JP2015519395A5 - - Google Patents
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- Publication number
- JP2015519395A5 JP2015519395A5 JP2015517245A JP2015517245A JP2015519395A5 JP 2015519395 A5 JP2015519395 A5 JP 2015519395A5 JP 2015517245 A JP2015517245 A JP 2015517245A JP 2015517245 A JP2015517245 A JP 2015517245A JP 2015519395 A5 JP2015519395 A5 JP 2015519395A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- acid
- matrix
- compound
- forming compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 16
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 claims description 8
- 239000000227 bioadhesive Substances 0.000 claims description 7
- 239000011159 matrix material Substances 0.000 claims description 6
- 208000019802 Sexually transmitted disease Diseases 0.000 claims description 5
- 239000003433 contraceptive agent Substances 0.000 claims description 5
- 230000002254 contraceptive effect Effects 0.000 claims description 5
- 239000003937 drug carrier Substances 0.000 claims description 3
- 239000000783 alginic acid Substances 0.000 claims 4
- 235000010443 alginic acid Nutrition 0.000 claims 4
- 229920000615 alginic acid Polymers 0.000 claims 4
- 229960001126 alginic acid Drugs 0.000 claims 4
- 150000004781 alginic acids Chemical class 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 244000005700 microbiome Species 0.000 claims 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- 229920001661 Chitosan Polymers 0.000 claims 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 2
- 229960001484 edetic acid Drugs 0.000 claims 2
- 239000000230 xanthan gum Substances 0.000 claims 2
- 229920001285 xanthan gum Polymers 0.000 claims 2
- 235000010493 xanthan gum Nutrition 0.000 claims 2
- 229940082509 xanthan gum Drugs 0.000 claims 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 1
- 208000004926 Bacterial Vaginosis Diseases 0.000 claims 1
- 239000005711 Benzoic acid Substances 0.000 claims 1
- 241000606161 Chlamydia Species 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- 229920002148 Gellan gum Polymers 0.000 claims 1
- 206010018612 Gonorrhoea Diseases 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 239000005642 Oleic acid Substances 0.000 claims 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 1
- 229920000148 Polycarbophil calcium Polymers 0.000 claims 1
- 229920002125 Sokalan® Polymers 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 1
- 208000005448 Trichomonas Infections Diseases 0.000 claims 1
- 206010044620 Trichomoniasis Diseases 0.000 claims 1
- 208000037009 Vaginitis bacterial Diseases 0.000 claims 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 235000010233 benzoic acid Nutrition 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 235000015165 citric acid Nutrition 0.000 claims 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims 1
- 239000001530 fumaric acid Substances 0.000 claims 1
- 235000011087 fumaric acid Nutrition 0.000 claims 1
- 230000000855 fungicidal effect Effects 0.000 claims 1
- 239000000417 fungicide Substances 0.000 claims 1
- 239000000216 gellan gum Substances 0.000 claims 1
- 235000010492 gellan gum Nutrition 0.000 claims 1
- 208000001786 gonorrhea Diseases 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 229940071676 hydroxypropylcellulose Drugs 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 1
- 239000001630 malic acid Substances 0.000 claims 1
- 235000011090 malic acid Nutrition 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 1
- 235000021313 oleic acid Nutrition 0.000 claims 1
- 229920001983 poloxamer Polymers 0.000 claims 1
- 229960000502 poloxamer Drugs 0.000 claims 1
- 229950005134 polycarbophil Drugs 0.000 claims 1
