JP2015520606A5 - - Google Patents
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- JP2015520606A5 JP2015520606A5 JP2015505034A JP2015505034A JP2015520606A5 JP 2015520606 A5 JP2015520606 A5 JP 2015520606A5 JP 2015505034 A JP2015505034 A JP 2015505034A JP 2015505034 A JP2015505034 A JP 2015505034A JP 2015520606 A5 JP2015520606 A5 JP 2015520606A5
- Authority
- JP
- Japan
- Prior art keywords
- maf
- gene
- breast cancer
- expression level
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102100039189 Transcription factor Maf Human genes 0.000 claims 39
- 108090000623 proteins and genes Proteins 0.000 claims 23
- 238000000034 method Methods 0.000 claims 21
- 230000014509 gene expression Effects 0.000 claims 19
- 210000000988 bone and bone Anatomy 0.000 claims 18
- 206010027476 Metastases Diseases 0.000 claims 15
- 230000009401 metastasis Effects 0.000 claims 15
- 206010006187 Breast cancer Diseases 0.000 claims 12
- 208000026310 Breast neoplasm Diseases 0.000 claims 12
- 238000000338 in vitro Methods 0.000 claims 10
- 239000003112 inhibitor Substances 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 102000014128 RANK Ligand Human genes 0.000 claims 5
- 108010025832 RANK Ligand Proteins 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 201000007281 estrogen-receptor positive breast cancer Diseases 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 238000011282 treatment Methods 0.000 claims 5
- 230000003321 amplification Effects 0.000 claims 4
- 238000003199 nucleic acid amplification method Methods 0.000 claims 4
- 230000015556 catabolic process Effects 0.000 claims 3
- 238000006731 degradation reaction Methods 0.000 claims 3
- 208000026535 luminal A breast carcinoma Diseases 0.000 claims 3
- 208000026534 luminal B breast carcinoma Diseases 0.000 claims 3
- 230000005945 translocation Effects 0.000 claims 3
- 229940122361 Bisphosphonate Drugs 0.000 claims 2
- 102000055006 Calcitonin Human genes 0.000 claims 2
- 108060001064 Calcitonin Proteins 0.000 claims 2
- 229940097000 DKK-1 inhibitor Drugs 0.000 claims 2
- 101001135738 Homo sapiens Parathyroid hormone-related protein Proteins 0.000 claims 2
- 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 claims 2
- 206010027452 Metastases to bone Diseases 0.000 claims 2
- 108090000445 Parathyroid hormone Proteins 0.000 claims 2
- 102100036899 Parathyroid hormone-related protein Human genes 0.000 claims 2
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 2
- QHLITPHIARVDJI-UHFFFAOYSA-N [1-[4-(2-naphthalenyl)-2-pyrimidinyl]-4-piperidinyl]methanamine Chemical compound C1CC(CN)CCN1C1=NC=CC(C=2C=C3C=CC=CC3=CC=2)=N1 QHLITPHIARVDJI-UHFFFAOYSA-N 0.000 claims 2
- 150000004663 bisphosphonates Chemical class 0.000 claims 2
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 claims 2
- 229960004015 calcitonin Drugs 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000002834 estrogen receptor modulator Substances 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- HCWPIIXVSYCSAN-OIOBTWANSA-N radium-223 Chemical compound [223Ra] HCWPIIXVSYCSAN-OIOBTWANSA-N 0.000 claims 2
- 229960005562 radium-223 Drugs 0.000 claims 2
- XXUZFRDUEGQHOV-UHFFFAOYSA-J strontium ranelate Chemical compound [Sr+2].[Sr+2].[O-]C(=O)CN(CC([O-])=O)C=1SC(C([O-])=O)=C(CC([O-])=O)C=1C#N XXUZFRDUEGQHOV-UHFFFAOYSA-J 0.000 claims 2
- 229940079488 strontium ranelate Drugs 0.000 claims 2
- 108090000994 Catalytic RNA Proteins 0.000 claims 1
- 102000053642 Catalytic RNA Human genes 0.000 claims 1
- 102000004171 Cathepsin K Human genes 0.000 claims 1
- 108090000625 Cathepsin K Proteins 0.000 claims 1
- 229940122156 Cathepsin K inhibitor Drugs 0.000 claims 1
- 230000004544 DNA amplification Effects 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 208000003076 Osteolysis Diseases 0.000 claims 1
