JP2015521996A5 - - Google Patents
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- JP2015521996A5 JP2015521996A5 JP2015519238A JP2015519238A JP2015521996A5 JP 2015521996 A5 JP2015521996 A5 JP 2015521996A5 JP 2015519238 A JP2015519238 A JP 2015519238A JP 2015519238 A JP2015519238 A JP 2015519238A JP 2015521996 A5 JP2015521996 A5 JP 2015521996A5
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- JP
- Japan
- Prior art keywords
- composition
- oil
- composition according
- acid
- copolymers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims description 74
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 27
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 13
- 239000002253 acid Substances 0.000 claims description 9
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 8
- 239000000194 fatty acid Substances 0.000 claims description 8
- 229930195729 fatty acid Natural products 0.000 claims description 8
- 239000004480 active ingredient Substances 0.000 claims description 7
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims description 6
- 150000004665 fatty acids Chemical class 0.000 claims description 6
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 claims description 6
- 150000003626 triacylglycerols Chemical class 0.000 claims description 6
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims description 5
- 239000003623 enhancer Substances 0.000 claims description 5
- 229960002446 octanoic acid Drugs 0.000 claims description 5
- 208000017520 skin disease Diseases 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 229940057917 medium chain triglycerides Drugs 0.000 claims description 4
- 208000024891 symptom Diseases 0.000 claims description 4
- SGRCVQDBWHCTIS-UHFFFAOYSA-N 2-nonanoyloxypropyl nonanoate Chemical group CCCCCCCCC(=O)OCC(C)OC(=O)CCCCCCCC SGRCVQDBWHCTIS-UHFFFAOYSA-N 0.000 claims description 3
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 claims description 3
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims description 3
- 201000004681 Psoriasis Diseases 0.000 claims description 3
- 150000005690 diesters Chemical class 0.000 claims description 3
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 3
- 229940043348 myristyl alcohol Drugs 0.000 claims description 3
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- GHHURQMJLARIDK-UHFFFAOYSA-N 2-hydroxypropyl octanoate Chemical compound CCCCCCCC(=O)OCC(C)O GHHURQMJLARIDK-UHFFFAOYSA-N 0.000 claims description 2
- 208000002874 Acne Vulgaris Diseases 0.000 claims description 2
- 201000004624 Dermatitis Diseases 0.000 claims description 2
- 206010012438 Dermatitis atopic Diseases 0.000 claims description 2
- 206010012442 Dermatitis contact Diseases 0.000 claims description 2
- 208000003251 Pruritus Diseases 0.000 claims description 2
- 206010000496 acne Diseases 0.000 claims description 2
- 208000009621 actinic keratosis Diseases 0.000 claims description 2
- 201000008937 atopic dermatitis Diseases 0.000 claims description 2
- 208000010668 atopic eczema Diseases 0.000 claims description 2
- 208000010247 contact dermatitis Diseases 0.000 claims description 2
- 206010021198 ichthyosis Diseases 0.000 claims description 2
- 201000004700 rosacea Diseases 0.000 claims description 2
- -1 polyoxypropylene Polymers 0.000 claims 12
- 229920001577 copolymer Polymers 0.000 claims 11
- ZFOZVQLOBQUTQQ-UHFFFAOYSA-N Tributyl citrate Chemical compound CCCCOC(=O)CC(O)(C(=O)OCCCC)CC(=O)OCCCC ZFOZVQLOBQUTQQ-UHFFFAOYSA-N 0.000 claims 8
- 229920000642 polymer Polymers 0.000 claims 8
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 8
- 239000008158 vegetable oil Substances 0.000 claims 8
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 6