- AVTYONGGKAJVTE-OLXYHTOASA-L potassium L-tartrate Chemical compound [K+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O AVTYONGGKAJVTE-OLXYHTOASA-L 0.000 claims 1
- 239000001472 potassium tartrate Substances 0.000 claims 1
- 229940111695 potassium tartrate Drugs 0.000 claims 1
- 235000011005 potassium tartrates Nutrition 0.000 claims 1
- 210000000582 semen Anatomy 0.000 claims 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 1
- 239000004334 sorbic acid Substances 0.000 claims 1
- 235000010199 sorbic acid Nutrition 0.000 claims 1
- 229940075582 sorbic acid Drugs 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
- 235000002906 tartaric acid Nutrition 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 6
- 235000014655 lactic acid Nutrition 0.000 description 3
- 239000004310 lactic acid Substances 0.000 description 3
- SGOIRFVFHAKUTI-UHFFFAOYSA-N 1-(6-aminopurin-9-yl)propan-2-yloxymethylphosphonic acid Chemical compound N1=CN=C2N(CC(C)OCP(O)(O)=O)C=NC2=C1N SGOIRFVFHAKUTI-UHFFFAOYSA-N 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
- 230000003139 buffering effect Effects 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261659368P | 2012-06-13 | 2012-06-13 | |
| US61/659,368 | 2012-06-13 | ||
| PCT/US2013/032510 WO2013187984A1 (en) | 2012-06-13 | 2013-03-15 | Compositions and methods for enhancing the efficacy of contraceptive microbicides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018026423A Division JP6738573B2 (ja) | 2012-06-13 | 2018-02-16 | 避妊殺菌剤の効果を増強するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015519395A JP2015519395A (ja) | 2015-07-09 |
| JP2015519395A5 true JP2015519395A5 (enExample) | 2016-05-12 |
| JP6352907B2 JP6352907B2 (ja) | 2018-07-04 |
Family
ID=49758600
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015517245A Active JP6352907B2 (ja) | 2012-06-13 | 2013-03-15 | 避妊殺菌剤の効果を増強するための組成物および方法 |
| JP2018026423A Active JP6738573B2 (ja) | 2012-06-13 | 2018-02-16 | 避妊殺菌剤の効果を増強するための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018026423A Active JP6738573B2 (ja) | 2012-06-13 | 2018-02-16 | 避妊殺菌剤の効果を増強するための組成物および方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (7) | US20150202216A1 (enExample) |
| EP (2) | EP3308771A1 (enExample) |
| JP (2) | JP6352907B2 (enExample) |
| KR (1) | KR102062599B1 (enExample) |
| CN (2) | CN104487054A (enExample) |
| AP (1) | AP2014008149A0 (enExample) |
| AU (2) | AU2013274815B2 (enExample) |
| BR (1) | BR112014030984B1 (enExample) |
| EA (1) | EA201590008A1 (enExample) |
| HK (1) | HK1208809A1 (enExample) |
| IL (1) | IL235812B (enExample) |
| MX (2) | MX365905B (enExample) |
| NZ (1) | NZ703203A (enExample) |
| SG (1) | SG11201408243VA (enExample) |
| UA (1) | UA115876C2 (enExample) |
| WO (1) | WO2013187984A1 (enExample) |
| ZA (1) | ZA201500111B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6352907B2 (ja) * | 2012-06-13 | 2018-07-04 | イボフェム， インコーポレイテッド | 避妊殺菌剤の効果を増強するための組成物および方法 |
| RU2691950C1 (ru) * | 2013-12-19 | 2019-06-19 | Ивофем, Инк. | Композиции и способы ингибирования воспаления и заболеваний с применением антимикробного соединения на основе альгиновой кислоты |
| EP3522879A4 (en) * | 2016-10-04 | 2020-06-03 | Evofem, Inc. | Method of treatment and prevention of bacterial vaginosis |
| USD920853S1 (en) * | 2018-09-14 | 2021-06-01 | Porsche Lizenz—und Handelsgesellschaft mbH & Co. KG | Bicycle |
| US11850303B2 (en) | 2020-10-27 | 2023-12-26 | Uqora, Inc. | Gel and a suppository and methods to provide the gel and suppository |
| IL313241A (en) * | 2021-12-02 | 2024-07-01 | Communitreat Ltd | Composition of sterilants, kits, and methods of using them |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
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| IT1213323B (it) * | 1986-08-07 | 1989-12-20 | Crinos Industria Farmaco | Composizione per uso locale ad atti vita' spermicida virulicida ,disinfettante e/o battericida |