- 102000008108 Osteoprotegerin Human genes 0.000 claims 1
- 108010035042 Osteoprotegerin Proteins 0.000 claims 1
- 208000020584 Polyploidy Diseases 0.000 claims 1
- 102000001332 SRC Human genes 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 239000000074 antisense oligonucleotide Substances 0.000 claims 1
- 238000012230 antisense oligonucleotides Methods 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229940111134 coxibs Drugs 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000009977 dual effect Effects 0.000 claims 1
- 229940125436 dual inhibitor Drugs 0.000 claims 1
- 238000011337 individualized treatment Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229940043355 kinase inhibitor Drugs 0.000 claims 1
- 208000029791 lytic metastatic bone lesion Diseases 0.000 claims 1
- 229940124302 mTOR inhibitor Drugs 0.000 claims 1
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 claims 1
- XXUPLYBCNPLTIW-UHFFFAOYSA-N octadec-7-ynoic acid Chemical compound CCCCCCCCCCC#CCCCCCC(O)=O XXUPLYBCNPLTIW-UHFFFAOYSA-N 0.000 claims 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 238000011002 quantification Methods 0.000 claims 1
- 108091092562 ribozyme Proteins 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 108010087686 src-Family Kinases Proteins 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000011269 treatment regimen Methods 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261621949P | 2012-04-09 | 2012-04-09 | |
| EP12382139.9A EP2650682A1 (en) | 2012-04-09 | 2012-04-09 | Method for the prognosis and treatment of cancer metastasis |
| EP12382139.9 | 2012-04-09 | ||
| US61/621,949 | 2012-04-09 | ||
| US201261724807P | 2012-11-09 | 2012-11-09 | |
| US61/724,807 | 2012-11-09 | ||
| US201261732175P | 2012-11-30 | 2012-11-30 | |
| US61/732,175 | 2012-11-30 | ||
| PCT/IB2013/001204 WO2013153458A2 (en) | 2012-04-09 | 2013-03-15 | Method for the prognosis and treatment of cancer metastasis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018059907A Division JP6781184B2 (ja) | 2012-04-09 | 2018-03-27 | がん転移の予後診断および処置のための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015520606A JP2015520606A (ja) | 2015-07-23 |
| JP2015520606A5 true JP2015520606A5 (https=) | 2016-05-12 |
| JP6381519B2 JP6381519B2 (ja) | 2018-08-29 |
Family
ID=45929479
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015505034A Active JP6381519B2 (ja) | 2012-04-09 | 2013-03-15 | がん転移の予後診断および処置のための方法 |
| JP2018059907A Active JP6781184B2 (ja) | 2012-04-09 | 2018-03-27 | がん転移の予後診断および処置のための方法 |
| JP2020174192A Withdrawn JP2021007408A (ja) | 2012-04-09 | 2020-10-15 | がん転移の予後診断および処置のための方法 |
| JP2022099476A Pending JP2022125079A (ja) | 2012-04-09 | 2022-06-21 | がん転移の予後診断および処置のための方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018059907A Active JP6781184B2 (ja) | 2012-04-09 | 2018-03-27 | がん転移の予後診断および処置のための方法 |
| JP2020174192A Withdrawn JP2021007408A (ja) | 2012-04-09 | 2020-10-15 | がん転移の予後診断および処置のための方法 |
| JP2022099476A Pending JP2022125079A (ja) | 2012-04-09 | 2022-06-21 | がん転移の予後診断および処置のための方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9702878B2 (https=) |
| EP (3) | EP2650682A1 (https=) |
| JP (4) | JP6381519B2 (https=) |
| KR (2) | KR102442275B1 (https=) |
| CN (1) | CN104797935B (https=) |
| AU (1) | AU2013246618B9 (https=) |
| BR (1) | BR112014025269B1 (https=) |
| CA (1) | CA2891609C (https=) |
| DK (2) | DK3825692T3 (https=) |
| ES (2) | ES2995194T3 (https=) |
| FI (1) | FI3825692T3 (https=) |
| MX (1) | MX374827B (https=) |
| WO (1) | WO2013153458A2 (https=) |
Families Citing this family (36)
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| CN108192972B (zh) | 2010-10-06 | 2022-09-09 | 生物医学研究机构基金会 | 用于乳腺癌转移的诊断、预后和治疗的方法 |
| EP2650682A1 (en) | 2012-04-09 | 2013-10-16 | Fundació Privada Institut de Recerca Biomèdica | Method for the prognosis and treatment of cancer metastasis |