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 6
- 239000004014 plasticizer Substances 0.000 claims 6
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 6
- 239000002904 solvent Substances 0.000 claims 6
- 239000003921 oil Substances 0.000 claims 5
- 235000019198 oils Nutrition 0.000 claims 5
- 229920001451 polypropylene glycol Polymers 0.000 claims 5
- SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 claims 4
- 229940122739 Calcineurin inhibitor Drugs 0.000 claims 4
- 102100024123 Calcineurin-binding protein cabin-1 Human genes 0.000 claims 4
- 101710192106 Calcineurin-binding protein cabin-1 Proteins 0.000 claims 4
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 4
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 4
- 150000005215 alkyl ethers Chemical class 0.000 claims 4
- 230000002821 anti-nucleating effect Effects 0.000 claims 4
- 230000003115 biocidal effect Effects 0.000 claims 4
- LWQQLNNNIPYSNX-UROSTWAQSA-N calcipotriol Chemical compound C1([C@H](O)/C=C/[C@@H](C)[C@@H]2[C@]3(CCCC(/[C@@H]3CC2)=C\C=C\2C([C@@H](O)C[C@H](O)C/2)=C)C)CC1 LWQQLNNNIPYSNX-UROSTWAQSA-N 0.000 claims 4
- 229920002678 cellulose Polymers 0.000 claims 4
- 239000001913 cellulose Substances 0.000 claims 4
- 239000003246 corticosteroid Substances 0.000 claims 4
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 4
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 4
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 4
- 239000003410 keratolytic agent Substances 0.000 claims 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 4
- 239000003589 local anesthetic agent Substances 0.000 claims 4
- 229920000609 methyl cellulose Polymers 0.000 claims 4
- 239000001923 methylcellulose Substances 0.000 claims 4
- 235000010981 methylcellulose Nutrition 0.000 claims 4
- 239000002480 mineral oil Substances 0.000 claims 4
- 235000010446 mineral oil Nutrition 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 229920000058 polyacrylate Polymers 0.000 claims 4
- 150000004492 retinoid derivatives Chemical class 0.000 claims 4
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical group OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims 4
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims 4
- 150000003710 vitamin D derivatives Chemical group 0.000 claims 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 150000001298 alcohols Chemical class 0.000 claims 3
- 235000019441 ethanol Nutrition 0.000 claims 3
- JHPBZFOKBAGZBL-UHFFFAOYSA-N (3-hydroxy-2,2,4-trimethylpentyl) 2-methylprop-2-enoate Chemical compound CC(C)C(O)C(C)(C)COC(=O)C(C)=C JHPBZFOKBAGZBL-UHFFFAOYSA-N 0.000 claims 2
- HANWHVWXFQSQGJ-UHFFFAOYSA-N 1-tetradecoxytetradecane Chemical compound CCCCCCCCCCCCCCOCCCCCCCCCCCCCC HANWHVWXFQSQGJ-UHFFFAOYSA-N 0.000 claims 2
- ZKYCLDTVJCJYIB-UHFFFAOYSA-N 2-methylidenedecanamide Chemical compound CCCCCCCCC(=C)C(N)=O ZKYCLDTVJCJYIB-UHFFFAOYSA-N 0.000 claims 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical group O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- 235000019489 Almond oil Nutrition 0.000 claims 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 2
- PYGXAGIECVVIOZ-UHFFFAOYSA-N Dibutyl decanedioate Chemical compound CCCCOC(=O)CCCCCCCCC(=O)OCCCC PYGXAGIECVVIOZ-UHFFFAOYSA-N 0.000 claims 2
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims 2
- 239000001856 Ethyl cellulose Substances 0.000 claims 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 2
- IECPWNUMDGFDKC-UHFFFAOYSA-N Fusicsaeure Natural products C12C(O)CC3C(=C(CCC=C(C)C)C(O)=O)C(OC(C)=O)CC3(C)C1(C)CCC1C2(C)CCC(O)C1C IECPWNUMDGFDKC-UHFFFAOYSA-N 0.000 claims 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 2
- 229940122245 Janus kinase inhibitor Drugs 0.000 claims 2