| US4999342A (en) | 1988-08-16 | 1991-03-12 | Ortho Pharmaceutical Corporation | Long lasting contraceptive suppository composition and methods of use |
| JP3202365B2 (ja) | 1992-12-04 | 2001-08-27 | 株式会社紀文フードケミファ | オリゴマンヌロン酸を重合度によって分離する方法 |
| US5592949A (en) | 1994-06-29 | 1997-01-14 | Moench; Thomas R. | Device for acidic buffering and method for inactivation of pathogens |
| US5667492A (en) * | 1994-10-07 | 1997-09-16 | Columbia Laboratories, Inc. | Use and composition of an anti-sexually transmitted diseases formulation |
| FR2728464B1 (fr) | 1994-12-22 | 1997-04-30 | Innothera Lab Sa | Forme galenique unitaire, son procede d'obtention et ses utilisations |
| US6093394A (en) | 1997-04-11 | 2000-07-25 | Gynelogix, Inc. | Vaginal lactobacillus medicant |
| WO2001038284A1 (en) | 1999-11-24 | 2001-05-31 | Cargill Dow Llc | Improved lactic acid processing; methods; arrangements; and, products |
| AU2001243431B2 (en) * | 2000-03-07 | 2006-05-25 | Rush University Medical Center | Compositions and methods for trapping and inactivating pathogenic microbes and spermatozoa |
| JP2009102407A (ja) | 2001-03-08 | 2009-05-14 | Rohto Pharmaceut Co Ltd | Ｇリッチなアルギン酸含有組成物 |
| US20020177624A1 (en) | 2001-03-16 | 2002-11-28 | Calvin Hanna | Acetate-lactate buffering vaginal gel and for method of making same and treating bacterial vaginosis |
| ITMI20010913A1 (it) | 2001-05-04 | 2002-11-04 | Univ Pavia | Composizioni a rilascio controllato di acido lattico a livello vaginale |
| JP2004537525A (ja) | 2001-06-11 | 2004-12-16 | メルク エンド カムパニー インコーポレーテッド | ＰＰＡＲδアゴニストの投与による炎症性疾患の治療法 |
| US20060105008A1 (en) | 2002-03-28 | 2006-05-18 | Nawaz Ahmad | Compositions and methods for reducing vaginal pH |
| US20130150810A1 (en) | 2002-04-30 | 2013-06-13 | The Population Council, Inc. | Intravaginal ring for the delivery of unique combinations of antimicrobial compositions |
| JP4712380B2 (ja) | 2002-07-26 | 2011-06-29 | 三笠製薬株式会社 | 外用剤 |
| US7820145B2 (en) | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
| EP1635847B1 (en) | 2003-06-13 | 2019-07-31 | IDH Holding ApS | Treatment of symptoms associated with bacterial vaginosis |
| US20050272700A1 (en) | 2004-05-10 | 2005-12-08 | Servet Buyuktimkin | Topical treatment and prevention of human papilloma virus (HPV) infection |
| RU2257197C1 (ru) | 2004-05-12 | 2005-07-27 | Дулькис Мария Дмитриевна | Вагинальные суппозитории, обладающие контрацептивным действием |
| UA93354C2 (ru) * | 2004-07-09 | 2011-02-10 | Гилиад Сайенсиз, Инк. | Местный противовирусный препарат |
| US20100069323A1 (en) | 2006-11-10 | 2010-03-18 | Rohto Pharmaceutical Co., Ltd. | Composition for application to skin or mucosa |
| US7659259B2 (en) | 2006-12-21 | 2010-02-09 | Bausch & Lomb Incorporated | Method of treating inflammation of the eye |
| BRPI0809330B8 (pt) | 2007-03-30 | 2021-05-25 | Laccure Ab | uso de um ou mais oligômeros de ácido láctico, e, composição farmacêutica |
| AU2008256689A1 (en) * | 2007-05-24 | 2008-12-04 | New York Blood Center Inc. | Rapidly dispersible vaginal tablet that provides a bioadhesive gel |
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| CN101559036B (zh) * | 2008-04-18 | 2012-02-08 | 上海医药工业研究院 | 一种阴道用避孕凝胶组合物及其制备方法和应用 |
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| EP2130531A1 (en) | 2008-06-04 | 2009-12-09 | Rolf Kullgren AB | Vaginal suppository comprising lactic acid |
| BRPI0803568B8 (pt) * | 2008-08-14 | 2021-05-25 | Biolab San Us Farm Ltda | composição mucoaderente |
| US20120070476A1 (en) | 2009-05-29 | 2012-03-22 | Moench Thomas R | Compositions and Methods for Inactivation of Pathogens at Genital Tract Surfaces |