| BR112014030750A2 (pt) | 2012-06-06 | 2017-08-22 | Inst Catalana Recerca Estudis Avancats | Método para diagnóstico, prognóstico e tratamento da metástase do câncer pulmonar |
| ES2906586T3 (es) * | 2012-10-12 | 2022-04-19 | Inbiomotion Sl | Método para el diagnóstico, pronóstico y tratamiento de metástasis de cáncer de próstata |
| US10119171B2 (en) | 2012-10-12 | 2018-11-06 | Inbiomotion S.L. | Method for the diagnosis, prognosis and treatment of prostate cancer metastasis |
| CA2906394A1 (en) * | 2013-03-15 | 2014-09-18 | Fundacio Institut De Recerca Biomedica (Irb Barcelona) | Method for the prognosis and treatment of cancer metastasis |
| US20160040247A1 (en) | 2013-03-15 | 2016-02-11 | Fundació Institut De Recerca Biomèdica (Irb Barcelona) | Method for the diagnosis, prognosis, and tratment of cancer metastasis |
| WO2014184679A2 (en) * | 2013-03-15 | 2014-11-20 | Inbiomotion S.L. | Method for the prognosis and treatment of renal cell carcinoma metastasis |
| DK3055429T3 (en) * | 2013-10-09 | 2019-04-23 | Fundacio Inst De Recerca Biomedica Irb Barcelona | Procedure for the prognosis and treatment of metastatic bone cancer resulting from breast cancer |
| KR20170093182A (ko) * | 2014-12-11 | 2017-08-14 | 인바이오모션 에스.엘. | 인간 c-maf에 대한 결합 구성원 |
| WO2016145294A1 (en) * | 2015-03-12 | 2016-09-15 | The University Of Chicago | Methods for determining prognosis for breast cancer patients |
| ES2883249T3 (es) * | 2015-03-17 | 2021-12-07 | Mayo Found Medical Education & Res | Métodos y materiales para evaluar y tratar el cáncer |
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| CN105907886A (zh) * | 2016-07-07 | 2016-08-31 | 蔡维泺 | miR-124在乳腺癌骨转移疾病中的应用 |
| JP7108631B2 (ja) | 2017-01-06 | 2022-07-28 | パルヴェラ セラピューティクス、インク． | ｍＴＯＲ阻害剤の無水組成物およびその使用方法 |
| CN108796071A (zh) * | 2017-04-26 | 2018-11-13 | 中国科学院上海生命科学研究院 | 转移性乳腺癌标记物及其在诊断和治疗中的应用 |
| KR20200104298A (ko) | 2017-11-22 | 2020-09-03 | 인바이오모션 에스.엘. | c-MAF 상태에 기반한 유방암의 요법 치료 |
| JP6826737B2 (ja) * | 2018-01-19 | 2021-02-10 | Ｄｅｌｔａ−Ｆｌｙ Ｐｈａｒｍａ株式会社 | がん患者の治療に有用な尿のアルカリ剤 |
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| CN110656171B (zh) * | 2018-06-28 | 2023-05-05 | 润安医学科技(苏州)有限公司 | 小核仁核糖核酸snord33作为生物标记物用于制备检测试剂盒中的用途 |
| US11000513B2 (en) | 2018-07-02 | 2021-05-11 | Palvella Therapeutics, Inc. | Anhydrous compositions of mTOR inhibitors and methods of use |
| WO2020102513A1 (en) * | 2018-11-14 | 2020-05-22 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Systems and methods for characterizing and treating cancer |
| WO2021062261A1 (en) * | 2019-09-25 | 2021-04-01 | The Trustees Of Columbia University In The City Of New York | Prognostic markers of metastatic cancer |
| CN112662763A (zh) * | 2020-03-10 | 2021-04-16 | 博尔诚（北京）科技有限公司 | 一种检测常见两性癌症的探针组合物 |
| CN112662764A (zh) * | 2020-03-17 | 2021-04-16 | 博尔诚（北京）科技有限公司 | 一种检测11种癌症的探针组合物 |
| JP7607330B2 (ja) * | 2021-04-30 | 2024-12-27 | 国立大学法人金沢大学 | 骨腫瘍の予後診断方法又は予後診断補助方法 |
| JP2024522808A (ja) * | 2021-06-21 | 2024-06-21 | パルヴェラ セラピューティクス、インク． | ゴーリン症候群を治療するための方法および組成物 |
| IT202200001817A1 (it) | 2022-02-02 | 2023-08-02 | Aizoon S R L | Procedimento per la prognosi di una malattia in seguito ad un trattamento terapeutico, relativo sistema e prodotto informatico |
| AU2023220082A1 (en) * | 2022-02-18 | 2024-10-03 | Vuja De Sciences, Inc. | Methods, compositions, and combinations for preventing or treating cancer recurrence |
| IT202200005861A1 (it) | 2022-03-24 | 2023-09-24 | Aizoon S R L | Procedimento per stimare una variabile di interesse associata ad una data malattia in funzione di una pluralità di diversi dati omici, relativo dispositivo e prodotto informatico |