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 2
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical group CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 2
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 claims 2
- 102000002002 Neurokinin-1 Receptors Human genes 0.000 claims 2
- 108010040718 Neurokinin-1 Receptors Proteins 0.000 claims 2
- 235000019483 Peanut oil Nutrition 0.000 claims 2
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 235000019485 Safflower oil Nutrition 0.000 claims 2
- 235000019486 Sunflower oil Nutrition 0.000 claims 2
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 2
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical group CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims 2
- 229930003316 Vitamin D Natural products 0.000 claims 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 2
- 235000009754 Vitis X bourquina Nutrition 0.000 claims 2
- 235000012333 Vitis X labruscana Nutrition 0.000 claims 2
- 240000006365 Vitis vinifera Species 0.000 claims 2
- 235000014787 Vitis vinifera Nutrition 0.000 claims 2
- 235000019498 Walnut oil Nutrition 0.000 claims 2
- 229920006243 acrylic copolymer Polymers 0.000 claims 2
- LZCDAPDGXCYOEH-UHFFFAOYSA-N adapalene Chemical compound C1=C(C(O)=O)C=CC2=CC(C3=CC=C(C(=C3)C34CC5CC(CC(C5)C3)C4)OC)=CC=C21 LZCDAPDGXCYOEH-UHFFFAOYSA-N 0.000 claims 2
- 229960002916 adapalene Drugs 0.000 claims 2
- 239000008168 almond oil Substances 0.000 claims 2
- 239000008163 avocado oil Substances 0.000 claims 2
- 235000021302 avocado oil Nutrition 0.000 claims 2
- DZGUJOWBVDZNNF-UHFFFAOYSA-N azanium;2-methylprop-2-enoate Chemical compound [NH4+].CC(=C)C([O-])=O DZGUJOWBVDZNNF-UHFFFAOYSA-N 0.000 claims 2
- 229960001102 betamethasone dipropionate Drugs 0.000 claims 2
- CIWBQSYVNNPZIQ-XYWKZLDCSA-N betamethasone dipropionate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O CIWBQSYVNNPZIQ-XYWKZLDCSA-N 0.000 claims 2
- 229960004311 betamethasone valerate Drugs 0.000 claims 2
- SNHRLVCMMWUAJD-SUYDQAKGSA-N betamethasone valerate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(OC(=O)CCCC)[C@@]1(C)C[C@@H]2O SNHRLVCMMWUAJD-SUYDQAKGSA-N 0.000 claims 2
- 229960002882 calcipotriol Drugs 0.000 claims 2
- 239000000828 canola oil Substances 0.000 claims 2
- 235000019519 canola oil Nutrition 0.000 claims 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 2
- 239000004359 castor oil Substances 0.000 claims 2
- 235000019438 castor oil Nutrition 0.000 claims 2
- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 claims 2
- 229960002227 clindamycin Drugs 0.000 claims 2
- 235000005687 corn oil Nutrition 0.000 claims 2
- 239000002285 corn oil Substances 0.000 claims 2
- 235000012343 cottonseed oil Nutrition 0.000 claims 2
- 239000002385 cottonseed oil Substances 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 229920001249 ethyl cellulose Polymers 0.000 claims 2
- 235000019325 ethyl cellulose Nutrition 0.000 claims 2
- 238000001704 evaporation Methods 0.000 claims 2
- IECPWNUMDGFDKC-MZJAQBGESA-N fusidic acid Chemical compound O[C@@H]([C@@H]12)C[C@H]3\C(=C(/CCC=C(C)C)C(O)=O)[C@@H](OC(C)=O)C[C@]3(C)[C@@]2(C)CC[C@@H]2[C@]1(C)CC[C@@H](O)[C@H]2C IECPWNUMDGFDKC-MZJAQBGESA-N 0.000 claims 2
- 229960004675 fusidic acid Drugs 0.000 claims 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 2
- 239000001087 glyceryl triacetate Substances 0.000 claims 2
- 235000013773 glyceryl triacetate Nutrition 0.000 claims 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 2
- VEBVPUXQAPLADL-POYOOMFHSA-N ingenol Chemical class C1=C(CO)[C@@H](O)[C@]2(O)[C@@H](O)C(C)=C[C@]32[C@H](C)C[C@H]2C(C)(C)[C@H]2[C@H]1C3=O VEBVPUXQAPLADL-POYOOMFHSA-N 0.000 claims 2
- 229940093629 isopropyl isostearate Drugs 0.000 claims 2