| EP2440560A1 (en) | 2009-06-10 | 2012-04-18 | Ultimorphix Technologies B.v. | The succinate of tenofovir disoproxil |
| EP2704694A4 (en) | 2011-05-02 | 2014-11-19 | Aptalis Pharmatech Inc | RAPID DISSOLUTION TABLET COMPOSITIONS FOR VAGINAL DELIVERY |
| AU2012275292B2 (en) | 2011-06-28 | 2015-11-12 | Chemo Research, S.L. | High dosage mucoadhesive metronidazole aqueous-based gel formulations their use to treat bacterial vaginosis |
| EP2827854A1 (en) | 2012-03-19 | 2015-01-28 | Dr. August Wolff GmbH & Co. KG Arzneimittel | Use of amphoteric surfactants for the prevention and treatment of pathogenic vaginal biofilms in vaginal infections |
| JP6352907B2 (ja) | 2012-06-13 | 2018-07-04 | イボフェム， インコーポレイテッド | 避妊殺菌剤の効果を増強するための組成物および方法 |
| US20150246065A1 (en) | 2012-09-14 | 2015-09-03 | Cipla Limited | Topical Pharmaceutical Composition |
| WO2015027071A1 (en) | 2013-08-21 | 2015-02-26 | Georgia Regents Research Institute, Inc. | Gpr81 agonists and methods thereof for promoting production of secretory iga |
| WO2015070072A1 (en) | 2013-11-07 | 2015-05-14 | Evofem, Inc. | Methods for manufacturing contraceptive microbicides with antiviral properties |
| RU2691950C1 (ru) | 2013-12-19 | 2019-06-19 | Ивофем, Инк. | Композиции и способы ингибирования воспаления и заболеваний с применением антимикробного соединения на основе альгиновой кислоты |
| US9801839B2 (en) | 2014-02-28 | 2017-10-31 | Macfarlane Burnet Institute For Medical Research And Public Health Pty Ltd | Therapeutic method |
| US20190209502A1 (en) | 2016-09-12 | 2019-07-11 | Evofem, Inc. | Combination gel for sexually transmitted infections |
| EP3522879A4 (en) | 2016-10-04 | 2020-06-03 | Evofem, Inc. | Method of treatment and prevention of bacterial vaginosis |
-
2013
- 2013-03-15 JP JP2015517245A patent/JP6352907B2/ja active Active
- 2013-03-15 SG SG11201408243VA patent/SG11201408243VA/en unknown
- 2013-03-15 AP AP2014008149A patent/AP2014008149A0/xx unknown
- 2013-03-15 EP EP17200193.5A patent/EP3308771A1/en not_active Withdrawn
- 2013-03-15 UA UAA201500194A patent/UA115876C2/uk unknown
- 2013-03-15 US US14/410,841 patent/US20150202216A1/en not_active Abandoned
- 2013-03-15 CN CN201380030151.5A patent/CN104487054A/zh active Pending
- 2013-03-15 HK HK15109540.9A patent/HK1208809A1/xx unknown
- 2013-03-15 MX MX2014015307A patent/MX365905B/es active IP Right Grant
- 2013-03-15 WO PCT/US2013/032510 patent/WO2013187984A1/en not_active Ceased
- 2013-03-15 BR BR112014030984-1A patent/BR112014030984B1/pt not_active IP Right Cessation
- 2013-03-15 EP EP13804259.3A patent/EP2861215A4/en not_active Withdrawn
- 2013-03-15 AU AU2013274815A patent/AU2013274815B2/en not_active Ceased
- 2013-03-15 NZ NZ703203A patent/NZ703203A/en not_active IP Right Cessation
- 2013-03-15 CN CN201910881646.8A patent/CN110693812A/zh active Pending
- 2013-03-15 KR KR1020157000465A patent/KR102062599B1/ko active Active
- 2013-03-15 EA EA201590008A patent/EA201590008A1/ru unknown
-
2014
- 2014-11-20 IL IL235812A patent/IL235812B/en active IP Right Grant
- 2014-12-11 MX MX2019007176A patent/MX2019007176A/es unknown
-
2015
- 2015-01-08 ZA ZA2015/00111A patent/ZA201500111B/en unknown
- 2015-09-24 US US14/864,673 patent/US9566232B2/en not_active Expired - Fee Related
-
2017
- 2017-01-19 US US15/410,632 patent/US20170128396A1/en not_active Abandoned
- 2017-07-19 AU AU2017206199A patent/AU2017206199B2/en not_active Ceased
-
2018
- 2018-02-16 JP JP2018026423A patent/JP6738573B2/ja active Active
-
2019
- 2019-01-03 US US16/239,314 patent/US10568855B2/en active Active
-
2020
- 2020-01-09 US US16/738,868 patent/US11439610B2/en active Active
-
2022
- 2022-08-29 US US17/823,020 patent/US11992472B2/en active Active
-
2024
- 2024-04-24 US US18/645,334 patent/US20240423936A1/en active Pending
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