| CA3207405A1 (en) | 2022-07-25 | 2024-01-25 | Aizoon S.r.l. | Method for providing a clinical decision support, corresponding system for providing a clinical decision support, and computer program product |
| CN115919464B (zh) * | 2023-03-02 | 2023-06-23 | 四川爱麓智能科技有限公司 | 肿瘤定位方法、系统、装置及肿瘤发展预测方法 |
| CN119614707A (zh) * | 2025-01-13 | 2025-03-14 | 中山大学 | ERα生物标志物在ER+乳腺癌骨转移诊断、治疗和预后中的应用 |
| CN119662833B (zh) * | 2025-01-22 | 2025-08-15 | 中山大学孙逸仙纪念医院 | 基于肿瘤小泡中circCCDC50的Luminal型乳腺癌骨转移标记物、预测诊断试剂盒 |
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| CN101796072B (zh) | 2007-05-24 | 2014-09-24 | 埃博灵克斯股份有限公司 | 用于治疗骨疾病和病症的针对rank-l的氨基酸序列以及包括其的多肽 |
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| US20110123617A1 (en) | 2007-10-18 | 2011-05-26 | University Health Network | Clioquinol for the treatment of hematological malignancies |
| WO2009114534A1 (en) | 2008-03-14 | 2009-09-17 | The Regents Of The University Of California | Multi-gene classifiers and prognostic indicators for cancers |
| CA2726537A1 (en) | 2008-06-06 | 2009-12-10 | University Health Network | 8-hydroxyquinoline derivatives for the treatment of hematological malignancies |
| ES2338843B1 (es) | 2008-07-02 | 2011-01-24 | Centro De Investigaciones Energeticas, Medioambientales Y Tecnologicas | Huella genomica de cancer de mama. |
| US8642270B2 (en) | 2009-02-09 | 2014-02-04 | Vm Institute Of Research | Prognostic biomarkers to predict overall survival and metastatic disease in patients with triple negative breast cancer |
| EP2435071A1 (en) | 2009-05-29 | 2012-04-04 | F. Hoffmann-La Roche AG | Modulators for her2 signaling in her2 expressing patients with gastric cancer |
| ES2546410T3 (es) | 2009-08-06 | 2015-09-23 | John Wayne Cancer Institute | Diagnosis de cáncer de mama, y otros tipos de cáncer, de tipo basal primario y metastásico |
| CN108192972B (zh) | 2010-10-06 | 2022-09-09 | 生物医学研究机构基金会 | 用于乳腺癌转移的诊断、预后和治疗的方法 |
| CA2826657A1 (en) | 2011-02-04 | 2012-08-09 | Bioarray Therapeutics, Inc. | Methods of using gene expression signatures to select a method of treatment, predict prognosis, survival, and/or predict response to treatment |
| AU2012229123B2 (en) | 2011-03-15 | 2017-02-02 | British Columbia Cancer Agency Branch | Methods of treating breast cancer with anthracycline therapy |
| AU2012340186A1 (en) | 2011-11-18 | 2014-06-19 | Vanderbilt University | Markers of triple-negative breast cancer and uses thereof |
| EP2650682A1 (en) | 2012-04-09 | 2013-10-16 | Fundació Privada Institut de Recerca Biomèdica | Method for the prognosis and treatment of cancer metastasis |
| BR112014030750A2 (pt) | 2012-06-06 | 2017-08-22 | Inst Catalana Recerca Estudis Avancats | Método para diagnóstico, prognóstico e tratamento da metástase do câncer pulmonar |
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| WO2014184679A2 (en) | 2013-03-15 | 2014-11-20 | Inbiomotion S.L. | Method for the prognosis and treatment of renal cell carcinoma metastasis |
| US20160040247A1 (en) | 2013-03-15 | 2016-02-11 | Fundació Institut De Recerca Biomèdica (Irb Barcelona) | Method for the diagnosis, prognosis, and tratment of cancer metastasis |
| CA2906394A1 (en) | 2013-03-15 | 2014-09-18 | Fundacio Institut De Recerca Biomedica (Irb Barcelona) | Method for the prognosis and treatment of cancer metastasis |
| DK3055429T3 (en) | 2013-10-09 | 2019-04-23 | Fundacio Inst De Recerca Biomedica Irb Barcelona | Procedure for the prognosis and treatment of metastatic bone cancer resulting from breast cancer |
| KR20170093182A (ko) | 2014-12-11 | 2017-08-14 | 인바이오모션 에스.엘. | 인간 c-maf에 대한 결합 구성원 |
| US11596642B2 (en) | 2016-05-25 | 2023-03-07 | Inbiomotion S.L. | Therapeutic treatment of breast cancer based on c-MAF status |
| KR20200104298A (ko) | 2017-11-22 | 2020-09-03 | 인바이오모션 에스.엘. | c-MAF 상태에 기반한 유방암의 요법 치료 |
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