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 claims 2
- 229940119170 jojoba wax Drugs 0.000 claims 2
- 235000014655 lactic acid Nutrition 0.000 claims 2
- 239000004310 lactic acid Substances 0.000 claims 2
- 229960004194 lidocaine Drugs 0.000 claims 2
- 229940057995 liquid paraffin Drugs 0.000 claims 2
- 229920003146 methacrylic ester copolymer Polymers 0.000 claims 2
- TZIHFWKZFHZASV-UHFFFAOYSA-N methyl formate Chemical compound COC=O TZIHFWKZFHZASV-UHFFFAOYSA-N 0.000 claims 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 2
- 239000004006 olive oil Substances 0.000 claims 2
- 235000008390 olive oil Nutrition 0.000 claims 2
- 239000003346 palm kernel oil Substances 0.000 claims 2
- 235000019865 palm kernel oil Nutrition 0.000 claims 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 2
- 239000000312 peanut oil Substances 0.000 claims 2
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims 2
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 claims 2
- KASDHRXLYQOAKZ-ZPSXYTITSA-N pimecrolimus Chemical compound C/C([C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H](C(C[C@H](O)[C@H]1C)=O)CC)=C\[C@@H]1CC[C@@H](Cl)[C@H](OC)C1 KASDHRXLYQOAKZ-ZPSXYTITSA-N 0.000 claims 2
- 229960005330 pimecrolimus Drugs 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 229920001296 polysiloxane Polymers 0.000 claims 2
- 229920002635 polyurethane Polymers 0.000 claims 2
- 239000004814 polyurethane Substances 0.000 claims 2
- 229920002689 polyvinyl acetate Polymers 0.000 claims 2
- 239000011118 polyvinyl acetate Substances 0.000 claims 2
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 2
- XEIOPEQGDSYOIH-MURFETPASA-N propan-2-yl (9z,12z)-octadeca-9,12-dienoate Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(=O)OC(C)C XEIOPEQGDSYOIH-MURFETPASA-N 0.000 claims 2
- PZQSQRCNMZGWFT-QXMHVHEDSA-N propan-2-yl (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC(C)C PZQSQRCNMZGWFT-QXMHVHEDSA-N 0.000 claims 2
- NEOZOXKVMDBOSG-UHFFFAOYSA-N propan-2-yl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OC(C)C NEOZOXKVMDBOSG-UHFFFAOYSA-N 0.000 claims 2
- 239000002464 receptor antagonist Substances 0.000 claims 2
- 229940044551 receptor antagonist Drugs 0.000 claims 2
- 235000005713 safflower oil Nutrition 0.000 claims 2
- 239000003813 safflower oil Substances 0.000 claims 2
- 229960004889 salicylic acid Drugs 0.000 claims 2
- 239000008159 sesame oil Substances 0.000 claims 2
- 235000011803 sesame oil Nutrition 0.000 claims 2
- 229920005573 silicon-containing polymer Polymers 0.000 claims 2
- 229920002545 silicone oil Polymers 0.000 claims 2
- 239000003549 soybean oil Substances 0.000 claims 2
- 235000012424 soybean oil Nutrition 0.000 claims 2
- 239000002600 sunflower oil Substances 0.000 claims 2
- 229960001967 tacrolimus Drugs 0.000 claims 2
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 2
- 229960002622 triacetin Drugs 0.000 claims 2
- WEAPVABOECTMGR-UHFFFAOYSA-N triethyl 2-acetyloxypropane-1,2,3-tricarboxylate Chemical compound CCOC(=O)CC(C(=O)OCC)(OC(C)=O)CC(=O)OCC WEAPVABOECTMGR-UHFFFAOYSA-N 0.000 claims 2
- 239000001069 triethyl citrate Substances 0.000 claims 2
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims 2
- 235000013769 triethyl citrate Nutrition 0.000 claims 2
- 235000019166 vitamin D Nutrition 0.000 claims 2
- 239000011710 vitamin D Substances 0.000 claims 2
- 229940046008 vitamin d Drugs 0.000 claims 2
- 239000008170 walnut oil Substances 0.000 claims 2
- HBXWUCXDUUJDRB-UHFFFAOYSA-N 1-octadecoxyoctadecane Chemical compound CCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCC HBXWUCXDUUJDRB-UHFFFAOYSA-N 0.000 claims 1
- UVBYRJHLFIXTOI-UHFFFAOYSA-N 1-octanoyloxypropan-2-yl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC(C)COC(=O)CCCCCCC UVBYRJHLFIXTOI-UHFFFAOYSA-N 0.000 claims 1
