan
- Prior art keywords
- halogen
- substituted
- compound
- formula
- branched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052736 halogen Inorganic materials 0.000 claims 10
- 150000002367 halogens Chemical class 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004008 6 membered carbocyclic group Chemical group 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000005145 Cerebral amyloid angiopathy Diseases 0.000 claims 1
- 201000010374 Down Syndrome Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 208000027061 mild cognitive impairment Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 0 *C(C(NNC([U]*)=O)=O)NC(*)=O Chemical compound *C(C(NNC([U]*)=O)=O)NC(*)=O 0.000 description 3
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261655544P | 2012-06-05 | 2012-06-05 | |
| US61/655,544 | 2012-06-05 | ||
| EP12170840.8 | 2012-06-05 | ||
| EP12170840.8A EP2671885A1 (en) | 2012-06-05 | 2012-06-05 | Imidazo-oxadiazole and Imidazo-thiadiazole derivatives |
| PCT/EP2013/001521 WO2013182274A1 (en) | 2012-06-05 | 2013-05-23 | Imidazo-oxadiazole and imidazo-thiadiazole derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015522556A JP2015522556A (ja) | 2015-08-06 |
| JP2015522556A5 true JP2015522556A5 (https=) | 2016-08-12 |
| JP6167465B2 JP6167465B2 (ja) | 2017-07-26 |
Family
ID=46320789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015515410A Active JP6167465B2 (ja) | 2012-06-05 | 2013-05-23 | イミダゾ−オキサジアゾール及びイミダゾ−チアジアゾール誘導体 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9932354B2 (https=) |
| EP (2) | EP2671885A1 (https=) |
| JP (1) | JP6167465B2 (https=) |
| CN (1) | CN104395324B (https=) |
| AU (1) | AU2013270979B2 (https=) |
| CA (1) | CA2875628C (https=) |
| ES (1) | ES2582556T3 (https=) |
| IL (1) | IL236076B (https=) |
| WO (1) | WO2013182274A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018224455A1 (en) | 2017-06-07 | 2018-12-13 | Basf Se | Substituted cyclopropyl derivatives |
| AU2018346597B2 (en) | 2017-10-06 | 2023-07-13 | Forma Therapeutics, Inc. | Inhibiting Ubiquitin Specific Peptidase 30 |
| JP7449242B2 (ja) | 2018-05-17 | 2024-03-13 | フォーマ セラピューティクス，インコーポレイテッド | ユビキチン特異的ペプチダーゼ３０（ｕｓｐ３０）阻害剤として有用な縮合二環化合物 |
| JP7530889B2 (ja) | 2018-10-05 | 2024-08-08 | フォーマ セラピューティクス，インコーポレイテッド | ユビキチン特異的プロテアーゼ３０（ｕｓｐ３０）阻害剤として作用する縮合ピロリン |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5691201A (en) * | 1993-04-26 | 1997-11-25 | Janssen Pharmaceutica, N.V. | Use of sabeluzole in chronic neurodegenerative diseases |
| ES2316546T3 (es) * | 2001-02-20 | 2009-04-16 | Astrazeneca Ab | 2-arilamino-pirimidinas para el tratamiento de trastornos asociados a gsk3. |
| CA2450769A1 (en) * | 2001-06-15 | 2002-12-27 | Vertex Pharmaceuticals Incorporated | 5-(2-aminopyrimidin-4-yl) benzisoxazoles as protein kinase inhibitors |
| TW200302722A (en) * | 2002-02-13 | 2003-08-16 | Astrazeneca Ab | Therapeutic agents |
| US20050154202A1 (en) * | 2002-04-05 | 2005-07-14 | Hagmann William K. | Substituted aryl amides |
| CN1319968C (zh) * | 2002-08-02 | 2007-06-06 | 沃泰克斯药物股份有限公司 | 用作gsk－3的抑制剂的吡唑组合物 |
| DK1910384T3 (da) * | 2005-08-04 | 2012-12-17 | Sirtris Pharmaceuticals Inc | Imidazo [2,1-b] thiazol-derivater som sirtuinmodulerende forbindelser |
| HUE025976T2 (en) * | 2007-09-27 | 2016-05-30 | Fund Centro Nac De Investig Oncologicas Carlos Iii | Imidazolothiadiazoles for use as protein kinase inhibitors |
| AU2009275544B2 (en) * | 2008-07-29 | 2013-09-12 | Merck Patent Gmbh | Imidazothiadiazoles derivatives |
| CA2737028C (en) * | 2008-09-23 | 2017-06-27 | Wista Laboratories Ltd. | Ligands for aggregated tau molecules |
-
2012
- 2012-06-05 EP EP12170840.8A patent/EP2671885A1/en not_active Withdrawn
-
2013
- 2013-05-23 WO PCT/EP2013/001521 patent/WO2013182274A1/en not_active Ceased
- 2013-05-23 CA CA2875628A patent/CA2875628C/en active Active
- 2013-05-23 CN CN201380029418.9A patent/CN104395324B/zh active Active
- 2013-05-23 JP JP2015515410A patent/JP6167465B2/ja active Active
- 2013-05-23 US US14/402,395 patent/US9932354B2/en active Active
- 2013-05-23 ES ES13724172.5T patent/ES2582556T3/es active Active
- 2013-05-23 EP EP13724172.5A patent/EP2855488B1/en active Active
- 2013-05-23 AU AU2013270979A patent/AU2013270979B2/en active Active
-
2014
- 2014-12-04 IL IL236076A patent/IL236076B/en active IP Right Grant
-
2017
- 2017-12-01 US US15/829,030 patent/US10696690B2/en active Active
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