- UHOPWFKONJYLCF-UHFFFAOYSA-N 2-(2-sulfanylethyl)isoindole-1,3-dione Chemical compound C1=CC=C2C(=O)N(CCS)C(=O)C2=C1 UHOPWFKONJYLCF-UHFFFAOYSA-N 0.000 claims 1
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 claims 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 claims 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical group CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims 1
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 claims 1
- 229920006322 acrylamide copolymer Polymers 0.000 claims 1
- 230000002051 biphasic effect Effects 0.000 claims 1
- 229940086555 cyclomethicone Drugs 0.000 claims 1
- 229940008099 dimethicone Drugs 0.000 claims 1
- 239000004205 dimethyl polysiloxane Substances 0.000 claims 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims 1
- LLRANSBEYQZKFY-UHFFFAOYSA-N dodecanoic acid;propane-1,2-diol Chemical group CC(O)CO.CCCCCCCCCCCC(O)=O LLRANSBEYQZKFY-UHFFFAOYSA-N 0.000 claims 1
- 230000008020 evaporation Effects 0.000 claims 1
- UQEAIHBTYFGYIE-UHFFFAOYSA-N hexamethyldisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)C UQEAIHBTYFGYIE-UHFFFAOYSA-N 0.000 claims 1
- 229940073561 hexamethyldisiloxane Drugs 0.000 claims 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims 1
- 229960005015 local anesthetics Drugs 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 239000002667 nucleating agent Substances 0.000 claims 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- BHIZVZJETFVJMJ-UHFFFAOYSA-N 2-hydroxypropyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCC(C)O BHIZVZJETFVJMJ-UHFFFAOYSA-N 0.000 description 1
- 206010004146 Basal cell carcinoma Diseases 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 238000009115 maintenance therapy Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 229940026235 propylene glycol monolaurate Drugs 0.000 description 1
- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- 230000037075 skin appearance Effects 0.000 description 1
- 206010041823 squamous cell carcinoma Diseases 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
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| PCT/EP2013/064301 WO2014006202A1 (en) | 2012-07-06 | 2013-07-05 | A topical composition comprising a film-forming polymer for delivering an active ingredient to skin |
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| JP2015521996A JP2015521996A (ja) | 2015-08-03 |
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| JP2015519238A Pending JP2015521996A (ja) | 2012-07-06 | 2013-07-05 | 活性成分を皮膚に送達するためのフィルム形成ポリマーを含む局所用組成物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2859886A1 (en) * | 2010-06-11 | 2015-04-15 | Leo Pharma A/S | A pharmaceutical spray composition |
| US10925689B2 (en) * | 2014-07-14 | 2021-02-23 | Novan, Inc. | Nitric oxide releasing nail coating compositions, nitric oxide releasing nail coatings, and methods of using the same |
| TW201636025A (zh) * | 2015-04-15 | 2016-10-16 | Maruho Kk | 皮膚用之醫藥組成物 |
| WO2017019614A1 (en) | 2015-07-28 | 2017-02-02 | Novan, Inc. | Combinations and methods for the treatment and/or prevention of fungal infections |
| ES2901481T3 (es) * | 2015-11-23 | 2022-03-22 | Nortic Holdings Inc | Pulverización filmógena tópica |
| EP3452023A1 (en) | 2016-05-05 | 2019-03-13 | Aquestive Therapeutics, Inc. | Enhanced delivery epinephrine compositions |
| US20180028767A1 (en) * | 2016-07-27 | 2018-02-01 | Sun Pharmaceutical Industries Limited | Topical spray system of halobetasol |
| US20180028766A1 (en) * | 2016-07-27 | 2018-02-01 | Sun Pharmaceutical Industries Limited | Touch-free topical spray of halobetasol |
| EP3556368B1 (en) | 2016-12-16 | 2021-05-26 | Kaneka Corporation | Onychomycosis therapeutic agent |
| JP2020535232A (ja) * | 2017-09-26 | 2020-12-03 | アクエスティブ セラピューティクス インコーポレイテッド | 透過エンハンサーを含む送達医薬組成物 |
| TWI655943B (zh) * | 2017-11-22 | 2019-04-11 | 台鉅生技股份有限公司 | 水性痤瘡隔離組成物、透明痤瘡隔離膜及其形成方法 |
| US11439986B2 (en) | 2017-12-13 | 2022-09-13 | Scientific Design Company, Inc. | Silver impregnation solution containing high-boiling oxygenated additive and its use in ethylene oxide catalyst preparation |
| CN108904445A (zh) * | 2018-08-06 | 2018-11-30 | 江苏知原药业有限公司 | 钙泊三醇纳米悬浮液 |
| WO2020161771A1 (ja) * | 2019-02-04 | 2020-08-13 | マルホ株式会社 | 皮膚用組成物 |
| CN110038010A (zh) * | 2019-04-28 | 2019-07-23 | 瑞雅科医药(北京)有限公司 | 一种苦味厌恶制剂及其制备方法与防咬笔 |
| CN110339184B (zh) * | 2019-08-13 | 2020-05-08 | 哈尔滨乾佰纳生物药业有限公司 | 一种医用修复涂膜剂及其制备方法 |
| WO2021202875A1 (en) * | 2020-04-02 | 2021-10-07 | Twinmedix Llc | Cosmetic compositions |
| WO2022029938A1 (ja) * | 2020-08-05 | 2022-02-10 | マルホ株式会社 | 皮膚用組成物 |
| US12465564B2 (en) | 2021-10-25 | 2025-11-11 | Aquestive Therapeutics, Inc. | Oral and nasal compositions and methods of treatment |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2238442A (en) * | 1939-05-25 | 1941-04-15 | Ernest F Drew | Mixed capric-caprylic esters and method of making same |
| JP2556075B2 (ja) * | 1987-12-23 | 1996-11-20 | 日産化学工業株式会社 | 消炎鎮痛外用剤 |
| HU219480B (hu) | 1991-05-23 | 2001-04-28 | Novartis Ag. | Eljárás gombás körömmegbetegségek ellen helyileg alkalmazható, allil-amin-származékot tartalmazó gyógyászati készítmények előállítására |
| TW247878B (cg-RX-API-DMAC7.html) * | 1991-07-02 | 1995-05-21 | Takeda Pharm Industry Co Ltd | |
| JP3803393B2 (ja) * | 1994-01-12 | 2006-08-02 | 久光製薬株式会社 | 爪白癬治療用組成物 |
| JPH10218793A (ja) * | 1997-02-03 | 1998-08-18 | Nichiban Co Ltd | 経皮吸収型消炎鎮痛用テープ剤及びその製造方法 |
| ES2209812T3 (es) * | 1999-02-05 | 2004-07-01 | Cipla Ltd. | Pulverizaciones topicas que contienen una composicion filmogena. |
| JP2000281570A (ja) * | 1999-03-30 | 2000-10-10 | Nichiban Co Ltd | 経皮投与用貼付剤 |
| US6962691B1 (en) | 1999-05-20 | 2005-11-08 | U & I Pharmaceuticals Ltd. | Topical spray compositions |
| US20070189978A1 (en) | 2004-06-07 | 2007-08-16 | Jie Zhang | Compositions and methods for dermally treating musculoskeletal pain |
| US20070196453A1 (en) | 2004-06-07 | 2007-08-23 | Jie Zhang | Two or more non-volatile solvent-containing compositions and methods for dermal delivery of drugs |
| US20070196325A1 (en) | 2004-06-07 | 2007-08-23 | Jie Zhang | Compositions and methods for dermally treating infections |
| US20070190124A1 (en) | 2004-06-07 | 2007-08-16 | Jie Zhang | Two or more solidifying agent-containing compositions and methods for dermal delivery of drugs |
| US8741332B2 (en) | 2004-06-07 | 2014-06-03 | Nuvo Research Inc. | Compositions and methods for dermally treating neuropathic pain |
| US20070196452A1 (en) | 2004-06-07 | 2007-08-23 | Jie Zhang | Flux-enabling compositions and methods for dermal delivery of drugs |
| US20070196293A1 (en) | 2004-06-07 | 2007-08-23 | Jie Zhang | Compositions and methods for treating photo damaged skin |
| US20070189980A1 (en) | 2004-06-07 | 2007-08-16 | Jie Zhang | Compositions and methods for treating alopecia |
| US8741333B2 (en) | 2004-06-07 | 2014-06-03 | Nuvo Research Inc. | Compositions and methods for treating dermatitis or psoriasis |
| US20080019927A1 (en) | 2004-06-07 | 2008-01-24 | Jie Zhang | Compositions and methods for dermally treating neuropathy with minoxidil |
| US20070196457A1 (en) | 2004-06-07 | 2007-08-23 | Jie Zhang | Two or more volatile solvent-containing compositions and methods for dermal delivery of drugs |
| US20070196323A1 (en) | 2004-06-07 | 2007-08-23 | Jie Zhang | Polyvinyl alcohol-containing compositions and methods for dermal delivery of drugs |
| US20070189977A1 (en) | 2004-06-07 | 2007-08-16 | Jie Zhang | Spray-on formulations and methods for dermal delivery of drugs |
| US8907153B2 (en) | 2004-06-07 | 2014-12-09 | Nuvo Research Inc. | Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same |
| FR2871698B1 (fr) * | 2004-06-17 | 2008-07-04 | Galderma Sa | Composition sous forme de spray comprenant une association d'actifs pharmaceutiques et une phase huileuse |
| WO2006111426A1 (en) | 2005-04-19 | 2006-10-26 | Galderma S.A. | Composition of film-forming solution type, comprising vitamin d or a derivative thereof and a corticosteroid, and use thereof in dermatology |
| GB0518769D0 (en) * | 2005-09-14 | 2005-10-19 | Medpharm Ltd | Topical formulations |
| CN101360506A (zh) * | 2005-11-25 | 2009-02-04 | 派普林研究股份有限公司 | 创伤愈合的方法 |
| WO2007070694A2 (en) * | 2005-12-14 | 2007-06-21 | Zars, Inc. | Spray-on formulations and methods for dermal delivery of drugs |
| EP1800671A1 (de) * | 2005-12-23 | 2007-06-27 | Bayer Schering Pharma Aktiengesellschaft | Verwendung filmbildender Haarpflegepolymere und diese Polymere enthaltenden pharmazeutischen Zubereitungen und Pflaster |
| US9393218B2 (en) * | 2005-12-23 | 2016-07-19 | Epinamics Gmbh | Use of film-forming hair care polymers from the group of polyurethanes and pharmaceutical preparations and patches that contain these polymers |
| KR101333100B1 (ko) * | 2005-12-23 | 2013-11-27 | 에피나믹스 게엠베하 | 폴리우레탄 군으로부터의 필름-형성 헤어 케어 폴리머의 용도 및 폴리머를 포함하는 약학적 제제와 패치 |
| US20070280972A1 (en) | 2006-04-25 | 2007-12-06 | Zars, Inc. | Adhesive solid gel-forming formulations for dermal drug delivery |
| EP2859886A1 (en) * | 2010-06-11 | 2015-04-15 | Leo Pharma A/S | A pharmaceutical spray composition |
| EP2444067A1 (en) * | 2010-10-20 | 2012-04-25 | Laboratorios Ojer Pharma S.L. | Anhydrous gel comprising mupirocin |
-
2013
- 2013-07-05 EP EP13737817.0A patent/EP2900211A1/en not_active Withdrawn
- 2013-07-05 IN IN11232DEN2014 patent/IN2014DN11232A/en unknown
- 2013-07-05 KR KR1020157003082A patent/KR20150028840A/ko not_active Withdrawn
- 2013-07-05 RU RU2015103911A patent/RU2015103911A/ru unknown
- 2013-07-05 WO PCT/EP2013/064300 patent/WO2014006201A1/en not_active Ceased
- 2013-07-05 NZ NZ703574A patent/NZ703574A/en not_active IP Right Cessation
- 2013-07-05 BR BR112015000147A patent/BR112015000147A2/pt not_active IP Right Cessation
- 2013-07-05 US US14/412,978 patent/US9345774B2/en not_active Expired - Fee Related
- 2013-07-05 AU AU2013285409A patent/AU2013285409B2/en not_active Ceased
- 2013-07-05 CN CN201380036067.4A patent/CN104427973A/zh active Pending
- 2013-07-05 CA CA2878102A patent/CA2878102A1/en not_active Abandoned
- 2013-07-05 MX MX2014015657A patent/MX2014015657A/es unknown
- 2013-07-05 KR KR1020157003084A patent/KR20150027831A/ko not_active Withdrawn
- 2013-07-05 CN CN201380040976.5A patent/CN104519869A/zh active Pending
- 2013-07-05 JP JP2015519237A patent/JP2015521995A/ja active Pending
- 2013-07-05 JP JP2015519238A patent/JP2015521996A/ja active Pending
- 2013-07-05 RU RU2015104019A patent/RU2015104019A/ru not_active Application Discontinuation
- 2013-07-05 EP EP13734410.7A patent/EP2900210A1/en not_active Withdrawn
- 2013-07-05 US US14/410,489 patent/US20150196646A1/en not_active Abandoned
- 2013-07-05 HK HK15108822.0A patent/HK1208170A1/xx unknown
- 2013-07-05 HK HK15109553.3A patent/HK1208812A1/xx unknown
- 2013-07-05 WO PCT/EP2013/064301 patent/WO2014006202A1/en not_active Ceased
-
2014
- 2014-12-11 IL IL236179A patent/IL236179A0/en unknown
- 2014-12-17 ZA ZA2014/09276A patent/ZA201409276B/en unknown
-
2016
- 2016-03-29 US US15/084,210 patent/US20160206629A1/en not_active Abandoned
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